Project name: d3d8b9e6ef3d2aa

Chain sequence(s)	H: QSLEESGGGPVKPGGTLTLTCKASGIDFSSFYYMCWVRQAPGKGLEWIACIVTDITGESYYATWAKGRFAISKTSSTTVTLQMTSLTAADTATYFCARGDTYGYGDTVYALNLWGPGTLVTVSS; L: GPVLTQTPPSASEPVGGTVTIKCQASQAIDEYLGWYQQKPGQRPKLLMYYASTLASGVPSRFKGSGSGTQFTLTISDLECADAATYYCQNYYVGSSTNYAFTFGGGTEVVVK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:05)

• Minimal score value: -2.438
• Maximal score value: 1.9042
• Average score: -0.427
• Total score value: -100.7675

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	G	L	-0.0256
2	P	L	0.1565
3	V	L	1.1192
4	L	L	0.0000
5	T	L	-0.3844
6	Q	L	-0.9969
7	T	L	-0.9039
8	P	L	-0.8806
9	P	L	-1.1068
10	S	L	-0.8416
11	A	L	-0.3983
12	S	L	-0.2883
13	E	L	-0.5956
14	P	L	-0.5716
15	V	L	0.2897
16	G	L	-1.0775
17	G	L	-1.0193
18	T	L	-0.8012
19	V	L	0.0000
20	T	L	-0.5645
21	I	L	0.0000
22	K	L	-1.6333
23	C	L	0.0000
24	Q	L	-1.3690
25	A	L	0.0000
26	S	L	-0.4520
27	Q	L	-1.1086
28	A	L	-1.2596
29	I	L	-1.2094
30	D	L	-2.3458
31	E	L	-1.8333
32	Y	L	-0.5853
33	L	L	0.0000
34	G	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.7255
40	P	L	-1.3089
41	G	L	-1.5846
42	Q	L	-2.4380
43	R	L	-2.3187
44	P	L	0.0000
45	K	L	-2.1786
46	L	L	0.0000
47	L	L	0.0000
48	M	L	0.0000
49	Y	L	0.1713
50	Y	L	-0.4452
51	A	L	0.0000
52	S	L	-0.6483
53	T	L	-0.0426
54	L	L	-0.0264
55	A	L	-0.2653
56	S	L	-0.3853
57	G	L	-0.5531
58	V	L	0.0000
59	P	L	-0.6079
60	S	L	-0.7718
61	R	L	-1.2933
62	F	L	0.0000
63	K	L	-1.8639
64	G	L	0.0000
65	S	L	-1.0755
66	G	L	-1.2972
67	S	L	-1.5162
68	G	L	-1.5739
69	T	L	-1.4440
70	Q	L	-1.7700
71	F	L	0.0000
72	T	L	-1.1672
73	L	L	0.0000
74	T	L	-0.8669
75	I	L	0.0000
76	S	L	-1.4603
77	D	L	-2.0786
78	L	L	0.0000
79	E	L	-1.0149
80	C	L	0.5488
81	A	L	0.1759
82	D	L	0.0000
83	A	L	-0.0456
84	A	L	0.0000
85	T	L	-0.9008
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	N	L	0.0000
91	Y	L	0.0000
92	Y	L	0.1721
93	V	L	0.0912
94	G	L	-0.5670
95	S	L	-0.7126
95A	S	L	-0.7107
95B	T	L	-0.7050
95C	N	L	-1.1692
95D	Y	L	-0.1810
95E	A	L	0.0000
96	F	L	0.0000
97	T	L	0.1133
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-0.7963
101	G	L	-1.2381
102	T	L	0.0000
103	E	L	-1.6237
104	V	L	0.0000
105	V	L	0.9666
106	V	L	0.1336
107	K	L	-1.0579
1	Q	H	-1.5405
2	S	H	-1.4022
3	L	H	0.0000
4	E	H	-2.3612
5	E	H	0.0000
6	S	H	-0.8841
7	G	H	-0.4177
8	G	H	-0.0094
9	G	H	0.0976
10	P	H	-0.4904
11	V	H	-0.9908
12	K	H	-2.0716
13	P	H	-1.4511
14	G	H	-1.1921
15	G	H	-0.9572
16	T	H	-0.6431
17	L	H	-0.4176
18	T	H	-0.4980
19	L	H	0.0000
20	T	H	-0.9903
21	C	H	0.0000
22	K	H	-1.8701
23	A	H	0.0000
24	S	H	-1.3887
25	G	H	-1.1694
26	I	H	-0.5502
27	D	H	-0.1995
28	F	H	1.6108
29	S	H	0.7480
30	S	H	0.8211
31	F	H	1.9042
32	Y	H	0.9857
33	Y	H	0.0000
34	M	H	0.0000
34A	C	H	0.0000
35	W	H	0.0000
36	V	H	0.0000
37	R	H	0.0000
38	Q	H	-0.8035
39	A	H	-0.8056
40	P	H	-0.9704
41	G	H	-1.5027
42	K	H	-2.2810
43	G	H	-1.4780
44	L	H	0.0000
45	E	H	-1.0647
46	W	H	0.0000
47	I	H	0.0000
48	A	H	0.0000
49	C	H	0.0000
50	I	H	0.0000
51	V	H	0.0000
51A	T	H	0.7600
51B	D	H	1.0539
52	I	H	1.7812
53	T	H	0.5375
54	G	H	-0.0468
55	E	H	-0.4762
56	S	H	-0.4420
57	Y	H	0.0000
58	Y	H	-0.3065
59	A	H	0.0000
60	T	H	-0.3845
61	W	H	-0.1547
62	A	H	0.0000
63	K	H	-1.8752
64	G	H	-1.4365
65	R	H	-1.3248
66	F	H	0.0000
67	A	H	-0.8136
68	I	H	0.0000
69	S	H	-0.6658
70	K	H	-0.6595
71	T	H	-0.5275
72	S	H	-0.6406
73	S	H	-0.4023
74	T	H	-0.5823
75	T	H	-0.9917
76	V	H	0.0000
77	T	H	-0.6782
78	L	H	0.0000
79	Q	H	-0.9255
80	M	H	0.0000
81	T	H	-0.6853
81A	S	H	-0.8503
81B	L	H	0.0000
82	T	H	-0.6028
83	A	H	-0.3251
84	A	H	0.0209
85	D	H	0.0000
86	T	H	0.1708
87	A	H	0.0000
88	T	H	0.3589
89	Y	H	0.0000
90	F	H	0.0000
91	C	H	0.0000
92	A	H	0.0000
93	R	H	0.0000
94	G	H	0.0000
95	D	H	0.0813
96	T	H	0.6959
97	Y	H	0.8356
98	G	H	0.3724
99	Y	H	0.6513
99A	G	H	-0.1710
99B	D	H	-1.2975
99C	T	H	-0.3976
99D	V	H	-0.0914
99E	Y	H	0.0000
99F	A	H	0.0000
99G	L	H	0.0000
100	N	H	-0.9579
101	L	H	-0.8112
102	W	H	0.0000
103	G	H	0.0000
104	P	H	-1.1553
105	G	H	-0.6926
106	T	H	0.1866
107	L	H	1.2280
108	V	H	0.0000
109	T	H	-0.1163
110	V	H	0.0000
111	S	H	-1.0341
112	S	H	-1.0013