| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKDGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKFGDTENPTEYQHETKDDRVNFSWDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPVGHPLPSAPPPSPLYVPPPPTSPYAVLPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEENVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9476 | |
| 2 | L | A | 1.9700 | |
| 3 | P | A | 0.6466 | |
| 4 | P | A | 0.3629 | |
| 5 | T | A | 0.1212 | |
| 6 | T | A | 0.1388 | |
| 7 | P | A | 0.1985 | |
| 8 | V | A | 1.2200 | |
| 9 | A | A | 0.0370 | |
| 10 | K | A | -1.1314 | |
| 11 | V | A | -0.3658 | |
| 12 | Q | A | -1.4914 | |
| 13 | S | A | -1.5982 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4548 | |
| 16 | E | A | -2.4523 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4474 | |
| 20 | P | A | 0.1012 | |
| 21 | T | A | 0.1147 | |
| 22 | S | A | -0.1689 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1053 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1490 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7083 | |
| 31 | R | A | -2.6202 | |
| 32 | L | A | -0.7767 | |
| 33 | L | A | 1.1303 | |
| 34 | T | A | 1.5266 | |
| 35 | V | A | 1.8447 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2547 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6119 | |
| 40 | K | A | -1.6161 | |
| 41 | D | A | -0.8868 | |
| 42 | I | A | 0.8372 | |
| 43 | V | A | 0.9049 | |
| 44 | K | A | -1.4286 | |
| 45 | D | A | -2.4398 | |
| 46 | G | A | -1.4821 | |
| 47 | K | A | -1.0932 | |
| 48 | V | A | 1.4309 | |
| 49 | V | A | 2.0021 | |
| 50 | V | A | 1.3056 | |
| 51 | P | A | 0.5065 | |
| 52 | K | A | -0.6006 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1310 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4823 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2975 | |
| 70 | K | A | -1.8140 | |
| 71 | F | A | -0.6689 | |
| 72 | A | A | -0.5694 | |
| 73 | L | A | -0.8524 | |
| 74 | P | A | -1.2529 | |
| 75 | Q | A | -2.4718 | |
| 76 | K | A | -3.0884 | |
| 77 | D | A | -2.9831 | |
| 78 | F | A | -1.6318 | |
| 79 | Y | A | -1.9176 | |
| 80 | D | A | -2.7460 | |
| 81 | P | A | -2.3423 | |
| 82 | E | A | -3.0653 | |
| 83 | K | A | -3.4378 | |
| 84 | E | A | -2.4966 | |
| 85 | R | A | -1.3114 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6352 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9713 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3379 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7455 | |
| 99 | G | A | -0.5294 | |
| 100 | P | A | -0.3995 | |
| 101 | L | A | -0.0027 | |
| 102 | G | A | -0.3152 | |
| 103 | K | A | -0.8401 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4856 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.0943 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1758 | |
| 110 | L | A | -0.0969 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2510 | |
| 113 | K | A | -0.4418 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4641 | |
| 117 | T | A | -0.9625 | |
| 118 | E | A | -1.8002 | |
| 119 | N | A | -2.2077 | |
| 120 | P | A | -1.9621 | |
| 121 | T | A | -1.6352 | |
| 122 | E | A | -2.3374 | |
| 123 | Y | A | -0.9576 | |
| 124 | Q | A | -1.9592 | |
| 125 | H | A | -2.0492 | |
| 126 | E | A | -3.0980 | |
| 127 | T | A | -2.7601 | |
| 128 | K | A | -3.1419 | |
| 129 | D | A | -3.1521 | |
| 130 | D | A | -2.3307 | |
| 131 | R | A | -1.5494 | |
| 132 | V | A | -0.4756 | |
| 133 | N | A | -0.8953 | |
| 134 | F | A | -0.3703 | |
| 135 | S | A | -0.3595 | |
| 136 | W | A | 0.0000 | |
| 137 | D | A | -0.7147 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5550 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2794 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0858 | |
| 157 | D | A | 0.3332 | |
| 158 | I | A | 0.8487 | |
| 159 | A | A | 0.1197 | |
| 160 | E | A | -1.4706 | |
| 161 | P | A | -0.2214 | |
| 162 | C | A | 0.1937 | |
| 163 | P | A | -0.1567 | |
| 164 | G | A | -0.0509 | |
| 165 | L | A | 0.6376 | |
| 166 | P | A | -0.0892 | |
| 167 | P | A | -0.3296 | |
| 168 | G | A | -0.4107 | |
| 169 | A | A | -0.0067 | |
| 170 | C | A | 0.7587 | |
| 171 | P | A | 0.5592 | |
| 172 | P | A | 0.7822 | |
| 173 | I | A | 2.0253 | |
| 174 | Q | A | 0.8276 | |
| 175 | L | A | 1.4137 | |
| 176 | V | A | 0.8011 | |
| 177 | N | A | -0.3573 | |
| 178 | S | A | -0.0173 | |
| 179 | V | A | 0.3646 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3565 | |
| 182 | D | A | 0.0630 | |
| 183 | G | A | -0.1614 | |
| 184 | D | A | -0.6023 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4892 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1149 | |
| 190 | F | A | 0.0223 | |
| 191 | G | A | -0.1557 | |
| 192 | N | A | -0.3607 | |
| 193 | M | A | -0.2103 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3973 | |
| 197 | E | A | -2.5832 | |
| 198 | L | A | -1.2041 | |
| 199 | Q | A | -2.5226 | |
| 200 | Q | A | -3.3304 | |
| 201 | D | A | -3.5968 | |
| 202 | R | A | -3.3299 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1881 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3862 | |
| 211 | S | A | -1.9021 | |
| 212 | T | A | -1.4979 | |
| 213 | R | A | -2.2384 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2285 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2607 | |
| 220 | L | A | 0.4513 | |
| 221 | K | A | -1.4074 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -1.0082 | |
| 224 | N | A | -1.7450 | |
| 225 | E | A | -1.3806 | |
| 226 | A | A | -0.6849 | |
| 227 | Y | A | -0.4710 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7177 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1415 | |
| 234 | F | A | 0.0295 | |
| 235 | G | A | -0.9207 | |
| 236 | R | A | -2.6698 | |
| 237 | R | A | -2.9175 | |
| 238 | E | A | -2.1223 | |
| 239 | Q | A | -0.1142 | |
| 240 | V | A | 1.5979 | |
| 241 | Y | A | 1.2670 | |
| 242 | A | A | 0.2020 | |
| 243 | R | A | -1.1893 | |
| 244 | H | A | -0.9442 | |
| 245 | F | A | 0.1380 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.4339 | |
| 249 | C | A | -1.2117 | |
| 250 | G | A | -1.0568 | |
| 251 | P | A | -0.6904 | |
| 252 | V | A | -0.5124 | |
| 253 | G | A | -0.9003 | |
| 254 | H | A | -1.1439 | |
| 255 | P | A | -0.5100 | |
| 256 | L | A | 0.4134 | |
| 257 | P | A | -0.0877 | |
| 258 | S | A | -0.1446 | |
| 259 | A | A | 0.1959 | |
| 260 | P | A | -0.2935 | |
| 261 | P | A | -0.0157 | |
| 262 | P | A | 0.0659 | |
| 263 | S | A | 0.5848 | |
| 264 | P | A | 0.6827 | |
| 265 | L | A | 1.8745 | |
| 266 | Y | A | 1.7268 | |
| 267 | V | A | 1.9442 | |
| 268 | P | A | 1.1877 | |
| 269 | P | A | 0.7665 | |
| 270 | P | A | -0.0896 | |
| 271 | P | A | -0.0569 | |
| 272 | T | A | 0.0079 | |
| 273 | S | A | 0.3071 | |
| 274 | P | A | 0.5518 | |
| 275 | Y | A | 1.7079 | |
| 276 | A | A | 1.3859 | |
| 277 | V | A | 2.2800 | |
| 278 | L | A | 1.7903 | |
| 279 | P | A | 0.3381 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.2956 | |
| 282 | D | A | -0.3008 | |
| 283 | Y | A | 1.0983 | |
| 284 | F | A | 0.8246 | |
| 285 | G | A | 0.2589 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9292 | |
| 291 | L | A | 1.6032 | |
| 292 | V | A | 0.5824 | |
| 293 | S | A | -0.1604 | |
| 294 | S | A | -0.9692 | |
