| Chain sequence(s) |
A: GPLPFNPEPPLRPTSEYVTPTDLLYVAETDKITFTGHPTKDIVVNGKVVTPKVSAYQWKVFKLTLPDPNKLPLPSEDYIDPSTEILIWRLLAFKIGRFGPLGKGSYGHPNFNKLGDVTNPTAYVHETEDDTVNYSFRPVRRQMYIVGDLPPLGKYITKAKPEPGLPPGAEPPLEVKTTLIEHGDMADIGFGAKDYKELEPSKDDVPDIILDTKTVVPDLEGMLADPYGRRLFDYDEYESSYDSKKLVRDGPELNPIPDEPPPSKLYTPPPASSPYATLPSTDYFTIPDQGEITEADEIFNKPYFFDKAKGLNNYILWHNQLYITIVDNTRAEIATNVTQISTPETNVYDPSNYVTSKTYSEEYQLSLIVQLCKIPLTPEVREELARLDPSILENANLPDIPPVVRPDPYAGKKFIEIDLTNKLSSNLSETELGQEYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2302 | |
| 2 | P | A | 0.5207 | |
| 3 | L | A | 1.5572 | |
| 4 | P | A | 0.8882 | |
| 5 | F | A | 1.2614 | |
| 6 | N | A | -0.8292 | |
| 7 | P | A | -1.2962 | |
| 8 | E | A | -2.1384 | |
| 9 | P | A | -1.8104 | |
| 10 | P | A | -0.8616 | |
| 11 | L | A | -0.3206 | |
| 12 | R | A | -0.8561 | |
| 13 | P | A | -0.6807 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.3888 | |
| 16 | E | A | -2.0313 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6367 | |
| 20 | P | A | -0.7524 | |
| 21 | T | A | -0.9558 | |
| 22 | D | A | -1.6445 | |
| 23 | L | A | -0.5299 | |
| 24 | L | A | -0.2110 | |
| 25 | Y | A | -0.1765 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -2.0130 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7908 | |
| 31 | K | A | -2.6201 | |
| 32 | I | A | -1.0654 | |
| 33 | T | A | -0.5841 | |
| 34 | F | A | -0.0995 | |
| 35 | T | A | -0.1643 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.4172 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4745 | |
| 40 | K | A | -2.0061 | |
| 41 | D | A | -0.7771 | |
| 42 | I | A | 1.2907 | |
| 43 | V | A | 2.3200 | |
| 44 | V | A | 1.7880 | |
| 45 | N | A | -0.4640 | |
| 46 | G | A | -0.2987 | |
| 47 | K | A | -0.0397 | |
| 48 | V | A | 2.0639 | |
| 49 | V | A | 2.6397 | |
| 50 | T | A | 1.0941 | |
| 51 | P | A | -0.0835 | |
| 52 | K | A | -1.0248 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1615 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3182 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.8147 | |
| 70 | K | A | -1.9664 | |
| 71 | L | A | -0.8319 | |
| 72 | P | A | -0.6864 | |
| 73 | L | A | -0.6433 | |
| 74 | P | A | -0.7038 | |
| 75 | S | A | -1.5434 | |
| 76 | E | A | -2.8202 | |
| 77 | D | A | -2.8501 | |
| 78 | Y | A | -1.4725 | |
| 79 | I | A | -1.5555 | |
| 80 | D | A | -2.1080 | |
| 81 | P | A | -1.5393 | |
| 82 | S | A | -1.2848 | |
| 83 | T | A | -0.7768 | |
| 84 | E | A | -1.0382 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.4060 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.8505 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.0025 | |
| 99 | G | A | -0.4612 | |
| 100 | P | A | -0.4340 | |
| 101 | L | A | -0.3541 | |
| 102 | G | A | 0.0000 | |
| 103 | K | A | -1.6063 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.7991 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9177 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.3607 | |
| 110 | N | A | -2.0837 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.4391 | |
| 113 | K | A | -0.9406 | |
| 114 | L | A | -0.9028 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -0.5433 | |
| 117 | V | A | 0.1588 | |
| 118 | T | A | -0.8167 | |
| 119 | N | A | -0.9815 | |
| 120 | P | A | -0.4767 | |
| 121 | T | A | -0.2216 | |
| 122 | A | A | -0.0546 | |
| 123 | Y | A | 0.1746 | |
| 124 | V | A | -0.4548 | |
| 125 | H | A | -1.5762 | |
| 126 | E | A | -3.1002 | |
| 127 | T | A | -2.7377 | |
| 128 | E | A | -3.2236 | |
| 129 | D | A | -3.2471 | |
| 130 | D | A | -2.2237 | |
| 131 | T | A | -1.4824 | |
| 132 | V | A | -0.7250 | |
| 133 | N | A | -1.4425 | |
| 134 | Y | A | -0.6942 | |
| 135 | S | A | -0.5855 | |
| 136 | F | A | 0.0000 | |
| 137 | R | A | -0.8122 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | -0.3374 | |
| 140 | R | A | 0.0000 | |
| 141 | R | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.0958 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.0904 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.4684 | |
| 155 | Y | A | 0.0000 | |
| 156 | I | A | 0.5572 | |
| 157 | T | A | 0.0000 | |
| 158 | K | A | -1.4839 | |
| 159 | A | A | -1.2689 | |
| 160 | K | A | -2.4580 | |
| 161 | P | A | -2.1107 | |
| 162 | E | A | -2.3938 | |
| 163 | P | A | -1.4409 | |
| 164 | G | A | -0.8030 | |
| 165 | L | A | -0.5444 | |
| 166 | P | A | -0.4940 | |
| 167 | P | A | -0.7223 | |
| 168 | G | A | -0.7406 | |
| 169 | A | A | -0.8302 | |
| 170 | E | A | -1.6049 | |
| 171 | P | A | -1.5042 | |
| 172 | P | A | -1.0503 | |
| 173 | L | A | 0.2819 | |
| 174 | E | A | -0.2740 | |
| 175 | V | A | 0.8832 | |
| 176 | K | A | -0.6861 | |
| 177 | T | A | -0.4829 | |
| 178 | T | A | -0.2144 | |
| 179 | L | A | -0.2563 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1317 | |
| 182 | H | A | -1.0457 | |
| 183 | G | A | -0.7087 | |
| 184 | D | A | -0.7501 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2960 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2616 | |
| 190 | F | A | 0.0211 | |
| 191 | G | A | -0.1871 | |
| 192 | A | A | -0.0570 | |
| 193 | K | A | -0.8027 | |
| 194 | D | A | -1.8129 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.6169 | |
| 197 | E | A | -2.5002 | |
| 198 | L | A | -1.3197 | |
| 199 | E | A | -2.0000 | |
| 200 | P | A | -1.8812 | |
| 201 | S | A | -1.6697 | |
| 202 | K | A | -2.9375 | |
| 203 | D | A | -2.0814 | |
| 204 | D | A | -1.3995 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6820 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -2.1597 | |
| 211 | D | A | -3.2125 | |
| 212 | T | A | -1.9383 | |
| 213 | K | A | -1.6105 | |
| 214 | T | A | 0.0000 | |
| 215 | V | A | 0.0000 | |
| 216 | V | A | -0.0620 | |
| 217 | P | A | -0.3093 | |
| 218 | D | A | -0.6373 | |
| 219 | L | A | -0.5524 | |
| 220 | E | A | -1.4882 | |
| 221 | G | A | -0.8897 | |
| 222 | M | A | 0.0000 | |
| 223 | L | A | 0.0635 | |
| 224 | A | A | -0.1513 | |
| 225 | D | A | -0.2879 | |
| 226 | P | A | 0.0185 | |
| 227 | Y | A | 0.3639 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.0416 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.7530 | |
| 234 | Y | A | -0.5216 | |
| 235 | D | A | -0.9093 | |
| 236 | E | A | -1.4053 | |
| 237 | Y | A | -1.0876 | |
| 238 | E | A | -1.5284 | |
| 239 | S | A | -0.6224 | |
| 240 | S | A | -0.3669 | |
| 241 | Y | A | -0.1244 | |
| 242 | D | A | -1.7968 | |
| 243 | S | A | -1.5496 | |
| 244 | K | A | -2.0466 | |
| 245 | K | A | -1.7673 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.8738 | |
| 249 | D | A | -1.8155 | |
| 250 | G | A | -1.3052 | |
| 251 | P | A | -0.6229 | |
| 252 | E | A | -0.5240 | |
| 253 | L | A | 0.2645 | |
| 254 | N | A | -0.7666 | |
| 255 | P | A | -0.6767 | |
| 256 | I | A | 0.2898 | |
| 257 | P | A | -1.0163 | |
| 258 | D | A | -1.8355 | |
| 259 | E | A | -1.7269 | |
| 260 | P | A | -1.3870 | |
| 261 | P | A | -1.0396 | |
| 262 | P | A | -0.8361 | |
| 263 | S | A | -1.1388 | |
| 264 | K | A | -1.1546 | |
| 265 | L | A | 0.5832 | |
| 266 | Y | A | 0.1856 | |
| 267 | T | A | -0.2157 | |
| 268 | P | A | -0.1888 | |
| 269 | P | A | 0.0644 | |
| 270 | P | A | -0.1868 | |
| 271 | A | A | -0.0394 | |
| 272 | S | A | -0.1412 | |
| 273 | S | A | 0.1297 | |
| 274 | P | A | 0.3794 | |
| 275 | Y | A | 1.1216 | |
| 276 | A | A | 0.5428 | |
| 277 | T | A | 0.1794 | |
| 278 | L | A | 0.4442 | |
| 279 | P | A | -0.2353 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.2521 | |
| 282 | D | A | -0.9365 | |
| 283 | Y | A | 0.6110 | |
| 284 | F | A | -0.0445 | |
| 285 | T | A | -0.7830 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.9193 | |
| 289 | Q | A | 0.0000 | |
| 290 | G | A | -1.0253 | |
| 291 | E | A | -1.7327 | |
| 292 | I | A | -1.2219 | |
| 293 | T | A | -1.3454 | |
| 294 | E | A | -1.9421 | |
| 295 | A | A | -1.1508 | |
| 296 | D | A | -1.2691 | |
| 297 | E | A | -1.3687 | |
| 298 | I | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0270 | |
| 301 | K | A | -1.1056 | |
| 302 | P | A | -0.7363 | |
| 303 | Y | A | -0.1321 | |
| 304 | F | A | -0.3639 | |
| 305 | F | A | 0.0000 | |
| 306 | D | A | -2.6390 | |
| 307 | K | A | -2.8462 | |
| 308 | A | A | 0.0000 | |
| 309 | K | A | -1.5738 | |
| 310 | G | A | -0.5844 | |
| 311 | L | A | -0.2067 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | Y | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7322 | |
| 319 | N | A | -0.5719 | |
| 320 | Q | A | -0.5513 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -1.9873 | |
| 333 | I | A | -1.3019 | |
| 334 | A | A | -0.9342 | |
| 335 | T | A | -0.8905 | |
| 336 | N | A | -0.2690 | |
| 337 | V | A | 1.4882 | |
| 338 | T | A | 1.0488 | |
| 339 | Q | A | 0.5277 | |
| 340 | I | A | 1.9154 | |
| 341 | S | A | 0.3976 | |
| 342 | T | A | -0.4158 | |
| 343 | P | A | -0.9218 | |
| 344 | E | A | -1.9017 | |
| 345 | T | A | -0.9104 | |
| 346 | N | A | -0.6532 | |
| 347 | V | A | 1.2054 | |
| 348 | Y | A | 1.1425 | |
| 349 | D | A | -0.3506 | |
| 350 | P | A | -0.1130 | |
| 351 | S | A | 0.0077 | |
| 352 | N | A | 0.2762 | |
| 353 | Y | A | 1.2725 | |
| 354 | V | A | 1.8722 | |
| 355 | T | A | 0.4605 | |
| 356 | S | A | -0.6528 | |
| 357 | K | A | -1.7637 | |
| 358 | T | A | -1.3336 | |
| 359 | Y | A | 0.0000 | |
| 360 | S | A | -0.4368 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.6041 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -1.4796 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4184 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.4684 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7461 | |
| 376 | L | A | -0.9036 | |
| 377 | T | A | -1.1761 | |
| 378 | P | A | -1.7984 | |
| 379 | E | A | -2.7466 | |
| 380 | V | A | 0.0000 | |
| 381 | R | A | -2.1610 | |
| 382 | E | A | -2.8959 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -1.3286 | |
| 386 | R | A | -1.0473 | |
| 387 | L | A | -0.4836 | |
| 388 | D | A | -0.4937 | |
| 389 | P | A | -0.7965 | |
| 390 | S | A | -0.6256 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | E | A | -1.1515 | |
| 394 | N | A | -1.7573 | |
| 395 | A | A | -1.7894 | |
| 396 | N | A | -2.1189 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | -1.5022 | |
| 399 | D | A | -2.0762 | |
| 400 | I | A | -1.1232 | |
| 401 | P | A | -0.6877 | |
| 402 | P | A | -0.4782 | |
| 403 | V | A | 0.8246 | |
| 404 | V | A | 0.8891 | |
| 405 | R | A | -1.3509 | |
| 406 | P | A | -1.2772 | |
| 407 | D | A | -1.8183 | |
| 408 | P | A | -1.3096 | |
| 409 | Y | A | -0.9943 | |
| 410 | A | A | -1.1710 | |
| 411 | G | A | -1.4338 | |
| 412 | K | A | -2.0927 | |
| 413 | K | A | -2.5195 | |
| 414 | F | A | -1.4378 | |
| 415 | I | A | -1.1164 | |
| 416 | E | A | -2.2017 | |
| 417 | I | A | -1.6869 | |
| 418 | D | A | -2.5757 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6075 | |
| 421 | N | A | -2.1988 | |
| 422 | K | A | -2.3133 | |
| 423 | L | A | -1.0128 | |
| 424 | S | A | -1.0688 | |
| 425 | S | A | -0.6001 | |
| 426 | N | A | -1.4220 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.7836 | |
| 429 | E | A | -2.7379 | |
| 430 | T | A | -2.4259 | |
| 431 | E | A | -2.8096 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | Q | A | -2.3181 | |
| 435 | E | A | -1.7475 | |
| 436 | Y | A | -0.7565 | |
| 437 | L | A | -0.0824 | |
| 438 | N | A | -1.7817 | |
| 439 | R | A | -2.0880 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine