| Chain sequence(s) |
A: LAFSPPFYPSPWANGQGEWAEAYQRAVAIVSQMTLDEKVNLTTGTGWELEKCVGQTGGVPRLNIGGMCLQDSPLGIRDSDYNSAFPAGVNVAATWDKNLAYLRGQAMGQEFSDKGIDVQLGPAAGPLGRSPDGGRNWEGFSPDPALTGVLFAETIKGIQDAGVVATAKHYILNEQEHFRQVAEAAGYGFNISDTISSNVDDKTIHEMYLWPFADAVRAGVGAIMCSYNQINNSYGCQNSYTLNKLLKAELGFQGFVMSDWGAHHSGVGSALAGLDMSMPGDITFDSATSFWGTNLTIAVLNGTVPQWRVDDMAVRIMAAYYKVGRDRLYQPPNFSSWTRDEYGFKYFYPQEGPYEKVNHFVNVQRNHSEVIRKLGADSTVLLKNNNALPLTGKERKVAILGEDAGSNSYGANGCSDRGCDNGTLAMAWGSGTAEFPYLVTPEQAIQAEVLKHKGSVYAITDNWALSQVETLAKQASVSLVFVNSDAGEGYISVDGNEGDRNNLTLWKNGDNLIKAAANNCNNTIVVIHSVGPVLVDEWYDHPNVTAILWAGLPGQESGNSLADVLYGRVNPGAKSPFTWGKTREAYGDYLVRELNNGNGAPQDDFSEGVFIDYRGFDKRNETPIYEFGHGLSYTTFNYSGLHIQVLNAVATETGAAPTFGQVGNASDYVYPEGLTRISKFIYPWLNSTDLKASSGDPYYGVDTAEHVPEGATDGSPQPVLPAGGGSGGNPRLYDELIRVSVTVKNTGRVAGDAVPQLYVSLGGPNEPKVVLRKFDRLTLKPSEETVWTTTLTRRDLSNWDVAAQDWVITSYPKKVHVGSSSRQLPLHAALPKVQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Mutated residues | LQ22A,FY24A,ST25A,ST653A,VK460A,TK304A,VK812A,YR430A,IR303A,YR724A,VI675A,VR827A |
| Energy difference between WT (input) and mutated protein (by FoldX) | -4.60725 kcal/mol |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] FoldX: Building mutant model (00:03:03)
[INFO] FoldX: Starting FoldX energy minimalization (00:06:07)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:09:07)
[INFO] Main: Simulation completed successfully. (00:09:15)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 22 | Q | A | -1.0282 | mutated: LQ22A |
| 23 | A | A | -0.3722 | |
| 24 | Y | A | 0.7392 | mutated: FY24A |
| 25 | T | A | 0.0000 | mutated: ST25A |
| 26 | P | A | 0.1702 | |
| 27 | P | A | -0.2252 | |
| 28 | F | A | 0.0672 | |
| 29 | Y | A | -0.2774 | |
| 30 | P | A | 0.0000 | |
| 31 | S | A | 0.0000 | |
| 32 | P | A | -0.2117 | |
| 33 | W | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | N | A | -1.6450 | |
| 36 | G | A | -1.5864 | |
| 37 | Q | A | -1.3527 | |
| 38 | G | A | -1.5112 | |
| 39 | E | A | -1.6756 | |
| 40 | W | A | 0.0000 | |
| 41 | A | A | -2.0434 | |
| 42 | E | A | -2.8273 | |
| 43 | A | A | 0.0000 | |
| 44 | Y | A | -1.7823 | |
| 45 | Q | A | -2.3333 | |
| 46 | R | A | -2.0969 | |
| 47 | A | A | 0.0000 | |
| 48 | V | A | -0.5806 | |
| 49 | A | A | -0.6867 | |
| 50 | I | A | -0.4625 | |
| 51 | V | A | 0.0000 | |
| 52 | S | A | -0.7942 | |
| 53 | Q | A | -1.1989 | |
| 54 | M | A | 0.0000 | |
| 55 | T | A | -0.8437 | |
| 56 | L | A | 0.0000 | |
| 57 | D | A | -0.4247 | |
| 58 | E | A | -0.7526 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | N | A | -0.3451 | |
| 62 | L | A | 0.0000 | |
| 63 | T | A | 0.0000 | |
| 64 | T | A | 0.0000 | |
| 65 | G | A | 0.0000 | |
| 66 | T | A | 0.0000 | |
| 67 | G | A | 0.0000 | |
| 68 | W | A | -0.0337 | |
| 69 | E | A | 0.1061 | |
| 70 | L | A | 0.0000 | |
| 71 | E | A | -0.2137 | |
| 72 | K | A | -0.4394 | |
| 73 | C | A | 0.0000 | |
| 74 | V | A | 0.0000 | |
| 75 | G | A | 0.0000 | |
| 76 | Q | A | 0.0000 | |
| 77 | T | A | 0.0000 | |
| 78 | G | A | -0.3251 | |
| 79 | G | A | 0.0000 | |
| 80 | V | A | 0.0000 | |
| 81 | P | A | -1.6466 | |
| 82 | R | A | -2.2803 | |
| 83 | L | A | -1.5206 | |
| 84 | N | A | -1.9093 | |
| 85 | I | A | 0.0000 | |
| 86 | G | A | -1.0177 | |
| 87 | G | A | -0.6017 | |
| 88 | M | A | 0.0000 | |
| 89 | C | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | Q | A | 0.0000 | |
| 92 | D | A | 0.0000 | |
| 93 | S | A | 0.0000 | |
| 94 | P | A | 0.0000 | |
| 95 | L | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | I | A | 0.0000 | |
| 98 | R | A | -0.6007 | |
| 99 | D | A | -0.8185 | |
| 100 | S | A | 0.0000 | |
| 101 | D | A | -0.5100 | |
| 102 | Y | A | 0.0701 | |
| 103 | N | A | 0.0000 | |
| 104 | S | A | 0.0000 | |
| 105 | A | A | 0.0000 | |
| 106 | F | A | 0.0000 | |
| 107 | P | A | 0.0000 | |
| 108 | A | A | 0.0000 | |
| 109 | G | A | 0.0000 | |
| 110 | V | A | 0.0000 | |
| 111 | N | A | 0.0000 | |
| 112 | V | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | A | A | 0.0000 | |
| 115 | T | A | 0.0000 | |
| 116 | W | A | 0.0000 | |
| 117 | D | A | -0.9566 | |
| 118 | K | A | -1.1691 | |
| 119 | N | A | -1.4559 | |
| 120 | L | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | Y | A | -0.7378 | |
| 123 | L | A | 0.1143 | |
| 124 | R | A | 0.0000 | |
| 125 | G | A | 0.0000 | |
| 126 | Q | A | -0.8142 | |
| 127 | A | A | 0.0000 | |
| 128 | M | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | Q | A | -1.0701 | |
| 131 | E | A | 0.0000 | |
| 132 | F | A | 0.0000 | |
| 133 | S | A | -0.3938 | |
| 134 | D | A | -0.8799 | |
| 135 | K | A | 0.0000 | |
| 136 | G | A | 0.0000 | |
| 137 | I | A | 0.0000 | |
| 138 | D | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | P | A | 0.0000 | |
| 144 | A | A | 0.0000 | |
| 145 | A | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | P | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | G | A | -0.0968 | |
| 150 | R | A | 0.0000 | |
| 151 | S | A | 0.0000 | |
| 152 | P | A | -0.1040 | |
| 153 | D | A | 0.0000 | |
| 154 | G | A | 0.0000 | |
| 155 | G | A | 0.0000 | |
| 156 | R | A | 0.0000 | |
| 157 | N | A | -0.1436 | |
| 158 | W | A | 0.0000 | |
| 159 | E | A | 0.0000 | |
| 160 | G | A | 0.0000 | |
| 161 | F | A | 0.0000 | |
| 162 | S | A | 0.0000 | |
| 163 | P | A | 0.0000 | |
| 164 | D | A | 0.0000 | |
| 165 | P | A | 0.0000 | |
| 166 | A | A | 0.0000 | |
| 167 | L | A | 0.0000 | |
| 168 | T | A | 0.0000 | |
| 169 | G | A | 0.0000 | |
| 170 | V | A | 0.1245 | |
| 171 | L | A | 0.0000 | |
| 172 | F | A | 0.0000 | |
| 173 | A | A | -0.5327 | |
| 174 | E | A | -0.8993 | |
| 175 | T | A | 0.0000 | |
| 176 | I | A | 0.0000 | |
| 177 | K | A | -1.6716 | |
| 178 | G | A | 0.0000 | |
| 179 | I | A | 0.0000 | |
| 180 | Q | A | -1.4830 | |
| 181 | D | A | -2.2848 | |
| 182 | A | A | -1.1553 | |
| 183 | G | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | T | A | 0.0000 | |
| 188 | A | A | 0.0000 | |
| 189 | K | A | 0.0000 | |
| 190 | H | A | 0.0000 | |
| 191 | Y | A | 0.0000 | |
| 192 | I | A | 0.0000 | |
| 193 | L | A | 0.0000 | |
| 194 | N | A | 0.0000 | |
| 195 | E | A | 0.0000 | |
| 196 | Q | A | 0.0000 | |
| 197 | E | A | 0.0000 | |
| 198 | H | A | -0.3571 | |
| 199 | F | A | 0.0000 | |
| 200 | R | A | 0.0000 | |
| 201 | Q | A | -0.0562 | |
| 202 | V | A | -0.0332 | |
| 203 | A | A | -0.1329 | |
| 204 | E | A | -0.2409 | |
| 205 | A | A | 0.0000 | |
| 206 | A | A | -0.4736 | |
| 207 | G | A | -0.4428 | |
| 208 | Y | A | -0.2502 | |
| 209 | G | A | -0.5881 | |
| 210 | F | A | -0.8648 | |
| 211 | N | A | -1.6583 | |
| 212 | I | A | 0.0000 | |
| 213 | S | A | -1.0696 | |
| 214 | D | A | -1.0079 | |
| 215 | T | A | 0.0000 | |
| 216 | I | A | 0.0000 | |
| 217 | S | A | 0.0000 | |
| 218 | S | A | 0.0000 | |
| 219 | N | A | -1.0574 | |
| 220 | V | A | -0.9110 | |
| 221 | D | A | -1.4199 | |
| 222 | D | A | -1.3743 | |
| 223 | K | A | -1.3723 | |
| 224 | T | A | 0.0000 | |
| 225 | I | A | 0.0000 | |
| 226 | H | A | 0.0000 | |
| 227 | E | A | -0.3151 | |
| 228 | M | A | 0.0000 | |
| 229 | Y | A | 0.0000 | |
| 230 | L | A | 0.0000 | |
| 231 | W | A | 0.0000 | |
| 232 | P | A | 0.0000 | |
| 233 | F | A | 0.0000 | |
| 234 | A | A | 0.0000 | |
| 235 | D | A | -0.4630 | |
| 236 | A | A | 0.0000 | |
| 237 | V | A | 0.0000 | |
| 238 | R | A | -1.1305 | |
| 239 | A | A | -0.8576 | |
| 240 | G | A | 0.0000 | |
| 241 | V | A | 0.0000 | |
| 242 | G | A | 0.0000 | |
| 243 | A | A | 0.0000 | |
| 244 | I | A | 0.0000 | |
| 245 | M | A | 0.0000 | |
| 246 | C | A | 0.0000 | |
| 247 | S | A | 0.0000 | |
| 248 | Y | A | 0.0000 | |
| 249 | N | A | 0.0000 | |
| 250 | Q | A | 0.0000 | |
| 251 | I | A | 0.0000 | |
| 252 | N | A | -0.4612 | |
| 253 | N | A | -0.4591 | |
| 254 | S | A | -0.2027 | |
| 255 | Y | A | 0.0000 | |
| 256 | G | A | 0.0000 | |
| 257 | C | A | 0.0000 | |
| 258 | Q | A | -0.3502 | |
| 259 | N | A | 0.0000 | |
| 260 | S | A | 0.0000 | |
| 261 | Y | A | 0.0812 | |
| 262 | T | A | 0.0000 | |
| 263 | L | A | 0.0000 | |
| 264 | N | A | 0.0000 | |
| 265 | K | A | -0.0043 | |
| 266 | L | A | 0.0000 | |
| 267 | L | A | 0.0000 | |
| 268 | K | A | 0.0000 | |
| 269 | A | A | 0.0411 | |
| 270 | E | A | 0.0000 | |
| 271 | L | A | 0.0000 | |
| 272 | G | A | -0.4541 | |
| 273 | F | A | 0.0000 | |
| 274 | Q | A | 0.0000 | |
| 275 | G | A | 0.0000 | |
| 276 | F | A | 0.0000 | |
| 277 | V | A | 0.0000 | |
| 278 | M | A | 0.0000 | |
| 279 | S | A | 0.0000 | |
| 280 | D | A | 0.0000 | |
| 281 | W | A | -0.0363 | |
| 282 | G | A | -0.4613 | |
| 283 | A | A | 0.0000 | |
| 284 | H | A | 0.0000 | |
| 285 | H | A | -0.6102 | |
| 286 | S | A | -0.2221 | |
| 287 | G | A | -0.0543 | |
| 288 | V | A | 0.2081 | |
| 289 | G | A | -0.1759 | |
| 290 | S | A | 0.0000 | |
| 291 | A | A | 0.0000 | |
| 292 | L | A | 0.0000 | |
| 293 | A | A | 0.0000 | |
| 294 | G | A | 0.0000 | |
| 295 | L | A | 0.0000 | |
| 296 | D | A | 0.0000 | |
| 297 | M | A | 0.0000 | |
| 298 | S | A | 0.0000 | |
| 299 | M | A | 0.0000 | |
| 300 | P | A | 0.0000 | |
| 301 | G | A | 0.0000 | |
| 302 | D | A | 0.0000 | |
| 303 | R | A | -1.1503 | mutated: IR303A |
| 304 | K | A | -1.5903 | mutated: TK304A |
| 305 | F | A | -0.2960 | |
| 306 | D | A | -0.6598 | |
| 307 | S | A | -0.7832 | |
| 308 | A | A | -0.5358 | |
| 309 | T | A | -0.5887 | |
| 310 | S | A | 0.0000 | |
| 311 | F | A | 0.0000 | |
| 312 | W | A | 0.0000 | |
| 313 | G | A | 0.0000 | |
| 314 | T | A | -0.1853 | |
| 315 | N | A | -0.3004 | |
| 316 | L | A | 0.0000 | |
| 317 | T | A | 0.0000 | |
| 318 | I | A | 0.0000 | |
| 319 | A | A | 0.0000 | |
| 320 | V | A | 0.0000 | |
| 321 | L | A | -0.3774 | |
| 322 | N | A | -0.9260 | |
| 323 | G | A | -0.7425 | |
| 324 | T | A | -0.3206 | |
| 325 | V | A | 0.0000 | |
| 326 | P | A | -0.4421 | |
| 327 | Q | A | -0.3769 | |
| 328 | W | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | V | A | 0.0000 | |
| 331 | D | A | 0.0000 | |
| 332 | D | A | 0.0000 | |
| 333 | M | A | 0.0000 | |
| 334 | A | A | 0.0000 | |
| 335 | V | A | 0.0000 | |
| 336 | R | A | 0.0000 | |
| 337 | I | A | 0.0000 | |
| 338 | M | A | 0.0000 | |
| 339 | A | A | 0.0000 | |
| 340 | A | A | 0.0000 | |
| 341 | Y | A | 0.0000 | |
| 342 | Y | A | 0.0000 | |
| 343 | K | A | -1.3965 | |
| 344 | V | A | -0.9020 | |
| 345 | G | A | 0.0000 | |
| 346 | R | A | 0.0000 | |
| 347 | D | A | -1.3190 | |
| 348 | R | A | -1.6638 | |
| 349 | L | A | -0.3455 | |
| 350 | Y | A | -0.7277 | |
| 351 | Q | A | -1.4214 | |
| 352 | P | A | -0.8993 | |
| 353 | P | A | 0.0000 | |
| 354 | N | A | -0.6650 | |
| 355 | F | A | 0.0000 | |
| 356 | S | A | 0.0000 | |
| 357 | S | A | 0.0000 | |
| 358 | W | A | -0.2276 | |
| 359 | T | A | -0.9497 | |
| 360 | R | A | -1.8598 | |
| 361 | D | A | -2.6701 | |
| 362 | E | A | -2.6226 | |
| 363 | Y | A | -1.3043 | |
| 364 | G | A | -0.7728 | |
| 365 | F | A | 0.1589 | |
| 366 | K | A | -0.9533 | |
| 367 | Y | A | -0.2334 | |
| 368 | F | A | 0.2187 | |
| 369 | Y | A | 0.2469 | |
| 370 | P | A | -0.4297 | |
| 371 | Q | A | -0.7118 | |
| 372 | E | A | -0.6772 | |
| 373 | G | A | -0.8106 | |
| 374 | P | A | -0.5665 | |
| 375 | Y | A | 0.1561 | |
| 376 | E | A | -1.6508 | |
| 377 | K | A | -2.0321 | |
| 378 | V | A | 0.0000 | |
| 379 | N | A | 0.0000 | |
| 380 | H | A | -1.0511 | |
| 381 | F | A | -0.0459 | |
| 382 | V | A | 0.0934 | |
| 383 | N | A | -1.1462 | |
| 384 | V | A | 0.0000 | |
| 385 | Q | A | -1.7105 | |
| 386 | R | A | -2.9428 | |
| 387 | N | A | -2.6843 | |
| 388 | H | A | 0.0000 | |
| 389 | S | A | -1.9439 | |
| 390 | E | A | -2.7900 | |
| 391 | V | A | -1.3283 | |
| 392 | I | A | 0.0000 | |
| 393 | R | A | -1.7672 | |
| 394 | K | A | -1.7895 | |
| 395 | L | A | 0.0000 | |
| 396 | G | A | 0.0000 | |
| 397 | A | A | 0.0000 | |
| 398 | D | A | 0.0000 | |
| 399 | S | A | 0.0000 | |
| 400 | T | A | 0.0000 | |
| 401 | V | A | 0.0000 | |
| 402 | L | A | 0.0000 | |
| 403 | L | A | 0.0000 | |
| 404 | K | A | -0.9746 | |
| 405 | N | A | -1.3512 | |
| 406 | N | A | -2.1823 | |
| 407 | N | A | -2.0214 | |
| 408 | A | A | -1.2330 | |
| 409 | L | A | 0.0000 | |
| 410 | P | A | -0.5866 | |
| 411 | L | A | 0.0000 | |
| 412 | T | A | -0.7471 | |
| 413 | G | A | 0.0000 | |
| 414 | K | A | -2.7195 | |
| 415 | E | A | -2.3250 | |
| 416 | R | A | -3.0641 | |
| 417 | K | A | -1.8638 | |
| 418 | V | A | 0.0000 | |
