Project name: db62fddbba1b6f1

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDFKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:03)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:04)

• Minimal score value: -3.0848
• Maximal score value: 1.8753
• Average score: -0.4759
• Total score value: -123.2624

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.3784
245	C	P	0.1597
246	G	P	-0.8020
247	E	P	-1.6033
248	L	P	0.0000
249	V	P	0.1966
250	W	P	0.4557
251	V	P	-0.6958
252	G	P	-1.6747
253	E	P	-2.2522
254	P	P	-0.7075
255	L	P	0.9035
256	T	P	0.7856
257	L	P	0.6703
258	R	P	-0.2534
259	T	P	-0.8643
260	A	P	-0.8359
261	E	P	-1.2416
262	T	P	-0.0042
263	I	P	1.3365
264	T	P	0.3942
265	G	P	-0.0312
266	K	P	0.4052
267	Y	P	0.9148
268	G	P	0.2687
269	V	P	0.0530
270	W	P	0.0000
271	M	P	0.0000
272	R	P	-0.5941
273	D	P	-0.7291
274	P	P	-0.6314
275	K	P	0.0000
276	P	P	-0.3356
277	T	P	0.2506
278	Y	P	1.3718
279	P	P	1.1111
280	Y	P	1.4672
281	T	P	0.3009
282	Q	P	-0.4353
283	E	P	-0.3605
284	T	P	0.0000
285	T	P	0.3076
286	W	P	0.0000
287	R	P	0.0844
288	I	P	0.0000
289	D	P	0.0000
290	T	P	0.2270
291	V	P	0.9979
292	G	P	-0.2774
293	T	P	-0.7817
294	D	P	-1.6764
295	V	P	-0.3996
296	R	P	-0.2610
297	Q	P	0.5284
298	V	P	0.0000
299	F	P	0.8350
300	E	P	0.0000
301	Y	P	1.3307
302	D	P	0.0000
303	L	P	1.2769
304	I	P	1.0327
305	S	P	0.3915
306	Q	P	-0.2724
307	F	P	1.0692
308	M	P	0.7797
309	Q	P	-0.6257
310	G	P	-0.3583
311	Y	P	0.1660
312	P	P	-0.2589
313	S	P	0.0676
314	K	P	-0.1525
315	V	P	1.1633
316	H	P	1.0567
317	I	P	1.8753
318	L	P	0.0000
319	P	P	-0.0703
320	R	P	-0.9823
321	P	P	-0.8725
322	L	P	-0.3389
323	E	P	-0.7504
324	S	P	-0.1742
325	T	P	-0.1213
326	G	P	-0.1856
327	A	P	0.0269
328	V	P	0.0000
329	V	P	0.2758
330	Y	P	0.0054
331	S	P	-0.4721
332	G	P	-0.5825
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	0.0000
339	A	P	-1.2398
340	E	P	-2.0464
341	S	P	-1.6177
342	R	P	-1.6477
343	T	P	-1.7727
344	V	P	0.0000
345	I	P	0.0000
346	R	P	-0.8547
347	Y	P	0.0000
348	E	P	-1.0611
349	L	P	0.0000
350	N	P	-1.4542
351	T	P	-0.9023
352	E	P	-1.0889
353	T	P	-0.5901
354	V	P	-0.2831
355	K	P	-1.2109
356	A	P	-1.0742
357	E	P	-1.9496
358	K	P	-2.5621
359	E	P	-2.6072
360	I	P	0.0000
361	P	P	-0.7351
362	G	P	0.0000
363	A	P	-1.0607
364	G	P	-0.6163
365	Y	P	0.3979
366	H	P	-0.5496
367	G	P	-0.7317
368	Q	P	-0.6414
369	F	P	0.0000
370	P	P	0.4078
371	Y	P	1.1128
372	S	P	0.0000
373	W	P	0.5221
374	G	P	-0.5560
375	G	P	-1.0894
376	Y	P	-0.7972
377	T	P	0.0000
378	D	P	-0.9381
379	I	P	0.0000
380	D	P	0.0000
381	L	P	0.0000
382	A	P	0.0000
383	V	P	0.0000
384	D	P	-1.0996
385	E	P	-1.8183
386	A	P	-1.0006
387	G	P	-1.0929
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	0.0000
393	S	P	-0.8215
394	T	P	0.0000
395	D	P	-2.6950
396	E	P	-2.5635
397	A	P	-1.5728
398	K	P	-2.3060
399	G	P	0.0000
400	A	P	0.0000
401	I	P	0.0000
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	-1.3072
406	L	P	0.0000
407	N	P	-2.0555
408	P	P	-1.6902
409	E	P	-2.8369
410	N	P	-2.7748
411	L	P	-2.5151
412	E	P	-2.8229
413	L	P	-1.9082
414	E	P	-2.5570
415	Q	P	-1.8889
416	T	P	-0.9962
417	W	P	-0.9669
418	E	P	-1.7173
419	T	P	-1.5307
420	N	P	-1.9440
421	I	P	-1.5588
422	R	P	-2.0091
423	K	P	-2.6380
424	Q	P	-1.9862
425	S	P	-0.6681
426	V	P	-0.3976
427	A	P	-0.6092
428	N	P	0.0000
429	A	P	0.0000
430	F	P	0.0000
431	I	P	0.0000
432	I	P	0.0000
433	C	P	-0.2083
434	G	P	-0.1104
435	T	P	-0.2398
436	L	P	0.0000
437	Y	P	0.0000
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.4228
441	S	P	-0.5305
442	Y	P	0.6609
443	T	P	-0.0186
444	S	P	-0.5711
445	A	P	-1.3002
446	D	P	-2.4785
447	A	P	0.0000
448	T	P	-0.6522
449	V	P	0.0000
450	N	P	0.0000
451	F	P	0.3182
452	A	P	0.0000
453	Y	P	0.2387
454	D	P	-0.0551
455	T	P	-0.4025
456	G	P	-0.4760
457	T	P	-0.1838
458	G	P	-0.3012
459	I	P	0.8285
460	S	P	0.2298
461	K	P	-0.2440
462	T	P	-0.0252
463	L	P	0.2179
464	T	P	0.2486
465	I	P	0.0000
466	P	P	-0.9465
467	F	P	0.0000
468	K	P	-2.6616
469	N	P	-3.0848
470	R	P	-3.0795
471	Y	P	0.0000
472	K	P	-2.2734
473	Y	P	-0.7692
474	S	P	-0.3129
475	S	P	-0.3862
476	M	P	0.0000
477	I	P	0.0000
478	D	P	-0.2648
479	Y	P	-0.8196
480	N	P	-1.1754
481	P	P	-1.0863
482	L	P	-0.1687
483	E	P	-2.1363
484	K	P	-2.5448
485	K	P	-2.2712
486	L	P	0.0000
487	F	P	0.0000
488	A	P	0.0000
489	W	P	-0.8145
490	D	P	-1.7702
491	N	P	-1.3231
492	L	P	-0.6233
493	N	P	-0.8271
494	M	P	0.0000
495	V	P	0.5709
496	T	P	-0.1493
497	Y	P	0.0000
498	D	P	-2.7158
499	F	P	0.0000
500	K	P	-1.7453
501	L	P	-0.6021
502	S	P	-0.7161