| Chain sequence(s) |
A: GPLPTNPEPPLRSTTEYVEDTDLLYIAQTDLLTRTGHPTKDIVVDGKVAIPQVNAYQWKLFKLTLPDPNKMPLPSDDFIDPSTHKLIWRLRAFKIHVGGPLGKGTYGHKNFNAFGDVTNPTTYQKEGSDDTQNLSFTPKRKQLYIIGDKPPLGKYTTKAAPEPGLPPGALPPLEVKTDILEDGDMADIGFGAKDYKELLPSKNDVPDIILDTKTKVPDFDGMKADPYGDRMFTYDEKESSKDVKKLVRSGPDLVPLPDAGPPSPLYTPPPPTSPYAVLPSQNYFTLPDEGEIKEEDLLFNKPIFLEKTEGLNQGVLWHNQLYILVLDNTRATIEKKETKIATPAENVYDPSYYVTSETYTEQYQISLVVQLCKIPLTPETLEYIRRRDPRILVNWNLPFVPPVERPDPYAGKKFINIDLTNKLSSDLSKYDLGREYLNK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2309 | |
| 2 | P | A | 0.1752 | |
| 3 | L | A | 0.9531 | |
| 4 | P | A | -0.3534 | |
| 5 | T | A | -0.7060 | |
| 6 | N | A | -1.8309 | |
| 7 | P | A | -1.7467 | |
| 8 | E | A | -2.4245 | |
| 9 | P | A | -1.4004 | |
| 10 | P | A | -0.6356 | |
| 11 | L | A | 0.1155 | |
| 12 | R | A | -0.5417 | |
| 13 | S | A | -0.5523 | |
| 14 | T | A | 0.0000 | |
| 15 | T | A | -1.5026 | |
| 16 | E | A | -2.1107 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.4848 | |
| 20 | D | A | -2.8176 | |
| 21 | T | A | -1.9081 | |
| 22 | D | A | -1.9355 | |
| 23 | L | A | -0.6592 | |
| 24 | L | A | -0.0959 | |
| 25 | Y | A | -0.1468 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | Q | A | -0.9014 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.1846 | |
| 31 | L | A | 0.5605 | |
| 32 | L | A | 0.3040 | |
| 33 | T | A | -0.1469 | |
| 34 | R | A | -0.5784 | |
| 35 | T | A | -0.2624 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.9522 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.3696 | |
| 40 | K | A | -1.8177 | |
| 41 | D | A | -0.6512 | |
| 42 | I | A | 1.3133 | |
| 43 | V | A | 2.1823 | |
| 44 | V | A | 1.6673 | |
| 45 | D | A | -0.9981 | |
| 46 | G | A | -0.6560 | |
| 47 | K | A | -0.4039 | |
| 48 | V | A | 1.6451 | |
| 49 | A | A | 1.6297 | |
| 50 | I | A | 1.5738 | |
| 51 | P | A | 0.1088 | |
| 52 | Q | A | -0.9415 | |
| 53 | V | A | 0.0000 | |
| 54 | N | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.0784 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1910 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3996 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.4274 | |
| 70 | K | A | -1.9750 | |
| 71 | M | A | -0.9113 | |
| 72 | P | A | -0.5711 | |
| 73 | L | A | -0.3915 | |
| 74 | P | A | -0.5084 | |
| 75 | S | A | -1.3885 | |
| 76 | D | A | -2.7129 | |
| 77 | D | A | -2.7675 | |
| 78 | F | A | -1.3549 | |
| 79 | I | A | -1.5123 | |
| 80 | D | A | -2.1934 | |
| 81 | P | A | -1.3554 | |
| 82 | S | A | -0.8781 | |
| 83 | T | A | -0.7595 | |
| 84 | H | A | -1.0253 | |
| 85 | K | A | -0.7441 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7499 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.8720 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.7960 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.3391 | |
| 99 | G | A | -0.5195 | |
| 100 | P | A | -0.3226 | |
| 101 | L | A | -0.2954 | |
| 102 | G | A | -0.6240 | |
| 103 | K | A | -1.3577 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3786 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.2135 | |
| 108 | H | A | 0.0000 | |
| 109 | K | A | -3.0519 | |
| 110 | N | A | -2.9593 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.6406 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.5541 | |
| 117 | V | A | -0.6582 | |
| 118 | T | A | -1.2792 | |
| 119 | N | A | -1.6504 | |
| 120 | P | A | -0.9732 | |
| 121 | T | A | -0.6343 | |
| 122 | T | A | -0.6015 | |
| 123 | Y | A | -0.2402 | |
| 124 | Q | A | -1.7048 | |
| 125 | K | A | -2.2042 | |
| 126 | E | A | -2.4544 | |
| 127 | G | A | -2.2505 | |
| 128 | S | A | -1.5951 | |
| 129 | D | A | -2.6176 | |
| 130 | D | A | -2.2219 | |
| 131 | T | A | -2.1941 | |
| 132 | Q | A | -2.6050 | |
| 133 | N | A | -2.7339 | |
| 134 | L | A | -1.4377 | |
