Project name: d87892571043e61

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGVIYSGNGDTSYAQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERDTRFGNWGQGTLVTVSS; L: DIVMTQSPLSLPVTPGEPASISCRASESVDIYGQSFMHWYLQKPGQSPQLLIYLASNLESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQNNEDPYTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:50)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:53)

• Minimal score value: -3.3486
• Maximal score value: 1.1543
• Average score: -0.6815
• Total score value: -155.3846

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4659
2	V	H	-1.0499
3	Q	H	-1.5679
4	L	H	0.0000
5	V	H	-0.2174
6	Q	H	0.0000
7	S	H	-0.5697
8	G	H	-0.5117
9	A	H	0.2590
11	E	H	0.0295
12	V	H	0.9585
13	K	H	-0.9694
14	K	H	-2.1425
15	P	H	-1.8728
16	G	H	-1.6253
17	A	H	-1.2396
18	S	H	-1.3720
19	V	H	0.0000
20	K	H	-1.9277
21	V	H	0.0000
22	S	H	-0.6175
23	C	H	0.0000
24	K	H	-0.9675
25	A	H	0.0000
26	S	H	-0.9118
27	G	H	-0.9944
28	Y	H	-0.3816
29	T	H	-0.2148
30	F	H	0.0000
35	T	H	-0.6175
36	S	H	-0.4416
37	Y	H	-0.5213
38	N	H	-0.7390
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.4738
45	A	H	-0.8891
46	P	H	-0.7408
47	G	H	-1.2136
48	Q	H	-1.7240
49	G	H	-1.0227
50	L	H	0.0000
51	E	H	-0.5337
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	V	H	0.0021
56	I	H	0.0000
57	Y	H	-0.5001
58	S	H	0.0000
59	G	H	-1.2000
62	N	H	-1.8560
63	G	H	-1.7749
64	D	H	-2.1107
65	T	H	-0.9041
66	S	H	-0.7721
67	Y	H	-1.0983
68	A	H	0.0000
69	Q	H	-2.9077
70	K	H	-2.7422
71	F	H	0.0000
72	K	H	-2.5362
74	G	H	-1.7444
75	R	H	-1.5326
76	V	H	0.0000
77	T	H	-0.8847
78	I	H	0.0000
79	T	H	-0.4940
80	A	H	-0.7816
81	D	H	-1.1881
82	K	H	-1.4133
83	S	H	-0.8775
84	T	H	-0.7896
85	S	H	-0.9311
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.6000
89	M	H	0.0000
90	E	H	-1.5859
91	L	H	0.0000
92	S	H	-1.2083
93	S	H	-1.2878
94	L	H	0.0000
95	R	H	-3.1222
96	S	H	-2.3748
97	E	H	-2.5645
98	D	H	0.0000
99	T	H	-0.7351
100	A	H	0.0000
101	V	H	0.5663
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.8880
107	E	H	-1.4467
108	R	H	-2.4383
109	D	H	-2.0602
113	T	H	0.0000
114	R	H	-1.3158
115	F	H	0.0000
116	G	H	-1.1208
117	N	H	-0.9926
118	W	H	-0.7389
119	G	H	0.0000
120	Q	H	-1.3178
121	G	H	-0.3882
122	T	H	0.0000
123	L	H	0.9615
124	V	H	0.0000
125	T	H	-0.1336
126	V	H	0.0000
127	S	H	-0.9842
128	S	H	-0.8444
1	D	L	-2.1099
2	I	L	0.0000
3	V	L	0.7928
4	M	L	0.0000
5	T	L	-0.4076
6	Q	L	0.0000
7	S	L	-0.2197
8	P	L	0.2853
9	L	L	1.1053
10	S	L	0.2079
11	L	L	0.0520
12	P	L	-0.4907
13	V	L	0.0000
14	T	L	-1.4063
15	P	L	-1.7456
16	G	L	-2.3097
17	E	L	-2.4387
18	P	L	-2.0123
19	A	L	0.0000
20	S	L	-0.7588
21	I	L	0.0000
22	S	L	-0.8473
23	C	L	0.0000
24	R	L	-2.2885
25	A	L	0.0000
26	S	L	-0.8791
27	E	L	-1.4060
28	S	L	-1.2242
29	V	L	0.0000
30	D	L	-0.5244
31	I	L	0.7939
34	Y	L	1.1543
35	G	L	-0.1198
36	Q	L	-0.6001
37	S	L	-0.4778
38	F	L	-0.2881
39	M	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	0.0000
44	Q	L	-0.8172
45	K	L	-1.2046
46	P	L	-0.8167
47	G	L	-1.3180
48	Q	L	-1.8318
49	S	L	-1.2802
50	P	L	0.0000
51	Q	L	-1.1857
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.1771
56	L	L	-0.4604
57	A	L	0.0000
65	S	L	-0.5970
66	N	L	-0.4954
67	L	L	-0.1755
68	E	L	-0.4139
69	S	L	-0.4844
70	G	L	-0.7474
71	V	L	0.0000
72	P	L	-1.1063
74	D	L	-2.1406
75	R	L	-2.0147
76	F	L	0.0000
77	S	L	-0.9612
78	G	L	-0.5549
79	S	L	-0.8186
80	G	L	-1.1258
83	S	L	-1.3090
84	G	L	-1.2176
85	T	L	-1.7306
86	D	L	-2.0669
87	F	L	0.0000
88	T	L	-1.0122
89	L	L	0.0000
90	K	L	-1.3750
91	I	L	0.0000
92	S	L	-2.2330
93	R	L	-3.3486
94	V	L	0.0000
95	E	L	-2.6454
96	A	L	-1.2632
97	E	L	-2.0797
98	D	L	0.0000
99	V	L	-0.3207
100	G	L	0.0000
101	V	L	0.0114
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	N	L	-0.8312
108	N	L	-1.1273
109	E	L	-2.3163
114	D	L	-2.4718
115	P	L	-2.0645
116	Y	L	-0.7461
117	T	L	-0.3028
118	F	L	0.2770
119	G	L	0.0000
120	G	L	-0.3415
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.5697
124	V	L	0.0000
125	E	L	-0.2046
126	I	L	0.0789
127	K	L	-1.3368