Project name: d64564c424fc25d

Chain sequence(s)	H: QVQLVESGGGVVQPGRSLRLSCAASGFKFSGYGMHWVRQAPGKGLEWVAVIWYDGSKKYYVDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQMGYWHFDLWGRGTLVTVSS; L: EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPLTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:46)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:48)

• Minimal score value: -2.5861
• Maximal score value: 1.8025
• Average score: -0.5934
• Total score value: -134.1018

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.1460
2	V	H	-0.4494
3	Q	H	-0.7422
4	L	H	0.0000
5	V	H	0.3726
6	E	H	0.0000
7	S	H	-0.3793
8	G	H	-0.7527
9	G	H	0.1684
11	G	H	0.9476
12	V	H	1.8025
13	V	H	-0.0213
14	Q	H	-1.1949
15	P	H	-1.8054
16	G	H	-2.0498
17	R	H	-2.5861
18	S	H	-1.9199
19	L	H	-1.2342
20	R	H	-2.0060
21	L	H	0.0000
22	S	H	-0.3949
23	C	H	0.0000
24	A	H	-0.2321
25	A	H	0.0000
26	S	H	-0.9172
27	G	H	-1.0528
28	F	H	-0.9945
29	K	H	-1.8319
30	F	H	0.0000
35	S	H	-1.2676
36	G	H	-0.8013
37	Y	H	-0.1325
38	G	H	0.0000
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6046
45	A	H	-1.0239
46	P	H	-0.8130
47	G	H	-1.4569
48	K	H	-2.2726
49	G	H	-1.3560
50	L	H	0.0000
51	E	H	-0.8436
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	V	H	0.0000
56	I	H	0.0000
57	W	H	-0.5788
58	Y	H	-0.1029
59	D	H	-1.4799
62	G	H	-1.2902
63	S	H	-1.3361
64	K	H	-1.8727
65	K	H	-1.2498
66	Y	H	-0.5982
67	Y	H	-0.7522
68	V	H	-1.0007
69	D	H	-2.3101
70	S	H	-1.6330
71	V	H	0.0000
72	K	H	-2.3018
74	G	H	-1.6643
75	R	H	-1.4907
76	F	H	0.0000
77	T	H	-0.8085
78	I	H	0.0000
79	S	H	-0.5186
80	R	H	-0.9213
81	D	H	-1.6229
82	N	H	-1.9302
83	S	H	-1.5524
84	K	H	-2.3787
85	N	H	-2.0740
86	T	H	-0.9943
87	L	H	0.0000
88	Y	H	-0.3838
89	L	H	0.0000
90	Q	H	-1.0961
91	M	H	0.0000
92	N	H	-1.7721
93	S	H	-1.7170
94	L	H	0.0000
95	R	H	-2.5173
96	A	H	-1.6577
97	E	H	-2.2689
98	D	H	0.0000
99	T	H	-0.3462
100	A	H	0.0000
101	V	H	0.7356
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.3577
107	Q	H	0.0724
108	M	H	0.2061
109	G	H	0.1233
110	Y	H	0.8294
113	W	H	0.4961
114	H	H	0.0000
115	F	H	0.0000
116	D	H	-0.7853
117	L	H	-0.3875
118	W	H	0.0000
119	G	H	-0.8614
120	R	H	-1.7948
121	G	H	0.0000
122	T	H	0.4020
123	L	H	1.5521
124	V	H	0.0000
125	T	H	0.5195
126	V	H	0.0000
127	S	H	-0.4954
128	S	H	-0.4581
1	E	L	-1.7692
2	I	L	0.0000
3	V	L	0.7094
4	L	L	0.0000
5	T	L	-0.6068
6	Q	L	-0.6691
7	S	L	-0.7340
8	P	L	-0.4003
9	A	L	-0.3407
10	T	L	-0.3946
11	L	L	-0.0671
12	S	L	-0.1669
13	L	L	-0.4802
14	S	L	-0.7879
15	P	L	-1.1656
16	G	L	-1.5039
17	E	L	-2.0724
18	R	L	-2.4155
19	A	L	0.0000
20	T	L	-0.6216
21	L	L	0.0000
22	S	L	-0.8512
23	C	L	0.0000
24	R	L	-2.3342
25	A	L	0.0000
26	S	L	-1.0297
27	Q	L	-1.8801
28	S	L	-1.4415
29	V	L	0.0000
36	S	L	-0.7011
37	S	L	-0.2805
38	Y	L	0.3096
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.1210
46	P	L	-0.8532
47	G	L	-1.4081
48	Q	L	-1.9588
49	A	L	-1.3599
50	P	L	0.0000
51	R	L	-0.9391
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.1044
56	D	L	-0.3063
57	A	L	0.0000
65	S	L	-0.8835
66	N	L	-1.2787
67	R	L	-1.4482
68	A	L	-0.9165
69	T	L	-0.6755
70	G	L	-0.5829
71	I	L	-0.5497
72	P	L	-0.3503
74	A	L	-0.3378
75	R	L	-0.6077
76	F	L	0.0000
77	S	L	-0.6021
78	G	L	0.0000
79	S	L	-0.7110
80	G	L	-1.0365
83	S	L	-0.9749
84	G	L	-1.1145
85	T	L	-1.7256
86	D	L	-2.0852
87	F	L	0.0000
88	T	L	-0.7440
89	L	L	0.0000
90	T	L	-0.5789
91	I	L	0.0000
92	S	L	-1.1976
93	S	L	-1.4514
94	L	L	0.0000
95	E	L	-1.6803
96	P	L	-1.0441
97	E	L	-1.6791
98	D	L	0.0000
99	F	L	-0.2037
100	A	L	0.0000
101	V	L	-0.0845
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	R	L	0.0000
108	S	L	-0.5506
109	N	L	-1.6606
113	W	L	-0.8055
114	P	L	-0.7266
115	P	L	-0.8679
116	L	L	0.0000
117	T	L	-0.1355
118	F	L	0.1926
119	G	L	0.0000
120	G	L	-0.6413
121	G	L	-0.6816
122	T	L	0.0000
123	K	L	-0.6324
124	V	L	0.0000
125	E	L	0.0619
126	I	L	0.9163
127	K	L	-0.8639