Project name: 1006-IGF

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLACAASGSTLDYYGIGWFRQAPGKEREGVSCITISGGGTRYSDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAGKSRLRTWCPLYNQGLDSWGQGTLVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:02)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:03)

• Minimal score value: -2.8511
• Maximal score value: 1.6093
• Average score: -0.7553
• Total score value: -95.9264

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.2559
2	V	H	-1.2921
3	Q	H	-1.3210
4	L	H	0.0000
5	V	H	0.7887
6	E	H	0.2713
7	S	H	-0.2196
8	G	H	-0.7965
9	G	H	0.1033
11	G	H	0.7037
12	L	H	1.4400
13	V	H	-0.0078
14	Q	H	-1.3599
15	P	H	-1.6118
16	G	H	-1.4277
17	G	H	-0.9601
18	S	H	-1.0690
19	L	H	-0.8632
20	R	H	-2.0103
21	L	H	0.0000
22	A	H	-0.3827
23	C	H	0.0000
24	A	H	-0.3622
25	A	H	-0.5739
26	S	H	-0.7798
27	G	H	-1.3045
28	S	H	-1.1736
29	T	H	-0.8371
30	L	H	0.0000
35	D	H	-1.3680
36	Y	H	-0.5024
37	Y	H	0.0000
38	G	H	0.0000
39	I	H	0.0000
40	G	H	0.0000
41	W	H	0.0000
42	F	H	0.0000
43	R	H	0.0000
44	Q	H	-1.1439
45	A	H	0.0000
46	P	H	-1.0581
47	G	H	-1.4806
48	K	H	-2.2448
49	E	H	-2.8213
50	R	H	-1.9954
51	E	H	-1.4619
52	G	H	-0.7689
53	V	H	0.0000
54	S	H	0.0000
55	C	H	0.0000
56	I	H	0.0000
57	T	H	0.0000
58	I	H	-0.5129
59	S	H	-0.8402
62	G	H	-0.7442
63	G	H	-0.6671
64	G	H	-0.6293
65	T	H	-0.7476
66	R	H	-1.4559
67	Y	H	-1.3974
68	S	H	-1.6481
69	D	H	-2.5819
70	S	H	-1.7609
71	V	H	0.0000
72	K	H	-2.6635
74	G	H	-1.6682
75	R	H	-1.5535
76	F	H	0.0000
77	T	H	-0.9683
78	I	H	0.0000
79	S	H	-0.4302
80	R	H	-1.0904
81	D	H	-1.7228
82	N	H	-2.3089
83	S	H	-1.7503
84	K	H	-2.5232
85	N	H	-2.1609
86	T	H	-1.0996
87	L	H	0.0000
88	Y	H	-0.5221
89	L	H	0.0000
90	Q	H	-1.3309
91	M	H	0.0000
92	N	H	-1.4367
93	S	H	-1.2998
94	L	H	0.0000
95	R	H	-2.4524
96	A	H	-1.7906
97	E	H	-2.2835
98	D	H	0.0000
99	T	H	-0.3758
100	A	H	0.0000
101	V	H	0.7550
102	Y	H	0.0000
103	Y	H	0.1514
104	C	H	0.0000
105	A	H	0.0000
106	A	H	0.0000
107	G	H	0.0000
108	K	H	-2.8511
109	S	H	0.0000
110	R	H	-2.4435
111	L	H	-1.5060
111A	R	H	-2.1307
111B	T	H	-0.9326
111C	W	H	-0.1839
112D	C	H	0.0000
112C	P	H	0.0000
112B	L	H	0.2055
112A	Y	H	-0.2223
112	N	H	-1.8958
113	Q	H	-2.0437
114	G	H	-1.9348
115	L	H	0.0000
116	D	H	-2.7060
117	S	H	-1.5638
118	W	H	-0.4368
119	G	H	0.0000
120	Q	H	-0.8285
121	G	H	-0.0110
122	T	H	0.5281
123	L	H	1.6093
124	V	H	0.0000
125	T	H	0.3908
126	V	H	0.0000
127	S	H	-0.6581
128	S	H	-0.6538