| Chain sequence(s) |
A: MSCRSYRISPGYSVTRTFSSCSAVAPKTGSRCCISAAPYRGVSCYRGLTGFGSRSVSALGSCGPRIAVSGFRAGSCGRSFGYRSGGVGGLSPPCITTVSVNESLLTPLNLEIDPNAQCVKHEEKEQIKNLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFNGYIETLRREAEHVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESNFLKRLYDEEIQILNAHISDTSVIVKMDNSRDLNMDCVVAEIKAQYDDIASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRVIQRLTAEIENAKCQRTKLEAAVAEAEQQGEAALNDARSKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVACGGLTYSSTAGRQIASGPVATGGSITVLAPDSCQPRASSFSCGSSRSVRFA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:09:29)
[INFO] Main: Simulation completed successfully. (00:09:33)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 1.1186 | |
| 2 | S | A | 0.1975 | |
| 3 | C | A | 0.0627 | |
| 4 | R | A | -1.5186 | |
| 5 | S | A | -0.5605 | |
| 6 | Y | A | 0.4195 | |
| 7 | R | A | -0.5650 | |
| 8 | I | A | 1.2051 | |
| 9 | S | A | 0.1998 | |
| 10 | P | A | -0.0399 | |
| 11 | G | A | 0.3744 | |
| 12 | Y | A | 1.4004 | |
| 13 | S | A | 0.9397 | |
| 14 | V | A | 1.4457 | |
| 15 | T | A | 0.1948 | |
| 16 | R | A | -0.9921 | |
| 17 | T | A | 0.0719 | |
| 18 | F | A | 1.3500 | |
| 19 | S | A | 0.5508 | |
| 20 | S | A | 0.4698 | |
| 21 | C | A | 0.7048 | |
| 22 | S | A | 0.5321 | |
| 23 | A | A | 0.9724 | |
| 24 | V | A | 1.5465 | |
| 25 | A | A | 0.3655 | |
| 26 | P | A | -0.7094 | |
| 27 | K | A | -1.7758 | |
| 28 | T | A | -1.2365 | |
| 29 | G | A | -1.3982 | |
| 30 | S | A | -1.1865 | |
| 31 | R | A | -1.2987 | |
| 32 | C | A | 0.5407 | |
| 33 | C | A | 1.5559 | |
| 34 | I | A | 2.2667 | |
| 35 | S | A | 1.0405 | |
| 36 | A | A | 0.6189 | |
| 37 | A | A | 0.2331 | |
| 38 | P | A | -0.1267 | |
| 39 | Y | A | 0.2146 | |
| 40 | R | A | -1.1085 | |
| 41 | G | A | -0.2128 | |
| 42 | V | A | 1.3387 | |
| 43 | S | A | 0.8281 | |
| 44 | C | A | 1.1233 | |
| 45 | Y | A | 0.9492 | |
| 46 | R | A | -0.9058 | |
| 47 | G | A | -0.2459 | |
| 48 | L | A | 1.1149 | |
| 49 | T | A | 0.5010 | |
| 50 | G | A | 0.5831 | |
| 51 | F | A | 1.3773 | |
| 52 | G | A | -0.2464 | |
| 53 | S | A | -0.8081 | |
| 54 | R | A | -1.5381 | |
| 55 | S | A | -0.3996 | |
| 56 | V | A | 1.2946 | |
| 57 | S | A | 0.7021 | |
| 58 | A | A | 0.9495 | |
| 59 | L | A | 1.5135 | |
| 60 | G | A | 0.4189 | |
| 61 | S | A | 0.1150 | |
| 62 | C | A | 0.1523 | |
| 63 | G | A | -0.5798 | |
| 64 | P | A | -0.6795 | |
| 65 | R | A | -0.7748 | |
| 66 | I | A | 1.4547 | |
| 67 | A | A | 1.2305 | |
| 68 | V | A | 2.0931 | |
| 69 | S | A | 0.9488 | |
| 70 | G | A | 0.3731 | |
| 71 | F | A | 0.9219 | |
| 72 | R | A | -1.1739 | |
| 73 | A | A | -0.5784 | |
| 74 | G | A | -0.6392 | |
| 75 | S | A | -0.6268 | |
| 76 | C | A | -0.2422 | |
| 77 | G | A | -0.9454 | |
| 78 | R | A | -1.5402 | |
| 79 | S | A | -0.1736 | |
| 80 | F | A | 1.1722 | |
| 81 | G | A | 0.2946 | |
| 82 | Y | A | 0.5490 | |
| 83 | R | A | -1.3947 | |
| 84 | S | A | -0.9729 | |
| 85 | G | A | -0.7589 | |
| 86 | G | A | -0.2740 | |
| 87 | V | A | 1.2268 | |
| 88 | G | A | 0.4212 | |
| 89 | G | A | 0.3133 | |
| 90 | L | A | 1.2012 | |
| 91 | S | A | 0.3310 | |
| 92 | P | A | 0.2381 | |
| 93 | P | A | 0.5913 | |
| 94 | C | A | 1.4604 | |
| 95 | I | A | 2.4697 | |
| 96 | T | A | 1.4981 | |
| 97 | T | A | 1.5620 | |
| 98 | V | A | 2.2447 | |
| 99 | S | A | 0.8930 | |
| 100 | V | A | 1.4489 | |
| 101 | N | A | -0.4918 | |
| 102 | E | A | -1.0804 | |
| 103 | S | A | -0.0738 | |
| 104 | L | A | 1.6604 | |
| 105 | L | A | 1.7769 | |
| 106 | T | A | 0.8909 | |
| 107 | P | A | 0.9567 | |
| 108 | L | A | 1.4347 | |
| 109 | N | A | -0.1018 | |
| 110 | L | A | 0.9330 | |
| 111 | E | A | -0.6097 | |
| 112 | I | A | 0.3567 | |
| 113 | D | A | -1.2345 | |
| 114 | P | A | -1.3189 | |
| 115 | N | A | -1.5003 | |
| 116 | A | A | -1.1669 | |
| 117 | Q | A | -1.9716 | |
| 118 | C | A | -1.4768 | |
| 119 | V | A | -1.3163 | |
| 120 | K | A | -3.7831 | |
| 121 | H | A | -4.0080 | |
| 122 | E | A | -4.5572 | |
| 123 | E | A | -4.9276 | |
| 124 | K | A | -4.8888 | |
| 125 | E | A | -5.0256 | |
| 126 | Q | A | -4.1771 | |
| 127 | I | A | -2.6316 | |
| 128 | K | A | -3.4817 | |
| 129 | N | A | -2.4884 | |
| 130 | L | A | -1.1285 | |
| 131 | N | A | -1.3812 | |
| 132 | S | A | -0.7615 | |
| 133 | R | A | -0.5980 | |
| 134 | F | A | 1.3394 | |
| 135 | A | A | 0.8602 | |
| 136 | A | A | 0.4689 | |
| 137 | F | A | 2.1705 | |
| 138 | I | A | 2.1604 | |
| 139 | D | A | -0.4788 | |
| 140 | K | A | -0.0502 | |
| 141 | V | A | 0.6818 | |
| 142 | R | A | -1.1685 | |
| 143 | F | A | 0.1517 | |
| 144 | L | A | -0.3446 | |
| 145 | E | A | -1.9704 | |
| 146 | Q | A | -2.2683 | |
| 147 | Q | A | -1.6965 | |
| 148 | N | A | -2.9190 | |
| 149 | K | A | -2.9776 | |
| 150 | L | A | -1.6263 | |
| 151 | L | A | -1.5123 | |
| 152 | E | A | -2.4492 | |
| 153 | T | A | -1.2821 | |
| 154 | K | A | -0.9126 | |
| 155 | W | A | -0.1037 | |
| 156 | Q | A | -1.0954 | |
| 157 | F | A | 0.4815 | |
| 158 | Y | A | 0.0650 | |
| 159 | Q | A | -1.5866 | |
| 160 | N | A | -1.8598 | |
| 161 | Q | A | -1.8216 | |
| 162 | R | A | -2.9340 | |
| 163 | C | A | -1.6269 | |
| 164 | C | A | -1.9069 | |
| 165 | E | A | -3.3025 | |
| 166 | S | A | -2.3759 | |
| 167 | N | A | -1.8103 | |
| 168 | L | A | -0.6708 | |
| 169 | E | A | -1.4935 | |
| 170 | P | A | -0.2491 | |
| 171 | L | A | 1.6909 | |
| 172 | F | A | 2.1125 | |
| 173 | N | A | 0.6078 | |
| 174 | G | A | 0.7694 | |
| 175 | Y | A | 1.8029 | |
| 176 | I | A | 1.1091 | |
| 177 | E | A | -1.1188 | |
| 178 | T | A | -1.1840 | |
| 179 | L | A | -1.4556 | |
| 180 | R | A | -3.3034 | |
| 181 | R | A | -4.2309 | |
| 182 | E | A | -3.7811 | |
| 183 | A | A | -3.2146 | |
| 184 | E | A | -4.1743 | |
| 185 | H | A | -3.2902 | |
| 186 | V | A | -1.7704 | |
| 187 | E | A | -2.9772 | |
| 188 | A | A | -2.2755 | |
| 189 | D | A | -2.0077 | |
| 190 | S | A | -1.6474 | |
| 191 | G | A | -1.6684 | |
| 192 | R | A | -2.1841 | |
| 193 | L | A | -0.5492 | |
| 194 | A | A | -0.5204 | |
| 195 | S | A | -1.4209 | |
| 196 | E | A | -1.7215 | |
| 197 | L | A | 0.0325 | |
| 198 | N | A | -1.5728 | |
| 199 | H | A | -1.4282 | |
| 200 | V | A | 0.3617 | |
| 201 | Q | A | -1.1289 | |
| 202 | E | A | -2.0152 | |
| 203 | V | A | 0.2064 | |
| 204 | L | A | -0.0310 | |
| 205 | E | A | -2.0100 | |
| 206 | G | A | -1.1268 | |
| 207 | Y | A | -0.8038 | |
| 208 | K | A | -2.9196 | |
| 209 | K | A | -3.7949 | |
| 210 | K | A | -3.5446 | |
| 211 | Y | A | -2.0405 | |
| 212 | E | A | -3.5536 | |
| 213 | E | A | -3.7695 | |
| 214 | E | A | -3.0650 | |
| 215 | V | A | -1.1871 | |
| 216 | A | A | -1.1643 | |
| 217 | L | A | -0.6261 | |
| 218 | R | A | -2.4873 | |
| 219 | A | A | -1.5646 | |
| 220 | T | A | -1.2562 | |
| 221 | A | A | -1.2418 | |
| 222 | E | A | -2.0254 | |
| 223 | N | A | -1.7701 | |
| 224 | E | A | -1.4960 | |
| 225 | F | A | 0.4082 | |
| 226 | V | A | 0.3652 | |
| 227 | V | A | 0.4656 | |
| 228 | L | A | 0.3013 | |
| 229 | K | A | -1.5133 | |
| 230 | K | A | -2.0687 | |
| 231 | D | A | -1.4666 | |
| 232 | V | A | -0.7484 | |
| 233 | D | A | -1.8370 | |
| 234 | C | A | -0.7884 | |
| 235 | A | A | -0.9117 | |
| 236 | Y | A | 0.2355 | |
| 237 | L | A | 0.0447 | |
| 238 | R | A | -1.8986 | |
| 239 | K | A | -2.1542 | |
| 240 | S | A | -1.5233 | |
| 241 | D | A | -2.5845 | |
| 242 | L | A | -1.3972 | |
| 243 | E | A | -2.3955 | |
| 244 | A | A | -1.7859 | |
| 245 | N | A | -1.2999 | |
| 246 | V | A | 0.2134 | |
| 247 | E | A | -1.5711 | |
| 248 | A | A | -0.8160 | |
| 249 | L | A | 0.6623 | |
| 250 | V | A | 0.5837 | |
| 251 | E | A | -1.6144 | |
| 252 | E | A | -1.5382 | |
| 253 | S | A | -0.9118 | |
| 254 | N | A | -0.8960 | |
| 255 | F | A | 0.1070 | |
| 256 | L | A | -0.6838 | |
| 257 | K | A | -2.6977 | |
| 258 | R | A | -2.6736 | |
| 259 | L | A | -1.1424 | |
| 260 | Y | A | -0.8193 | |
| 261 | D | A | -2.5625 | |
| 262 | E | A | -2.9747 | |
| 263 | E | A | -1.7530 | |
| 264 | I | A | 0.0617 | |
| 265 | Q | A | -0.9948 | |
| 266 | I | A | 0.3091 | |
| 267 | L | A | 0.7423 | |
| 268 | N | A | -0.3257 | |
| 269 | A | A | -0.2822 | |
| 270 | H | A | -0.2901 | |
| 271 | I | A | 1.0203 | |
| 272 | S | A | -0.2684 | |
| 273 | D | A | -1.4721 | |
| 274 | T | A | 0.0786 | |
| 275 | S | A | 1.0816 | |
| 276 | V | A | 2.9334 | |
| 277 | I | A | 3.3322 | |
| 278 | V | A | 2.5405 | |
| 279 | K | A | -0.1457 | |
| 280 | M | A | -0.4329 | |
| 281 | D | A | -2.5310 | |
| 282 | N | A | -2.8196 | |
| 283 | S | A | -2.3734 | |
| 284 | R | A | -3.1851 | |
| 285 | D | A | -2.5732 | |
| 286 | L | A | -0.8311 | |
| 287 | N | A | -1.1731 | |
| 288 | M | A | -0.0872 | |
| 289 | D | A | -1.0196 | |
| 290 | C | A | -0.2314 | |
| 291 | V | A | 0.4060 | |
| 292 | V | A | 0.0257 | |
| 293 | A | A | -0.6637 | |
| 294 | E | A | -1.6407 | |
| 295 | I | A | -0.7617 | |
| 296 | K | A | -1.7805 | |
| 297 | A | A | -1.7990 | |
| 298 | Q | A | -1.6317 | |
| 299 | Y | A | -0.7678 | |
| 300 | D | A | -2.5878 | |
| 301 | D | A | -2.6172 | |
| 302 | I | A | -0.5960 | |
| 303 | A | A | -1.4866 | |
| 304 | S | A | -2.4687 | |
| 305 | R | A | -3.1735 | |
| 306 | S | A | -2.7123 | |
| 307 | R | A | -3.3069 | |
| 308 | A | A | -2.5007 | |
| 309 | E | A | -3.1367 | |
| 310 | A | A | -2.0698 | |
| 311 | E | A | -2.5746 | |
| 312 | S | A | -1.6093 | |
| 313 | W | A | -0.4760 | |
| 314 | Y | A | -0.5752 | |
| 315 | R | A | -2.3867 | |
| 316 | S | A | -1.9576 | |
| 317 | K | A | -2.0372 | |
| 318 | C | A | -1.7303 | |
| 319 | E | A | -3.0122 | |
| 320 | E | A | -2.5995 | |
| 321 | M | A | -0.9377 | |
| 322 | K | A | -1.2437 | |
| 323 | A | A | -0.8860 | |
| 324 | T | A | -0.3683 | |
| 325 | V | A | 0.9432 | |
| 326 | I | A | 1.0435 | |
| 327 | R | A | -1.2852 | |
| 328 | H | A | -1.2674 | |
| 329 | G | A | -0.8387 | |
| 330 | E | A | -2.0645 | |
| 331 | T | A | -1.8310 | |
| 332 | L | A | -1.4927 | |
| 333 | R | A | -3.6299 | |
| 334 | R | A | -4.0262 | |
| 335 | T | A | -2.9622 | |
| 336 | K | A | -3.7832 | |
| 337 | E | A | -4.6031 | |
| 338 | E | A | -3.9656 | |
| 339 | I | A | -1.7732 | |
| 340 | N | A | -3.0733 | |
| 341 | E | A | -3.1154 | |
| 342 | L | A | -1.0153 | |
| 343 | N | A | -1.8744 | |
| 344 | R | A | -2.1569 | |
| 345 | V | A | -0.1668 | |
| 346 | I | A | 0.2028 | |
| 347 | Q | A | -1.5415 | |
| 348 | R | A | -1.6984 | |
| 349 | L | A | -0.2960 | |
| 350 | T | A | -0.6328 | |
| 351 | A | A | -1.6759 | |
| 352 | E | A | -2.1767 | |
| 353 | I | A | -0.7651 | |
| 354 | E | A | -2.6452 | |
| 355 | N | A | -2.8160 | |
| 356 | A | A | -2.5269 | |
| 357 | K | A | -3.1874 | |
| 358 | C | A | -2.3739 | |
| 359 | Q | A | -2.8200 | |
| 360 | R | A | -3.6441 | |
| 361 | T | A | -2.3201 | |
| 362 | K | A | -2.4070 | |
| 363 | L | A | -1.2174 | |
| 364 | E | A | -1.9747 | |
| 365 | A | A | -1.4859 | |
| 366 | A | A | -0.8930 | |
| 367 | V | A | -0.0924 | |
| 368 | A | A | -1.5713 | |
| 369 | E | A | -2.8425 | |
| 370 | A | A | -2.3574 | |
| 371 | E | A | -3.3950 | |
| 372 | Q | A | -3.5406 | |
| 373 | Q | A | -3.1698 | |
| 374 | G | A | -2.9084 | |
| 375 | E | A | -3.2244 | |
| 376 | A | A | -2.3021 | |
| 377 | A | A | -1.7132 | |
| 378 | L | A | -1.1612 | |
| 379 | N | A | -2.2090 | |
| 380 | D | A | -2.7767 | |
| 381 | A | A | -1.8618 | |
| 382 | R | A | -2.2064 | |
| 383 | S | A | -2.0540 | |
| 384 | K | A | -2.1730 | |
| 385 | L | A | -0.5884 | |
| 386 | A | A | -0.9241 | |
| 387 | G | A | -1.0533 | |
| 388 | L | A | -0.0873 | |
| 389 | E | A | -1.8823 | |
| 390 | E | A | -2.7726 | |
| 391 | A | A | -1.3326 | |
| 392 | L | A | -1.1770 | |
| 393 | Q | A | -3.2363 | |
| 394 | K | A | -3.6478 | |
| 395 | A | A | -2.6120 | |
| 396 | K | A | -3.1470 | |
| 397 | Q | A | -3.0287 | |
| 398 | D | A | -2.7176 | |
| 399 | M | A | -1.2899 | |
| 400 | A | A | -1.1256 | |
| 401 | C | A | -0.9422 | |
| 402 | L | A | -0.5388 | |
| 403 | L | A | -0.2892 | |
| 404 | K | A | -2.0382 | |
| 405 | E | A | -1.9719 | |
| 406 | Y | A | -0.1984 | |
| 407 | Q | A | -1.7705 | |
| 408 | E | A | -2.3571 | |
| 409 | V | A | -0.2310 | |
| 410 | M | A | -0.0409 | |
| 411 | N | A | -1.3262 | |
| 412 | S | A | -0.5273 | |
| 413 | K | A | -0.9318 | |
| 414 | L | A | 0.7672 | |
| 415 | G | A | 0.6577 | |
| 416 | L | A | 1.0137 | |
| 417 | D | A | 0.1010 | |
| 418 | I | A | 1.5395 | |
| 419 | E | A | 0.3324 | |
| 420 | I | A | 1.5839 | |
| 421 | A | A | 0.5059 | |
| 422 | T | A | 0.4021 | |
| 423 | Y | A | 0.9691 | |
| 424 | R | A | -1.0741 | |
| 425 | R | A | -1.7888 | |
| 426 | L | A | 0.2190 | |
| 427 | L | A | -0.7330 | |
| 428 | E | A | -2.2434 | |
| 429 | G | A | -2.1332 | |
| 430 | E | A | -3.2702 | |
| 431 | E | A | -3.2716 | |
| 432 | Q | A | -3.1068 | |
| 433 | R | A | -3.1633 | |
| 434 | L | A | -0.9086 | |
| 435 | C | A | -0.8417 | |
| 436 | E | A | -2.2002 | |
| 437 | G | A | -0.7488 | |
| 438 | V | A | 1.1942 | |
| 439 | G | A | 0.0810 | |
| 440 | S | A | 0.3553 | |
| 441 | V | A | 1.6330 | |
| 442 | N | A | 0.7211 | |
| 443 | V | A | 2.3137 | |
| 444 | C | A | 2.2511 | |
| 445 | V | A | 2.2832 | |
| 446 | S | A | 0.8518 | |
| 447 | S | A | -0.4347 | |
| 448 | S | A | -1.3679 | |
| 449 | R | A | -2.3370 | |
| 450 | G | A | -1.2389 | |
| 451 | G | A | -0.2997 | |
| 452 | V | A | 1.6166 | |
| 453 | A | A | 0.9554 | |
| 454 | C | A | 0.7657 | |
| 455 | G | A | -0.0008 | |
| 456 | G | A | 0.1764 | |
| 457 | L | A | 1.4898 | |
| 458 | T | A | 1.1932 | |
| 459 | Y | A | 1.5073 | |
| 460 | S | A | 0.4587 | |
| 461 | S | A | -0.1001 | |
| 462 | T | A | -0.3069 | |
| 463 | A | A | -0.7134 | |
| 464 | G | A | -1.6111 | |
| 465 | R | A | -2.2118 | |
| 466 | Q | A | -1.1630 | |
| 467 | I | A | 0.9730 | |
| 468 | A | A | 0.5639 | |
| 469 | S | A | -0.0704 | |
| 470 | G | A | -0.3060 | |
| 471 | P | A | 0.3524 | |
| 472 | V | A | 1.5126 | |
| 473 | A | A | 0.6780 | |
| 474 | T | A | -0.0265 | |
| 475 | G | A | -0.3728 | |
| 476 | G | A | -0.3219 | |
| 477 | S | A | 0.6076 | |
| 478 | I | A | 2.3621 | |
| 479 | T | A | 2.0685 | |
| 480 | V | A | 2.9770 | |
| 481 | L | A | 2.3832 | |
| 482 | A | A | 0.6831 | |
| 483 | P | A | -0.4960 | |
| 484 | D | A | -1.7639 | |
| 485 | S | A | -1.1069 | |
| 486 | C | A | -0.7017 | |
| 487 | Q | A | -1.6403 | |
| 488 | P | A | -1.5864 | |
| 489 | R | A | -2.2129 | |
| 490 | A | A | -0.9904 | |
| 491 | S | A | -0.3243 | |
| 492 | S | A | 0.4700 | |
| 493 | F | A | 1.8186 | |
| 494 | S | A | 0.9141 | |
| 495 | C | A | 0.8090 | |
| 496 | G | A | -0.2977 | |
| 497 | S | A | -0.8419 | |
| 498 | S | A | -1.1998 | |
| 499 | R | A | -1.9053 | |
| 500 | S | A | -0.5905 | |
| 501 | V | A | 0.7728 | |
| 502 | R | A | -0.2497 | |
| 503 | F | A | 1.4716 | |
| 504 | A | A | 0.7352 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine