Chain sequence(s) |
C: EVQLVESGGGLVQPGGSLRLSCAASDFTFRSYEMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARLRDGFNKGFDYWGQGTLVTVSS
input PDB |
Selected Chain(s) | C |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Mutated residues | AD23C,SV85C,LK81C,NL77C,ST119C,SC7C |
Energy difference between WT (input) and mutated protein (by FoldX) | 6.39412 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with C chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] FoldX: Building mutant model (00:00:24) [INFO] FoldX: Starting FoldX energy minimalization (00:00:38) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:05) [INFO] Main: Simulation completed successfully. (00:01:05) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | E | C | -2.0063 | |
2 | V | C | -0.9168 | |
3 | Q | C | -1.6551 | |
4 | L | C | 0.0000 | |
5 | V | C | -0.3351 | |
6 | E | C | 0.0000 | |
7 | C | C | -0.2284 | mutated: SC7C |
8 | G | C | -0.6124 | |
9 | G | C | 0.0993 | |
10 | G | C | 0.9130 | |
11 | L | C | 1.4288 | |
12 | V | C | -0.0245 | |
13 | Q | C | -1.0923 | |
14 | P | C | -1.0066 | |
15 | G | C | -0.5493 | |
16 | G | C | -0.3968 | |
17 | S | C | -0.7209 | |
18 | L | C | -0.7607 | |
19 | R | C | -2.0847 | |
20 | L | C | 0.0000 | |
21 | S | C | -0.8061 | |
22 | C | C | 0.0000 | |
23 | D | C | -1.8641 | mutated: AD23C |
24 | A | C | 0.0000 | |
25 | S | C | -0.5288 | |
26 | D | C | 0.0000 | |
27 | F | C | 1.6591 | |
28 | T | C | 0.3524 | |
29 | F | C | 0.0000 | |
30 | R | C | -1.8732 | |
31 | S | C | -0.8784 | |
32 | Y | C | -1.2148 | |
33 | E | C | -1.1446 | |
34 | M | C | 0.0000 | |
35 | S | C | 0.0000 | |
36 | W | C | 0.0000 | |
37 | V | C | 0.0000 | |
38 | R | C | 0.0000 | |
39 | Q | C | -0.2969 | |
40 | A | C | -0.9853 | |
41 | P | C | -1.2938 | |
42 | G | C | -1.4348 | |
43 | K | C | -2.1351 | |
44 | G | C | -1.0592 | |
45 | L | C | 0.3943 | |
46 | E | C | -0.3920 | |
47 | W | C | 0.3381 | |
48 | V | C | 0.0000 | |
49 | S | C | 0.0000 | |
50 | A | C | 0.0000 | |
51 | I | C | 0.0000 | |
52 | S | C | -0.5822 | |
53 | G | C | -1.2341 | |
54 | S | C | -1.2157 | |
55 | G | C | -1.0731 | |
56 | G | C | -0.7345 | |
57 | S | C | -0.3016 | |
58 | T | C | 0.2005 | |
59 | Y | C | 0.6114 | |
60 | Y | C | -0.3563 | |
61 | A | C | -1.1395 | |
62 | D | C | -2.3451 | |
63 | S | C | -1.7170 | |
64 | V | C | 0.0000 | |
65 | K | C | -2.3851 | |
66 | G | C | -1.3914 | |
67 | R | C | 0.0000 | |
68 | F | C | 0.0000 | |
69 | T | C | -0.6633 | |
70 | I | C | 0.0000 | |
71 | S | C | -0.5551 | |
72 | R | C | -1.2124 | |
73 | D | C | -1.7370 | |
74 | N | C | -1.8249 | |
75 | S | C | -1.5287 | |
76 | K | C | -2.2152 | |
77 | L | C | -1.3197 | mutated: NL77C |
78 | T | C | 0.0000 | |
79 | L | C | 0.0000 | |
80 | Y | C | -0.8134 | |
81 | K | C | 0.0000 | mutated: LK81C |
82 | Q | C | -1.2188 | |
83 | M | C | 0.0000 | |
84 | N | C | -0.3712 | |
85 | V | C | 0.6627 | mutated: SV85C |
86 | L | C | 0.0000 | |
87 | R | C | -1.8512 | |
88 | A | C | -1.7863 | |
89 | E | C | -2.2840 | |
90 | D | C | 0.0000 | |
91 | T | C | -0.3871 | |
92 | A | C | 0.0000 | |
93 | I | C | 1.0713 | |
94 | Y | C | 0.0000 | |
95 | Y | C | 0.6206 | |
96 | C | C | 0.0000 | |
97 | A | C | 0.0000 | |
98 | R | C | 0.0000 | |
99 | L | C | 0.0000 | |
100 | R | C | -3.1904 | |
101 | D | C | -3.3330 | |
102 | G | C | -2.0864 | |
103 | F | C | -1.2304 | |
104 | N | C | -2.4286 | |
105 | K | C | -3.1848 | |
106 | G | C | -1.9076 | |
107 | F | C | -0.9859 | |
108 | D | C | -1.0994 | |
109 | Y | C | -0.2104 | |
110 | W | C | 0.5120 | |
111 | G | C | -0.4090 | |
112 | Q | C | -0.9030 | |
113 | G | C | 0.1528 | |
114 | T | C | 0.6825 | |
115 | L | C | 1.8238 | |
116 | V | C | 0.0000 | |
117 | T | C | 0.3574 | |
118 | V | C | 0.0000 | |
119 | T | C | -0.6439 | mutated: ST119C |
120 | S | C | -0.9794 |