Project name: d808d2704bcff2

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGFSLSNYDVHWVRQAPGKGLEWLGVIWSGGNTDYNTPFTSRLTISVDTSKNQFSLKLSSVTAADTAVYYCARALDYYDYEFAYWGQGTLVTVSS; L: EIVLTQSPDFQSVTPKEKVTITCRASQSIGTNIHWYQQKPDQSPKLLIKYASESISGIPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQNNEWPTSFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:50)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:54)

• Minimal score value: -3.3117
• Maximal score value: 1.909
• Average score: -0.5961
• Total score value: -134.7242

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5475
2	V	H	-1.0473
3	Q	H	-1.8327
4	L	H	0.0000
5	Q	H	-1.8613
6	E	H	0.0000
7	S	H	-0.8457
8	G	H	-0.4722
9	P	H	-0.0681
11	G	H	0.3342
12	L	H	0.8688
13	V	H	0.0000
14	K	H	-1.1998
15	P	H	-1.1928
16	S	H	-1.3109
17	E	H	-1.9235
18	T	H	-1.4251
19	L	H	0.0000
20	S	H	-0.9760
21	L	H	0.0000
22	T	H	-0.6664
23	C	H	0.0000
24	T	H	-1.2963
25	V	H	0.0000
26	S	H	-1.4051
27	G	H	-1.1471
28	F	H	-0.6848
29	S	H	-0.6283
30	L	H	0.0000
35	S	H	-0.8290
36	N	H	-1.0029
37	Y	H	0.3179
38	D	H	0.0000
39	V	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6541
45	A	H	-0.7324
46	P	H	-0.8642
47	G	H	-1.4396
48	K	H	-2.2940
49	G	H	-1.4409
50	L	H	0.0000
51	E	H	-0.8604
52	W	H	0.0000
53	L	H	0.0000
54	G	H	0.0000
55	V	H	0.0000
56	I	H	0.0000
57	W	H	-0.2454
58	S	H	-0.6877
59	G	H	-1.1043
63	G	H	-1.2656
64	N	H	-1.5901
65	T	H	-0.8501
66	D	H	-0.4282
67	Y	H	-0.0769
68	N	H	-0.3506
69	T	H	-0.3956
70	P	H	-0.4097
71	F	H	0.0000
72	T	H	-0.4056
74	S	H	-0.5033
75	R	H	-0.8816
76	L	H	0.0000
77	T	H	-0.7475
78	I	H	0.0000
79	S	H	-0.6122
80	V	H	-0.7125
81	D	H	-1.4645
82	T	H	-1.3674
83	S	H	-1.4297
84	K	H	-2.2991
85	N	H	-1.6907
86	Q	H	-1.4609
87	F	H	0.0000
88	S	H	-0.6033
89	L	H	0.0000
90	K	H	-1.5850
91	L	H	0.0000
92	S	H	-1.1848
93	S	H	-1.0878
94	V	H	0.0000
95	T	H	-0.5280
96	A	H	-0.1529
97	A	H	0.0513
98	D	H	0.0000
99	T	H	0.2841
100	A	H	0.0000
101	V	H	0.4902
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	A	H	0.0000
108	L	H	0.7740
109	D	H	0.5423
110	Y	H	1.6072
111	Y	H	1.9090
112	D	H	0.0000
113	Y	H	0.0000
114	E	H	0.0000
115	F	H	0.0000
116	A	H	0.1360
117	Y	H	0.0315
118	W	H	-0.6380
119	G	H	0.0000
120	Q	H	-1.9950
121	G	H	-0.9505
122	T	H	-0.1153
123	L	H	0.9478
124	V	H	0.0000
125	T	H	0.4237
126	V	H	0.0000
127	S	H	-0.2794
128	S	H	-0.4250
1	E	L	-1.3936
2	I	L	0.0000
3	V	L	0.8130
4	L	L	0.0000
5	T	L	-0.7909
6	Q	L	0.0000
7	S	L	-0.9882
8	P	L	-0.6673
9	D	L	-1.4673
10	F	L	0.2279
11	Q	L	-0.3642
12	S	L	-0.5726
13	V	L	0.0000
14	T	L	-2.0870
15	P	L	-2.4835
16	K	L	-3.1740
17	E	L	-3.3117
18	K	L	-3.1280
19	V	L	0.0000
20	T	L	-0.6099
21	I	L	0.0000
22	T	L	-0.9813
23	C	L	0.0000
24	R	L	-2.1706
25	A	L	0.0000
26	S	L	-0.7179
27	Q	L	-1.1553
28	S	L	-1.2960
29	I	L	0.0000
36	G	L	-0.9347
37	T	L	-0.7165
38	N	L	-0.7464
39	I	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.1585
45	K	L	-1.6186
46	P	L	-1.6433
47	D	L	-2.6866
48	Q	L	-2.5156
49	S	L	-1.4674
50	P	L	0.0000
51	K	L	-0.8020
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	-0.7942
56	Y	L	-0.6721
57	A	L	0.0000
65	S	L	-1.2499
66	E	L	-2.0133
67	S	L	-1.1405
68	I	L	-0.5103
69	S	L	-0.4677
70	G	L	-0.4252
71	I	L	-0.1414
72	P	L	-0.2353
74	S	L	-0.4437
75	R	L	-0.9205
76	F	L	0.0000
77	S	L	-0.7249
78	G	L	-0.6950
79	S	L	-0.7770
80	G	L	-0.9704
83	S	L	-1.0185
84	G	L	-1.1240
85	T	L	-1.5755
86	D	L	-2.0577
87	F	L	0.0000
88	T	L	-0.7061
89	L	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	N	L	-2.1447
93	S	L	-2.5606
94	L	L	0.0000
95	E	L	-2.5153
96	A	L	-1.6011
97	E	L	-1.6730
98	D	L	0.0000
99	A	L	-0.9433
100	A	L	0.0000
101	T	L	-0.7201
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	N	L	-0.7302
108	N	L	-1.3593
109	E	L	-1.1726
114	W	L	0.0591
115	P	L	0.0000
116	T	L	0.0000
117	S	L	-0.2118
118	F	L	0.1487
119	G	L	0.0000
120	Q	L	-1.3535
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.0189
124	L	L	0.0000
125	E	L	-0.9457
126	I	L	-1.4129
127	K	L	-1.8432