| 419 | A | A | 0.0000 | |
| 420 | I | A | 0.0000 | |
| 421 | L | A | 0.0000 | |
| 422 | G | A | 0.0000 | |
| 423 | E | A | -0.9521 | |
| 424 | D | A | 0.0000 | |
| 425 | A | A | 0.0000 | |
| 426 | G | A | 0.0000 | |
| 427 | S | A | -1.0093 | |
| 428 | N | A | -1.3086 | |
| 429 | S | A | -1.4303 | |
| 430 | R | A | -2.3889 | mutated: YR430A |
| 431 | G | A | -1.5024 | |
| 432 | A | A | -0.9881 | |
| 433 | N | A | -1.2853 | |
| 434 | G | A | -1.5352 | |
| 435 | C | A | 0.0000 | |
| 436 | S | A | -0.6639 | |
| 437 | D | A | -0.7794 | |
| 438 | R | A | 0.0000 | |
| 439 | G | A | -0.2657 | |
| 440 | C | A | -0.3970 | |
| 441 | D | A | 0.0000 | |
| 442 | N | A | -1.0054 | |
| 443 | G | A | 0.0000 | |
| 444 | T | A | 0.0000 | |
| 445 | L | A | 0.0000 | |
| 446 | A | A | 0.0000 | |
| 447 | M | A | 0.0000 | |
| 448 | A | A | 0.0000 | |
| 449 | W | A | 0.0000 | |
| 450 | G | A | 0.0000 | |
| 451 | S | A | -0.1369 | |
| 452 | G | A | 0.0000 | |
| 453 | T | A | 0.0000 | |
| 454 | A | A | 0.0000 | |
| 455 | E | A | -0.7395 | |
| 456 | F | A | 0.0000 | |
| 457 | P | A | 0.1523 | |
| 458 | Y | A | 0.5019 | |
| 459 | L | A | 0.0447 | |
| 460 | K | A | -0.4619 | mutated: VK460A |
| 461 | T | A | 0.0000 | |
| 462 | P | A | 0.0000 | |
| 463 | E | A | -1.0004 | |
| 464 | Q | A | -1.3714 | |
| 465 | A | A | 0.0000 | |
| 466 | I | A | 0.0000 | |
| 467 | Q | A | -0.7839 | |
| 468 | A | A | -0.9266 | |
| 469 | E | A | -1.0159 | |
| 470 | V | A | 0.0000 | |
| 471 | L | A | -0.6826 | |
| 472 | K | A | -1.9461 | |
| 473 | H | A | -2.2122 | |
| 474 | K | A | -2.5370 | |
| 475 | G | A | -2.1558 | |
| 476 | S | A | -0.7786 | |
| 477 | V | A | -0.0317 | |
| 478 | Y | A | 0.9094 | |
| 479 | A | A | 0.1182 | |
| 480 | I | A | -0.1784 | |
| 481 | T | A | -0.7302 | |
| 482 | D | A | -1.6007 | |
| 483 | N | A | 0.0000 | |
| 484 | W | A | 0.2785 | |
| 485 | A | A | -0.3155 | |
| 486 | L | A | -0.4734 | |
| 487 | S | A | -0.6972 | |
| 488 | Q | A | -1.4513 | |
| 489 | V | A | 0.0000 | |
| 490 | E | A | -2.0527 | |
| 491 | T | A | -1.6682 | |
| 492 | L | A | 0.0000 | |
| 493 | A | A | 0.0000 | |
| 494 | K | A | -2.9294 | |
| 495 | Q | A | -2.4506 | |
| 496 | A | A | -1.7429 | |
| 497 | S | A | -1.7356 | |
| 498 | V | A | 0.0000 | |
| 499 | S | A | 0.0000 | |
| 500 | L | A | 0.0000 | |
| 501 | V | A | 0.0000 | |
| 502 | F | A | 0.0000 | |
| 503 | V | A | 0.0000 | |
| 504 | N | A | 0.0000 | |
| 505 | S | A | 0.0000 | |
| 506 | D | A | 0.0000 | |
| 507 | A | A | 0.0000 | |
| 508 | G | A | 0.0000 | |
| 509 | E | A | 0.0000 | |
| 510 | G | A | 0.0000 | |
| 511 | Y | A | 0.4606 | |
| 512 | I | A | 0.0799 | |
| 513 | S | A | -0.4405 | |
| 514 | V | A | -0.8777 | |
| 515 | D | A | -2.0535 | |
| 516 | G | A | -1.4968 | |
| 517 | N | A | 0.0000 | |
| 518 | E | A | -0.6999 | |
| 519 | G | A | 0.0000 | |
| 520 | D | A | 0.0000 | |
| 521 | R | A | 0.0000 | |
| 522 | N | A | -1.9018 | |
| 523 | N | A | -1.5868 | |
| 524 | L | A | 0.0000 | |
| 525 | T | A | -0.5342 | |
| 526 | L | A | 0.0000 | |
| 527 | W | A | -0.4834 | |
| 528 | K | A | -0.7665 | |
| 529 | N | A | -0.8342 | |
| 530 | G | A | 0.0000 | |
| 531 | D | A | -1.6964 | |
| 532 | N | A | -1.7653 | |
| 533 | L | A | 0.0000 | |
| 534 | I | A | 0.0000 | |
| 535 | K | A | -1.9132 | |
| 536 | A | A | 0.0000 | |
| 537 | A | A | 0.0000 | |
| 538 | A | A | 0.0000 | |
| 539 | N | A | -2.2322 | |
| 540 | N | A | -2.2717 | |
| 541 | C | A | 0.0000 | |
| 542 | N | A | -2.0540 | |
| 543 | N | A | -1.1689 | |
| 544 | T | A | 0.0000 | |
| 545 | I | A | 0.0000 | |
| 546 | V | A | 0.0000 | |
| 547 | V | A | 0.0000 | |
| 548 | I | A | 0.0000 | |
| 549 | H | A | 0.0000 | |
| 550 | S | A | 0.0000 | |
| 551 | V | A | 0.0000 | |
| 552 | G | A | 0.0000 | |
| 553 | P | A | 0.0000 | |
| 554 | V | A | 0.0000 | |
| 555 | L | A | -0.8478 | |
| 556 | V | A | 0.0000 | |
| 557 | D | A | -2.7791 | |
| 558 | E | A | -3.1530 | |
| 559 | W | A | 0.0000 | |
| 560 | Y | A | -1.6521 | |
| 561 | D | A | -2.4403 | |
| 562 | H | A | -1.9930 | |
| 563 | P | A | -1.4131 | |
| 564 | N | A | -1.6863 | |
| 565 | V | A | 0.0000 | |
| 566 | T | A | -1.4616 | |
| 567 | A | A | 0.0000 | |
| 568 | I | A | 0.0000 | |
| 569 | L | A | 0.0000 | |
| 570 | W | A | 0.0000 | |
| 571 | A | A | 0.0000 | |
| 572 | G | A | 0.0000 | |
| 573 | L | A | 0.0000 | |
| 574 | P | A | 0.0000 | |
| 575 | G | A | 0.0000 | |
| 576 | Q | A | 0.0000 | |
| 577 | E | A | 0.0000 | |
| 578 | S | A | 0.0000 | |
| 579 | G | A | 0.0000 | |
| 580 | N | A | -0.7029 | |
| 581 | S | A | 0.0000 | |
| 582 | L | A | 0.0000 | |
| 583 | A | A | 0.0000 | |
| 584 | D | A | 0.0000 | |
| 585 | V | A | 0.0000 | |
| 586 | L | A | 0.0000 | |
| 587 | Y | A | -0.4603 | |
| 588 | G | A | -0.7448 | |
| 589 | R | A | -1.4548 | |
| 590 | V | A | -0.7790 | |
| 591 | N | A | -0.2211 | |
| 592 | P | A | 0.0000 | |
| 593 | G | A | 0.0000 | |
| 594 | A | A | 0.0000 | |
| 595 | K | A | 0.0000 | |
| 596 | S | A | 0.0000 | |
| 597 | P | A | 0.0000 | |
| 598 | F | A | 0.0000 | |
| 599 | T | A | 0.0000 | |
| 600 | W | A | 0.0000 | |
| 601 | G | A | 0.0000 | |
| 602 | K | A | -1.6947 | |
| 603 | T | A | -1.2797 | |
| 604 | R | A | -1.2975 | |
| 605 | E | A | -1.9192 | |
| 606 | A | A | -1.4203 | |
| 607 | Y | A | 0.0000 | |
| 608 | G | A | -0.4991 | |
| 609 | D | A | 0.0000 | |
| 610 | Y | A | 0.6499 | |
| 611 | L | A | 0.0000 | |
| 612 | V | A | -0.6759 | |
| 613 | R | A | -1.3487 | |
| 614 | E | A | -2.2503 | |
| 615 | L | A | -1.9328 | |
| 616 | N | A | -2.1976 | |
| 617 | N | A | -1.8955 | |
| 618 | G | A | -1.9770 | |
| 619 | N | A | -2.2495 | |
| 620 | G | A | -1.5920 | |
| 621 | A | A | 0.0000 | |
| 622 | P | A | 0.0000 | |
| 623 | Q | A | -1.3991 | |
| 624 | D | A | 0.0000 | |
| 625 | D | A | -2.0353 | |
| 626 | F | A | 0.0000 | |
| 627 | S | A | -1.0648 | |
| 628 | E | A | -0.7173 | |
| 629 | G | A | -0.8668 | |
| 630 | V | A | 0.0000 | |
| 631 | F | A | 0.0000 | |
| 632 | I | A | 0.0000 | |
| 633 | D | A | 0.0000 | |
| 634 | Y | A | 0.0000 | |
| 635 | R | A | 0.0000 | |
| 636 | G | A | 0.0000 | |
| 637 | F | A | 0.0000 | |
| 638 | D | A | 0.0000 | |
| 639 | K | A | -3.0438 | |
| 640 | R | A | -2.5229 | |
| 641 | N | A | -2.5223 | |
| 642 | E | A | -1.8795 | |
| 643 | T | A | -0.9845 | |
| 644 | P | A | 0.0000 | |
| 645 | I | A | -0.4679 | |
| 646 | Y | A | 0.0000 | |
| 647 | E | A | -0.4513 | |
| 648 | F | A | 0.0000 | |
| 649 | G | A | 0.0000 | |
| 650 | H | A | 0.0000 | |
| 651 | G | A | 0.0833 | |
| 652 | L | A | 0.3549 | |
| 653 | T | A | 0.3302 | mutated: ST653A |
| 654 | Y | A | -0.0807 | |
| 655 | T | A | 0.0000 | |
| 656 | T | A | -0.2773 | |
| 657 | F | A | -0.7075 | |
| 658 | N | A | -1.2206 | |
| 659 | Y | A | 0.0000 | |
| 660 | S | A | -0.7673 | |
| 661 | G | A | -0.6726 | |
| 662 | L | A | -0.7017 | |
| 663 | H | A | -1.2725 | |
| 664 | I | A | -0.4262 | |
| 665 | Q | A | -0.7868 | |
| 666 | V | A | 0.4845 | |
| 667 | L | A | -0.2592 | |
| 668 | N | A | -1.1011 | |
| 669 | A | A | -1.0039 | |
| 675 | I | A | 1.5687 | mutated: VI675A |
| 676 | A | A | 0.4346 | |
| 677 | T | A | -0.4233 | |
| 678 | E | A | -1.7541 | |
| 679 | T | A | -1.4498 | |
| 680 | G | A | -1.2186 | |
| 681 | A | A | -0.6866 | |
| 682 | A | A | -0.5518 | |
| 683 | P | A | -0.2832 | |
| 684 | T | A | -0.2828 | |
| 685 | F | A | -0.3123 | |
| 686 | G | A | -0.8980 | |
| 687 | Q | A | -1.2807 | |
| 688 | V | A | -0.7566 | |
| 689 | G | A | -1.4248 | |
| 690 | N | A | -1.8585 | |
| 691 | A | A | -1.4461 | |
| 692 | S | A | -1.7190 | |
| 693 | D | A | -2.1816 | |
| 694 | Y | A | 0.0000 | |
| 695 | V | A | -0.9950 | |
| 696 | Y | A | -0.8314 | |
| 697 | P | A | -1.2869 | |
| 698 | E | A | -1.8500 | |
| 699 | G | A | -1.3077 | |
| 700 | L | A | -0.6773 | |
| 701 | T | A | -0.9060 | |
| 702 | R | A | -1.4437 | |
| 703 | I | A | -0.8718 | |
| 704 | S | A | -0.8424 | |
| 705 | K | A | -0.6861 | |
| 706 | F | A | -0.3553 | |
| 707 | I | A | 0.0000 | |
| 708 | Y | A | -0.1087 | |
| 709 | P | A | 0.0000 | |
| 710 | W | A | -0.2389 | |
| 711 | L | A | 0.0000 | |
| 712 | N | A | -1.3758 | |
| 713 | S | A | -1.4338 | |
| 714 | T | A | -1.7016 | |
| 715 | D | A | -2.2501 | |
| 716 | L | A | -1.7576 | |
| 717 | K | A | -2.5744 | |
| 718 | A | A | -1.6366 | |
| 719 | S | A | -1.4914 | |
| 720 | S | A | -1.5063 | |
| 721 | G | A | -1.2575 | |
| 722 | D | A | -1.3762 | |
| 723 | P | A | -1.3389 | |
| 724 | R | A | -2.0172 | mutated: YR724A |
| 725 | Y | A | -1.3376 | |
| 726 | G | A | -0.9712 | |
| 727 | V | A | -0.5374 | |
| 728 | D | A | -2.1421 | |
| 729 | T | A | -1.5492 | |
| 730 | A | A | -1.6622 | |
| 731 | E | A | -2.7731 | |
| 732 | H | A | -2.1018 | |
| 733 | V | A | -1.3617 | |
| 734 | P | A | -1.4450 | |
| 735 | E | A | -2.2326 | |
| 736 | G | A | -1.1510 | |
| 737 | A | A | 0.0000 | |
| 738 | T | A | -0.8263 | |
| 739 | D | A | -1.1982 | |
| 740 | G | A | -0.6974 | |
| 741 | S | A | -0.6307 | |
| 742 | P | A | -1.0454 | |
| 743 | Q | A | -1.0663 | |
| 744 | P | A | -0.9779 | |
| 745 | V | A | -0.2178 | |
| 746 | L | A | -0.2294 | |
| 747 | P | A | -0.0633 | |
| 748 | A | A | 0.0000 | |
| 749 | G | A | 0.0000 | |
| 750 | G | A | -0.0561 | |
| 751 | G | A | 0.0000 | |
| 752 | S | A | -0.7494 | |
| 753 | G | A | 0.0000 | |
| 754 | G | A | 0.0000 | |
| 755 | N | A | -0.3802 | |
| 756 | P | A | -0.5718 | |
| 757 | R | A | -1.5082 | |
| 758 | L | A | 0.0000 | |
| 759 | Y | A | -0.8378 | |
| 760 | D | A | -1.3953 | |
| 761 | E | A | -1.6131 | |
| 762 | L | A | 0.0000 | |
| 763 | I | A | 0.0000 | |
| 764 | R | A | -1.1748 | |
| 765 | V | A | 0.0000 | |
| 766 | S | A | -1.0943 | |
| 767 | V | A | 0.0000 | |
| 768 | T | A | 0.0000 | |
| 769 | V | A | 0.0000 | |
| 770 | K | A | -2.3065 | |
| 771 | N | A | 0.0000 | |
| 772 | T | A | -1.2832 | |
| 773 | G | A | -1.1635 | |
| 774 | R | A | -1.6573 | |
| 775 | V | A | -0.3003 | |
| 776 | A | A | -0.8890 | |
| 777 | G | A | 0.0000 | |
| 778 | D | A | -0.3895 | |
| 779 | A | A | 0.0000 | |
| 780 | V | A | 0.0000 | |
| 781 | P | A | 0.0000 | |
| 782 | Q | A | 0.0000 | |
| 783 | L | A | 0.0000 | |
| 784 | Y | A | 0.0000 | |
| 785 | V | A | 0.0000 | |
| 786 | S | A | -0.8289 | |
| 787 | L | A | 0.0000 | |
| 788 | G | A | -0.7432 | |
| 789 | G | A | -0.8118 | |
| 790 | P | A | -1.1443 | |
| 791 | N | A | -2.0158 | |
| 792 | E | A | -1.6537 | |
| 793 | P | A | 0.0000 | |
| 794 | K | A | -2.2417 | |
| 795 | V | A | -1.1180 | |
| 796 | V | A | 0.0000 | |
| 797 | L | A | 0.0000 | |
| 798 | R | A | -0.2968 | |
| 799 | K | A | -0.4071 | |
| 800 | F | A | 0.0000 | |
| 801 | D | A | -0.8408 | |
| 802 | R | A | -0.6885 | |
| 803 | L | A | -0.1555 | |
| 804 | T | A | -0.8353 | |
| 805 | L | A | 0.0000 | |
| 806 | K | A | -2.5862 | |
| 807 | P | A | -1.9474 | |
| 808 | S | A | -1.9544 | |
| 809 | E | A | -2.7872 | |
| 810 | E | A | -3.3083 | |
| 811 | T | A | -2.0640 | |
| 812 | K | A | -2.2087 | mutated: VK812A |
| 813 | W | A | 0.0000 | |
| 814 | T | A | -0.8463 | |
| 815 | T | A | -0.7135 | |
| 816 | T | A | -0.7599 | |
| 817 | L | A | 0.0000 | |
| 818 | T | A | -1.0036 | |
| 819 | R | A | -0.9354 | |
| 820 | R | A | 0.0000 | |
| 821 | D | A | 0.0000 | |
| 822 | L | A | 0.0000 | |
| 823 | S | A | 0.0000 | |
| 824 | N | A | 0.0000 | |
| 825 | W | A | 0.0000 | |
| 826 | D | A | -1.5288 | |
| 827 | R | A | -2.4289 | mutated: VR827A |
| 828 | A | A | -1.1128 | |
| 829 | A | A | -0.8819 | |
| 830 | Q | A | -1.2550 | |
| 831 | D | A | -0.9250 | |
| 832 | W | A | -0.3634 | |
| 833 | V | A | 0.0134 | |
| 834 | I | A | 0.0117 | |
| 835 | T | A | 0.0058 | |
| 836 | S | A | -0.1125 | |
| 837 | Y | A | 0.3392 | |
| 838 | P | A | -0.3853 | |
| 839 | K | A | 0.0000 | |
| 840 | K | A | -1.0396 | |
| 841 | V | A | 0.0000 | |
| 842 | H | A | -0.7108 | |
| 843 | V | A | 0.0000 | |
| 844 | G | A | 0.0000 | |
| 845 | S | A | -0.5172 | |
| 846 | S | A | 0.0000 | |
| 847 | S | A | 0.0000 | |
| 848 | R | A | -1.3505 | |
| 849 | Q | A | -1.4213 | |
| 850 | L | A | -0.8300 | |
| 851 | P | A | -0.7736 | |
| 852 | L | A | -0.5921 | |
| 853 | H | A | -1.1704 | |
| 854 | A | A | -0.7119 | |
| 855 | A | A | -0.6820 | |
| 856 | L | A | -0.5677 | |
| 857 | P | A | -0.8887 | |
| 858 | K | A | -1.6166 | |
| 859 | V | A | -0.9262 | |
| 860 | Q | A | -1.4021 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine