Project name: 6R8X

Chain sequence(s)	H: QVQLLESGGGLVQPGGSLRLSCAASGFTFSTAAMSWVRQAPGKGLEWVSGISGSGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARELSYLYSGYYFDYWGQGTLVTVSS; L: QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNDVSWYQQLPGTAPKLLIYKNYNRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCSAWDQRQFDVVFGGGTKLTVL
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:54)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:56)

• Minimal score value: -2.5541
• Maximal score value: 2.8123
• Average score: -0.4311
• Total score value: -100.0101

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.3958
2	V	H	-0.7318
3	Q	H	-0.6288
4	L	H	0.0000
5	L	H	0.8314
6	E	H	0.2101
7	S	H	-0.2675
8	G	H	-0.6365
9	G	H	0.1713
11	G	H	0.6808
12	L	H	1.3302
13	V	H	0.0000
14	Q	H	-1.3725
15	P	H	-1.4619
16	G	H	-1.5844
17	G	H	-1.3616
18	S	H	-1.4486
19	L	H	-1.0096
20	R	H	-1.7297
21	L	H	0.0000
22	S	H	-0.3425
23	C	H	0.0000
24	A	H	-0.1368
25	A	H	0.0000
26	S	H	-0.6710
27	G	H	-0.8937
28	F	H	-0.3294
29	T	H	-0.2228
30	F	H	0.0000
35	S	H	-0.6280
36	T	H	-0.2559
37	A	H	0.0000
38	A	H	-0.0381
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6166
45	A	H	-1.0293
46	P	H	-0.8119
47	G	H	-1.4514
48	K	H	-2.2590
49	G	H	-1.5159
50	L	H	0.0000
51	E	H	-0.9437
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	G	H	0.0000
56	I	H	0.0000
57	S	H	-0.1917
58	G	H	-0.4806
59	S	H	-0.6482
62	G	H	-0.6500
63	S	H	-0.4479
64	S	H	-0.0176
65	T	H	0.4998
66	Y	H	1.0965
67	Y	H	-0.0862
68	A	H	0.0000
69	D	H	-2.4337
70	S	H	-1.6894
71	V	H	0.0000
72	K	H	-2.3583
74	G	H	-1.8052
75	R	H	-1.8537
76	F	H	0.0000
77	T	H	-0.7880
78	I	H	0.0000
79	S	H	-0.4513
80	R	H	-0.9846
81	D	H	-1.5222
82	N	H	-1.7669
83	S	H	-1.5950
84	K	H	-2.3413
85	N	H	-1.6653
86	T	H	-0.9817
87	L	H	0.0000
88	Y	H	-0.4459
89	L	H	0.0000
90	Q	H	-1.3984
91	M	H	0.0000
92	N	H	-2.1273
93	S	H	-1.5816
94	L	H	0.0000
95	R	H	-2.2324
96	A	H	-1.6506
97	E	H	-2.1555
98	D	H	0.0000
99	T	H	-0.3819
100	A	H	0.0000
101	V	H	0.7649
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.0149
107	E	H	0.0000
108	L	H	0.8071
109	S	H	1.3029
110	Y	H	2.4668
111	L	H	2.8123
111A	Y	H	2.2537
112A	S	H	1.2782
112	G	H	0.9413
113	Y	H	0.7925
114	Y	H	0.0000
115	F	H	0.0000
116	D	H	-0.0236
117	Y	H	0.2289
118	W	H	-0.0565
119	G	H	0.0000
120	Q	H	-0.7971
121	G	H	-0.0655
122	T	H	0.4763
123	L	H	1.5261
124	V	H	0.0000
125	T	H	0.2881
126	V	H	0.0000
127	S	H	-0.7300
128	S	H	-0.5612
1	Q	L	-0.8150
2	S	L	-0.1310
3	V	L	1.1545
4	L	L	0.0000
5	T	L	0.1288
6	Q	L	-0.3742
7	P	L	-0.6159
8	P	L	-0.8504
9	S	L	-0.8761
11	A	L	-0.5338
12	S	L	-0.3173
13	G	L	0.0000
14	T	L	-0.2384
15	P	L	-0.9462
16	G	L	-1.6993
17	Q	L	-2.3410
18	R	L	-2.5541
19	V	L	-1.1304
20	T	L	-0.4899
21	I	L	0.0000
22	S	L	-0.3694
23	C	L	0.0000
24	S	L	-0.1849
25	G	L	0.0383
26	S	L	-0.3502
27	S	L	-0.8922
28	S	L	-1.1063
29	N	L	0.0000
30	I	L	0.0000
35	G	L	-0.8519
36	S	L	-0.7666
37	N	L	-0.7998
38	D	L	-0.6458
39	V	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	L	L	-0.6169
46	P	L	-0.4735
47	G	L	-0.6437
48	T	L	-0.6209
49	A	L	-0.5820
50	P	L	0.0000
51	K	L	-0.8952
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.2643
56	K	L	-0.5071
57	N	L	-0.4268
65	Y	L	0.3717
66	N	L	-0.5697
67	R	L	-1.3459
68	P	L	-0.7029
69	S	L	-0.7522
70	G	L	-0.9478
71	V	L	0.0000
72	P	L	-1.4439
74	D	L	-2.2654
75	R	L	-1.6050
76	F	L	0.0000
77	S	L	-0.6451
78	G	L	-0.1058
79	S	L	-0.3615
80	K	L	-0.9734
83	S	L	-0.8629
84	G	L	-0.9028
85	T	L	-0.7397
86	S	L	-0.6953
87	A	L	0.0000
88	S	L	-0.3079
89	L	L	0.0000
90	A	L	-0.5612
91	I	L	0.0000
92	S	L	-1.8234
93	G	L	-1.7109
94	L	L	0.0000
95	Q	L	-1.5502
96	S	L	-1.3290
97	E	L	-2.1737
98	D	L	0.0000
99	E	L	-1.2967
100	A	L	0.0000
101	D	L	-1.1808
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	S	L	0.0000
106	A	L	0.0000
107	W	L	-0.1874
108	D	L	0.0000
109	Q	L	-1.5685
110	R	L	-2.2944
113	Q	L	-1.5149
114	F	L	0.6915
115	D	L	-0.1547
116	V	L	0.0000
117	V	L	0.0000
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.7323
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4284
124	L	L	0.0000
125	T	L	-0.3520
126	V	L	0.1679
127	L	L	1.4301