Project name: 1C10

Chain sequence(s)	H: SVKESGGGLFKPGGTLTLTCTASGFSLSSYGVSWVRQAPGNGLEWIGAIGFSGSGGSTYYASWAKSRSTITRNTNLNTVTLKMISLTAADTATYFCARDYAGGGDGYGNRGFDPWGPGTLVTVSS; L: ALVMTQTPASVEAAVGGTVTINCQASQNIYSNLAWYQQKPGQRPKLLIYDASDLASGVSTRFKGSGSGTQFTLTISDLESADAATYYCQQGYTSNNIDNNFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:31)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:33)

• Minimal score value: -2.8096
• Maximal score value: 1.4776
• Average score: -0.4517
• Total score value: -106.1394

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	S	H	-0.8273
4	V	H	0.0000
5	K	H	-1.8722
6	E	H	0.0000
7	S	H	-0.6567
8	G	H	-0.4640
9	G	H	0.3173
11	G	H	0.8831
12	L	H	1.4236
13	F	H	0.1379
14	K	H	-1.4644
15	P	H	-0.9475
16	G	H	-0.8355
17	G	H	-0.6552
18	T	H	-0.2860
19	L	H	0.0000
20	T	H	-0.4637
21	L	H	0.0000
22	T	H	-0.6459
23	C	H	0.0000
24	T	H	-0.5985
25	A	H	0.0000
26	S	H	-0.6923
27	G	H	-0.4673
28	F	H	-0.1051
29	S	H	-0.0606
30	L	H	0.0000
35	S	H	-0.5079
36	S	H	-0.1412
37	Y	H	0.1266
38	G	H	0.0000
39	V	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6930
45	A	H	-0.6950
46	P	H	-0.7739
47	G	H	-1.2549
48	N	H	-1.8468
49	G	H	-1.2497
50	L	H	0.0000
51	E	H	-1.0343
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	A	H	0.0000
56	I	H	0.0000
57	G	H	-0.1753
58	F	H	-0.1578
59	S	H	-0.6238
60	G	H	-0.8021
61	S	H	-0.5587
62	G	H	-0.7682
63	G	H	-0.4982
64	S	H	-0.2753
65	T	H	0.0482
66	Y	H	-0.3105
67	Y	H	-0.6420
68	A	H	0.0000
69	S	H	-0.9665
70	W	H	-0.3769
71	A	H	0.0000
72	K	H	-1.8209
74	S	H	-1.0208
75	R	H	-0.7093
76	S	H	0.0000
77	T	H	-0.5328
78	I	H	0.0000
79	T	H	-0.4562
80	R	H	-0.5794
81	N	H	-0.6947
82	T	H	-0.6654
83	N	H	-0.8487
84	L	H	0.5626
85	N	H	-0.1630
86	T	H	-0.3746
87	V	H	0.0000
88	T	H	-0.4643
89	L	H	0.0000
90	K	H	-0.7174
91	M	H	0.0000
92	I	H	0.2649
93	S	H	-0.3390
94	L	H	0.0000
95	T	H	-0.3307
96	A	H	-0.2324
97	A	H	0.0675
98	D	H	0.0000
99	T	H	0.4180
100	A	H	0.0000
101	T	H	0.4604
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.3280
107	D	H	0.0000
108	Y	H	0.3404
109	A	H	-0.1758
110	G	H	-0.8018
111	G	H	-1.0848
111A	G	H	-1.1461
111B	D	H	-1.1160
112C	G	H	-0.3436
112B	Y	H	0.4056
112A	G	H	0.0000
112	N	H	0.0000
113	R	H	-0.5759
114	G	H	0.0000
115	F	H	0.0000
116	D	H	-0.9521
117	P	H	-0.9988
118	W	H	0.0000
119	G	H	0.0000
120	P	H	-1.0785
121	G	H	-0.5792
122	T	H	0.2164
123	L	H	1.4776
124	V	H	0.0000
125	T	H	0.6610
126	V	H	0.0000
127	S	H	-0.4162
128	S	H	-0.5680
1	A	L	-0.3252
2	L	L	0.0000
3	V	L	1.2081
4	M	L	0.0000
5	T	L	-0.2672
6	Q	L	-0.5662
7	T	L	-0.5079
8	P	L	-0.4244
9	A	L	-0.4525
10	S	L	-1.1752
11	V	L	-1.3354
12	E	L	-2.8096
13	A	L	-1.2732
14	A	L	-0.9011
15	V	L	0.3744
16	G	L	-0.9724
17	G	L	-0.8919
18	T	L	-0.8360
19	V	L	0.0000
20	T	L	-0.2550
21	I	L	0.0000
22	N	L	-0.9875
23	C	L	0.0000
24	Q	L	-1.3839
25	A	L	0.0000
26	S	L	-0.5877
27	Q	L	-1.4250
28	N	L	-1.2889
29	I	L	0.0000
36	Y	L	0.5680
37	S	L	0.0775
38	N	L	0.0832
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.9546
44	Q	L	-1.4358
45	K	L	-1.5498
46	P	L	-1.2508
47	G	L	-1.5248
48	Q	L	-2.3598
49	R	L	-2.1855
50	P	L	0.0000
51	K	L	-1.5509
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.4972
56	D	L	-0.8060
57	A	L	0.0000
65	S	L	-1.2696
66	D	L	-1.6977
67	L	L	-0.6410
68	A	L	0.0000
69	S	L	-0.4526
70	G	L	-0.4107
71	V	L	-0.2245
72	S	L	-0.2902
74	T	L	-0.5602
75	R	L	-1.1217
76	F	L	0.0000
77	K	L	-1.2733
78	G	L	0.0000
79	S	L	-1.1319
80	G	L	-0.8826
83	S	L	-0.6699
84	G	L	-0.7209
85	T	L	-1.3604
86	Q	L	-1.8825
87	F	L	0.0000
88	T	L	-0.9132
89	L	L	0.0000
90	T	L	-0.5249
91	I	L	0.0000
92	S	L	-1.2993
93	D	L	-2.0818
94	L	L	0.0000
95	E	L	-1.4035
96	S	L	-0.7702
97	A	L	-0.3222
98	D	L	0.0000
99	A	L	-1.1419
100	A	L	0.0000
101	T	L	-0.9209
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	G	L	0.0000
108	Y	L	0.3961
109	T	L	-0.1793
110	S	L	-0.6296
112	N	L	-1.6940
113	N	L	-1.7156
114	I	L	0.0000
115	D	L	-0.6580
116	N	L	0.0000
117	N	L	-0.1291
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.6942
121	G	L	-0.8436
122	T	L	0.0000
123	K	L	-1.7052
124	L	L	0.0000
125	E	L	-2.7834
126	I	L	-1.5059
127	K	L	-1.8623