| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVDGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPLHEGADDRVSFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRSGPMGHPLPSAPPPSPLYTPPPASSPYAVPPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPAPNVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9496 | |
| 2 | L | A | 1.9748 | |
| 3 | P | A | 0.6479 | |
| 4 | P | A | 0.3501 | |
| 5 | T | A | 0.1099 | |
| 6 | T | A | 0.1277 | |
| 7 | P | A | 0.1620 | |
| 8 | V | A | 1.2212 | |
| 9 | A | A | 0.0275 | |
| 10 | K | A | -1.1546 | |
| 11 | V | A | -0.3880 | |
| 12 | Q | A | -1.5226 | |
| 13 | S | A | -1.5893 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.3954 | |
| 16 | E | A | -2.4283 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4684 | |
| 20 | P | A | 0.1330 | |
| 21 | T | A | 0.1640 | |
| 22 | S | A | -0.0971 | |
| 23 | L | A | 0.1000 | |
| 24 | F | A | -0.0287 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1863 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8315 | |
| 31 | R | A | -2.6591 | |
| 32 | L | A | -0.7789 | |
| 33 | L | A | 1.2098 | |
| 34 | T | A | 1.4557 | |
| 35 | V | A | 1.9855 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2252 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6367 | |
| 40 | K | A | -1.8673 | |
| 41 | D | A | -0.7263 | |
| 42 | I | A | 1.2570 | |
| 43 | V | A | 2.1134 | |
| 44 | V | A | 1.4955 | |
| 45 | D | A | -0.9953 | |
| 46 | G | A | -0.5913 | |
| 47 | K | A | -0.2574 | |
| 48 | V | A | 2.1375 | |
| 49 | L | A | 2.4827 | |
| 50 | V | A | 1.4819 | |
| 51 | P | A | 0.3634 | |
| 52 | K | A | -0.6744 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1114 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4379 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2560 | |
| 70 | K | A | -1.8015 | |
| 71 | F | A | -0.6572 | |
| 72 | A | A | -0.5851 | |
| 73 | L | A | -0.8610 | |
| 74 | P | A | -1.2571 | |
| 75 | Q | A | -2.4830 | |
| 76 | K | A | -3.0973 | |
| 77 | D | A | -2.9829 | |
| 78 | F | A | -1.6347 | |
| 79 | Y | A | -1.8965 | |
| 80 | D | A | -2.7317 | |
| 81 | P | A | -2.3347 | |
| 82 | E | A | -3.0647 | |
| 83 | K | A | -3.4365 | |
| 84 | E | A | -2.4973 | |
| 85 | R | A | -1.3100 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6726 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9730 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3345 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7408 | |
| 99 | G | A | -0.5266 | |
| 100 | P | A | -0.4159 | |
| 101 | L | A | 0.0156 | |
| 102 | G | A | -0.3149 | |
| 103 | K | A | -0.8403 | |
| 104 | G | A | -0.5932 | |
| 105 | T | A | -0.5024 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1018 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3296 | |
| 110 | L | A | 0.3154 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1376 | |
| 113 | K | A | -0.4791 | |
| 114 | L | A | -1.1820 | |
| 115 | G | A | -0.9280 | |
| 116 | D | A | -1.3601 | |
| 117 | T | A | -1.1771 | |
| 118 | E | A | -2.4703 | |
| 119 | N | A | -2.3668 | |
| 120 | P | A | -1.5195 | |
| 121 | T | A | -0.7673 | |
| 122 | A | A | -0.3901 | |
| 123 | P | A | -0.1347 | |
| 124 | L | A | -0.6575 | |
| 125 | H | A | -1.7197 | |
| 126 | E | A | -2.6596 | |
| 127 | G | A | -2.2043 | |
| 128 | A | A | -1.5891 | |
| 129 | D | A | -2.4706 | |
| 130 | D | A | -2.0851 | |
| 131 | R | A | -1.1908 | |
| 132 | V | A | 0.1243 | |
| 133 | S | A | 0.1945 | |
| 134 | F | A | 0.1504 | |
| 135 | S | A | -0.1386 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7433 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2467 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5575 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2421 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0980 | |
| 157 | D | A | 0.2776 | |
| 158 | I | A | 0.8289 | |
| 159 | A | A | 0.1070 | |
| 160 | E | A | -1.4787 | |
| 161 | P | A | -0.2357 | |
| 162 | C | A | 0.1820 | |
| 163 | P | A | -0.1730 | |
| 164 | G | A | -0.0666 | |
| 165 | L | A | 0.6083 | |
| 166 | P | A | -0.1013 | |
| 167 | P | A | -0.3336 | |
| 168 | G | A | -0.4169 | |
| 169 | A | A | -0.0150 | |
| 170 | C | A | 0.7601 | |
| 171 | P | A | 0.5632 | |
| 172 | P | A | 0.8112 | |
| 173 | I | A | 2.0347 | |
| 174 | Q | A | 0.8414 | |
| 175 | L | A | 1.4328 | |
| 176 | V | A | 0.8205 | |
| 177 | N | A | -0.3151 | |
| 178 | S | A | 0.0327 | |
| 179 | V | A | 0.4456 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3808 | |
| 182 | D | A | 0.0828 | |
| 183 | G | A | -0.1629 | |
| 184 | D | A | -0.5959 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.5065 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0699 | |
| 190 | F | A | 0.0182 | |
| 191 | G | A | -0.1622 | |
| 192 | N | A | -0.3570 | |
| 193 | M | A | -0.2028 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4140 | |
| 197 | E | A | -2.6101 | |
| 198 | L | A | -1.2114 | |
| 199 | Q | A | -2.5243 | |
| 200 | Q | A | -3.3454 | |
| 201 | D | A | -3.6014 | |
| 202 | R | A | -3.3299 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1908 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3937 | |
| 211 | S | A | -1.9205 | |
| 212 | T | A | -1.4999 | |
| 213 | R | A | -2.2452 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2289 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3143 | |
| 220 | L | A | 0.5327 | |
| 221 | K | A | -1.2367 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9436 | |
| 224 | N | A | -1.5530 | |
| 225 | E | A | -1.3080 | |
| 226 | A | A | -0.6658 | |
| 227 | Y | A | -0.4470 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7009 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1427 | |
| 234 | F | A | 0.0238 | |
| 235 | G | A | -0.9422 | |
| 236 | R | A | -2.6954 | |
| 237 | R | A | -2.9889 | |
| 238 | E | A | -2.1499 | |
| 239 | Q | A | -0.1841 | |
| 240 | V | A | 1.5040 | |
| 241 | Y | A | 1.2132 | |
| 242 | A | A | 0.1376 | |
| 243 | R | A | -1.1999 | |
| 244 | H | A | -1.2070 | |
| 245 | F | A | -0.2448 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.6881 | |
| 249 | S | A | -1.2777 | |
| 250 | G | A | -1.0005 | |
| 251 | P | A | -0.8127 | |
| 252 | M | A | -0.6987 | |
| 253 | G | A | -0.9828 | |
| 254 | H | A | -1.0889 | |
| 255 | P | A | -0.6472 | |
| 256 | L | A | 0.4696 | |
| 257 | P | A | -0.0010 | |
| 258 | S | A | -0.2553 | |
| 259 | A | A | -0.1481 | |
| 260 | P | A | -0.5439 | |
| 261 | P | A | -0.4284 | |
| 262 | P | A | -0.2870 | |
| 263 | S | A | 0.1838 | |
| 264 | P | A | 0.4686 | |
| 265 | L | A | 1.5823 | |
| 266 | Y | A | 0.9701 | |
| 267 | T | A | 0.1413 | |
| 268 | P | A | 0.1891 | |
| 269 | P | A | 0.1574 | |
| 270 | P | A | -0.2693 | |
| 271 | A | A | 0.1402 | |
| 272 | S | A | -0.2088 | |
| 273 | S | A | 0.2280 | |
| 274 | P | A | 0.3128 | |
| 275 | Y | A | 1.1769 | |
| 276 | A | A | 1.0763 | |
| 277 | V | A | 2.0092 | |
| 278 | P | A | 1.0096 | |
| 279 | P | A | 0.0153 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.1150 | |
| 282 | D | A | -0.2930 | |
| 283 | Y | A | 1.0483 | |
| 284 | F | A | 0.7922 | |
| 285 | G | A | 0.1169 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8909 | |
| 291 | L | A | 1.5835 | |
| 292 | V | A | 0.5804 | |
| 293 | S | A | -0.1695 | |
| 294 | S | A | -0.9685 | |
| 295 | D | A | -1.8457 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1482 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6501 | |
| 301 | R | A | -1.8852 | |
| 302 | P | A | -0.9758 | |
| 303 | F | A | -0.1965 | |
| 304 | W | A | -0.5298 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0892 | |
| 307 | R | A | -2.9235 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6502 | |
| 310 | G | A | -1.4091 | |
| 311 | N | A | -1.3716 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8803 | |
| 319 | N | A | -0.8702 | |
| 320 | E | A | -1.0405 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3796 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2152 | |
| 333 | N | A | 0.3933 | |
| 334 | F | A | 1.4710 | |
| 335 | T | A | 0.7913 | |
| 336 | I | A | 0.4002 | |
| 337 | S | A | -1.0813 | |
| 338 | Q | A | -1.9629 | |
| 339 | Q | A | -1.7400 | |
| 340 | L | A | -0.0847 | |
| 341 | S | A | -0.1326 | |
| 342 | T | A | -0.2544 | |
| 343 | P | A | -0.5301 | |
| 344 | A | A | -0.1711 | |
| 345 | P | A | -0.1671 | |
| 346 | N | A | -0.3095 | |
| 347 | V | A | 1.4807 | |
| 348 | Y | A | 1.3514 | |
| 349 | D | A | -0.1422 | |
| 350 | P | A | -0.7333 | |
| 351 | S | A | -0.6458 | |
| 352 | N | A | -0.5608 | |
| 353 | F | A | -1.2344 | |
| 354 | K | A | -2.1956 | |
| 355 | N | A | -1.7914 | |
| 356 | Y | A | 0.0314 | |
| 357 | L | A | 0.6709 | |
| 358 | R | A | 0.9507 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4706 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0075 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9724 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6953 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2722 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3198 | |
| 376 | L | A | -1.7526 | |
| 377 | D | A | -2.0300 | |
| 378 | P | A | -1.0602 | |
| 379 | G | A | -1.0191 | |
| 380 | V | A | -0.9296 | |
| 381 | L | A | -0.5389 | |
| 382 | A | A | -0.6585 | |
| 383 | H | A | -0.8464 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3978 | |
| 386 | T | A | -0.5744 | |
| 387 | M | A | -0.3286 | |
| 388 | N | A | -0.8616 | |
| 389 | P | A | -1.2588 | |
| 390 | T | A | -1.4985 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4993 | |
| 393 | E | A | -2.8718 | |
| 394 | N | A | -2.7667 | |
| 395 | W | A | -1.4788 | |
| 396 | N | A | -1.3234 | |
| 397 | L | A | -0.1924 | |
| 398 | G | A | 0.5552 | |
| 399 | F | A | 2.4253 | |
| 400 | V | A | 1.8461 | |
| 401 | P | A | 0.0535 | |
| 402 | P | A | -1.8696 | |
| 403 | K | A | -3.4748 | |
| 404 | E | A | -3.8995 | |
| 405 | R | A | -4.0041 | |
| 406 | E | A | -3.7850 | |
| 407 | D | A | -2.8895 | |
| 408 | P | A | -1.7437 | |
| 409 | Y | A | -0.9698 | |
| 410 | K | A | -2.0809 | |
| 411 | G | A | -0.6232 | |
| 412 | L | A | 0.7636 | |
| 413 | I | A | 1.5893 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3941 | |
| 416 | E | A | -1.6625 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8356 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8703 | |
| 421 | E | A | -2.4768 | |
| 422 | R | A | -2.0371 | |
| 423 | F | A | -0.9987 | |
| 424 | S | A | -1.3018 | |
| 425 | Q | A | -1.7941 | |
| 426 | D | A | -2.8931 | |
| 427 | L | A | -2.0192 | |
| 428 | D | A | -2.8304 | |
| 429 | Q | A | -2.6353 | |
| 430 | F | A | -1.4799 | |
| 431 | A | A | -0.9365 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6629 | |
| 435 | K | A | -0.7892 | |
| 436 | F | A | 0.1074 | |
| 437 | L | A | 1.0037 | |
| 438 | Y | A | 0.8008 | |
| 439 | Q | A | -0.2826 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine