| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKLGDTENPTAPVHEGADVRVAFSYDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPEGHPLPDADPPSKLYVKPPPSSPYAVRPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPPINVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9406 | |
| 2 | L | A | 1.9624 | |
| 3 | P | A | 0.8357 | |
| 4 | P | A | 0.3764 | |
| 5 | T | A | 0.1311 | |
| 6 | T | A | 0.1307 | |
| 7 | P | A | 0.1828 | |
| 8 | V | A | 1.2074 | |
| 9 | A | A | 0.0841 | |
| 10 | K | A | -1.0300 | |
| 11 | V | A | -0.1832 | |
| 12 | Q | A | -1.4183 | |
| 13 | S | A | -1.5505 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.3929 | |
| 16 | E | A | -2.4279 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4627 | |
| 20 | P | A | 0.1316 | |
| 21 | T | A | 0.1779 | |
| 22 | S | A | -0.0972 | |
| 23 | L | A | 0.0880 | |
| 24 | F | A | -0.0290 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2944 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9049 | |
| 31 | R | A | -2.6928 | |
| 32 | L | A | -0.8096 | |
| 33 | L | A | 1.1507 | |
| 34 | T | A | 1.3633 | |
| 35 | V | A | 1.8187 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2658 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6728 | |
| 40 | E | A | -1.7865 | |
| 41 | D | A | -0.7081 | |
| 42 | I | A | 1.3735 | |
| 43 | V | A | 2.3256 | |
| 44 | V | A | 1.8718 | |
| 45 | N | A | -0.4451 | |
| 46 | G | A | -0.2930 | |
| 47 | K | A | -0.0190 | |
| 48 | V | A | 2.1357 | |
| 49 | V | A | 2.7829 | |
| 50 | V | A | 1.5649 | |
| 51 | P | A | 0.3489 | |
| 52 | K | A | -0.7196 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1643 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3846 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2661 | |
| 70 | K | A | -1.7826 | |
| 71 | F | A | -0.6260 | |
| 72 | A | A | -0.5700 | |
| 73 | L | A | -0.8636 | |
| 74 | P | A | -1.2077 | |
| 75 | Q | A | -2.5053 | |
| 76 | K | A | -3.1093 | |
| 77 | D | A | -2.9928 | |
| 78 | F | A | -1.6775 | |
| 79 | Y | A | -1.8858 | |
| 80 | D | A | -2.6781 | |
| 81 | P | A | -2.3033 | |
| 82 | E | A | -3.0457 | |
| 83 | K | A | -3.3904 | |
| 84 | E | A | -2.4549 | |
| 85 | R | A | -1.2870 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6435 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9660 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3582 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6990 | |
| 99 | G | A | -0.5426 | |
| 100 | P | A | -0.3967 | |
| 101 | L | A | 0.0590 | |
| 102 | G | A | -0.1530 | |
| 103 | K | A | -0.5212 | |
| 104 | G | A | -0.4410 | |
| 105 | S | A | -0.5269 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1051 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4186 | |
| 110 | L | A | 0.4173 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9782 | |
| 113 | K | A | -0.3621 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.1757 | |
| 117 | T | A | -0.8365 | |
| 118 | E | A | -1.8207 | |
| 119 | N | A | -1.9824 | |
| 120 | P | A | -1.3179 | |
| 121 | T | A | -0.6496 | |
| 122 | A | A | -0.3175 | |
| 123 | P | A | 0.0291 | |
| 124 | V | A | -0.4427 | |
| 125 | H | A | -1.3253 | |
| 126 | E | A | -2.4034 | |
| 127 | G | A | -1.9728 | |
| 128 | A | A | -1.4071 | |
| 129 | D | A | -2.1315 | |
| 130 | V | A | -1.4002 | |
| 131 | R | A | -0.7383 | |
| 132 | V | A | 0.4293 | |
| 133 | A | A | 0.4530 | |
| 134 | F | A | 0.2787 | |
| 135 | S | A | -0.1124 | |
| 136 | Y | A | 0.0000 | |
| 137 | D | A | -0.6029 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5596 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2079 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1435 | |
| 157 | D | A | 0.3206 | |
| 158 | I | A | 0.8597 | |
| 159 | A | A | 0.1240 | |
| 160 | E | A | -1.4764 | |
| 161 | P | A | -0.2299 | |
| 162 | C | A | 0.1826 | |
| 163 | P | A | -0.1721 | |
| 164 | G | A | -0.0796 | |
| 165 | L | A | 0.5858 | |
| 166 | P | A | -0.1126 | |
| 167 | P | A | -0.3394 | |
| 168 | G | A | -0.4218 | |
| 169 | A | A | -0.0258 | |
| 170 | C | A | 0.7417 | |
| 171 | P | A | 0.5557 | |
| 172 | P | A | 0.7918 | |
| 173 | I | A | 2.0500 | |
| 174 | Q | A | 0.8522 | |
| 175 | L | A | 1.4496 | |
| 176 | V | A | 0.8348 | |
| 177 | N | A | -0.3190 | |
| 178 | S | A | -0.0933 | |
| 179 | V | A | 0.4229 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3846 | |
| 182 | D | A | 0.0801 | |
| 183 | G | A | -0.1544 | |
| 184 | D | A | -0.5206 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1323 | |
| 190 | F | A | 0.0689 | |
| 191 | G | A | -0.1018 | |
| 192 | N | A | -0.2473 | |
| 193 | M | A | -0.1014 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3596 | |
| 197 | E | A | -2.5733 | |
| 198 | L | A | -1.1918 | |
| 199 | Q | A | -2.5421 | |
| 200 | Q | A | -3.3102 | |
| 201 | D | A | -3.5807 | |
| 202 | R | A | -3.3387 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1605 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3521 | |
| 211 | S | A | -1.9018 | |
| 212 | T | A | -1.4181 | |
| 213 | R | A | -2.0249 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1511 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3229 | |
| 220 | L | A | 0.5803 | |
| 221 | K | A | -1.1632 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8303 | |
| 224 | N | A | -1.5945 | |
| 225 | E | A | -1.2502 | |
| 226 | A | A | -0.6074 | |
| 227 | Y | A | -0.3626 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6659 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0751 | |
| 234 | F | A | 0.2588 | |
| 235 | G | A | -0.8204 | |
| 236 | R | A | -2.6066 | |
| 237 | R | A | -2.8804 | |
| 238 | E | A | -2.1682 | |
| 239 | Q | A | -0.1971 | |
| 240 | V | A | 1.4164 | |
| 241 | Y | A | 1.2209 | |
| 242 | A | A | 0.1952 | |
| 243 | R | A | -1.1418 | |
| 244 | H | A | -0.9921 | |
| 245 | F | A | 0.0446 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5842 | |
| 249 | A | A | -1.3142 | |
| 250 | G | A | -1.1324 | |
| 251 | P | A | -1.1328 | |
| 252 | E | A | -1.3366 | |
| 253 | G | A | -1.2627 | |
| 254 | H | A | -1.4458 | |
| 255 | P | A | -1.3578 | |
| 256 | L | A | -0.3833 | |
| 257 | P | A | -1.2867 | |
| 258 | D | A | -2.4322 | |
| 259 | A | A | -1.7351 | |
| 260 | D | A | -2.6352 | |
| 261 | P | A | -1.5901 | |
| 262 | P | A | -1.1417 | |
| 263 | S | A | -1.4170 | |
| 264 | K | A | -1.2024 | |
| 265 | L | A | 0.5651 | |
| 266 | Y | A | 0.5144 | |
| 267 | V | A | 0.4749 | |
| 268 | K | A | -1.2638 | |
| 269 | P | A | -0.2358 | |
| 270 | P | A | -0.5072 | |
| 271 | P | A | -0.3268 | |
| 272 | S | A | -0.0972 | |
| 273 | S | A | 0.1477 | |
| 274 | P | A | 0.4502 | |
| 275 | Y | A | 1.0698 | |
| 276 | A | A | 0.6470 | |
| 277 | V | A | 1.2313 | |
| 278 | R | A | -0.1809 | |
| 279 | P | A | -0.5256 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.5627 | |
| 282 | D | A | -0.9063 | |
| 283 | Y | A | 0.8342 | |
| 284 | F | A | 0.7080 | |
| 285 | G | A | 0.2460 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8878 | |
| 291 | L | A | 1.6182 | |
| 292 | V | A | 0.6499 | |
| 293 | S | A | -0.1625 | |
| 294 | S | A | -0.9615 | |
| 295 | D | A | -1.8420 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1027 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6279 | |
| 301 | R | A | -1.8488 | |
| 302 | P | A | -0.9745 | |
| 303 | F | A | -0.1890 | |
| 304 | W | A | -0.5591 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0810 | |
| 307 | R | A | -2.8252 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.3721 | |
| 310 | G | A | -1.2175 | |
| 311 | N | A | -1.2634 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8070 | |
| 319 | N | A | -0.9323 | |
| 320 | E | A | -1.0399 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3171 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0535 | |
| 333 | N | A | 0.5537 | |
| 334 | F | A | 1.7645 | |
| 335 | T | A | 0.8765 | |
| 336 | I | A | 0.4331 | |
| 337 | S | A | -0.9460 | |
| 338 | Q | A | -1.6603 | |
| 339 | Q | A | -1.1536 | |
| 340 | L | A | 0.4587 | |
| 341 | S | A | 0.1668 | |
| 342 | T | A | -0.0961 | |
| 343 | P | A | -0.4214 | |
| 344 | P | A | -0.2645 | |
| 345 | I | A | 0.3964 | |
| 346 | N | A | -0.0734 | |
| 347 | V | A | 1.6460 | |
| 348 | Y | A | 1.4841 | |
| 349 | D | A | -0.0491 | |
| 350 | P | A | -0.7058 | |
| 351 | S | A | -0.5560 | |
| 352 | N | A | -0.2850 | |
| 353 | F | A | -0.8863 | |
| 354 | K | A | -1.9257 | |
| 355 | N | A | -1.7780 | |
| 356 | Y | A | -0.1234 | |
| 357 | L | A | 0.6416 | |
| 358 | R | A | 0.9620 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3810 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0905 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0561 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6889 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3018 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3107 | |
| 376 | L | A | -1.7082 | |
| 377 | D | A | -1.9889 | |
| 378 | P | A | -1.0377 | |
| 379 | G | A | -1.0115 | |
| 380 | V | A | -0.9310 | |
| 381 | L | A | -0.5304 | |
| 382 | A | A | -0.6521 | |
| 383 | H | A | -0.8068 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3923 | |
| 386 | T | A | -0.5449 | |
| 387 | M | A | -0.2945 | |
| 388 | N | A | -0.8579 | |
| 389 | P | A | -1.2302 | |
| 390 | T | A | -1.4167 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4102 | |
| 393 | E | A | -2.7443 | |
| 394 | N | A | -2.3286 | |
| 395 | W | A | -1.3346 | |
| 396 | N | A | -1.0641 | |
| 397 | L | A | -0.1956 | |
| 398 | G | A | 0.5464 | |
| 399 | F | A | 2.4172 | |
| 400 | V | A | 1.8351 | |
| 401 | P | A | 0.0518 | |
| 402 | P | A | -1.7733 | |
| 403 | K | A | -3.3076 | |
| 404 | E | A | -3.7529 | |
| 405 | R | A | -3.8607 | |
| 406 | E | A | -3.7642 | |
| 407 | D | A | -2.8692 | |
| 408 | P | A | -1.7605 | |
| 409 | Y | A | -0.9862 | |
| 410 | K | A | -2.1155 | |
| 411 | G | A | -0.6355 | |
| 412 | L | A | 0.6788 | |
| 413 | I | A | 1.5872 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4019 | |
| 416 | E | A | -1.7084 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9594 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0578 | |
| 421 | E | A | -2.7885 | |
| 422 | R | A | -2.5739 | |
| 423 | F | A | -1.2814 | |
| 424 | S | A | -1.4728 | |
| 425 | Q | A | -1.7417 | |
| 426 | D | A | -2.9035 | |
| 427 | L | A | -1.9869 | |
| 428 | D | A | -2.7743 | |
| 429 | Q | A | -2.6166 | |
| 430 | F | A | -1.4150 | |
| 431 | A | A | -0.8920 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5798 | |
| 435 | K | A | -0.7097 | |
| 436 | F | A | 0.1435 | |
| 437 | L | A | 1.0270 | |
| 438 | Y | A | 0.8265 | |
| 439 | Q | A | -0.2759 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine