Project name: cfd962e513f0e8a

Chain sequence(s)	I: MENVLTQSPAIMSASPGEKVTMTCSASSSVSYMHWYQQKSSTSPKLWIYDTSKLASGVPGRFSGSGSGNSYSLTISSMEAEDVATYYCFQGSGYPLTFGAGTKLELKGGGGSGGGGSGGGGSEVQLQQSGAELVRAGSSVKMSCKASGYTFTSYGINWVKQRPGQGLEWIGYINPGNGYTKYNEKFKGKTTLTVDKSSSTAYMQLRSLTSEDSAVYFCARKKSYAMDYWGQGTSVTVS
Selected Chain(s)	I
Distance of aggregation	5 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with I chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:58)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:59)

• Minimal score value: -2.3137
• Maximal score value: 1.8246
• Average score: -0.2412
• Total score value: -57.417

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	I	0.7209
2	E	I	-1.6500
3	N	I	-0.1355
4	V	I	1.7505
5	L	I	0.0000
6	T	I	-0.0709
7	Q	I	0.0000
8	S	I	-0.1706
9	P	I	-0.1531
10	A	I	0.3856
11	I	I	1.8246
12	M	I	0.4663
13	S	I	-0.1854
14	A	I	0.0000
15	S	I	-0.2752
16	P	I	-0.2316
17	G	I	-0.7695
18	E	I	-1.7566
19	K	I	-1.9243
20	V	I	-0.1244
21	T	I	-0.0108
22	M	I	0.0000
23	T	I	-0.0391
24	C	I	0.0000
25	S	I	-0.0976
26	A	I	0.0000
27	S	I	-0.2352
28	S	I	-0.1990
29	S	I	-0.2063
30	V	I	0.1906
31	S	I	0.0892
32	Y	I	0.5442
33	M	I	0.0000
34	H	I	0.0000
35	W	I	0.0000
36	Y	I	0.0000
37	Q	I	0.0000
38	Q	I	0.0000
39	K	I	-1.0074
40	S	I	-0.4282
41	S	I	-0.2565
42	T	I	-0.0751
43	S	I	-0.0373
44	P	I	0.0000
45	K	I	-0.3277
46	L	I	0.0000
47	W	I	0.0000
48	I	I	0.0000
49	Y	I	0.4078
50	D	I	-0.3633
51	T	I	-0.1292
52	S	I	-0.4885
53	K	I	-1.4366
54	L	I	0.3444
55	A	I	0.0000
56	S	I	-0.2971
57	G	I	-0.5279
58	V	I	0.0000
59	P	I	-0.1281
60	G	I	-0.5240
61	R	I	-0.3591
62	F	I	0.0000
63	S	I	-0.1541
64	G	I	0.0000
65	S	I	-0.2528
66	G	I	-0.2952
67	S	I	-0.2759
68	G	I	-0.3463
69	N	I	-0.9403
70	S	I	-0.3792
71	Y	I	0.0000
72	S	I	-0.0464
73	L	I	0.0000
74	T	I	-0.0194
75	I	I	0.0000
76	S	I	-0.3345
77	S	I	-0.2737
78	M	I	0.0000
79	E	I	-0.2060
80	A	I	-0.3503
81	E	I	-1.8141
82	D	I	0.0000
83	V	I	0.6536
84	A	I	0.0000
85	T	I	-0.1381
86	Y	I	0.0000
87	Y	I	0.0000
88	C	I	0.0000
89	F	I	0.0000
90	Q	I	0.0000
91	G	I	0.0000
92	S	I	-0.1465
93	G	I	-0.0966
94	Y	I	0.9516
95	P	I	0.2392
96	L	I	0.0000
97	T	I	-0.0102
98	F	I	0.0000
99	G	I	0.0000
100	A	I	0.0585
101	G	I	0.0000
