Project name: e1674cdb0b5589d

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYTIHWVRQATGQGLEWMGWIYPLRGSINYAQKFQGRVTMTADKSISTVYMELSSLRSEDTAVYFCARHGAYYSNAFDYWGQGTLVTVSS; L: EIVMTQSPATLSVSPGERATLSCRASESVDNDGIRFLHWYQQKPGQAPRLLIYRASTRATGIPARFSGSGSRTEFTLTISSLQSEDFAVYYCQQSNKDPYTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:18)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:20)

• Minimal score value: -3.1854
• Maximal score value: 1.8721
• Average score: -0.6257
• Total score value: -144.5276

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4695
2	V	H	-1.0129
3	Q	H	-1.3075
4	L	H	0.0000
5	V	H	0.1039
6	Q	H	0.0000
7	S	H	-0.5327
8	G	H	-0.5186
9	A	H	0.1803
11	E	H	0.0213
12	V	H	1.0075
13	K	H	-0.8405
14	K	H	-2.0616
15	P	H	-2.0858
16	G	H	-1.4458
17	A	H	-1.1333
18	S	H	-1.2419
19	V	H	0.0000
20	K	H	-1.8764
21	V	H	0.0000
22	S	H	-0.4755
23	C	H	0.0000
24	K	H	-0.3864
25	A	H	0.0000
26	S	H	-0.6387
27	G	H	-1.0526
28	Y	H	-0.5536
29	T	H	-0.3107
30	F	H	0.0000
35	T	H	-0.9016
36	D	H	-0.9169
37	Y	H	0.1725
38	T	H	0.3857
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5039
45	A	H	-0.8505
46	T	H	-0.5816
47	G	H	-1.1254
48	Q	H	-1.6903
49	G	H	-1.0915
50	L	H	0.0000
51	E	H	-0.7782
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	W	H	0.4854
56	I	H	0.0000
57	Y	H	0.0037
58	P	H	0.0000
59	L	H	-0.9683
62	R	H	-1.8381
63	G	H	-1.0000
64	S	H	-0.2585
65	I	H	0.6476
66	N	H	-0.0753
67	Y	H	-0.7929
68	A	H	0.0000
69	Q	H	-2.8123
70	K	H	-2.7464
71	F	H	0.0000
72	Q	H	-2.4971
74	G	H	-1.6567
75	R	H	-1.5334
76	V	H	0.0000
77	T	H	-0.5730
78	M	H	0.0000
79	T	H	-0.3267
80	A	H	-0.7049
81	D	H	-1.0241
82	K	H	-1.3757
83	S	H	-0.2168
84	I	H	0.9040
85	S	H	-0.2408
86	T	H	0.0000
87	V	H	0.0000
88	Y	H	-0.4697
89	M	H	0.0000
90	E	H	-1.1040
91	L	H	0.0000
92	S	H	-1.0354
93	S	H	-1.1471
94	L	H	0.0000
95	R	H	-2.6822
96	S	H	-2.1670
97	E	H	-2.4243
98	D	H	0.0000
99	T	H	-0.6769
100	A	H	0.0000
101	V	H	0.4145
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	H	H	0.0000
108	G	H	0.3081
109	A	H	0.7844
110	Y	H	1.7889
111	Y	H	1.8721
112	S	H	0.7519
113	N	H	0.1328
114	A	H	0.0000
115	F	H	0.0000
116	D	H	-0.5469
117	Y	H	-0.4161
118	W	H	-0.4314
119	G	H	0.0000
120	Q	H	-1.2565
121	G	H	-0.5013
122	T	H	0.0000
123	L	H	0.7214
124	V	H	0.0000
125	T	H	-0.0977
126	V	H	0.0000
127	S	H	-1.0422
128	S	H	-0.9077
1	E	L	-2.1985
2	I	L	0.0000
3	V	L	0.5685
4	M	L	0.0000
5	T	L	-0.6502
6	Q	L	-0.7117
7	S	L	-0.8063
8	P	L	-0.4852
9	A	L	-0.4872
10	T	L	-0.6168
11	L	L	-0.2353
12	S	L	-0.2824
13	V	L	0.0000
14	S	L	-1.3165
15	P	L	-1.4524
16	G	L	-2.0406
17	E	L	-3.0964
18	R	L	-2.9307
19	A	L	0.0000
20	T	L	-0.5448
21	L	L	0.0000
22	S	L	-0.8561
23	C	L	0.0000
24	R	L	-2.5803
25	A	L	0.0000
26	S	L	-1.4470
27	E	L	-2.6005
28	S	L	-2.6692
29	V	L	0.0000
30	D	L	-2.5062
31	N	L	-2.6759
34	D	L	-2.6022
35	G	L	-1.8946
36	I	L	-1.2308
37	R	L	-1.6122
38	F	L	-0.8452
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.3685
46	P	L	-0.9448
47	G	L	-1.3997
48	Q	L	-2.0228
49	A	L	-1.3032
50	P	L	0.0000
51	R	L	-1.4750
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3002
56	R	L	-0.5995
57	A	L	0.0000
65	S	L	-0.5894
66	T	L	-0.7014
67	R	L	-1.1863
68	A	L	-0.8442
69	T	L	-0.6081
70	G	L	-0.6692
71	I	L	0.0000
72	P	L	-0.4293
74	A	L	-0.3682
75	R	L	-0.6276
76	F	L	0.0000
77	S	L	-0.4582
78	G	L	0.0000
79	S	L	-0.5693
80	G	L	-1.3578
83	S	L	-1.9769
84	R	L	-3.1854
85	T	L	-2.6862
86	E	L	-2.4547
87	F	L	0.0000
88	T	L	-0.6782
89	L	L	0.0000
90	T	L	-0.5578
91	I	L	0.0000
92	S	L	-1.3749
93	S	L	-1.8153
94	L	L	0.0000
95	Q	L	-1.6885
96	S	L	-0.9958
97	E	L	-1.6009
98	D	L	0.0000
99	F	L	-0.3178
100	A	L	0.0000
101	V	L	-0.4453
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	N	L	-1.7814
109	K	L	-2.5014
114	D	L	-2.0353
115	P	L	-1.8563
116	Y	L	0.0000
117	T	L	-0.4818
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.7428
121	G	L	-0.8124
122	T	L	0.0000
123	K	L	-1.2373
124	V	L	0.0000
125	E	L	-0.1097
126	I	L	0.7292
127	K	L	-1.0460