| Chain sequence(s) |
A: MGSSHHHHHHSSGENLYFQGAMAVERNSGDLQLPQEIAMLVPNKTQVVPKSGGEGKVKDIFASPALVRAGGVMIAFVEGRTKNKLFPEVIDLSSSDIVAGYIKAPETWQSLVAEVTKEYWQAHTVLESANNSNHRVGVARLPTGITRGNKVFLLVGSYEERREIDDYIWKAEAWNIKVIEGEATQSTEVQPTQPINWSEPKPLFQTDSPNNKGDLKEFLGGGGSGIVMGNGTLVFPLTAKDESNKVFSLITYSTDDGQKWEIPGGVSSVACRSPRVTEWEEGTLLMVTYCEDGRKVFESRDMGKTWTEARGTLPGVWLKSGPELPEVSLRVDALITATIEGRKVMLYTQKVRHFREVDEPNALHLWVTDNNRTFHLGPFSVDCAENKTFANTLLYSDDALHLLQAKGDHESTAVSLARLTEELNTI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:07:00)
[INFO] Main: Simulation completed successfully. (00:07:02)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.7717 | |
| 2 | G | A | -0.0828 | |
| 3 | S | A | -0.6755 | |
| 4 | S | A | -1.1322 | |
| 5 | H | A | -1.8942 | |
| 6 | H | A | -2.4023 | |
| 7 | H | A | -2.6090 | |
| 8 | H | A | -2.4577 | |
| 9 | H | A | -2.4418 | |
| 10 | H | A | -2.0919 | |
| 11 | S | A | -1.6272 | |
| 12 | S | A | -1.5890 | |
| 13 | G | A | -1.7396 | |
| 14 | E | A | -2.1011 | |
| 15 | N | A | -0.9963 | |
| 16 | L | A | 1.0196 | |
| 17 | Y | A | 1.2971 | |
| 18 | F | A | 1.0410 | |
| 19 | Q | A | -0.0795 | |
| 20 | G | A | -0.2901 | |
| 21 | A | A | 0.5189 | |
| 22 | M | A | 1.1841 | |
| 23 | A | A | 0.5087 | |
| 24 | V | A | 0.7830 | |
| 25 | E | A | -1.5798 | |
| 26 | R | A | -2.1992 | |
| 27 | N | A | -2.4665 | |
| 28 | S | A | -1.6027 | |
| 29 | G | A | -1.6181 | |
| 30 | D | A | -1.7964 | |
| 31 | L | A | 0.0831 | |
| 32 | Q | A | -1.2751 | |
| 33 | L | A | -0.1294 | |
| 34 | P | A | 0.0000 | |
| 35 | Q | A | -0.8071 | |
| 36 | E | A | -0.3797 | |
| 37 | I | A | 0.0000 | |
| 38 | A | A | 0.1712 | |
| 39 | M | A | 0.0000 | |
| 40 | L | A | 0.0000 | |
| 41 | V | A | -0.4715 | |
| 42 | P | A | -1.0993 | |
| 43 | N | A | -1.9939 | |
| 44 | K | A | -2.1379 | |
| 45 | T | A | -1.3764 | |
| 46 | Q | A | -1.5227 | |
| 47 | V | A | 0.0000 | |
| 48 | V | A | -1.2383 | |
| 49 | P | A | -1.6247 | |
| 50 | K | A | -1.5694 | |
| 51 | S | A | -1.1825 | |
| 52 | G | A | -1.5091 | |
| 53 | G | A | -1.9498 | |
| 54 | E | A | -2.5522 | |
| 55 | G | A | -1.8977 | |
| 56 | K | A | -1.9196 | |
| 57 | V | A | -0.7822 | |
| 58 | K | A | 0.0000 | |
| 59 | D | A | -1.0260 | |
| 60 | I | A | -0.7702 | |
| 61 | F | A | 0.0000 | |
| 62 | A | A | 0.0066 | |
| 63 | S | A | 0.0214 | |
| 64 | P | A | 0.0000 | |
| 65 | A | A | 0.0000 | |
| 66 | L | A | 0.0000 | |
| 67 | V | A | 0.0000 | |
| 68 | R | A | -1.0522 | |
| 69 | A | A | 0.0000 | |
| 70 | G | A | -1.7109 | |
| 71 | G | A | -1.4899 | |
| 72 | V | A | 0.0000 | |
| 73 | M | A | 0.0000 | |
| 74 | I | A | 0.0000 | |
| 75 | A | A | 0.0000 | |
| 76 | F | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | E | A | 0.0000 | |
| 79 | G | A | 0.0000 | |
| 80 | R | A | -0.4436 | |
| 81 | T | A | -0.9276 | |
| 82 | K | A | -1.3107 | |
| 83 | N | A | -1.4421 | |
| 84 | K | A | -1.4969 | |
| 85 | L | A | -0.0714 | |
| 86 | F | A | 0.0000 | |
| 87 | P | A | -1.0566 | |
| 88 | E | A | -1.4103 | |
| 89 | V | A | 0.3762 | |
| 90 | I | A | 0.8000 | |
| 91 | D | A | -1.4999 | |
| 92 | L | A | 0.0000 | |
| 93 | S | A | 0.0000 | |
| 94 | S | A | 0.0000 | |
| 95 | S | A | 0.0000 | |
| 96 | D | A | 0.0000 | |
| 97 | I | A | 0.0000 | |
| 98 | V | A | 0.0000 | |
| 99 | A | A | 0.0000 | |
| 100 | G | A | 0.0000 | |
| 101 | Y | A | 0.0000 | |
| 102 | I | A | 0.0000 | |
| 103 | K | A | -1.9559 | |
| 104 | A | A | -1.3627 | |
| 105 | P | A | -1.5028 | |
| 106 | E | A | -2.4096 | |
| 107 | T | A | -1.2660 | |
| 108 | W | A | -0.9541 | |
| 109 | Q | A | -1.3551 | |
| 110 | S | A | -1.1952 | |
| 111 | L | A | 0.0000 | |
| 112 | V | A | -0.3051 | |
| 113 | A | A | -0.5724 | |
| 114 | E | A | -0.7707 | |
| 115 | V | A | 0.0000 | |
| 116 | T | A | -0.5587 | |
| 117 | K | A | -0.9680 | |
| 118 | E | A | -1.4428 | |
| 119 | Y | A | 0.1338 | |
| 120 | W | A | -0.2447 | |
| 121 | Q | A | -0.5047 | |
| 122 | A | A | 0.0000 | |
| 123 | H | A | 0.0000 | |
| 124 | T | A | 0.0000 | |
| 125 | V | A | 0.0000 | |
| 126 | L | A | 0.0000 | |
| 127 | E | A | -1.1977 | |
| 128 | S | A | -1.0048 | |
| 129 | A | A | -1.2404 | |
| 130 | N | A | -2.4256 | |
| 131 | N | A | -2.6596 | |
| 132 | S | A | -2.1847 | |
| 133 | N | A | -2.1427 | |
| 134 | H | A | -2.1081 | |
| 135 | R | A | -2.8467 | |
| 136 | V | A | 0.0000 | |
| 137 | G | A | 0.0000 | |
| 138 | V | A | 0.0000 | |
| 139 | A | A | 0.0000 | |
| 140 | R | A | -0.3572 | |
| 141 | L | A | 0.0387 | |
| 142 | P | A | 0.0000 | |
| 143 | T | A | 0.0000 | |
| 144 | G | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | T | A | -0.9929 | |
| 147 | R | A | -1.6704 | |
| 148 | G | A | -1.6462 | |
| 149 | N | A | -1.9754 | |
| 150 | K | A | -2.1442 | |
| 151 | V | A | 0.0000 | |
| 152 | F | A | 0.0000 | |
| 153 | L | A | 0.0000 | |
| 154 | L | A | 0.0000 | |
| 155 | V | A | 0.0000 | |
| 156 | G | A | 0.0000 | |
| 157 | S | A | -0.6275 | |
| 158 | Y | A | 0.0000 | |
| 159 | E | A | -1.6458 | |
| 160 | E | A | -1.7182 | |
| 161 | R | A | -1.9307 | |
| 162 | R | A | -1.1348 | |
| 163 | E | A | -0.5902 | |
| 164 | I | A | 0.7480 | |
| 165 | D | A | -1.3099 | |
| 166 | D | A | -1.2380 | |
| 167 | Y | A | 0.8698 | |
| 168 | I | A | 0.6609 | |
| 169 | W | A | -0.2878 | |
| 170 | K | A | -1.2616 | |
| 171 | A | A | -1.2271 | |
| 172 | E | A | -1.3565 | |
| 173 | A | A | -0.7877 | |
| 174 | W | A | -0.8384 | |
| 175 | N | A | -1.4242 | |
| 176 | I | A | 0.0000 | |
| 177 | K | A | -1.2059 | |
| 178 | V | A | 0.0000 | |
| 179 | I | A | 0.0000 | |
| 180 | E | A | -1.7107 | |
| 181 | G | A | 0.0000 | |
| 182 | E | A | -2.3797 | |
| 183 | A | A | 0.0000 | |
| 184 | T | A | -1.5899 | |
| 185 | Q | A | -1.8499 | |
| 186 | S | A | -1.3172 | |
| 187 | T | A | -1.0099 | |
| 188 | E | A | -1.5330 | |
| 189 | V | A | 0.4785 | |
| 190 | Q | A | -0.9008 | |
| 191 | P | A | -1.1538 | |
| 192 | T | A | -0.4815 | |
| 193 | Q | A | -1.0892 | |
| 194 | P | A | 0.0000 | |
| 195 | I | A | 0.0000 | |
| 196 | N | A | -1.8490 | |
| 197 | W | A | -1.5972 | |
| 198 | S | A | -1.6743 | |
| 199 | E | A | -2.2711 | |
| 200 | P | A | -1.7224 | |
| 201 | K | A | -2.1202 | |
| 202 | P | A | -1.5479 | |
| 203 | L | A | 0.0000 | |
| 204 | F | A | -1.7834 | |
| 205 | Q | A | -2.3560 | |
| 206 | T | A | -1.6609 | |
| 207 | D | A | -2.4812 | |
| 208 | S | A | -2.1893 | |
| 209 | P | A | -1.6273 | |
| 210 | N | A | -1.9563 | |
| 211 | N | A | -2.7748 | |
| 212 | K | A | -2.4565 | |
| 213 | G | A | -2.5196 | |
| 214 | D | A | -3.3189 | |
| 215 | L | A | -2.8133 | |
| 216 | K | A | -2.9033 | |
| 217 | E | A | -1.5444 | |
| 218 | F | A | -0.5323 | |
| 219 | L | A | -0.2097 | |
| 220 | G | A | 0.0000 | |
| 221 | G | A | 0.0000 | |
| 222 | G | A | 0.0000 | |
| 223 | G | A | 0.0000 | |
| 224 | S | A | 0.1215 | |
| 225 | G | A | 0.0000 | |
| 226 | I | A | 0.3225 | |
| 227 | V | A | 0.1617 | |
| 228 | M | A | 0.0000 | |
| 229 | G | A | -1.6300 | |
| 230 | N | A | -1.7702 | |
| 231 | G | A | -1.0157 | |
| 232 | T | A | 0.0000 | |
| 233 | L | A | 0.0000 | |
| 234 | V | A | 0.0000 | |
| 235 | F | A | 0.0000 | |
| 236 | P | A | 0.0000 | |
| 237 | L | A | 0.0000 | |
| 238 | T | A | -0.2718 | |
| 239 | A | A | 0.0000 | |
| 240 | K | A | -2.1756 | |
| 241 | D | A | -2.9789 | |
| 242 | E | A | -3.5502 | |
| 243 | S | A | -2.3989 | |
| 244 | N | A | -2.8772 | |
| 245 | K | A | -1.9926 | |
| 246 | V | A | -0.9448 | |
| 247 | F | A | 0.0576 | |
| 248 | S | A | 0.0000 | |
| 249 | L | A | 0.0000 | |
| 250 | I | A | 0.0000 | |
| 251 | T | A | 0.0000 | |
| 252 | Y | A | -0.5134 | |
| 253 | S | A | 0.0000 | |
| 254 | T | A | -1.3329 | |
| 255 | D | A | -1.6540 | |
| 256 | D | A | -1.8945 | |
| 257 | G | A | 0.0000 | |
| 258 | Q | A | -2.5673 | |
| 259 | K | A | -2.9216 | |
| 260 | W | A | 0.0000 | |
| 261 | E | A | -1.7193 | |
| 262 | I | A | 0.0000 | |
| 263 | P | A | 0.0000 | |
| 264 | G | A | -1.2666 | |
| 265 | G | A | -0.8143 | |
| 266 | V | A | 0.3314 | |
| 267 | S | A | 0.0000 | |
| 268 | S | A | 0.4290 | |
| 269 | V | A | 0.9314 | |
| 270 | A | A | -0.5580 | |
| 271 | C | A | 0.0000 | |
| 272 | R | A | -1.0179 | |
| 273 | S | A | -0.5681 | |
| 274 | P | A | 0.0000 | |
| 275 | R | A | -0.2873 | |
| 276 | V | A | 0.0000 | |
| 277 | T | A | 0.0000 | |
| 278 | E | A | -0.9497 | |
| 279 | W | A | -1.5037 | |
| 280 | E | A | -3.0814 | |
| 281 | E | A | -3.3391 | |
| 282 | G | A | -2.4879 | |
| 283 | T | A | 0.0000 | |
| 284 | L | A | 0.0000 | |
| 285 | L | A | 0.0000 | |
| 286 | M | A | 0.0000 | |
| 287 | V | A | 0.0000 | |
| 288 | T | A | 0.0000 | |
| 289 | Y | A | -1.2789 | |
| 290 | C | A | 0.0000 | |
| 291 | E | A | -3.0297 | |
| 292 | D | A | -3.1745 | |
| 293 | G | A | 0.0000 | |
| 294 | R | A | 0.0000 | |
| 295 | K | A | -1.3271 | |
| 296 | V | A | 0.0000 | |
| 297 | F | A | 0.0000 | |
| 298 | E | A | -1.1433 | |
| 299 | S | A | 0.0000 | |
| 300 | R | A | -2.9090 | |
| 301 | D | A | -1.9776 | |
| 302 | M | A | -1.2168 | |
| 303 | G | A | 0.0000 | |
| 304 | K | A | -2.2106 | |
| 305 | T | A | -1.3649 | |
| 306 | W | A | -0.8362 | |
| 307 | T | A | -0.7993 | |
| 308 | E | A | -1.2479 | |
| 309 | A | A | -1.4473 | |
| 310 | R | A | -2.3213 | |
| 311 | G | A | -1.6659 | |
| 312 | T | A | -1.3070 | |
| 313 | L | A | 0.0000 | |
| 314 | P | A | -1.1006 | |
| 315 | G | A | -0.1238 | |
| 316 | V | A | 0.0000 | |
| 317 | W | A | -0.3994 | |
| 318 | L | A | -0.6487 | |
| 319 | K | A | -2.2750 | |
| 320 | S | A | -2.2677 | |
| 321 | G | A | -1.4878 | |
| 322 | P | A | -1.3385 | |
| 323 | E | A | -1.9119 | |
| 324 | L | A | -1.2128 | |
| 325 | P | A | -1.2291 | |
| 326 | E | A | -2.0439 | |
| 327 | V | A | -0.4608 | |
| 328 | S | A | 0.0000 | |
| 329 | L | A | 0.0000 | |
| 330 | R | A | -0.6708 | |
| 331 | V | A | 0.0000 | |
| 332 | D | A | 0.0000 | |
| 333 | A | A | 0.0000 | |
| 334 | L | A | 0.0000 | |
| 335 | I | A | 0.2574 | |
| 336 | T | A | -0.0364 | |
| 337 | A | A | 0.0000 | |
| 338 | T | A | -1.7512 | |
| 339 | I | A | -1.9606 | |
| 340 | E | A | -2.7675 | |
| 341 | G | A | -2.3979 | |
| 342 | R | A | -3.0367 | |
| 343 | K | A | -2.3395 | |
| 344 | V | A | 0.0000 | |
| 345 | M | A | 0.0000 | |
| 346 | L | A | 0.0000 | |
| 347 | Y | A | 0.0000 | |
| 348 | T | A | 0.0000 | |
| 349 | Q | A | 0.0000 | |
| 350 | K | A | 0.0000 | |
| 351 | V | A | -0.0731 | |
| 352 | R | A | -1.2592 | |
| 353 | H | A | -1.5437 | |
| 354 | F | A | -0.0613 | |
| 355 | R | A | -2.1247 | |
| 356 | E | A | -2.2596 | |
| 357 | V | A | -0.5245 | |
| 358 | D | A | -2.2716 | |
| 359 | E | A | -2.3424 | |
| 360 | P | A | -1.2099 | |
| 361 | N | A | -0.8264 | |
| 362 | A | A | 0.0000 | |
| 363 | L | A | 0.0000 | |
| 364 | H | A | 0.0000 | |
| 365 | L | A | 0.0000 | |
| 366 | W | A | 0.5283 | |
| 367 | V | A | 0.4136 | |
| 368 | T | A | 0.0000 | |
| 369 | D | A | -1.6130 | |
| 370 | N | A | -1.7315 | |
| 371 | N | A | -2.5420 | |
| 372 | R | A | -2.2436 | |
| 373 | T | A | -0.5134 | |
| 374 | F | A | 1.3414 | |
| 375 | H | A | 0.3426 | |
| 376 | L | A | 0.0000 | |
| 377 | G | A | -0.3202 | |
| 378 | P | A | 0.0772 | |
| 379 | F | A | 0.0000 | |
| 380 | S | A | 0.0000 | |
| 381 | V | A | 0.4231 | |
| 382 | D | A | 0.0000 | |
| 383 | C | A | -0.9886 | |
| 384 | A | A | -1.1898 | |
| 385 | E | A | -2.6101 | |
| 386 | N | A | -2.1944 | |
| 387 | K | A | -1.4605 | |
| 388 | T | A | 0.0000 | |
| 389 | F | A | -0.1041 | |
| 390 | A | A | 0.0898 | |
| 391 | N | A | 0.0000 | |
| 392 | T | A | 0.0000 | |
| 393 | L | A | 0.0000 | |
| 394 | L | A | 0.0385 | |
| 395 | Y | A | -0.4742 | |
| 396 | S | A | -1.3797 | |
| 397 | D | A | -2.8859 | |
| 398 | D | A | -2.7836 | |
| 399 | A | A | -1.7396 | |
| 400 | L | A | 0.0000 | |
| 401 | H | A | 0.0000 | |
| 402 | L | A | 0.0000 | |
| 403 | L | A | 0.0000 | |
| 404 | Q | A | 0.0000 | |
| 405 | A | A | 0.0000 | |
| 406 | K | A | -1.0592 | |
| 407 | G | A | 0.0000 | |
| 408 | D | A | -2.6778 | |
| 409 | H | A | -2.8618 | |
| 410 | E | A | -2.8733 | |
| 411 | S | A | -1.9998 | |
| 412 | T | A | 0.0000 | |
| 413 | A | A | -0.4982 | |
| 414 | V | A | 0.0000 | |
| 415 | S | A | 0.0000 | |
| 416 | L | A | 0.0000 | |
| 417 | A | A | 0.0000 | |
| 418 | R | A | -0.6870 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5070 | |
| 421 | E | A | -2.2880 | |
| 422 | E | A | -1.4539 | |
| 423 | L | A | -1.1377 | |
| 424 | N | A | -1.6929 | |
| 425 | T | A | -0.8463 | |
| 426 | I | A | 0.0494 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine