| Chain sequence(s) |
A: GPLPLAPEPPLRSTDDYVTPTDLYYVAETDLITETGNPTADIVVDGKVLVPRVSAYQFRVFLLKLPDPNTMPLPSADAVDPSTEILIWRLLAFEIGVGGPLGTGSYGHSDYNRFGDVDNPTSYQHEGADDTVNLSWRPKRKQLYIIGDKPPLAKYTTPAAPAPGLPPGAIPPTTTVTDIVEHGDMADIGFGARDYAALLPRKDEVPDIIRDTSTKVFDFDGMRAEPTGNRMFDYDRKEKSYSVKNYVRDGPDPVPLPDAPPPSPLYTKPPPTSPYAVLPSYNFFTIPDQGEITEDDLLFNKPRFFTKTPGLNNGVLWYNRLYVTVLDNSRATIETKTTQTSTPAVNVYNPADYVTSKTYTREYQLSFILQLCKIPLTPETLAYLSRLDPRILVNAKLPDVPPVEREDPLKGKKFIEIDLTNKLSTDLSSTSLGRLFLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2117 | |
| 2 | P | A | 0.4164 | |
| 3 | L | A | 1.5917 | |
| 4 | P | A | 1.0829 | |
| 5 | L | A | 1.4758 | |
| 6 | A | A | 0.3345 | |
| 7 | P | A | -0.8522 | |
| 8 | E | A | -1.7820 | |
| 9 | P | A | -1.2538 | |
| 10 | P | A | -0.8261 | |
| 11 | L | A | -0.2698 | |
| 12 | R | A | -1.3190 | |
| 13 | S | A | -1.2690 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.5855 | |
| 16 | D | A | -2.6152 | |
| 17 | Y | A | -1.6032 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.8617 | |
| 20 | P | A | -0.8498 | |
| 21 | T | A | -0.8809 | |
| 22 | D | A | -1.6189 | |
| 23 | L | A | -0.4926 | |
| 24 | Y | A | -0.1685 | |
| 25 | Y | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1917 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3135 | |
| 31 | L | A | 0.3724 | |
| 32 | I | A | 0.1566 | |
| 33 | T | A | -0.2120 | |
| 34 | E | A | -0.4855 | |
| 35 | T | A | -0.3359 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.7949 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.7542 | |
| 40 | A | A | -0.4148 | |
| 41 | D | A | 0.2502 | |
| 42 | I | A | 2.1754 | |
| 43 | V | A | 2.6447 | |
| 44 | V | A | 1.6513 | |
| 45 | D | A | -1.0046 | |
| 46 | G | A | -0.5399 | |
| 47 | K | A | -0.1622 | |
| 48 | V | A | 2.2563 | |
| 49 | L | A | 2.6903 | |
| 50 | V | A | 1.8341 | |
| 51 | P | A | 0.4435 | |
| 52 | R | A | -0.3482 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -1.8866 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.0040 | |
| 67 | D | A | -0.8481 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.0338 | |
| 70 | T | A | -0.5665 | |
| 71 | M | A | -0.1889 | |
| 72 | P | A | -0.1701 | |
| 73 | L | A | -0.1167 | |
| 74 | P | A | -0.3715 | |
| 75 | S | A | -0.6705 | |
| 76 | A | A | -0.9970 | |
| 77 | D | A | -1.9767 | |
| 78 | A | A | -1.2947 | |
| 79 | V | A | -1.2868 | |
| 80 | D | A | -1.9083 | |
| 81 | P | A | -1.1713 | |
| 82 | S | A | -0.8216 | |
| 83 | T | A | -0.8038 | |
| 84 | E | A | -1.0740 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.1795 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.1124 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | E | A | -1.1517 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -0.7779 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.5294 | |
| 99 | G | A | -0.6517 | |
| 100 | P | A | -0.2840 | |
| 101 | L | A | -0.0090 | |
| 102 | G | A | -0.0702 | |
| 103 | T | A | -0.3178 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.4256 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9950 | |
| 108 | H | A | 0.0000 | |
| 109 | S | A | -1.6475 | |
| 110 | D | A | -2.7437 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -1.1927 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.0917 | |
| 117 | V | A | -0.5085 | |
| 118 | D | A | -1.7928 | |
| 119 | N | A | -2.0067 | |
| 120 | P | A | -1.1375 | |
| 121 | T | A | -0.6786 | |
| 122 | S | A | -0.4261 | |
| 123 | Y | A | 0.1263 | |
| 124 | Q | A | -0.9130 | |
| 125 | H | A | -0.9433 | |
| 126 | E | A | -2.4105 | |
| 127 | G | A | -2.1174 | |
| 128 | A | A | -1.5277 | |
| 129 | D | A | -2.6749 | |
| 130 | D | A | -2.1855 | |
| 131 | T | A | -1.8677 | |
| 132 | V | A | -1.3330 | |
| 133 | N | A | -1.7440 | |
| 134 | L | A | -0.8820 | |
| 135 | S | A | -0.6419 | |
| 136 | W | A | 0.0000 | |
| 137 | R | A | -0.8045 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -0.9214 | |
| 140 | R | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | K | A | -0.4981 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1931 | |
| 153 | A | A | 0.0000 | |
| 154 | K | A | -0.2068 | |
| 155 | Y | A | -0.1779 | |
| 156 | T | A | -0.2342 | |
| 157 | T | A | -0.2385 | |
| 158 | P | A | -0.2660 | |
| 159 | A | A | -0.1377 | |
| 160 | A | A | -0.1676 | |
| 161 | P | A | -0.0728 | |
| 162 | A | A | -0.1695 | |
| 163 | P | A | -0.3598 | |
| 164 | G | A | -0.3915 | |
| 165 | L | A | 0.3133 | |
| 166 | P | A | -0.0841 | |
| 167 | P | A | -0.2534 | |
| 168 | G | A | -0.1139 | |
| 169 | A | A | 0.7871 | |
| 170 | I | A | 1.9531 | |
| 171 | P | A | 0.7027 | |
| 172 | P | A | 0.2781 | |
| 173 | T | A | 0.0189 | |
| 174 | T | A | -0.0379 | |
| 175 | T | A | -0.0592 | |
| 176 | V | A | 0.1878 | |
| 177 | T | A | -0.0450 | |
| 178 | D | A | -0.3753 | |
| 179 | I | A | -0.3901 | |
| 180 | V | A | 0.0000 | |
| 181 | E | A | -1.1105 | |
| 182 | H | A | -1.0922 | |
| 183 | G | A | -0.7156 | |
| 184 | D | A | -0.6652 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4816 | |
| 190 | F | A | -0.1691 | |
| 191 | G | A | -0.2894 | |
| 192 | A | A | -0.2962 | |
| 193 | R | A | -0.5769 | |
| 194 | D | A | -0.8673 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.2376 | |
| 197 | A | A | -0.5224 | |
| 198 | L | A | 0.0465 | |
| 199 | L | A | -0.9519 | |
| 200 | P | A | -1.2087 | |
| 201 | R | A | -1.7961 | |
| 202 | K | A | -2.4191 | |
| 203 | D | A | -1.8791 | |
| 204 | E | A | -1.4182 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.5894 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.1543 | |
| 211 | D | A | -2.3679 | |
| 212 | T | A | -1.3175 | |
| 213 | S | A | -0.8340 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.5860 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.0000 | |
| 220 | D | A | -2.5220 | |
| 221 | G | A | -1.7231 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.7427 | |
| 224 | A | A | -1.6410 | |
| 225 | E | A | -1.3197 | |
| 226 | P | A | -0.6914 | |
| 227 | T | A | -0.3599 | |
| 228 | G | A | 0.0000 | |
| 229 | N | A | 0.0000 | |
| 230 | R | A | -0.7594 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.6214 | |
| 234 | Y | A | -0.4927 | |
| 235 | D | A | -1.3605 | |
| 236 | R | A | -2.3252 | |
| 237 | K | A | -2.3753 | |
| 238 | E | A | -2.3748 | |
| 239 | K | A | -2.2018 | |
| 240 | S | A | -0.9855 | |
| 241 | Y | A | 0.3901 | |
| 242 | S | A | 0.2649 | |
| 243 | V | A | 0.3247 | |
| 244 | K | A | -0.9758 | |
| 245 | N | A | -0.7195 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.3618 | |
| 249 | D | A | -1.4213 | |
| 250 | G | A | -1.1201 | |
| 251 | P | A | -0.6257 | |
| 252 | D | A | -0.0886 | |
| 253 | P | A | 0.6167 | |
| 254 | V | A | 1.7080 | |
| 255 | P | A | 0.3735 | |
| 256 | L | A | 0.6065 | |
| 257 | P | A | -0.3935 | |
| 258 | D | A | -1.9108 | |
| 259 | A | A | -1.1071 | |
| 260 | P | A | -1.2086 | |
| 261 | P | A | -1.0020 | |
| 262 | P | A | -0.5816 | |
| 263 | S | A | -0.5106 | |
| 264 | P | A | 0.3987 | |
| 265 | L | A | 1.1296 | |
| 266 | Y | A | 0.2504 | |
| 267 | T | A | -0.6913 | |
| 268 | K | A | -1.6563 | |
| 269 | P | A | -0.6224 | |
| 270 | P | A | -0.6913 | |
| 271 | P | A | -0.4138 | |
| 272 | T | A | -0.1015 | |
| 273 | S | A | -0.0226 | |
| 274 | P | A | 0.3820 | |
| 275 | Y | A | 0.9930 | |
| 276 | A | A | 0.4689 | |
| 277 | V | A | 0.8432 | |
| 278 | L | A | 0.7868 | |
| 279 | P | A | -0.0522 | |
| 280 | S | A | -0.1464 | |
| 281 | Y | A | 0.7497 | |
| 282 | N | A | 0.4757 | |
| 283 | F | A | 1.7813 | |
| 284 | F | A | 0.7993 | |
| 285 | T | A | 0.2522 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | Q | A | 0.0000 | |
| 290 | G | A | -1.0969 | |
| 291 | E | A | -1.9509 | |
| 292 | I | A | -1.2418 | |
| 293 | T | A | -1.8206 | |
| 294 | E | A | -2.6614 | |
| 295 | D | A | -2.8135 | |
| 296 | D | A | -2.0914 | |
| 297 | L | A | -1.4412 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6273 | |
| 301 | K | A | -1.7839 | |
| 302 | P | A | -0.9888 | |
| 303 | R | A | -0.7406 | |
| 304 | F | A | -0.1718 | |
| 305 | F | A | -0.2580 | |
| 306 | T | A | -0.6630 | |
| 307 | K | A | -1.8108 | |
| 308 | T | A | 0.0000 | |
| 309 | P | A | -0.9983 | |
| 310 | G | A | -0.7794 | |
| 311 | L | A | -0.5031 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | Y | A | -0.3552 | |
| 319 | N | A | -0.6564 | |
| 320 | R | A | -1.1046 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | T | A | -0.3069 | |
| 333 | I | A | -1.0864 | |
| 334 | E | A | -2.3013 | |
| 335 | T | A | -2.2720 | |
| 336 | K | A | -2.2904 | |
| 337 | T | A | -0.7589 | |
| 338 | T | A | -0.2302 | |
| 339 | Q | A | -0.2983 | |
| 340 | T | A | -0.0577 | |
| 341 | S | A | -0.4080 | |
| 342 | T | A | -0.3558 | |
| 343 | P | A | -0.4488 | |
| 344 | A | A | -0.1692 | |
| 345 | V | A | 0.3600 | |
| 346 | N | A | -0.0128 | |
| 347 | V | A | 1.6783 | |
| 348 | Y | A | 1.5024 | |
| 349 | N | A | 0.0050 | |
| 350 | P | A | 0.0633 | |
| 351 | A | A | 0.0118 | |
| 352 | D | A | 0.1783 | |
| 353 | Y | A | 0.5202 | |
| 354 | V | A | 1.2871 | |
| 355 | T | A | -0.2381 | |
| 356 | S | A | -1.4149 | |
| 357 | K | A | -2.6859 | |
| 358 | T | A | -1.6918 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.5444 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.4744 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.8297 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | F | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6305 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6062 | |
| 376 | L | A | -0.2749 | |
| 377 | T | A | -0.6173 | |
| 378 | P | A | -0.9573 | |
| 379 | E | A | -1.7618 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.2922 | |
| 382 | A | A | -0.6346 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | S | A | -0.3831 | |
| 386 | R | A | -0.7869 | |
| 387 | L | A | -0.1986 | |
| 388 | D | A | -0.5022 | |
| 389 | P | A | -0.3602 | |
| 390 | R | A | -1.1818 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.4793 | |
| 394 | N | A | -0.8049 | |
| 395 | A | A | -0.9574 | |
| 396 | K | A | -2.0060 | |
| 397 | L | A | -1.1017 | |
| 398 | P | A | -1.2562 | |
| 399 | D | A | -1.8774 | |
| 400 | V | A | -0.7660 | |
| 401 | P | A | -0.7276 | |
| 402 | P | A | -1.0886 | |
| 403 | V | A | -1.2229 | |
| 404 | E | A | -3.1840 | |
| 405 | R | A | -3.8528 | |
| 406 | E | A | -3.9976 | |
| 407 | D | A | -3.4342 | |
| 408 | P | A | -2.1706 | |
| 409 | L | A | -1.8961 | |
| 410 | K | A | -3.0249 | |
| 411 | G | A | -2.0461 | |
| 412 | K | A | -1.9958 | |
| 413 | K | A | -2.4855 | |
| 414 | F | A | -1.2622 | |
| 415 | I | A | -1.0529 | |
| 416 | E | A | -2.3094 | |
| 417 | I | A | -1.8802 | |
| 418 | D | A | -2.7331 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.4906 | |
| 421 | N | A | -1.8440 | |
| 422 | K | A | -1.7750 | |
| 423 | L | A | -0.7737 | |
| 424 | S | A | -0.9296 | |
| 425 | T | A | -0.7777 | |
| 426 | D | A | -1.9042 | |
| 427 | L | A | -0.8003 | |
| 428 | S | A | -1.1725 | |
| 429 | S | A | -1.1716 | |
| 430 | T | A | -0.9386 | |
| 431 | S | A | -0.7441 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7466 | |
| 435 | L | A | -0.4531 | |
| 436 | F | A | -0.1791 | |
| 437 | L | A | 0.0727 | |
| 438 | N | A | -1.5635 | |
| 439 | R | A | -1.8709 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine