| Chain sequence(s) |
A: GPLPLNPEPELRSTDEYVIPTDLLYVAETELITEVGNPEKDIVENGKVVVEKVSAYQYRVFKLKLPDPNKLPLPTEDFVDPETEILIWRLRAFYIGIGGPLGKGTYGHPNFNKFGDVSNPTEYQHETEDDTVNYSFTPKLLQEYVIGDRPPIGKYIAKAKPTPGLPPGAPPPTEIVETVIEHGDMADIGFGAKDYKALEPSKNNVPLIIIDTTTKVLDYEKMKAEPDGRRMFDYDRREKSYSVKKYVRSGPDLFPLPDSPPPSPLYVKPPASSPYSVLPSYNYFDIPDSGEITEEDLLFNRPVFLTETAGKNNGILWHNQLYVTVLDNTRATIETIETQISTPENNVYDPSNYITSKRYTREYQLSLILQLCRIPLTPDILAELERLDRSILVNANLPDIPPVEEPDPLAGKKFLELDLTNKLSRDLSKYPLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2214 | |
| 2 | P | A | 0.4650 | |
| 3 | L | A | 1.3658 | |
| 4 | P | A | 0.4095 | |
| 5 | L | A | 0.9136 | |
| 6 | N | A | -1.0600 | |
| 7 | P | A | -1.6293 | |
| 8 | E | A | -2.7243 | |
| 9 | P | A | -2.3046 | |
| 10 | E | A | -2.6366 | |
| 11 | L | A | -1.5902 | |
| 12 | R | A | -1.8781 | |
| 13 | S | A | -1.9626 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.8274 | |
| 16 | E | A | -2.6754 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | I | A | 0.5292 | |
| 20 | P | A | -0.2897 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.7624 | |
| 23 | L | A | 0.0000 | |
| 24 | L | A | -0.7926 | |
| 25 | Y | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9379 | |
| 29 | T | A | 0.0000 | |
| 30 | E | A | -1.3223 | |
| 31 | L | A | 0.4186 | |
| 32 | I | A | 0.1832 | |
| 33 | T | A | 0.2182 | |
| 34 | E | A | 0.2017 | |
| 35 | V | A | 0.7986 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.8453 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.6688 | |
| 40 | K | A | -2.3667 | |
| 41 | D | A | -1.6647 | |
| 42 | I | A | 0.2422 | |
| 43 | V | A | 0.5191 | |
| 44 | E | A | -1.4832 | |
| 45 | N | A | -2.1152 | |
| 46 | G | A | -1.4457 | |
| 47 | K | A | -1.2224 | |
| 48 | V | A | 0.5960 | |
| 49 | V | A | 1.2348 | |
| 50 | V | A | 0.5106 | |
| 51 | E | A | -1.0888 | |
| 52 | K | A | -1.6947 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | -0.3434 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.7672 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -3.0703 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.6367 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.8940 | |
| 70 | K | A | -2.1070 | |
| 71 | L | A | -0.9369 | |
| 72 | P | A | -0.6826 | |
| 73 | L | A | -0.6075 | |
| 74 | P | A | -0.6015 | |
| 75 | T | A | -1.3860 | |
| 76 | E | A | -2.7261 | |
| 77 | D | A | -2.7676 | |
| 78 | F | A | -1.3819 | |
| 79 | V | A | -1.7298 | |
| 80 | D | A | -2.5739 | |
| 81 | P | A | -2.0444 | |
| 82 | E | A | -2.3981 | |
| 83 | T | A | -1.5281 | |
| 84 | E | A | -1.4165 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3491 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.3957 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | Y | A | -0.3096 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | I | A | 0.0000 | |
| 98 | G | A | -0.5063 | |
| 99 | G | A | -0.7177 | |
| 100 | P | A | -0.4584 | |
| 101 | L | A | -0.3135 | |
| 102 | G | A | -0.4829 | |
| 103 | K | A | -1.2347 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3490 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.5027 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.1057 | |
| 110 | N | A | -1.8579 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1980 | |
| 113 | K | A | -0.6718 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.3638 | |
| 117 | V | A | -0.6648 | |
| 118 | S | A | -1.1759 | |
| 119 | N | A | -1.9628 | |
| 120 | P | A | -1.4454 | |
| 121 | T | A | -1.4579 | |
| 122 | E | A | -2.2832 | |
| 123 | Y | A | -1.1127 | |
| 124 | Q | A | -2.0250 | |
| 125 | H | A | -1.8481 | |
| 126 | E | A | -2.8308 | |
| 127 | T | A | -2.6147 | |
| 128 | E | A | -3.0874 | |
| 129 | D | A | -3.1034 | |
| 130 | D | A | -2.1108 | |
| 131 | T | A | -1.3869 | |
| 132 | V | A | -0.6515 | |
| 133 | N | A | -1.3410 | |
| 134 | Y | A | -0.6466 | |
| 135 | S | A | -0.2957 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4804 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.6430 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.0137 | |
| 155 | Y | A | 0.6156 | |
| 156 | I | A | 0.9022 | |
| 157 | A | A | -0.6710 | |
| 158 | K | A | -1.9772 | |
| 159 | A | A | -1.6414 | |
| 160 | K | A | -2.3905 | |
| 161 | P | A | -1.2626 | |
| 162 | T | A | -0.5924 | |
| 163 | P | A | -0.5231 | |
| 164 | G | A | -0.2352 | |
| 165 | L | A | 0.3602 | |
| 166 | P | A | -0.1783 | |
| 167 | P | A | -0.4355 | |
| 168 | G | A | -0.3621 | |
| 169 | A | A | -0.0508 | |
| 170 | P | A | -0.2710 | |
| 171 | P | A | -0.9942 | |
| 172 | P | A | -1.2287 | |
| 173 | T | A | -0.9548 | |
| 174 | E | A | -0.6899 | |
| 175 | I | A | 1.3858 | |
| 176 | V | A | 0.4088 | |
| 177 | E | A | -0.5336 | |
| 178 | T | A | -0.2995 | |
| 179 | V | A | -0.5338 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0580 | |
| 182 | H | A | -1.0720 | |
| 183 | G | A | -0.8360 | |
| 184 | D | A | -0.6168 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.1602 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3809 | |
| 190 | F | A | -0.1546 | |
| 191 | G | A | -0.0402 | |
| 192 | A | A | 0.2645 | |
| 193 | K | A | -0.1959 | |
| 194 | D | A | -1.1305 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -2.9355 | |
| 197 | A | A | -1.5842 | |
| 198 | L | A | -0.9856 | |
| 199 | E | A | -1.5630 | |
| 200 | P | A | -1.5001 | |
| 201 | S | A | -1.3265 | |
| 202 | K | A | -2.3450 | |
| 203 | N | A | -1.3762 | |
| 204 | N | A | -0.9554 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | -0.6006 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | I | A | -1.7195 | |
| 211 | D | A | -2.8288 | |
| 212 | T | A | -1.6162 | |
| 213 | T | A | -0.8685 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1401 | |
| 217 | L | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | 0.0000 | |
| 220 | E | A | -2.6979 | |
| 221 | K | A | -2.3155 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4258 | |
| 224 | A | A | -1.6424 | |
| 225 | E | A | -1.4738 | |
| 226 | P | A | -1.2019 | |
| 227 | D | A | -1.0255 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.7350 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.5403 | |
| 234 | Y | A | -0.4798 | |
| 235 | D | A | -1.3683 | |
| 236 | R | A | -2.1244 | |
| 237 | R | A | -2.2419 | |
| 238 | E | A | -2.0910 | |
| 239 | K | A | -1.4369 | |
| 240 | S | A | -0.1467 | |
| 241 | Y | A | 0.8051 | |
| 242 | S | A | 0.3581 | |
| 243 | V | A | 0.9915 | |
| 244 | K | A | -0.9796 | |
| 245 | K | A | -1.6056 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | S | A | -1.4209 | |
| 250 | G | A | -1.0624 | |
| 251 | P | A | -0.4112 | |
| 252 | D | A | -0.0192 | |
| 253 | L | A | 1.6487 | |
| 254 | F | A | 2.2168 | |
| 255 | P | A | 0.8304 | |
| 256 | L | A | 0.8554 | |
| 257 | P | A | -0.1155 | |
| 258 | D | A | -1.1723 | |
| 259 | S | A | -1.0712 | |
| 260 | P | A | -0.9291 | |
| 261 | P | A | -0.9445 | |
| 262 | P | A | -0.4987 | |
| 263 | S | A | -0.1600 | |
| 264 | P | A | 0.4915 | |
| 265 | L | A | 1.5495 | |
| 266 | Y | A | 1.1064 | |
| 267 | V | A | 1.0098 | |
| 268 | K | A | -0.4665 | |
| 269 | P | A | -0.0786 | |
| 270 | P | A | -0.2793 | |
| 271 | A | A | -0.1279 | |
| 272 | S | A | -0.2287 | |
| 273 | S | A | 0.0449 | |
| 274 | P | A | 0.3396 | |
| 275 | Y | A | 1.0274 | |
| 276 | S | A | 0.7969 | |
| 277 | V | A | 1.8704 | |
| 278 | L | A | 1.3347 | |
| 279 | P | A | 0.1578 | |
| 280 | S | A | -0.4251 | |
| 281 | Y | A | 0.1453 | |
| 282 | N | A | -0.6616 | |
| 283 | Y | A | 0.4257 | |
| 284 | F | A | -0.3880 | |
| 285 | D | A | -1.0495 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.2359 | |
| 289 | S | A | 0.0000 | |
| 290 | G | A | -0.7554 | |
| 291 | E | A | -1.8957 | |
| 292 | I | A | -1.5556 | |
| 293 | T | A | -1.8815 | |
| 294 | E | A | -2.6968 | |
| 295 | E | A | -2.8814 | |
| 296 | D | A | -2.1782 | |
| 297 | L | A | -1.4750 | |
| 298 | L | A | -1.3064 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3150 | |
| 301 | R | A | -1.8555 | |
| 302 | P | A | -0.8746 | |
| 303 | V | A | 0.0377 | |
| 304 | F | A | -0.2075 | |
| 305 | L | A | 0.0000 | |
| 306 | T | A | -0.8799 | |
| 307 | E | A | -2.1528 | |
| 308 | T | A | -1.0904 | |
| 309 | A | A | -0.8633 | |
| 310 | G | A | -1.1411 | |
| 311 | K | A | -1.6486 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -1.0267 | |
| 319 | N | A | -1.1639 | |
| 320 | Q | A | -1.3644 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4814 | |
| 331 | A | A | 0.0000 | |
| 332 | T | A | -0.9112 | |
| 333 | I | A | -1.2732 | |
| 334 | E | A | -2.1113 | |
| 335 | T | A | -1.5233 | |
| 336 | I | A | -0.7664 | |
| 337 | E | A | -1.0641 | |
| 338 | T | A | -0.0865 | |
| 339 | Q | A | -0.2196 | |
| 340 | I | A | 1.6067 | |
| 341 | S | A | 0.3722 | |
| 342 | T | A | -0.6604 | |
| 343 | P | A | -1.0929 | |
| 344 | E | A | -2.3372 | |
| 345 | N | A | -2.0720 | |
| 346 | N | A | -1.4393 | |
| 347 | V | A | 0.6140 | |
| 348 | Y | A | 0.9275 | |
| 349 | D | A | -0.3856 | |
| 350 | P | A | -0.0152 | |
| 351 | S | A | 0.1180 | |
| 352 | N | A | 0.0485 | |
| 353 | Y | A | 0.7646 | |
| 354 | I | A | 1.6935 | |
| 355 | T | A | -0.1379 | |
| 356 | S | A | -0.9970 | |
| 357 | K | A | -2.3367 | |
| 358 | R | A | -1.9262 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.2119 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.2368 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.5303 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.0715 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.4319 | |
| 376 | L | A | -0.4721 | |
| 377 | T | A | -0.4280 | |
| 378 | P | A | -0.6937 | |
| 379 | D | A | -1.3151 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -0.3974 | |
| 382 | A | A | -0.7685 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -1.4613 | |
| 386 | R | A | -1.2876 | |
| 387 | L | A | -0.8284 | |
| 388 | D | A | -1.0527 | |
| 389 | R | A | -1.4429 | |
| 390 | S | A | -1.3242 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.1147 | |
| 394 | N | A | -1.7629 | |
| 395 | A | A | -1.3288 | |
| 396 | N | A | -1.9393 | |
| 397 | L | A | -1.4991 | |
| 398 | P | A | -1.4802 | |
| 399 | D | A | -1.9537 | |
| 400 | I | A | -1.1016 | |
| 401 | P | A | -0.7120 | |
| 402 | P | A | -0.9525 | |
| 403 | V | A | -0.3817 | |
| 404 | E | A | -2.5198 | |
| 405 | E | A | -3.1123 | |
| 406 | P | A | -2.3562 | |
| 407 | D | A | -2.7371 | |
| 408 | P | A | -1.5153 | |
| 409 | L | A | -1.1043 | |
| 410 | A | A | -1.2669 | |
| 411 | G | A | -1.3891 | |
| 412 | K | A | -1.7058 | |
| 413 | K | A | -2.3088 | |
| 414 | F | A | -1.3712 | |
| 415 | L | A | -1.1193 | |
| 416 | E | A | -2.6129 | |
| 417 | L | A | -2.2116 | |
| 418 | D | A | -3.2011 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9669 | |
| 421 | N | A | -2.2895 | |
| 422 | K | A | -2.2895 | |
| 423 | L | A | -1.2633 | |
| 424 | S | A | -1.7416 | |
| 425 | R | A | -2.3400 | |
| 426 | D | A | -2.2342 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.8737 | |
| 429 | K | A | -2.3788 | |
| 430 | Y | A | -1.4037 | |
| 431 | P | A | -1.2051 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2332 | |
| 435 | E | A | -2.0030 | |
| 436 | Y | A | -0.9318 | |
| 437 | L | A | -0.3731 | |
| 438 | N | A | -2.0692 | |
| 439 | R | A | -2.2723 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine