| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEYQHDGADVRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPDGVPLPDAPPPSPLYVPPPPTSPYAVLPSTNYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQISTPEKNVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9486 | |
| 2 | L | A | 1.9731 | |
| 3 | P | A | 0.6571 | |
| 4 | P | A | 0.3571 | |
| 5 | T | A | 0.1098 | |
| 6 | T | A | 0.1298 | |
| 7 | P | A | 0.1680 | |
| 8 | V | A | 1.2109 | |
| 9 | A | A | 0.0272 | |
| 10 | K | A | -1.1488 | |
| 11 | V | A | -0.4057 | |
| 12 | Q | A | -1.5229 | |
| 13 | S | A | -1.6116 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4495 | |
| 16 | E | A | -2.4539 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4549 | |
| 20 | P | A | 0.1052 | |
| 21 | T | A | 0.1139 | |
| 22 | S | A | -0.1709 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1016 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2280 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7332 | |
| 31 | R | A | -2.5988 | |
| 32 | L | A | -0.7416 | |
| 33 | L | A | 1.2383 | |
| 34 | T | A | 1.6533 | |
| 35 | V | A | 2.0197 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2308 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6343 | |
| 40 | K | A | -1.8790 | |
| 41 | D | A | -0.7675 | |
| 42 | I | A | 1.2170 | |
| 43 | V | A | 2.1821 | |
| 44 | V | A | 1.6293 | |
| 45 | N | A | -0.5317 | |
| 46 | G | A | -0.3701 | |
| 47 | K | A | -0.1320 | |
| 48 | V | A | 2.1872 | |
| 49 | L | A | 2.5247 | |
| 50 | V | A | 1.4738 | |
| 51 | P | A | 0.3548 | |
| 52 | K | A | -0.6837 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1566 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4692 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3062 | |
| 70 | K | A | -1.8211 | |
| 71 | F | A | -0.6754 | |
| 72 | A | A | -0.5643 | |
| 73 | L | A | -0.9138 | |
| 74 | P | A | -1.2532 | |
| 75 | Q | A | -2.4658 | |
| 76 | K | A | -3.0860 | |
| 77 | D | A | -2.9853 | |
| 78 | F | A | -1.6336 | |
| 79 | Y | A | -1.8989 | |
| 80 | D | A | -2.7482 | |
| 81 | P | A | -2.3485 | |
| 82 | E | A | -3.0628 | |
| 83 | K | A | -3.4351 | |
| 84 | E | A | -2.4915 | |
| 85 | R | A | -1.2992 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6189 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -1.0158 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3304 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6719 | |
| 99 | G | A | -0.5447 | |
| 100 | P | A | -0.4357 | |
| 101 | L | A | -0.0142 | |
| 102 | G | A | -0.2351 | |
| 103 | K | A | -0.6478 | |
| 104 | G | A | -0.4880 | |
| 105 | T | A | -0.4539 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1505 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4207 | |
| 110 | L | A | 0.4048 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9673 | |
| 113 | K | A | -0.3396 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.5046 | |
| 117 | T | A | -1.1082 | |
| 118 | E | A | -1.9387 | |
| 119 | N | A | -2.2699 | |
| 120 | P | A | -1.9532 | |
| 121 | T | A | -1.5996 | |
| 122 | E | A | -2.1652 | |
| 123 | Y | A | -0.4435 | |
| 124 | Q | A | -1.3365 | |
| 125 | H | A | -1.3005 | |
| 126 | D | A | -2.3540 | |
| 127 | G | A | -2.0108 | |
| 128 | A | A | -1.3982 | |
| 129 | D | A | -2.1133 | |
| 130 | V | A | -1.2832 | |
| 131 | R | A | -0.7553 | |
| 132 | V | A | 0.4075 | |
| 133 | A | A | 0.4392 | |
| 134 | F | A | 0.2777 | |
| 135 | S | A | -0.0687 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6961 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2266 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5491 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2777 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1070 | |
| 157 | D | A | 0.3479 | |
| 158 | I | A | 0.8407 | |
| 159 | A | A | 0.1025 | |
| 160 | E | A | -1.4896 | |
| 161 | P | A | -0.2775 | |
| 162 | C | A | 0.1585 | |
| 163 | P | A | -0.1855 | |
| 164 | G | A | -0.0975 | |
| 165 | L | A | 0.5540 | |
| 166 | P | A | -0.1289 | |
| 167 | P | A | -0.3491 | |
| 168 | G | A | -0.4280 | |
| 169 | A | A | 0.2868 | |
| 170 | C | A | 1.0890 | |
| 171 | P | A | 0.5397 | |
| 172 | P | A | 0.6794 | |
| 173 | I | A | 2.0281 | |
| 174 | Q | A | 0.8321 | |
| 175 | L | A | 1.4295 | |
| 176 | V | A | 0.8099 | |
| 177 | N | A | -0.3591 | |
| 178 | S | A | -0.0277 | |
| 179 | V | A | 0.3376 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3525 | |
| 182 | D | A | 0.0536 | |
| 183 | G | A | -0.1612 | |
| 184 | D | A | -0.5825 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1396 | |
| 190 | F | A | 0.0580 | |
| 191 | G | A | -0.1083 | |
| 192 | N | A | -0.2938 | |
| 193 | M | A | -0.1655 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4001 | |
| 197 | E | A | -2.5774 | |
| 198 | L | A | -1.2028 | |
| 199 | Q | A | -2.5301 | |
| 200 | Q | A | -3.3402 | |
| 201 | D | A | -3.5994 | |
| 202 | R | A | -3.3392 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2025 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3854 | |
| 211 | S | A | -1.9163 | |
| 212 | T | A | -1.4995 | |
| 213 | R | A | -2.2014 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1743 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2700 | |
| 220 | L | A | 0.4376 | |
| 221 | K | A | -1.4320 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9224 | |
| 224 | N | A | -1.6132 | |
| 225 | E | A | -1.3428 | |
| 226 | A | A | -0.6772 | |
| 227 | Y | A | -0.4121 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7056 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0958 | |
| 234 | F | A | 0.2816 | |
| 235 | G | A | -0.8447 | |
| 236 | R | A | -2.6851 | |
| 237 | R | A | -3.0671 | |
| 238 | E | A | -2.2491 | |
| 239 | Q | A | -0.2235 | |
| 240 | V | A | 1.4925 | |
| 241 | Y | A | 1.1988 | |
| 242 | A | A | 0.1361 | |
| 243 | R | A | -1.2866 | |
| 244 | H | A | -1.0609 | |
| 245 | F | A | -0.0025 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6548 | |
| 249 | A | A | -1.3040 | |
| 250 | G | A | -1.2476 | |
| 251 | P | A | -0.7747 | |
| 252 | D | A | -0.3109 | |
| 253 | G | A | 0.1099 | |
| 254 | V | A | 1.3400 | |
| 255 | P | A | 0.1811 | |
| 256 | L | A | 0.4216 | |
| 257 | P | A | -0.4628 | |
| 258 | D | A | -1.9008 | |
| 259 | A | A | -0.5940 | |
| 260 | P | A | -0.7350 | |
| 261 | P | A | -0.3800 | |
| 262 | P | A | 0.0783 | |
| 263 | S | A | 0.3161 | |
| 264 | P | A | 0.6897 | |
| 265 | L | A | 1.9035 | |
| 266 | Y | A | 1.5807 | |
| 267 | V | A | 1.9498 | |
| 268 | P | A | 0.7830 | |
| 269 | P | A | 0.7535 | |
| 270 | P | A | -0.0898 | |
| 271 | P | A | -0.0649 | |
| 272 | T | A | 0.0156 | |
| 273 | S | A | 0.3143 | |
| 274 | P | A | 0.6624 | |
| 275 | Y | A | 1.6626 | |
| 276 | A | A | 1.3643 | |
| 277 | V | A | 2.0946 | |
| 278 | L | A | 1.5436 | |
| 279 | P | A | 0.1790 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | 0.1522 | |
| 282 | N | A | -0.2849 | |
| 283 | Y | A | 0.9896 | |
| 284 | F | A | 0.7689 | |
| 285 | G | A | 0.1960 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9155 | |
| 291 | L | A | 1.6300 | |
| 292 | V | A | 0.6380 | |
| 293 | S | A | -0.1574 | |
| 294 | S | A | -0.9722 | |
| 295 | D | A | -1.8402 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1794 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6886 | |
| 301 | R | A | -1.9964 | |
| 302 | P | A | -1.0135 | |
| 303 | F | A | -0.1703 | |
| 304 | W | A | -0.5149 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0714 | |
| 307 | R | A | -2.8252 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2312 | |
| 310 | G | A | -1.2119 | |
| 311 | N | A | -1.3112 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8337 | |
| 319 | N | A | -0.8754 | |
| 320 | E | A | -1.0428 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3555 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1656 | |
| 333 | N | A | 0.4197 | |
| 334 | F | A | 1.4552 | |
| 335 | T | A | 0.7742 | |
| 336 | I | A | 0.3843 | |
| 337 | S | A | -1.0753 | |
| 338 | Q | A | -1.8644 | |
| 339 | Q | A | -1.5292 | |
| 340 | I | A | 0.5017 | |
| 341 | S | A | -0.0738 | |
| 342 | T | A | -0.7398 | |
| 343 | P | A | -1.2012 | |
| 344 | E | A | -2.4525 | |
| 345 | K | A | -2.5411 | |
| 346 | N | A | -1.4630 | |
| 347 | V | A | 0.5860 | |
| 348 | Y | A | 0.8745 | |
| 349 | D | A | -0.2459 | |
| 350 | P | A | -0.7350 | |
| 351 | S | A | -0.5656 | |
| 352 | N | A | -0.7866 | |
| 353 | F | A | -1.1343 | |
| 354 | K | A | -2.0836 | |
| 355 | N | A | -1.8270 | |
| 356 | Y | A | 0.0028 | |
| 357 | L | A | 0.6624 | |
| 358 | R | A | 0.9622 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4737 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | 0.0130 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9066 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.7065 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3085 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3395 | |
| 376 | L | A | -1.7440 | |
| 377 | D | A | -2.0376 | |
| 378 | P | A | -1.0672 | |
| 379 | G | A | -1.0180 | |
| 380 | V | A | -0.9257 | |
| 381 | L | A | -0.5362 | |
| 382 | A | A | -0.6497 | |
| 383 | H | A | -0.8334 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3601 | |
| 386 | T | A | -0.5551 | |
| 387 | M | A | -0.3180 | |
| 388 | N | A | -0.8516 | |
| 389 | P | A | -1.2364 | |
| 390 | T | A | -1.4390 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4266 | |
| 393 | E | A | -2.7686 | |
| 394 | N | A | -2.5587 | |
| 395 | W | A | -1.3694 | |
| 396 | N | A | -1.1664 | |
| 397 | L | A | -0.1065 | |
| 398 | G | A | 0.7020 | |
| 399 | F | A | 2.4391 | |
| 400 | V | A | 1.8666 | |
| 401 | P | A | 0.0800 | |
| 402 | P | A | -1.7961 | |
| 403 | K | A | -3.4043 | |
| 404 | E | A | -3.8089 | |
| 405 | R | A | -3.8342 | |
| 406 | E | A | -3.7259 | |
| 407 | D | A | -2.8540 | |
| 408 | P | A | -1.7492 | |
| 409 | Y | A | -1.0036 | |
| 410 | K | A | -2.1022 | |
| 411 | G | A | -0.6412 | |
| 412 | L | A | 0.6515 | |
| 413 | I | A | 1.5659 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4136 | |
| 416 | E | A | -1.7092 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8579 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8912 | |
| 421 | E | A | -2.4805 | |
| 422 | R | A | -1.9746 | |
| 423 | F | A | -1.0124 | |
| 424 | S | A | -1.3256 | |
| 425 | Q | A | -1.7568 | |
| 426 | D | A | -2.9013 | |
| 427 | L | A | -1.9916 | |
| 428 | D | A | -2.7866 | |
| 429 | Q | A | -2.6209 | |
| 430 | F | A | -1.4539 | |
| 431 | A | A | -0.8907 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5429 | |
| 435 | K | A | -0.6876 | |
| 436 | F | A | 0.1865 | |
| 437 | L | A | 1.0540 | |
| 438 | Y | A | 0.8461 | |
| 439 | Q | A | -0.2575 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine