Project name: wild type

Chain sequence(s)	C: EVQLLESGGGLVQPGGSLRLSCAASGFTFSYYYMGWVRQAPGKGLEWVSGISPSSGYTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYYYGYYYSHMDYWGQGTLVTVSSDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRSGLHTFGQGTKLEIK
Selected Chain(s)	C
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with C chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:27)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:28)

• Minimal score value: -2.7115
• Maximal score value: 2.1758
• Average score: -0.4441
• Total score value: -101.2655

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	E	C	-1.9415
4	V	C	-0.8795
5	Q	C	-0.8178
6	L	C	0.0000
7	L	C	0.4560
8	E	C	0.0000
9	S	C	-0.3921
10	G	C	-0.6007
11	G	C	0.0838
12	G	C	0.7757
13	L	C	1.3065
14	V	C	0.0000
15	Q	C	-1.3916
16	P	C	-1.6489
17	G	C	-1.4137
18	G	C	-1.1379
19	S	C	-1.1127
20	L	C	-1.0731
21	R	C	-2.0574
22	L	C	0.0000
23	S	C	-0.5111
24	C	C	0.0000
25	A	C	-0.2194
26	A	C	0.0000
27	S	C	-0.8875
28	G	C	-0.9918
29	F	C	-0.1872
30	T	C	0.2056
31	F	C	0.0000
32	S	C	-0.0349
33	Y	C	1.5427
34	Y	C	0.0000
35	Y	C	0.8885
36	M	C	0.0000
37	G	C	0.0000
38	W	C	0.0000
39	V	C	0.0000
40	R	C	0.0000
41	Q	C	-0.6569
42	A	C	-1.0687
43	P	C	-0.8508
44	G	C	-1.4648
45	K	C	-2.3302
46	G	C	-1.5741
47	L	C	0.0000
48	E	C	-1.0836
49	W	C	0.0000
50	V	C	0.0000
51	S	C	0.0000
52	G	C	0.0000
53	I	C	0.0000
54	S	C	0.0000
55	P	C	0.2566
56	S	C	-0.1879
57	S	C	-0.2532
58	G	C	-0.0062
59	Y	C	1.0223
60	T	C	0.5274
61	Y	C	0.1037
62	Y	C	-0.8317
63	A	C	-1.5442
64	D	C	-2.6210
65	S	C	-1.7465
66	V	C	0.0000
67	K	C	-2.5091
68	G	C	-1.6327
69	R	C	0.0000
70	F	C	0.0000
71	T	C	-0.7558
72	I	C	0.0000
73	S	C	-0.4560
74	R	C	-0.9447
75	D	C	-1.5020
76	N	C	-1.5001
77	S	C	-1.5807
78	K	C	-2.3475
79	N	C	-1.6746
80	T	C	-1.0093
81	L	C	0.0000
82	Y	C	-0.5418
83	L	C	0.0000
84	Q	C	-1.1706
85	M	C	0.0000
86	N	C	-1.3246
87	S	C	-1.2128
88	L	C	0.0000
89	R	C	-2.3274
90	A	C	-1.7651
91	E	C	-2.2305
92	D	C	0.0000
93	T	C	-0.3953
94	A	C	0.0000
95	V	C	0.7048
96	Y	C	0.0000
97	Y	C	0.0000
98	C	C	0.0000
99	A	C	0.0000
100	R	C	0.0000
101	Y	C	0.0000
102	Y	C	1.8658
103	Y	C	2.1758
104	G	C	1.3930
105	Y	C	0.0000
106	Y	C	1.7064
107	Y	C	1.9325
108	S	C	0.0000
109	H	C	0.0000
110	M	C	0.0000
111	D	C	0.0000
112	Y	C	0.6035
113	W	C	0.0195
114	G	C	0.0000
115	Q	C	-1.3057
116	G	C	-0.3108
117	T	C	0.4592
118	L	C	1.6119
119	V	C	0.0000
120	T	C	0.2766
121	V	C	0.0000
122	S	C	-0.4707
123	S	C	-0.6643
139	D	C	-2.4137
140	I	C	0.0000
141	Q	C	-2.2580
142	M	C	0.0000
143	T	C	-1.2961
144	Q	C	0.0000
145	S	C	-0.7453
146	P	C	-0.6396
147	S	C	-0.8989
148	S	C	-1.0745
149	L	C	-0.5768
150	S	C	-0.7157
151	A	C	0.0000
152	S	C	-0.1084
153	V	C	0.7519
154	G	C	-0.5769
155	D	C	-1.4217
156	R	C	-2.1787
157	V	C	0.0000
158	T	C	-0.5775
159	I	C	0.0000
160	T	C	-0.8365
161	C	C	0.0000
162	R	C	-2.7115
163	A	C	0.0000
164	S	C	-1.9003
165	Q	C	-1.8679
166	S	C	-1.1922
167	I	C	0.0000
168	S	C	-0.4582
169	S	C	-0.1692
170	Y	C	0.5525
171	L	C	0.0000
172	N	C	0.0000
173	W	C	0.0000
174	Y	C	0.0000
175	Q	C	0.0000
176	Q	C	-1.3512
177	K	C	-1.8715
178	P	C	-1.2324
179	G	C	-1.5570
180	K	C	-2.5425
181	A	C	-1.5520
182	P	C	0.0000
183	K	C	-1.1787
184	L	C	0.0000
185	L	C	0.0000
186	I	C	0.0000
187	Y	C	0.5654
188	A	C	0.3665
189	A	C	0.0000
190	S	C	-0.1675
191	S	C	0.1210
192	L	C	0.3096
193	Q	C	-0.1782
194	S	C	-0.4018
195	G	C	-0.5626
196	V	C	0.0000
197	P	C	-0.3772
198	S	C	-0.4225
199	R	C	-0.7056
200	F	C	0.0000
201	S	C	-0.2748
202	G	C	-0.2098
203	S	C	-0.5936
204	G	C	-0.9560
205	S	C	-0.7334
206	G	C	-1.0472
207	T	C	-1.6393
208	D	C	-2.0736
209	F	C	0.0000
210	T	C	-0.7182
211	L	C	0.0000
212	T	C	-0.5848
213	I	C	0.0000
214	S	C	-1.2235
215	S	C	-1.0305
216	L	C	0.0000
217	Q	C	-0.7712
218	P	C	-0.6210
219	E	C	-1.8753
220	D	C	0.0000
221	F	C	-0.6514
222	A	C	0.0000
223	T	C	-1.1376
224	Y	C	0.0000
225	Y	C	0.0000
226	C	C	0.0000
227	Q	C	0.0000
228	Q	C	0.0000
229	S	C	0.0000
230	R	C	0.0856
231	S	C	-0.1088
232	G	C	0.1408
233	L	C	-0.2619
234	H	C	0.0000
235	T	C	-0.7476
236	F	C	0.0000
237	G	C	0.0000
238	Q	C	-1.6442
239	G	C	0.0000
240	T	C	0.0000
241	K	C	-1.8440
242	L	C	0.0000
243	E	C	-1.2209
244	I	C	0.6174
245	K	C	-0.8564