| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGEAAAKEAAAKEAAAKFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:40)
[INFO] Main: Simulation completed successfully. (00:03:42)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4939 | |
| 2 | S | A | -0.0593 | |
| 3 | R | A | -1.3557 | |
| 4 | P | A | -0.9284 | |
| 5 | G | A | -0.9275 | |
| 6 | L | A | -0.5526 | |
| 7 | P | A | -0.1391 | |
| 8 | V | A | 0.1859 | |
| 9 | E | A | 0.0284 | |
| 10 | Y | A | 0.7383 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.7552 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.4667 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9587 | |
| 17 | S | A | -0.7207 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3182 | |
| 20 | R | A | -1.8860 | |
| 21 | D | A | -2.4437 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.4786 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8557 | |
| 29 | G | A | -1.0682 | |
| 30 | G | A | -1.6164 | |
| 31 | N | A | -2.3896 | |
| 32 | N | A | -2.4400 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0138 | |
| 43 | R | A | -2.4258 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.3085 | |
| 46 | D | A | -2.8464 | |
| 47 | D | A | -1.8248 | |
| 48 | Y | A | -0.2113 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9007 | |
| 54 | N | A | -0.0169 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.0366 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.6319 | |
| 60 | W | A | -0.2737 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.0494 | |
| 63 | Q | A | -1.0701 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.2367 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | -1.5574 | |
| 74 | G | A | -1.0443 | |
| 75 | Q | A | -1.3332 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6696 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9408 | |
| 84 | S | A | 0.0864 | |
| 85 | P | A | -0.1564 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.4530 | |
| 88 | G | A | -1.3911 | |
| 89 | K | A | -1.8880 | |
| 90 | A | A | -0.8310 | |
| 91 | G | A | -0.5266 | |
| 92 | C | A | 0.0854 | |
| 93 | Q | A | -0.5405 | |
| 94 | T | A | -0.4731 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.9052 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5887 | |
| 99 | T | A | -0.5234 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3670 | |
| 103 | S | A | -0.5151 | |
| 104 | E | A | -0.6670 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4578 | |
| 108 | W | A | -0.8601 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.3326 | |
| 111 | A | A | -0.8844 | |
| 112 | N | A | -1.3042 | |
| 113 | R | A | -1.6480 | |
| 114 | A | A | -1.6752 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.3016 | |
| 117 | P | A | -0.9690 | |
| 118 | T | A | -0.7128 | |
| 119 | G | A | -0.4152 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | 0.0999 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2401 | |
| 139 | H | A | -0.4275 | |
| 140 | P | A | -0.9508 | |
| 141 | Q | A | -1.2695 | |
| 142 | Q | A | -0.7275 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.2808 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.0864 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -1.1097 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.4542 | |
| 157 | Q | A | -1.4315 | |
| 158 | G | A | -0.4496 | |
| 159 | M | A | 0.5750 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0779 | |
| 162 | S | A | 0.5235 | |
| 163 | L | A | 0.9861 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | 0.0333 | |
| 166 | L | A | 0.7679 | |
| 167 | A | A | -0.2685 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.2157 | |
| 170 | D | A | -1.8702 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | 0.0000 | |
| 173 | G | A | -1.5236 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.6196 | |
| 176 | A | A | -0.6972 | |
| 177 | A | A | -0.6425 | |
| 178 | D | A | -0.4544 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6129 | |
| 183 | S | A | -0.9698 | |
| 184 | S | A | -0.8946 | |
| 185 | D | A | -1.1270 | |
| 186 | P | A | -1.2876 | |
| 187 | A | A | -0.9578 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -2.7429 | |
| 190 | R | A | -1.6945 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.4976 | |
| 195 | Q | A | -2.0660 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.0819 | |
| 199 | K | A | -1.3629 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2668 | |
| 202 | A | A | -0.9381 | |
| 203 | N | A | -1.4681 | |
| 204 | N | A | -1.8257 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.8230 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.1192 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.7357 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -0.8003 | |
| 216 | P | A | -1.1511 | |
| 217 | N | A | -1.4814 | |
| 218 | E | A | -1.8932 | |
| 219 | L | A | -0.7857 | |
| 220 | G | A | -0.9955 | |
| 221 | G | A | -0.7604 | |
| 222 | A | A | -0.5113 | |
| 223 | N | A | -0.0607 | |
| 224 | I | A | 1.7462 | |
| 225 | P | A | 0.8479 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.3686 | |
| 228 | F | A | 1.8505 | |
| 229 | L | A | 1.2299 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.5814 | |
| 232 | F | A | 0.5280 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5884 | |
| 235 | S | A | -0.5960 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.6160 | |
| 239 | K | A | -1.8678 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.5784 | |
| 242 | D | A | -2.5982 | |
| 243 | A | A | -1.8187 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4305 | |
| 246 | A | A | -1.3388 | |
| 247 | A | A | -0.9969 | |
| 248 | G | A | -1.1368 | |
| 249 | G | A | -1.7746 | |
| 250 | H | A | -1.7060 | |
| 251 | N | A | -1.2919 | |
| 252 | A | A | -0.5853 | |
| 253 | V | A | 0.2412 | |
| 254 | F | A | 0.4792 | |
| 255 | N | A | 0.0881 | |
| 256 | F | A | 0.1213 | |
| 257 | P | A | -0.2731 | |
| 258 | P | A | -0.5954 | |
| 259 | N | A | -0.8961 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.3859 | |
| 263 | S | A | -0.5547 | |
| 264 | W | A | -0.4172 | |
| 265 | E | A | -1.0226 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.4180 | |
| 270 | Q | A | -0.5334 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.8285 | |
| 273 | A | A | -0.5776 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0271 | |
| 276 | G | A | -1.0766 | |
| 277 | D | A | -0.8524 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.1840 | |
| 280 | S | A | -1.0091 | |
| 281 | S | A | -0.5394 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -1.0952 | |
| 284 | A | A | -1.2562 | |
| 285 | G | A | -2.1791 | |
| 286 | E | A | -2.8387 | |
| 287 | A | A | -2.4532 | |
| 288 | A | A | -2.0437 | |
| 289 | A | A | -1.9887 | |
| 290 | K | A | -3.1604 | |
| 291 | E | A | -3.0845 | |
| 292 | A | A | -2.2553 | |
| 293 | A | A | -2.0331 | |
| 294 | A | A | -2.3429 | |
| 295 | K | A | -3.0822 | |
| 296 | E | A | -3.0846 | |
| 297 | A | A | -1.5266 | |
| 298 | A | A | -0.6624 | |
| 299 | A | A | -0.7452 | |
| 300 | K | A | -0.9966 | |
| 301 | F | A | 0.7556 | |
| 302 | A | A | 0.4262 | |
| 303 | V | A | 0.8021 | |
| 304 | T | A | 0.0456 | |
| 305 | N | A | -0.7403 | |
| 306 | D | A | -0.9594 | |
| 307 | G | A | -0.0172 | |
| 308 | V | A | 1.6440 | |
| 309 | I | A | 2.2392 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine