Project name: dd756462c4addc7

Chain sequence(s)	A: NKTKVIGIGINLEELSPEKIEKKIEEKLEEIDKEYAALKAEGVKHIRFNINIDINDANAENALYALEKLAYRCKELGVDVRLSINLNTDAETTDKVLERLLEIALEFDNVELSVHVNYADAGLVALDKVLEFAEKGIKVGLTITVSYAEDAPAVIEKTIETVKELREKGITGQHIIIVITCELTEEQLQLLRELIEEAKKALEASGKGNSVLVICEGPSKGAKELNEESAKMAQEGSGPYSGSGSG
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:24)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:25)

• Minimal score value: -4.5407
• Maximal score value: 0.9144
• Average score: -1.3662
• Total score value: -336.0893

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	N	A	-2.6401
2	K	A	-2.8264
3	T	A	-2.2786
4	K	A	-1.6817
5	V	A	-0.3536
6	I	A	-0.1720
7	G	A	-0.6321
8	I	A	0.0000
9	G	A	-1.2819
10	I	A	0.0000
11	N	A	-2.1169
12	L	A	0.0000
13	E	A	-2.4836
14	E	A	-2.5319
15	L	A	-2.0430
16	S	A	-1.7929
17	P	A	-2.3363
18	E	A	-3.3390
19	K	A	-3.4719
20	I	A	0.0000
21	E	A	-3.9011
22	K	A	-4.4545
23	K	A	-3.5878
24	I	A	0.0000
25	E	A	-4.5407
26	E	A	-4.3470
27	K	A	-3.4069
28	L	A	-3.0139
29	E	A	-4.0889
30	E	A	-3.5099
31	I	A	0.0000
32	D	A	-2.3875
33	K	A	-3.1650
34	E	A	-2.2486
35	Y	A	-1.7012
36	A	A	-1.6886
37	A	A	-1.5953
38	L	A	0.0000
39	K	A	-2.8776
40	A	A	-1.7125
41	E	A	-2.6259
42	G	A	-2.2608
43	V	A	-2.5617
44	K	A	-3.1498
45	H	A	-2.8690
46	I	A	0.0000
47	R	A	-1.5268
48	F	A	0.0000
49	N	A	-1.1596
50	I	A	0.0000
51	N	A	-1.5708
52	I	A	0.0000
53	D	A	-1.7486
54	I	A	0.0000
55	N	A	-2.0523
56	D	A	-2.4859
57	A	A	-1.6418
58	N	A	0.0000
59	A	A	0.0000
60	E	A	-2.3672
61	N	A	-1.5413
62	A	A	0.0000
63	L	A	0.0000
64	Y	A	-0.6887
65	A	A	0.0000
66	L	A	0.0000
67	E	A	-0.7266
68	K	A	-1.1686
69	L	A	0.0000
70	A	A	0.0000
71	Y	A	-1.2681
72	R	A	-1.7310
73	C	A	0.0000
74	K	A	-2.9922
75	E	A	-2.4305
76	L	A	-1.4926
77	G	A	-1.7902
78	V	A	-2.1162
79	D	A	-3.0071
80	V	A	0.0000
81	R	A	-1.8420
82	L	A	0.0000
83	S	A	0.0000
84	I	A	0.0000
85	N	A	-1.1833
86	L	A	0.0000
87	N	A	-1.6210
88	T	A	0.0000
89	D	A	-2.3945
90	A	A	-2.1621
91	E	A	-2.9936
92	T	A	-2.7695
93	T	A	0.0000
94	D	A	-2.8169
95	K	A	-2.8908
96	V	A	0.0000
97	L	A	0.0000
98	E	A	-3.1334
99	R	A	-2.4786
100	L	A	0.0000
101	L	A	0.0000
102	E	A	-1.9114
103	I	A	0.0000
104	A	A	0.0000
105	L	A	-0.8315
106	E	A	-2.0357
107	F	A	-2.2060
108	D	A	-2.8434
109	N	A	-3.1647
110	V	A	-2.5149
111	E	A	-2.5303
112	L	A	0.0000
113	S	A	-0.9901
114	V	A	0.0000
115	H	A	-0.6231
116	V	A	0.0000
117	N	A	-0.6263
118	Y	A	-0.1634
119	A	A	0.0000
120	D	A	-1.5910
121	A	A	0.0000
122	G	A	0.0000
123	L	A	-0.6450
124	V	A	-1.1046
125	A	A	0.0000
126	L	A	0.0000
127	D	A	-2.1735
128	K	A	0.0000
129	V	A	0.0000
130	L	A	-1.8525
131	E	A	-2.6305
132	F	A	0.0000
133	A	A	0.0000
134	E	A	-3.3093
135	K	A	-2.8177
136	G	A	-2.2992
137	I	A	0.0000
138	K	A	-2.2617
139	V	A	0.0000
140	G	A	-0.7355
141	L	A	0.0000
142	T	A	-0.0287
143	I	A	0.0000
144	T	A	0.3709
145	V	A	0.0000
146	S	A	-0.1229
147	Y	A	0.3158
148	A	A	-0.9213
149	E	A	-1.7237
150	D	A	-1.2556
151	A	A	0.0000
152	P	A	-1.3166
153	A	A	-1.2132
154	V	A	0.0000
155	I	A	0.0000
156	E	A	-2.1186
157	K	A	-2.1549
158	T	A	0.0000
159	I	A	-2.0252
160	E	A	-3.0456
161	T	A	0.0000
162	V	A	0.0000
163	K	A	-2.9781
164	E	A	-2.7256
165	L	A	0.0000
166	R	A	-2.9466
167	E	A	-3.1970
168	K	A	-2.9103
169	G	A	-2.0526
170	I	A	-1.4540
171	T	A	-1.0604
172	G	A	-0.9395
173	Q	A	0.0000
174	H	A	-0.4838
175	I	A	0.0000
176	I	A	0.6605
177	I	A	0.0000
178	V	A	0.1926
179	I	A	0.0000
180	T	A	-0.7912
181	C	A	-1.1272
182	E	A	-2.4121
183	L	A	0.0000
184	T	A	-2.4368
185	E	A	-3.3221
186	E	A	-3.0644
187	Q	A	-2.4115
188	L	A	0.0000
189	Q	A	-2.4030
190	L	A	-2.0260
191	L	A	0.0000
192	R	A	-3.1049
193	E	A	-2.6641
194	L	A	0.0000
195	I	A	0.0000
196	E	A	-3.2151
197	E	A	0.0000
198	A	A	0.0000
199	K	A	-3.0105
200	K	A	-3.2880
201	A	A	0.0000
202	L	A	-2.5618
203	E	A	-3.1406
204	A	A	-2.0787
205	S	A	-1.5939
206	G	A	-2.0407
207	K	A	-2.1989
208	G	A	-1.3480
209	N	A	0.0000
210	S	A	-0.7804
211	V	A	0.0000
212	L	A	0.0581
213	V	A	0.0000
214	I	A	-0.1802
215	C	A	0.0000
216	E	A	-2.2308
217	G	A	-1.8195
218	P	A	-1.9023
219	S	A	0.0000
220	K	A	-2.9175
221	G	A	-2.3879
222	A	A	0.0000
223	K	A	-3.8349
224	E	A	-3.9160
225	L	A	0.0000
226	N	A	-2.9562
227	E	A	-3.9384
228	E	A	-3.5945
229	S	A	0.0000
230	A	A	-2.4544
231	K	A	-3.4162
232	M	A	0.0000
233	A	A	-1.8633
234	Q	A	-2.7531
235	E	A	-3.3922
236	G	A	0.0000
237	S	A	-1.2498
238	G	A	-0.7592
239	P	A	0.0786
240	Y	A	0.9144
241	S	A	-0.2357
242	G	A	-0.6885
243	S	A	-0.6748
244	G	A	-0.9642
245	S	A	-0.7994
246	G	A	-0.7279