| 135 | S | A | -0.8800 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.6167 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | -1.5033 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | K | A | -0.5132 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.3109 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.6210 | |
| 155 | Y | A | 0.0000 | |
| 156 | T | A | -0.3471 | |
| 157 | T | A | 0.0000 | |
| 158 | K | A | -0.7879 | |
| 159 | A | A | -0.5342 | |
| 160 | A | A | -0.7288 | |
| 161 | P | A | -1.1779 | |
| 162 | E | A | -1.9830 | |
| 163 | P | A | -1.2062 | |
| 164 | G | A | -0.7245 | |
| 165 | L | A | 0.0968 | |
| 166 | P | A | -0.0120 | |
| 167 | P | A | -0.2431 | |
| 168 | G | A | 0.3109 | |
| 169 | A | A | 1.1065 | |
| 170 | L | A | 1.8070 | |
| 171 | P | A | 0.3625 | |
| 172 | P | A | 0.0017 | |
| 173 | L | A | 0.6877 | |
| 174 | E | A | 0.0595 | |
| 175 | V | A | 0.7686 | |
| 176 | K | A | -0.6907 | |
| 177 | T | A | -0.6054 | |
| 178 | D | A | -0.8182 | |
| 179 | I | A | -0.4662 | |
| 180 | L | A | 0.0000 | |
| 181 | E | A | -1.2353 | |
| 182 | D | A | -1.0213 | |
| 183 | G | A | -0.7151 | |
| 184 | D | A | -0.8632 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5986 | |
| 190 | F | A | -0.0789 | |
| 191 | G | A | -0.3588 | |
| 192 | A | A | -0.4378 | |
| 193 | K | A | -1.3985 | |
| 194 | D | A | 0.0000 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.1446 | |
| 197 | E | A | -2.3725 | |
| 198 | L | A | -1.1609 | |
| 199 | L | A | -1.3394 | |
| 200 | P | A | -1.3770 | |
| 201 | S | A | -1.1421 | |
| 202 | K | A | -2.1033 | |
| 203 | N | A | -1.7307 | |
| 204 | D | A | -0.9637 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7533 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6774 | |
| 211 | D | A | -2.5766 | |
| 212 | T | A | -1.8450 | |
| 213 | K | A | -1.9072 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.0592 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -1.0514 | |
| 219 | F | A | -1.1792 | |
| 220 | D | A | -2.3674 | |
| 221 | G | A | -1.6921 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.7758 | |
| 224 | A | A | -1.4928 | |
| 225 | D | A | -1.1803 | |
| 226 | P | A | -0.4427 | |
| 227 | Y | A | -0.3776 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6656 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.7675 | |
| 234 | Y | A | -0.3406 | |
| 235 | D | A | -1.0481 | |
| 236 | E | A | -1.5957 | |
| 237 | K | A | -2.0412 | |
| 238 | E | A | -2.1309 | |
| 239 | S | A | -1.7552 | |
| 240 | S | A | -1.9508 | |
| 241 | K | A | -2.6744 | |
| 242 | D | A | -2.3285 | |
| 243 | V | A | -0.3065 | |
| 244 | K | A | -1.5427 | |
| 245 | K | A | -1.6762 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.9231 | |
| 249 | S | A | -1.4675 | |
| 250 | G | A | -1.1124 | |
| 251 | P | A | -0.4118 | |
| 252 | D | A | -0.0177 | |
| 253 | L | A | 2.0690 | |
| 254 | V | A | 2.1278 | |
| 255 | P | A | 0.5442 | |
| 256 | L | A | 0.4123 | |
| 257 | P | A | -0.8596 | |
| 258 | D | A | -1.4869 | |
| 259 | A | A | -0.9555 | |
| 260 | G | A | -0.8664 | |
| 261 | P | A | -0.5832 | |
| 262 | P | A | -0.2541 | |
| 263 | S | A | 0.0382 | |
| 264 | P | A | 0.4563 | |
| 265 | L | A | 1.5273 | |
| 266 | Y | A | 0.8762 | |
| 267 | T | A | 0.1469 | |
| 268 | P | A | -0.0507 | |
| 269 | P | A | 0.0151 | |
| 270 | P | A | -0.3405 | |
| 271 | P | A | -0.2934 | |
| 272 | T | A | -0.2043 | |
| 273 | S | A | 0.2475 | |
| 274 | P | A | 0.3865 | |
| 275 | Y | A | 1.2161 | |
| 276 | A | A | 0.8662 | |
| 277 | V | A | 1.4255 | |
| 278 | L | A | 0.6575 | |
| 279 | P | A | -0.4621 | |
| 280 | S | A | 0.0000 | |
| 281 | Q | A | -1.3771 | |
| 282 | N | A | -0.8457 | |
| 283 | Y | A | 0.2898 | |
| 284 | F | A | -0.2296 | |
| 285 | T | A | -0.9110 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.5489 | |
| 289 | E | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -2.7007 | |
| 292 | I | A | -2.1799 | |
| 293 | K | A | -3.2837 | |
| 294 | E | A | -3.5934 | |
| 295 | E | A | -3.3912 | |
| 296 | D | A | -2.7431 | |
| 297 | L | A | 0.0000 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3053 | |
| 301 | K | A | -1.6811 | |
| 302 | P | A | -0.8914 | |
| 303 | I | A | -0.2075 | |
| 304 | F | A | -0.5754 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5988 | |
| 307 | K | A | -3.0056 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.4166 | |
| 310 | G | A | -1.4741 | |
| 311 | L | A | -0.4716 | |
| 312 | N | A | 0.0000 | |
| 313 | Q | A | -1.1110 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8243 | |
| 319 | N | A | -0.5898 | |
| 320 | Q | A | -0.7720 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | L | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3876 | |
| 331 | A | A | 0.0000 | |
| 332 | T | A | -0.9383 | |
| 333 | I | A | -1.4569 | |
| 334 | E | A | -2.7336 | |
| 335 | K | A | -3.8791 | |
| 336 | K | A | -3.6927 | |
| 337 | E | A | -2.7637 | |
| 338 | T | A | -0.9928 | |
| 339 | K | A | -0.5669 | |
| 340 | I | A | 1.4992 | |
| 341 | A | A | 0.7962 | |
| 342 | T | A | -0.2405 | |
| 343 | P | A | -0.3845 | |
| 344 | A | A | -0.8789 | |
| 345 | E | A | -1.6960 | |
| 346 | N | A | -1.0818 | |
| 347 | V | A | 0.9783 | |
| 348 | Y | A | 1.2664 | |
| 349 | D | A | 0.0010 | |
| 350 | P | A | 0.0928 | |
| 351 | S | A | 0.2322 | |
| 352 | Y | A | 0.5408 | |
| 353 | Y | A | 0.4056 | |
| 354 | V | A | 0.7647 | |
| 355 | T | A | -1.3957 | |
| 356 | S | A | -1.9011 | |
| 357 | E | A | -2.4739 | |
| 358 | T | A | -1.4368 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.5786 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.2746 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.4682 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | V | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.6202 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -1.2225 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7714 | |
| 376 | L | A | -0.5145 | |
| 377 | T | A | -0.8695 | |
| 378 | P | A | -1.4563 | |
| 379 | E | A | -2.5051 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.6507 | |
| 382 | E | A | -2.6995 | |
| 383 | Y | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -2.5085 | |
| 386 | R | A | -1.7011 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.3903 | |
| 390 | R | A | -1.3482 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.0371 | |
| 394 | N | A | -1.8596 | |
| 395 | W | A | -1.2932 | |
| 396 | N | A | -1.3686 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.3903 | |
| 399 | F | A | 1.6958 | |
| 400 | V | A | 0.8181 | |
| 401 | P | A | 0.2544 | |
| 402 | P | A | -0.3643 | |
| 403 | V | A | -0.0198 | |
| 404 | E | A | -2.0511 | |
| 405 | R | A | -2.1849 | |
| 406 | P | A | -1.7731 | |
| 407 | D | A | -2.1809 | |
| 408 | P | A | -1.1851 | |
| 409 | Y | A | -1.0266 | |
| 410 | A | A | -1.1601 | |
| 411 | G | A | -1.3782 | |
| 412 | K | A | -1.8855 | |
| 413 | K | A | -2.3467 | |
| 414 | F | A | -1.2461 | |
| 415 | I | A | -0.8048 | |
| 416 | N | A | -1.7588 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.5125 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5454 | |
| 421 | N | A | -2.0574 | |
| 422 | K | A | -2.1145 | |
| 423 | L | A | -0.7802 | |
| 424 | S | A | -0.8459 | |
| 425 | S | A | -0.5479 | |
| 426 | D | A | -1.3464 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.5851 | |
| 429 | K | A | -2.3363 | |
| 430 | Y | A | -1.6719 | |
| 431 | D | A | -1.8820 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2155 | |
| 435 | E | A | -1.7447 | |
| 436 | Y | A | -0.7555 | |
| 437 | L | A | -0.1406 | |
| 438 | N | A | -1.8006 | |
| 439 | K | A | -2.0071 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine