Project name: d727e3567c88e72

Chain sequence(s)	A: MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKPEAAKPIENERMQRARFMRQSNFGTIGQTPETSLAQTESSKKFLRSEELRQRLMSESEAASESRSPSAAAMGPETSGPGPGGDLPVTFWEGQGVGLGPGPGVSAYSFSITAYFPEGAAYKVKVSVTTLGPGPGVLFSGTLRF
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:39)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:41)

• Minimal score value: -3.6507
• Maximal score value: 5.9676
• Average score: -0.15
• Total score value: -30.7547

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.3482
2	R	A	0.4982
3	V	A	2.7603
4	L	A	3.3559
5	Y	A	3.4915
6	L	A	3.5949
7	L	A	4.6261
8	F	A	5.2660
9	S	A	4.8011
10	F	A	5.6372
11	L	A	5.7876
12	F	A	5.9676
13	I	A	5.9520
14	F	A	5.5627
15	L	A	4.7059
16	M	A	3.4273
17	P	A	2.3618
18	L	A	2.4343
19	P	A	0.7915
20	G	A	0.8535
21	V	A	2.4332
22	F	A	2.4316
23	G	A	0.7341
24	G	A	0.1865
25	I	A	-0.0485
26	G	A	-0.5534
27	D	A	-0.2950
28	P	A	0.6709
29	V	A	1.4559
30	T	A	0.2913
31	C	A	0.0000
32	L	A	1.2953
33	K	A	-0.5467
34	S	A	-0.2223
35	G	A	-0.6233
36	A	A	0.0000
37	I	A	0.6983
38	C	A	0.9939
39	H	A	0.4271
40	P	A	0.9558
41	V	A	2.0316
42	F	A	1.6172
43	C	A	-0.3963
44	P	A	-1.4412
45	R	A	-2.8419
46	R	A	-3.3883
47	Y	A	-2.8098
48	K	A	-3.0148
49	Q	A	-1.7574
50	I	A	-0.8794
51	G	A	-0.9742
52	T	A	-0.6542
53	C	A	0.0000
54	G	A	-0.1761
55	L	A	0.7610
56	P	A	0.2604
57	G	A	0.3513
58	T	A	0.3437
59	K	A	-0.3055
60	C	A	0.0000
61	C	A	0.0000
62	K	A	-2.1377
63	K	A	-3.2687
64	P	A	-2.6944
65	E	A	-2.6402
66	A	A	-1.6071
67	A	A	-1.0017
68	K	A	-1.8092
69	P	A	-0.7638
70	I	A	0.0781
71	E	A	-2.1710
72	N	A	-2.4536
73	E	A	-3.5374
74	R	A	-3.6507
75	M	A	-2.2888
76	Q	A	-2.8646
77	R	A	-2.9956
78	A	A	-2.0225
79	R	A	-2.3807
80	F	A	-0.4930
81	M	A	-0.4610
82	R	A	-2.2573
83	Q	A	-1.6836
84	S	A	-0.8552
85	N	A	-0.7806
86	F	A	0.7256
87	G	A	0.2275
88	T	A	0.5066
89	I	A	1.5292
90	G	A	-0.2104
91	Q	A	-1.2958
92	T	A	-1.3781
93	P	A	-1.3014
94	E	A	-1.8238
95	T	A	-0.9079
96	S	A	-0.7173
97	L	A	0.1555
98	A	A	-0.7348
99	Q	A	-1.6658
100	T	A	-1.6028
101	E	A	-2.5519
102	S	A	-1.8343
103	S	A	-1.5797
104	K	A	-2.9261
105	K	A	-2.7440
106	F	A	-0.1856
107	L	A	-0.9310
108	R	A	-2.7777
109	S	A	-1.9970
110	E	A	-3.1278
111	E	A	-3.2857
112	L	A	-1.4633
113	R	A	-2.8986
114	Q	A	-3.2771
115	R	A	-2.7752
116	L	A	-1.0992
117	M	A	-0.9138
118	S	A	-1.8021
119	E	A	-2.4438
120	S	A	-1.5891
121	E	A	-2.4318
122	A	A	-1.9294
123	A	A	-1.6093
124	S	A	-2.0086
125	E	A	-2.7945
126	S	A	-2.1235
127	R	A	-2.6445
128	S	A	-1.6385
129	P	A	-0.9318
130	S	A	-0.5458
131	A	A	-0.0885
132	A	A	0.2821
133	A	A	0.5260
134	M	A	0.8064
135	G	A	-0.5150
136	P	A	-1.1695
137	E	A	-2.1853
138	T	A	-1.3236
139	S	A	-1.0238
140	G	A	-1.1026
141	P	A	-1.1102
142	G	A	-1.1062
143	P	A	-0.9387
144	G	A	-1.1592
145	G	A	-1.5131
146	D	A	-1.2862
147	L	A	0.8877
148	P	A	1.0606
149	V	A	2.3845
150	T	A	1.7010
151	F	A	2.4639
152	W	A	1.0107
153	E	A	-1.4057
154	G	A	-1.2677
155	Q	A	-1.5882
156	G	A	-0.2354
157	V	A	1.3203
158	G	A	0.8393
159	L	A	1.3274
160	G	A	0.0975
161	P	A	-0.3849
162	G	A	-0.4596
163	P	A	-0.5143
164	G	A	0.2522
165	V	A	1.6807
166	S	A	1.1262
167	A	A	1.1958
168	Y	A	1.4478
169	S	A	0.3692
170	F	A	0.1409
171	S	A	-0.4929
172	I	A	0.4291
173	T	A	0.2682
174	A	A	1.1600
175	Y	A	1.2528
176	F	A	0.4876
177	P	A	-0.7245
178	E	A	-1.8060
179	G	A	-0.8350
180	A	A	-0.1791
181	A	A	0.4795
182	Y	A	0.7856
183	K	A	-0.9548
184	V	A	-0.5104
185	K	A	-1.3592
186	V	A	-0.0003
187	S	A	0.1986
188	V	A	0.7457
189	T	A	1.0127
190	T	A	1.1998
191	L	A	1.5305
192	G	A	0.1483
193	P	A	-0.4259
194	G	A	-0.4571
195	P	A	-0.2244
196	G	A	0.8152
197	V	A	2.6761
198	L	A	3.2646
199	F	A	3.1131
200	S	A	1.6513
201	G	A	0.4967
202	T	A	0.2174
203	L	A	0.4547
204	R	A	-0.8491
205	F	A	0.9943