102	T	I	0.0000
103	K	I	-0.7167
104	L	I	0.0000
105	E	I	-1.2119
106	L	I	0.0000
107	K	I	-1.7934
108	G	I	-0.7795
109	G	I	0.0000
110	G	I	-0.5543
111	G	I	-0.5934
112	S	I	-0.3829
113	G	I	-0.5885
114	G	I	-0.6028
115	G	I	-0.4582
116	G	I	-0.5444
117	S	I	-0.4343
118	G	I	-0.5929
119	G	I	-0.6382
120	G	I	-0.6359
121	G	I	-0.5902
122	S	I	-0.5470
123	E	I	-1.3506
124	V	I	-0.1573
125	Q	I	-0.5798
126	L	I	0.0000
127	Q	I	-0.9001
128	Q	I	-0.2790
129	S	I	-0.2326
130	G	I	-0.4785
131	A	I	-0.2038
132	E	I	-0.6006
133	L	I	1.4156
134	V	I	0.1271
135	R	I	-1.8275
136	A	I	-0.3904
137	G	I	-0.5019
138	S	I	-0.1691
139	S	I	-0.2986
140	V	I	0.0000
141	K	I	-1.7484
142	M	I	0.0000
143	S	I	-0.0186
144	C	I	0.0000
145	K	I	-1.3193
146	A	I	0.0000
147	S	I	-0.2261
148	G	I	-0.4213
149	Y	I	0.1013
150	T	I	-0.0345
151	F	I	0.0000
152	T	I	-0.1145
153	S	I	-0.1775
154	Y	I	-0.0582
155	G	I	0.0000
156	I	I	0.0000
157	N	I	0.0000
158	W	I	0.0000
159	V	I	0.0000
160	K	I	0.0000
161	Q	I	-0.2456
162	R	I	-0.4969
163	P	I	-0.4147
164	G	I	-0.6130
165	Q	I	-0.6481
166	G	I	-0.1770
167	L	I	0.0000
168	E	I	-0.4481
169	W	I	0.0000
170	I	I	0.0000
171	G	I	0.0000
172	Y	I	0.1529
173	I	I	0.0000
174	N	I	-0.4067
175	P	I	0.0000
176	G	I	-0.6117
177	N	I	-1.3984
178	G	I	-0.4071
179	Y	I	0.6989
180	T	I	0.0197
181	K	I	-0.4687
182	Y	I	0.1537
183	N	I	0.0000
184	E	I	-2.3137
185	K	I	-2.0372
186	F	I	0.0000
187	K	I	-1.9747
188	G	I	-0.8440
189	K	I	-0.4961
190	T	I	0.0000
191	T	I	-0.0282
192	L	I	0.0000
193	T	I	0.0329
194	V	I	0.2139
195	D	I	-0.9136
196	K	I	-1.8646
197	S	I	-0.5323
198	S	I	-0.1252
199	S	I	-0.2315
200	T	I	0.0000
201	A	I	0.0000
202	Y	I	0.2668
203	M	I	0.0000
204	Q	I	-0.6117
205	L	I	0.0000
206	R	I	-1.4440
207	S	I	-0.5331
208	L	I	0.0000
209	T	I	-0.0566
210	S	I	-0.5412
211	E	I	-1.8579
212	D	I	0.0000
213	S	I	-0.0501
214	A	I	0.0000
215	V	I	0.4632
216	Y	I	0.0000
217	F	I	0.0000
218	C	I	0.0000
219	A	I	0.0000
220	R	I	0.0000
221	K	I	0.0000
222	K	I	-1.6828
223	S	I	-0.2267
224	Y	I	0.8898
225	A	I	0.0000
226	M	I	0.0000
227	D	I	-0.3279
228	Y	I	0.5053
229	W	I	0.2236
230	G	I	0.0000
231	Q	I	-1.0851
232	G	I	-0.2554
233	T	I	0.0000
234	S	I	-0.0295
235	V	I	0.0000
236	T	I	-0.0585
237	V	I	0.0000
238	S	I	-0.3977