| 295 | D | A | -1.8439 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1398 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6468 | |
| 301 | R | A | -1.9207 | |
| 302 | P | A | -0.9792 | |
| 303 | F | A | -0.1878 | |
| 304 | W | A | -0.5176 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0802 | |
| 307 | R | A | -2.9288 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7866 | |
| 310 | G | A | -1.4339 | |
| 311 | N | A | -1.4028 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9315 | |
| 319 | N | A | -0.8993 | |
| 320 | E | A | -1.0566 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4232 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2390 | |
| 333 | N | A | 0.3522 | |
| 334 | F | A | 1.4157 | |
| 335 | T | A | 0.7361 | |
| 336 | I | A | 0.4015 | |
| 337 | S | A | -0.9633 | |
| 338 | Q | A | -1.7276 | |
| 339 | Q | A | -1.2972 | |
| 340 | L | A | 0.6685 | |
| 341 | C | A | 0.3284 | |
| 342 | T | A | -0.5037 | |
| 343 | P | A | -0.9637 | |
| 344 | E | A | -2.3501 | |
| 345 | E | A | -2.6354 | |
| 346 | N | A | -1.5876 | |
| 347 | V | A | 0.3042 | |
| 348 | Y | A | 0.8472 | |
| 349 | D | A | -0.0968 | |
| 350 | P | A | -0.3537 | |
| 351 | S | A | -0.2819 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7541 | |
| 354 | K | A | -1.7583 | |
| 355 | N | A | -1.7459 | |
| 356 | Y | A | -0.0925 | |
| 357 | L | A | 0.5692 | |
| 358 | R | A | 0.8452 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.1660 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.1631 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9118 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6577 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3134 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3279 | |
| 376 | L | A | -1.7611 | |
| 377 | D | A | -2.0484 | |
| 378 | P | A | -1.0671 | |
| 379 | G | A | -1.0205 | |
| 380 | V | A | -0.9278 | |
| 381 | L | A | -0.5373 | |
| 382 | A | A | -0.6572 | |
| 383 | H | A | -0.8423 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3930 | |
| 386 | T | A | -0.5600 | |
| 387 | M | A | -0.3228 | |
| 388 | N | A | -0.8656 | |
| 389 | P | A | -1.2695 | |
| 390 | T | A | -1.5465 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5481 | |
| 393 | E | A | -2.9560 | |
| 394 | N | A | -2.7020 | |
| 395 | W | A | -1.5558 | |
| 396 | N | A | -1.4296 | |
| 397 | L | A | -0.2804 | |
| 398 | G | A | 0.4992 | |
| 399 | F | A | 2.4116 | |
| 400 | V | A | 1.8398 | |
| 401 | P | A | 0.0404 | |
| 402 | P | A | -1.8998 | |
| 403 | K | A | -3.5411 | |
| 404 | E | A | -3.8937 | |
| 405 | R | A | -4.2111 | |
| 406 | E | A | -3.8868 | |
| 407 | D | A | -2.8951 | |
| 408 | P | A | -1.7759 | |
| 409 | Y | A | -0.9833 | |
| 410 | K | A | -2.0876 | |
| 411 | G | A | -0.6380 | |
| 412 | L | A | 0.6549 | |
| 413 | I | A | 1.5728 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3997 | |
| 416 | E | A | -1.6756 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8445 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8921 | |
| 421 | E | A | -2.4977 | |
| 422 | R | A | -2.0650 | |
| 423 | F | A | -1.0277 | |
| 424 | S | A | -1.3391 | |
| 425 | Q | A | -1.8885 | |
| 426 | D | A | -2.9032 | |
| 427 | L | A | -1.9838 | |
| 428 | D | A | -2.7535 | |
| 429 | Q | A | -2.6001 | |
| 430 | F | A | -1.4116 | |
| 431 | A | A | -0.8676 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5035 | |
| 435 | K | A | -0.6725 | |
| 436 | F | A | 0.1878 | |
| 437 | L | A | 1.0600 | |
| 438 | Y | A | 0.8506 | |
| 439 | Q | A | -0.2514 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine