| Chain sequence(s) |
A: GPLPTNPEPKLLSTDEYVEPTDLYYVAETGLITETGHPTKDIVENGKVVEPRVSAYDFRVFLLKLPDPNTLPLPSPDFLDPSTEIRIWRLEAYKIHVGGPLGVGEYGHPNFNALGDVTNPTSPLHETSDDTVNLSFTPILRQQYIIGDRPPLGKYTTKAAPAPGLPPGAIPPLVTKTTIIEHGDRADIGFGAKNYKELDPDKDNVPDLILDTTTKVFDYDGMKAEPYGTRLFDYDERRSSRPVRHLRRDGPDLVPLPDLPPPSPLYVRPPASSPYAVRPSYNYFTLPDRGEVTEEDLLFNRPRFLTETSGLNNGILWHNRLYITILDNRRAEIETIKTKLSTPETDVYDPSYYKTSKKYTREYRIELVVRLCKIPLTPETLALLERIDPSILIDAKLPDIPPVERADPLAGKKFLEIDLTNKLSSNLEETELGRLFLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2049 | |
| 2 | P | A | 0.1739 | |
| 3 | L | A | 0.9807 | |
| 4 | P | A | -0.0371 | |
| 5 | T | A | -0.7402 | |
| 6 | N | A | -1.7886 | |
| 7 | P | A | -2.1580 | |
| 8 | E | A | -2.7480 | |
| 9 | P | A | -1.9463 | |
| 10 | K | A | -1.8216 | |
| 11 | L | A | -0.0240 | |
| 12 | L | A | -0.2851 | |
| 13 | S | A | -0.8487 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.9816 | |
| 16 | E | A | -2.7089 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -1.9102 | |
| 20 | P | A | -1.4837 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6675 | |
| 23 | L | A | -0.5352 | |
| 24 | Y | A | -0.2200 | |
| 25 | Y | A | -0.0158 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.7844 | |
| 29 | T | A | 0.0000 | |
| 30 | G | A | 0.1375 | |
| 31 | L | A | 1.0760 | |
| 32 | I | A | 0.5169 | |
| 33 | T | A | -0.0512 | |
| 34 | E | A | -0.4713 | |
| 35 | T | A | -0.5878 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.8849 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.6176 | |
| 40 | K | A | -2.2385 | |
| 41 | D | A | -1.4615 | |
| 42 | I | A | 0.1953 | |
| 43 | V | A | 0.6262 | |
| 44 | E | A | -1.4958 | |
| 45 | N | A | -2.0193 | |
| 46 | G | A | -1.3284 | |
| 47 | K | A | -1.1396 | |
| 48 | V | A | 1.0583 | |
| 49 | V | A | 1.3812 | |
| 50 | E | A | 0.1388 | |
| 51 | P | A | -0.3477 | |
| 52 | R | A | -1.5160 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -1.7718 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.6927 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.7503 | |
| 70 | T | A | -0.3743 | |
| 71 | L | A | 0.0326 | |
| 72 | P | A | -0.1213 | |
| 73 | L | A | 0.0799 | |
| 74 | P | A | -0.2959 | |
| 75 | S | A | -0.4835 | |
| 76 | P | A | -0.8694 | |
| 77 | D | A | -1.4459 | |
| 78 | F | A | -0.0339 | |
| 79 | L | A | -0.4424 | |
| 80 | D | A | -1.3221 | |
| 81 | P | A | -1.0016 | |
| 82 | S | A | -0.9793 | |
| 83 | T | A | -0.6674 | |
| 84 | E | A | -0.6483 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.4436 | |
| 90 | L | A | 0.0000 | |
| 91 | E | A | -0.3329 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.7653 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.5327 | |
| 99 | G | A | -0.7870 | |
| 100 | P | A | -0.3148 | |
| 101 | L | A | 0.0953 | |
| 102 | G | A | 0.3066 | |
| 103 | V | A | 0.6238 | |
| 104 | G | A | 0.0000 | |
| 105 | E | A | -1.7243 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.2224 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.3750 | |
| 110 | N | A | -2.1571 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.5729 | |
| 115 | G | A | -1.0494 | |
| 116 | D | A | -1.9224 | |
| 117 | V | A | -0.9650 | |
| 118 | T | A | -1.4254 | |
| 119 | N | A | -1.7233 | |
| 120 | P | A | -1.1873 | |
| 121 | T | A | -0.7240 | |
| 122 | S | A | -0.6938 | |
| 123 | P | A | -0.2557 | |
| 124 | L | A | -0.5814 | |
| 125 | H | A | -1.2667 | |
| 126 | E | A | -2.1419 | |
| 127 | T | A | -1.6232 | |
| 128 | S | A | -1.4656 | |
| 129 | D | A | -2.3388 | |
| 130 | D | A | -1.6331 | |
| 131 | T | A | -1.1621 | |
| 132 | V | A | -0.5448 | |
| 133 | N | A | -1.3334 | |
| 134 | L | A | -0.6155 | |
| 135 | S | A | -0.8599 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4458 | |
| 138 | P | A | 0.0000 | |
| 139 | I | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | R | A | -1.2684 | |
| 142 | Q | A | 0.0000 | |
| 143 | Q | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.9239 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.2088 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.8856 | |
| 155 | Y | A | -0.7008 | |
| 156 | T | A | -0.2344 | |
| 157 | T | A | 0.0000 | |
| 158 | K | A | -0.2548 | |
| 159 | A | A | 0.2819 | |
| 160 | A | A | 0.0663 | |
| 161 | P | A | 0.0749 | |
| 162 | A | A | -0.1468 | |
| 163 | P | A | -0.3265 | |
| 164 | G | A | -0.3372 | |
| 165 | L | A | 0.4344 | |
| 166 | P | A | -0.0581 | |
| 167 | P | A | -0.2190 | |
| 168 | G | A | 0.1942 | |
| 169 | A | A | 1.1926 | |
| 170 | I | A | 2.4675 | |
| 171 | P | A | 1.0912 | |
| 172 | P | A | 1.1508 | |
| 173 | L | A | 1.6871 | |
| 174 | V | A | 0.9445 | |
| 175 | T | A | -0.2275 | |
| 176 | K | A | -1.1320 | |
| 177 | T | A | -0.6687 | |
| 178 | T | A | -0.3096 | |
| 179 | I | A | -0.2583 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0742 | |
| 182 | H | A | -1.1141 | |
| 183 | G | A | -0.6683 | |
| 184 | D | A | -0.6161 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4513 | |
| 190 | F | A | -0.0801 | |
| 191 | G | A | -0.2629 | |
| 192 | A | A | -0.4430 | |
| 193 | K | A | -1.0940 | |
| 194 | N | A | -1.6689 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.3050 | |
| 197 | E | A | -2.4730 | |
| 198 | L | A | -1.4447 | |
| 199 | D | A | 0.0000 | |
| 200 | P | A | -2.3933 | |
| 201 | D | A | -3.0319 | |
| 202 | K | A | -3.5109 | |
| 203 | D | A | -2.1389 | |
| 204 | N | A | -1.4465 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7020 | |
| 208 | L | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.5825 | |
| 211 | D | A | -2.5922 | |
| 212 | T | A | -1.4847 | |
| 213 | T | A | -1.0757 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.0174 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | -1.0731 | |
| 219 | Y | A | -1.2989 | |
| 220 | D | A | -2.4369 | |
| 221 | G | A | -1.6917 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.5511 | |
| 224 | A | A | -1.5469 | |
| 225 | E | A | -1.2716 | |
| 226 | P | A | -0.4045 | |
| 227 | Y | A | -0.0225 | |
| 228 | G | A | 0.0000 | |
| 229 | T | A | 0.0000 | |
| 230 | R | A | -0.8439 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.6018 | |
| 234 | Y | A | -0.1464 | |
| 235 | D | A | -0.8798 | |
| 236 | E | A | -1.7278 | |
| 237 | R | A | -2.4453 | |
| 238 | R | A | -2.3942 | |
| 239 | S | A | -1.8935 | |
| 240 | S | A | -1.7343 | |
| 241 | R | A | -2.1181 | |
| 242 | P | A | -0.9829 | |
| 243 | V | A | 0.1034 | |
| 244 | R | A | -1.5703 | |
| 245 | H | A | -1.0733 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | D | A | -1.2048 | |
| 250 | G | A | -0.8706 | |
| 251 | P | A | -0.2245 | |
| 252 | D | A | 0.7148 | |
| 253 | L | A | 2.4437 | |
| 254 | V | A | 2.6647 | |
| 255 | P | A | 0.8688 | |
| 256 | L | A | 0.8509 | |
| 257 | P | A | -0.1546 | |
| 258 | D | A | -1.6776 | |
| 259 | L | A | -0.4313 | |
| 260 | P | A | -0.7604 | |
| 261 | P | A | -0.4758 | |
| 262 | P | A | -0.1093 | |
| 263 | S | A | 0.1243 | |
| 264 | P | A | 0.7761 | |
| 265 | L | A | 1.5590 | |
| 266 | Y | A | 1.1580 | |
| 267 | V | A | 1.1156 | |
| 268 | R | A | -1.0299 | |
| 269 | P | A | -0.2685 | |
| 270 | P | A | -0.4477 | |
| 271 | A | A | -0.0586 | |
| 272 | S | A | 0.0048 | |
| 273 | S | A | 0.1227 | |
| 274 | P | A | 0.3331 | |
| 275 | Y | A | 0.9736 | |
| 276 | A | A | 0.7013 | |
| 277 | V | A | 1.6327 | |
| 278 | R | A | 0.3434 | |
| 279 | P | A | -0.1816 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.3396 | |
| 282 | N | A | -0.4302 | |
| 283 | Y | A | 0.7796 | |
| 284 | F | A | 0.1285 | |
| 285 | T | A | -0.4037 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.2072 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.5473 | |
| 291 | E | A | -1.9177 | |
| 292 | V | A | -0.9536 | |
| 293 | T | A | -1.8605 | |
| 294 | E | A | -2.7430 | |
| 295 | E | A | -2.9973 | |
| 296 | D | A | -2.3179 | |
| 297 | L | A | -1.7121 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3816 | |
| 301 | R | A | -1.6077 | |
| 302 | P | A | -0.9534 | |
| 303 | R | A | -0.7037 | |
| 304 | F | A | -0.2665 | |
| 305 | L | A | -0.4898 | |
| 306 | T | A | -0.8777 | |
| 307 | E | A | -2.0602 | |
| 308 | T | A | -1.0352 | |
| 309 | S | A | -0.9668 | |
| 310 | G | A | -0.7926 | |
| 311 | L | A | -0.2496 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.0815 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.6712 | |
| 319 | N | A | -0.7997 | |
| 320 | R | A | -1.0439 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -1.6275 | |
| 333 | I | A | -1.7651 | |
| 334 | E | A | -2.5534 | |
| 335 | T | A | -1.6627 | |
| 336 | I | A | -1.1979 | |
| 337 | K | A | -2.3474 | |
| 338 | T | A | -1.6177 | |
| 339 | K | A | -1.6700 | |
| 340 | L | A | 0.2348 | |
| 341 | S | A | -0.0776 | |
| 342 | T | A | -0.7112 | |
| 343 | P | A | -1.1676 | |
| 344 | E | A | -2.1757 | |
| 345 | T | A | -1.0804 | |
| 346 | D | A | -1.1630 | |
| 347 | V | A | 1.0952 | |
| 348 | Y | A | 1.4734 | |
| 349 | D | A | 0.3035 | |
| 350 | P | A | -0.3742 | |
| 351 | S | A | -0.2980 | |
| 352 | Y | A | -0.1416 | |
| 353 | Y | A | -0.9311 | |
| 354 | K | A | -2.0356 | |
| 355 | T | A | -1.8433 | |
| 356 | S | A | -1.6658 | |
| 357 | K | A | -2.1347 | |
| 358 | K | A | -2.0004 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.9201 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.5479 | |
| 363 | Y | A | 0.0000 | |
| 364 | R | A | -0.5259 | |
| 365 | I | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | V | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | R | A | -0.4843 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.9023 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7302 | |
| 376 | L | A | -0.2998 | |
| 377 | T | A | -0.5926 | |
| 378 | P | A | -0.9281 | |
| 379 | E | A | -1.9293 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.7074 | |
| 382 | A | A | -1.2227 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -2.3131 | |
| 386 | R | A | -1.7359 | |
| 387 | I | A | -0.7611 | |
| 388 | D | A | -0.9981 | |
| 389 | P | A | -1.1703 | |
| 390 | S | A | 0.0000 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -0.4264 | |
| 393 | I | A | -0.3388 | |
| 394 | D | A | -1.0324 | |
| 395 | A | A | -1.0091 | |
| 396 | K | A | -1.7550 | |
| 397 | L | A | -1.2920 | |
| 398 | P | A | -1.3904 | |
| 399 | D | A | -1.8715 | |
| 400 | I | A | -0.3519 | |
| 401 | P | A | -0.3651 | |
| 402 | P | A | -0.4178 | |
| 403 | V | A | 0.5079 | |
| 404 | E | A | -1.3978 | |
| 405 | R | A | -1.2176 | |
| 406 | A | A | -0.8328 | |
| 407 | D | A | -1.2493 | |
| 408 | P | A | -0.7305 | |
| 409 | L | A | -0.8032 | |
| 410 | A | A | -0.9014 | |
| 411 | G | A | -1.3522 | |
| 412 | K | A | -1.9759 | |
| 413 | K | A | -2.4609 | |
| 414 | F | A | -1.3880 | |
| 415 | L | A | -1.0700 | |
| 416 | E | A | -2.3064 | |
| 417 | I | A | -1.5951 | |
| 418 | D | A | -2.7284 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6388 | |
| 421 | N | A | -2.0601 | |
| 422 | K | A | -2.0003 | |
| 423 | L | A | -0.8685 | |
| 424 | S | A | -1.1951 | |
| 425 | S | A | -0.8556 | |
| 426 | N | A | -2.1138 | |
| 427 | L | A | -2.0114 | |
| 428 | E | A | -3.5100 | |
| 429 | E | A | -3.5542 | |
| 430 | T | A | -2.5958 | |
| 431 | E | A | -2.3298 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.0548 | |
| 435 | L | A | -1.1858 | |
| 436 | F | A | -0.8082 | |
| 437 | L | A | -0.5246 | |
| 438 | N | A | -1.7378 | |
| 439 | R | A | -2.0021 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine