| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIIKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKFGDTENPTEYQHEGADDRVAYSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFHRRCGPEGHPLPSEPPPSPLYVPPPPSSPYAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAINVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9448 | |
| 2 | L | A | 1.9668 | |
| 3 | P | A | 0.8366 | |
| 4 | P | A | 0.3725 | |
| 5 | T | A | 0.1209 | |
| 6 | T | A | 0.1288 | |
| 7 | P | A | 0.1572 | |
| 8 | V | A | 1.2032 | |
| 9 | A | A | 0.0772 | |
| 10 | K | A | -1.0386 | |
| 11 | V | A | -0.2003 | |
| 12 | Q | A | -1.4406 | |
| 13 | S | A | -1.5802 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4519 | |
| 16 | E | A | -2.4587 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4513 | |
| 20 | P | A | 0.1220 | |
| 21 | T | A | 0.1589 | |
| 22 | S | A | -0.0966 | |
| 23 | L | A | 0.0957 | |
| 24 | F | A | -0.0316 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2950 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8989 | |
| 31 | R | A | -2.6781 | |
| 32 | L | A | -0.7981 | |
| 33 | L | A | 1.1613 | |
| 34 | T | A | 1.3709 | |
| 35 | V | A | 1.8325 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1823 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5776 | |
| 40 | K | A | -1.5068 | |
| 41 | D | A | -0.6808 | |
| 42 | I | A | 1.0300 | |
| 43 | I | A | 1.2834 | |
| 44 | K | A | -1.0469 | |
| 45 | N | A | -1.8749 | |
| 46 | G | A | -1.1741 | |
| 47 | K | A | -0.8859 | |
| 48 | V | A | 1.5658 | |
| 49 | V | A | 2.1152 | |
| 50 | V | A | 1.3297 | |
| 51 | P | A | 0.5327 | |
| 52 | K | A | -0.5771 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1366 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4038 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2691 | |
| 70 | K | A | -1.7907 | |
| 71 | F | A | -0.6387 | |
| 72 | A | A | -0.5755 | |
| 73 | L | A | -0.8642 | |
| 74 | P | A | -1.2698 | |
| 75 | Q | A | -2.5038 | |
| 76 | K | A | -3.1085 | |
| 77 | D | A | -2.9941 | |
| 78 | F | A | -1.6748 | |
| 79 | Y | A | -1.8930 | |
| 80 | D | A | -2.6928 | |
| 81 | P | A | -2.3044 | |
| 82 | E | A | -3.0493 | |
| 83 | K | A | -3.3980 | |
| 84 | E | A | -2.4622 | |
| 85 | R | A | -1.2903 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6672 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9526 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3445 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6873 | |
| 99 | G | A | -0.5237 | |
| 100 | P | A | -0.3771 | |
| 101 | L | A | 0.0986 | |
| 102 | G | A | -0.1836 | |
| 103 | K | A | -0.6137 | |
| 104 | G | A | -0.4392 | |
| 105 | T | A | -0.4323 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1375 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4164 | |
| 110 | L | A | 0.3053 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1099 | |
| 113 | K | A | -0.3260 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | -1.3698 | |
| 116 | D | A | -1.7980 | |
| 117 | T | A | -1.1607 | |
| 118 | E | A | -1.8258 | |
| 119 | N | A | -2.2655 | |
| 120 | P | A | -2.0280 | |
| 121 | T | A | -1.6308 | |
| 122 | E | A | -2.2867 | |
| 123 | Y | A | -0.6433 | |
| 124 | Q | A | -1.7110 | |
| 125 | H | A | -1.6264 | |
| 126 | E | A | -2.1251 | |
| 127 | G | A | -2.0056 | |
| 128 | A | A | -1.4456 | |
| 129 | D | A | -2.3541 | |
| 130 | D | A | -1.9736 | |
| 131 | R | A | -1.0833 | |
| 132 | V | A | 0.2479 | |
| 133 | A | A | 0.4365 | |
| 134 | Y | A | 0.2289 | |
| 135 | S | A | -0.0857 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4357 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2503 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5640 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1929 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1621 | |
| 157 | D | A | 0.3219 | |
| 158 | L | A | 0.7753 | |
| 159 | A | A | 0.1620 | |
| 160 | E | A | -1.4603 | |
| 161 | P | A | -0.2155 | |
| 162 | C | A | 0.1896 | |
| 163 | P | A | -0.1734 | |
| 164 | G | A | -0.0809 | |
| 165 | L | A | 0.5889 | |
| 166 | P | A | -0.1231 | |
| 167 | P | A | -0.3446 | |
| 168 | G | A | -0.4518 | |
| 169 | A | A | -0.0259 | |
| 170 | C | A | 0.6528 | |
| 171 | P | A | 0.5143 | |
| 172 | P | A | 0.7490 | |
| 173 | I | A | 1.9967 | |
| 174 | Q | A | 0.8590 | |
| 175 | L | A | 1.5022 | |
| 176 | V | A | 0.8585 | |
| 177 | N | A | -0.2988 | |
| 178 | S | A | 0.0266 | |
| 179 | V | A | 0.4276 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3801 | |
| 182 | D | A | 0.0811 | |
| 183 | G | A | -0.1581 | |
| 184 | D | A | -0.5282 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1098 | |
| 190 | F | A | 0.0656 | |
| 191 | G | A | -0.1009 | |
| 192 | N | A | -0.2480 | |
| 193 | M | A | -0.1041 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4011 | |
| 197 | E | A | -2.6223 | |
| 198 | L | A | -1.2396 | |
| 199 | Q | A | -2.5651 | |
| 200 | Q | A | -3.3170 | |
| 201 | D | A | -3.5729 | |
| 202 | R | A | -3.3271 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2098 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3500 | |
| 211 | S | A | -1.8750 | |
| 212 | T | A | -1.4178 | |
| 213 | R | A | -2.0499 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1550 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3733 | |
| 220 | L | A | 0.6064 | |
| 221 | K | A | -1.1112 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8136 | |
| 224 | N | A | -1.4935 | |
| 225 | E | A | -1.2344 | |
| 226 | A | A | -0.6088 | |
| 227 | Y | A | -0.3616 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6765 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0781 | |
| 234 | F | A | 0.2669 | |
| 235 | G | A | -0.8255 | |
| 236 | R | A | -2.6204 | |
| 237 | R | A | -2.9254 | |
| 238 | E | A | -2.1820 | |
| 239 | Q | A | -0.2355 | |
| 240 | V | A | 1.4240 | |
| 241 | Y | A | 1.2240 | |
| 242 | A | A | 0.3814 | |
| 243 | R | A | -0.6241 | |
| 244 | H | A | -0.8580 | |
| 245 | F | A | 0.0414 | |
| 246 | H | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6383 | |
| 249 | C | A | -1.2018 | |
| 250 | G | A | -1.0475 | |
| 251 | P | A | -1.0828 | |
| 252 | E | A | -1.3563 | |
| 253 | G | A | -1.2954 | |
| 254 | H | A | -1.4696 | |
| 255 | P | A | -0.9269 | |
| 256 | L | A | 0.0455 | |
| 257 | P | A | -0.6535 | |
| 258 | S | A | -0.8519 | |
| 259 | E | A | -2.2382 | |
| 260 | P | A | -1.6731 | |
| 261 | P | A | -0.8690 | |
| 262 | P | A | -0.3721 | |
| 263 | S | A | 0.0231 | |
| 264 | P | A | 0.4403 | |
| 265 | L | A | 1.8364 | |
| 266 | Y | A | 1.6798 | |
| 267 | V | A | 1.8824 | |
| 268 | P | A | 1.0471 | |
| 269 | P | A | 0.6365 | |
| 270 | P | A | -0.1852 | |
| 271 | P | A | -0.1658 | |
| 272 | S | A | -0.1441 | |
| 273 | S | A | 0.1924 | |
| 274 | P | A | 0.4754 | |
| 275 | Y | A | 1.4601 | |
| 276 | A | A | 1.2497 | |
| 277 | V | A | 2.1045 | |
| 278 | L | A | 1.6411 | |
| 279 | P | A | 0.2387 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.3427 | |
| 282 | D | A | -1.0136 | |
| 283 | Y | A | 0.7538 | |
| 284 | F | A | 0.6392 | |
| 285 | G | A | 0.3101 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9548 | |
| 291 | L | A | 1.6053 | |
| 292 | V | A | 0.6329 | |
| 293 | S | A | -0.1507 | |
| 294 | S | A | -0.9517 | |
| 295 | D | A | -1.8431 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1137 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6160 | |
| 301 | R | A | -1.8306 | |
| 302 | P | A | -0.9373 | |
| 303 | F | A | -0.1894 | |
| 304 | W | A | -0.5684 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0842 | |
| 307 | R | A | -2.8348 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2500 | |
| 310 | G | A | -1.2191 | |
| 311 | N | A | -1.2814 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8285 | |
| 319 | N | A | -0.8519 | |
| 320 | E | A | -1.0360 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3216 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0699 | |
| 333 | N | A | 0.5598 | |
| 334 | F | A | 1.7630 | |
| 335 | T | A | 0.8837 | |
| 336 | I | A | 0.4542 | |
| 337 | S | A | -0.8505 | |
| 338 | Q | A | -1.5332 | |
| 339 | Q | A | -0.8641 | |
| 340 | L | A | 0.8430 | |
| 341 | C | A | 0.6518 | |
| 342 | T | A | 0.2767 | |
| 343 | P | A | -0.1052 | |
| 344 | A | A | 0.3749 | |
| 345 | I | A | 0.7368 | |
| 346 | N | A | 0.0166 | |
| 347 | V | A | 1.7498 | |
| 348 | Y | A | 1.5827 | |
| 349 | D | A | 0.0853 | |
| 350 | P | A | -0.3567 | |
| 351 | S | A | -0.2944 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.6601 | |
| 354 | K | A | -1.7526 | |
| 355 | N | A | -1.7230 | |
| 356 | Y | A | -0.0920 | |
| 357 | L | A | 0.6493 | |
| 358 | R | A | 0.9681 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3904 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0774 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0346 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6820 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3044 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3139 | |
| 376 | L | A | -1.7116 | |
| 377 | D | A | -1.9898 | |
| 378 | P | A | -1.0376 | |
| 379 | G | A | -1.0130 | |
| 380 | V | A | -0.9336 | |
| 381 | L | A | -0.5300 | |
| 382 | A | A | -0.6539 | |
| 383 | H | A | -0.8133 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4046 | |
| 386 | T | A | -0.5510 | |
| 387 | M | A | -0.3006 | |
| 388 | N | A | -0.8651 | |
| 389 | P | A | -1.2490 | |
| 390 | T | A | -1.4448 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4287 | |
| 393 | E | A | -2.7606 | |
| 394 | N | A | -2.3664 | |
| 395 | W | A | -1.3407 | |
| 396 | N | A | -1.0399 | |
| 397 | L | A | -0.1482 | |
| 398 | G | A | 0.5500 | |
| 399 | F | A | 2.4311 | |
| 400 | V | A | 1.8486 | |
| 401 | P | A | 0.0630 | |
| 402 | P | A | -1.8409 | |
| 403 | K | A | -3.3257 | |
| 404 | E | A | -3.7818 | |
| 405 | R | A | -3.9328 | |
| 406 | E | A | -3.7955 | |
| 407 | D | A | -2.8829 | |
| 408 | P | A | -1.7707 | |
| 409 | Y | A | -0.9883 | |
| 410 | K | A | -2.1222 | |
| 411 | G | A | -0.6326 | |
| 412 | L | A | 0.6799 | |
| 413 | I | A | 1.5901 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3935 | |
| 416 | E | A | -1.6916 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9523 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0627 | |
| 421 | E | A | -2.8009 | |
| 422 | R | A | -2.6721 | |
| 423 | F | A | -1.2949 | |
| 424 | S | A | -1.4670 | |
| 425 | Q | A | -1.8513 | |
| 426 | D | A | -2.8682 | |
| 427 | L | A | -1.9506 | |
| 428 | D | A | -2.7081 | |
| 429 | Q | A | -2.5848 | |
| 430 | F | A | -1.4059 | |
| 431 | A | A | -0.8878 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5727 | |
| 435 | K | A | -0.7003 | |
| 436 | F | A | 0.1444 | |
| 437 | L | A | 1.0325 | |
| 438 | Y | A | 0.8297 | |
| 439 | Q | A | -0.2769 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine