Project name: 2510-16.pdb

Chain sequence(s)	H: EVQLQQSGAELARPGASVKMSCKASGYTFTSYTIQWVKQRPGQGLEWIGYINPSSGYTNYNQKFKDKATLTADKSSSTAYMQLSSLTSEDSAVYYCARRAVAFDYWGQGTTLTVSS; L: DIQMIQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSGVPKRFSGSRSGSDYSLTISSLESEDFADYYCLQYASYPYTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:06)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:07)

• Minimal score value: -3.4641
• Maximal score value: 1.8485
• Average score: -0.5977
• Total score value: -133.2792

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0942
2	V	H	-1.2785
3	Q	H	-2.0912
4	L	H	0.0000
5	Q	H	-2.1626
6	Q	H	0.0000
7	S	H	-1.0234
8	G	H	-0.9434
9	A	H	-0.1873
11	E	H	-0.2370
12	L	H	0.7625
13	A	H	-0.4987
14	R	H	-1.8782
15	P	H	-1.4332
16	G	H	-1.1582
17	A	H	-0.9449
18	S	H	-0.9566
19	V	H	-0.7282
20	K	H	-1.2634
21	M	H	0.0000
22	S	H	-0.6818
23	C	H	0.0000
24	K	H	-1.5211
25	A	H	0.0000
26	S	H	-1.3941
27	G	H	-1.2679
28	Y	H	-0.5318
29	T	H	-0.2445
30	F	H	0.0000
35	T	H	-0.5788
36	S	H	-0.1641
37	Y	H	0.2409
38	T	H	-0.1017
39	I	H	0.0000
40	Q	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	-0.7280
45	R	H	-1.2704
46	P	H	-0.9489
47	G	H	-1.2079
48	Q	H	-1.6550
49	G	H	-1.1652
50	L	H	0.0000
51	E	H	-0.9397
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	Y	H	0.0000
56	I	H	0.0000
57	N	H	-0.1231
58	P	H	0.0000
59	S	H	-0.5421
62	S	H	-0.2532
63	G	H	-0.2279
64	Y	H	0.8896
65	T	H	0.3854
66	N	H	-0.0951
67	Y	H	-0.9703
68	N	H	0.0000
69	Q	H	-2.9590
70	K	H	-3.0748
71	F	H	0.0000
72	K	H	-3.4641
74	D	H	-3.1957
75	K	H	-2.2198
76	A	H	0.0000
77	T	H	-0.9858
78	L	H	0.0000
79	T	H	-0.1819
80	A	H	-0.7139
81	D	H	-1.4504
82	K	H	-2.0091
83	S	H	-1.1622
84	S	H	-0.9653
85	S	H	-1.1162
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.3047
89	M	H	0.0000
90	Q	H	-0.9768
91	L	H	0.0000
92	S	H	-1.0175
93	S	H	-0.9981
94	L	H	0.0000
95	T	H	-1.2442
96	S	H	-1.3247
97	E	H	-1.8782
98	D	H	0.0000
99	S	H	-0.6235
100	A	H	0.0000
101	V	H	0.0862
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	R	H	0.0873
108	A	H	0.6890
109	V	H	1.8485
114	A	H	0.0000
115	F	H	0.0000
116	D	H	0.0947
117	Y	H	-0.1619
118	W	H	-0.5049
119	G	H	0.0000
120	Q	H	-1.7920
121	G	H	-0.7854
122	T	H	0.0000
123	T	H	-0.1112
124	L	H	0.0000
125	T	H	-0.1776
126	V	H	0.0000
127	S	H	-0.7169
128	S	H	-0.8825
1	D	L	-2.2007
2	I	L	-1.6625
3	Q	L	-1.8855
4	M	L	0.0000
5	I	L	-0.1336
6	Q	L	-0.5118
7	S	L	-0.5584
8	P	L	-0.4145
9	S	L	-0.6442
10	S	L	-0.9239
11	L	L	-0.4472
12	S	L	-0.6196
13	A	L	0.0000
14	S	L	-0.4361
15	L	L	0.0185
16	G	L	-1.0052
17	E	L	-1.6347
18	R	L	-2.2343
19	V	L	0.0000
20	S	L	-0.6523
21	L	L	0.0000
22	T	L	-0.6899
23	C	L	0.0000
24	R	L	-2.4259
25	A	L	0.0000
26	S	L	-1.9412
27	Q	L	-2.8305
28	E	L	-2.6460
29	I	L	0.0000
36	S	L	-0.6851
37	G	L	-0.0243
38	Y	L	1.2356
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	L	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.6127
46	P	L	-1.3896
47	D	L	-2.2712
48	G	L	-1.5423
49	T	L	-1.3467
50	I	L	0.0000
51	K	L	-0.9365
52	R	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.8125
56	A	L	0.7852
57	A	L	0.0000
65	S	L	-0.2143
66	T	L	0.0402
67	L	L	-0.1469
68	D	L	-0.4091
69	S	L	-0.4759
70	G	L	-0.8204
71	V	L	0.0000
72	P	L	-1.2276
74	K	L	-1.8852
75	R	L	-1.5168
76	F	L	0.0000
77	S	L	-0.6024
78	G	L	-0.4141
79	S	L	-0.9060
80	R	L	-1.6662
83	S	L	-1.2901
84	G	L	-1.4207
85	S	L	-1.9798
86	D	L	-1.7334
87	Y	L	0.0000
88	S	L	-0.8515
89	L	L	0.0000
90	T	L	-0.6344
91	I	L	0.0000
92	S	L	-1.5376
93	S	L	-1.5322
94	L	L	0.0000
95	E	L	-1.7159
96	S	L	-1.0932
97	E	L	-2.0689
98	D	L	0.0000
99	F	L	-0.7033
100	A	L	0.0000
101	D	L	-1.0062
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	A	L	0.0665
109	S	L	-0.2336
114	Y	L	0.1274
115	P	L	-0.6816
116	Y	L	0.0000
117	T	L	-0.6318
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.7290
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.5667
124	L	L	0.0000
125	E	L	-0.9014
126	I	L	0.8224
127	K	L	-0.8791