| Chain sequence(s) |
A: MEEAPVASQSKAEKDYDAAMKKSEAAKKAYEEAKKKAEDAQKKYDEGQKKTEEKARKAEEASKEIAKATSEVQNAYVKYQRVQRNSRLNEKERKKQLAEIDEEINKAKQILNEKNEDFKKVREEVIPEPTELAKDQRKAEEAKAEEKVAKRKYDYATLKVALAKSKVEAEEAELDNKAENLQNKVADLEKEIANAEKTVADLEKEVAKLEKDVEDFKNSNGEQAEQYLAAAEKDLVAKKAELAEAKIKAATKKAELEKAEAELENLLSTLDPEGKTQDELDKEAAEAELNKKVEALQNQVAELEEELSKLEDNLKDAETNNVEDYIKEGLEEAIATKKAELEKTQKELDAALNELGPDGDEEETPAPAPQPEKPAPAPAPKP
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:09)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:09)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:09)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:09)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:09)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:13:06)
[INFO] Main: Simulation completed successfully. (00:13:08)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | -0.3200 | |
| 2 | E | A | -2.2152 | |
| 3 | E | A | -2.1768 | |
| 4 | A | A | -0.8167 | |
| 5 | P | A | -0.1821 | |
| 6 | V | A | 1.1798 | |
| 7 | A | A | 0.5381 | |
| 8 | S | A | -0.7128 | |
| 9 | Q | A | -1.5091 | |
| 10 | S | A | 0.0000 | |
| 11 | K | A | -3.1587 | |
| 12 | A | A | -2.9916 | |
| 13 | E | A | -3.2749 | |
| 14 | K | A | -3.5028 | |
| 15 | D | A | -3.5939 | |
| 16 | Y | A | -2.6649 | |
| 17 | D | A | -2.6535 | |
| 18 | A | A | -2.2898 | |
| 19 | A | A | -2.1899 | |
| 20 | M | A | -2.0511 | |
| 21 | K | A | -3.2869 | |
| 22 | K | A | -3.3180 | |
| 23 | S | A | -3.0814 | |
| 24 | E | A | -3.5413 | |
| 25 | A | A | -2.8057 | |
| 26 | A | A | -3.3059 | |
| 27 | K | A | -4.0650 | |
| 28 | K | A | -3.5940 | |
| 29 | A | A | -3.1110 | |
| 30 | Y | A | -3.8358 | |
| 31 | E | A | -3.9626 | |
| 32 | E | A | -4.3280 | |
| 33 | A | A | 0.0000 | |
| 34 | K | A | -4.6435 | |
| 35 | K | A | -4.8255 | |
| 36 | K | A | -4.9447 | |
| 37 | A | A | 0.0000 | |
| 38 | E | A | -4.9335 | |
| 39 | D | A | -4.6018 | |
| 40 | A | A | 0.0000 | |
| 41 | Q | A | -4.2689 | |
| 42 | K | A | -4.5038 | |
| 43 | K | A | -4.2756 | |
| 44 | Y | A | -3.7946 | |
| 45 | D | A | -3.5902 | |
| 46 | E | A | -4.2660 | |
| 47 | G | A | -3.5217 | |
| 48 | Q | A | -3.4289 | |
| 49 | K | A | -4.1405 | |
| 50 | K | A | -3.7610 | |
| 51 | T | A | -3.1743 | |
| 52 | E | A | -4.2223 | |
| 53 | E | A | -4.0300 | |
| 54 | K | A | -3.7531 | |
| 55 | A | A | -3.5502 | |
| 56 | R | A | -4.4777 | |
| 57 | K | A | -4.2101 | |
| 58 | A | A | -4.0471 | |
| 59 | E | A | -4.2802 | |
| 60 | E | A | -4.2725 | |
| 61 | A | A | -3.6918 | |
| 62 | S | A | -3.1003 | |
| 63 | K | A | -3.6936 | |
| 64 | E | A | -2.9964 | |
| 65 | I | A | -2.4936 | |
| 66 | A | A | -1.9986 | |
| 67 | K | A | -2.9374 | |
| 68 | A | A | 0.0000 | |
| 69 | T | A | -2.0016 | |
| 70 | S | A | -2.2597 | |
| 71 | E | A | -3.1557 | |
| 72 | V | A | -2.4479 | |
| 73 | Q | A | -2.3219 | |
| 74 | N | A | -2.5300 | |
| 75 | A | A | -2.3914 | |
| 76 | Y | A | -1.2311 | |
| 77 | V | A | -1.5786 | |
| 78 | K | A | -2.3665 | |
| 79 | Y | A | -2.4126 | |
| 80 | Q | A | -3.0170 | |
| 81 | R | A | -3.4775 | |
| 82 | V | A | -3.0949 | |
| 83 | Q | A | -3.6364 | |
| 84 | R | A | -3.6314 | |
| 85 | N | A | -2.7962 | |
| 86 | S | A | -2.3198 | |
| 87 | R | A | -2.6349 | |
| 88 | L | A | -2.8589 | |
| 89 | N | A | -3.4396 | |
| 90 | E | A | -4.6155 | |
| 91 | K | A | -4.7115 | |
| 92 | E | A | -4.6554 | |
| 93 | R | A | -4.5418 | |
| 94 | K | A | -4.7895 | |
| 95 | K | A | -4.5499 | |
| 96 | Q | A | -3.5216 | |
| 97 | L | A | 0.0000 | |
| 98 | A | A | -2.9443 | |
| 99 | E | A | -3.5310 | |
| 100 | I | A | 0.0000 | |
| 101 | D | A | -3.2502 | |
| 102 | E | A | -4.1753 | |
| 103 | E | A | -3.9270 | |
| 104 | I | A | 0.0000 | |
| 105 | N | A | -3.6053 | |
| 106 | K | A | -3.8738 | |
| 107 | A | A | 0.0000 | |
| 108 | K | A | -3.2695 | |
| 109 | Q | A | -3.1857 | |
| 110 | I | A | -2.2997 | |
| 111 | L | A | -2.8797 | |
| 112 | N | A | -3.5794 | |
| 113 | E | A | -4.0291 | |
| 114 | K | A | -3.9162 | |
| 115 | N | A | -3.6665 | |
| 116 | E | A | -4.7002 | |
| 117 | D | A | -4.7578 | |
| 118 | F | A | -4.2703 | |
| 119 | K | A | -4.7325 | |
| 120 | K | A | -4.8338 | |
| 121 | V | A | 0.0000 | |
| 122 | R | A | -4.2469 | |
| 123 | E | A | -3.8835 | |
| 124 | E | A | -2.5849 | |
| 125 | V | A | 0.1646 | |
| 126 | I | A | -0.8794 | |
| 127 | P | A | -1.1505 | |
| 128 | E | A | -2.1492 | |
| 129 | P | A | -1.7391 | |
| 130 | T | A | -1.9055 | |
| 131 | E | A | -2.6983 | |
| 132 | L | A | -2.5804 | |
| 133 | A | A | -2.2253 | |
| 134 | K | A | -3.4404 | |
| 135 | D | A | -3.6618 | |
| 136 | Q | A | -3.3086 | |
| 137 | R | A | -3.4734 | |
| 138 | K | A | -3.7583 | |
| 139 | A | A | 0.0000 | |
| 140 | E | A | -3.7452 | |
| 141 | E | A | -4.2126 | |
| 142 | A | A | 0.0000 | |
| 143 | K | A | -4.1367 | |
| 144 | A | A | -3.2853 | |
| 145 | E | A | -3.6646 | |
| 146 | E | A | -4.0898 | |
| 147 | K | A | -2.4447 | |
| 148 | V | A | -1.9213 | |
| 149 | A | A | 0.0000 | |
| 150 | K | A | -2.7482 | |
| 151 | R | A | -2.1577 | |
| 152 | K | A | -3.0352 | |
| 153 | Y | A | -3.0061 | |
| 154 | D | A | -2.5281 | |
| 155 | Y | A | -1.4812 | |
| 156 | A | A | -1.9066 | |
| 157 | T | A | -1.2473 | |
| 158 | L | A | -0.4765 | |
| 159 | K | A | -0.8371 | |
| 160 | V | A | -0.9923 | |
| 161 | A | A | -0.3032 | |
| 162 | L | A | -0.5013 | |
| 163 | A | A | 0.0000 | |
| 164 | K | A | -2.2040 | |
| 165 | S | A | -1.9939 | |
| 166 | K | A | -2.6424 | |
| 167 | V | A | 0.0000 | |
| 168 | E | A | -3.6628 | |
| 169 | A | A | -3.0135 | |
| 170 | E | A | -3.4953 | |
| 171 | E | A | -4.1286 | |
| 172 | A | A | -3.6288 | |
| 173 | E | A | -4.0628 | |
| 174 | L | A | -3.2393 | |
| 175 | D | A | -4.1381 | |
| 176 | N | A | -4.4038 | |
| 177 | K | A | -3.8620 | |
| 178 | A | A | -3.5185 | |
| 179 | E | A | -4.2960 | |
| 180 | N | A | -3.8364 | |
| 181 | L | A | -3.5864 | |
| 182 | Q | A | -3.4123 | |
| 183 | N | A | -3.6051 | |
| 184 | K | A | -3.3370 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | -3.0836 | |
| 187 | D | A | -4.0299 | |
| 188 | L | A | 0.0000 | |
| 189 | E | A | -4.3688 | |
| 190 | K | A | -4.3751 | |
| 191 | E | A | -4.4448 | |
| 192 | I | A | 0.0000 | |
| 193 | A | A | -3.2312 | |
| 194 | N | A | -3.4382 | |
| 195 | A | A | 0.0000 | |
| 196 | E | A | -3.2901 | |
| 197 | K | A | -3.4178 | |
| 198 | T | A | -2.5358 | |
| 199 | V | A | -2.7941 | |
| 200 | A | A | -2.9204 | |
| 201 | D | A | -3.5755 | |
| 202 | L | A | -3.4927 | |
| 203 | E | A | -3.8222 | |
| 204 | K | A | -4.0925 | |
| 205 | E | A | -4.0660 | |
| 206 | V | A | -3.4990 | |
| 207 | A | A | -3.4476 | |
| 208 | K | A | -4.0728 | |
| 209 | L | A | -3.9980 | |
| 210 | E | A | -4.3527 | |
| 211 | K | A | -4.6373 | |
| 212 | D | A | -3.5772 | |
| 213 | V | A | 0.0000 | |
| 214 | E | A | -4.9546 | |
| 215 | D | A | -4.3178 | |
| 216 | F | A | -3.4196 | |
| 217 | K | A | -3.9587 | |
| 218 | N | A | -3.4505 | |
| 219 | S | A | -3.1388 | |
| 220 | N | A | -2.7678 | |
| 221 | G | A | -2.3856 | |
| 222 | E | A | -3.2947 | |
| 223 | Q | A | -2.8851 | |
| 224 | A | A | -2.8697 | |
| 225 | E | A | -3.0326 | |
| 226 | Q | A | -2.0583 | |
| 227 | Y | A | -0.5616 | |
| 228 | L | A | -2.1029 | |
| 229 | A | A | -1.5899 | |
| 230 | A | A | -1.4269 | |
| 231 | A | A | 0.0000 | |
| 232 | E | A | -2.4942 | |
| 233 | K | A | -2.5292 | |
| 234 | D | A | -2.7991 | |
| 235 | L | A | 0.0000 | |
| 236 | V | A | -0.5889 | |
| 237 | A | A | -1.3229 | |
| 238 | K | A | -2.4078 | |
| 239 | K | A | -2.2570 | |
| 240 | A | A | -1.7477 | |
| 241 | E | A | -2.5351 | |
| 242 | L | A | -2.2662 | |
| 243 | A | A | -1.7875 | |
| 244 | E | A | -2.4259 | |
| 245 | A | A | 0.0000 | |
| 246 | K | A | -1.4151 | |
| 247 | I | A | 0.0802 | |
| 248 | K | A | -1.3599 | |
| 249 | A | A | 0.0000 | |
| 250 | A | A | -0.7779 | |
| 251 | T | A | -0.7399 | |
| 252 | K | A | -2.3030 | |
| 253 | K | A | -2.4197 | |
| 254 | A | A | -2.3288 | |
| 255 | E | A | -3.1087 | |
| 256 | L | A | -3.6384 | |
| 257 | E | A | -3.8556 | |
| 258 | K | A | -4.1281 | |
| 259 | A | A | 0.0000 | |
| 260 | E | A | -3.9609 | |
| 261 | A | A | -3.4385 | |
| 262 | E | A | -3.6028 | |
| 263 | L | A | -3.2532 | |
| 264 | E | A | -2.8999 | |
| 265 | N | A | -2.3966 | |
| 266 | L | A | -1.1834 | |
| 267 | L | A | 0.0030 | |
| 268 | S | A | -0.5474 | |
| 269 | T | A | -0.4408 | |
| 270 | L | A | 0.1256 | |
| 271 | D | A | -0.2607 | |
| 272 | P | A | -1.5446 | |
| 273 | E | A | -2.5406 | |
| 274 | G | A | -2.1698 | |
| 275 | K | A | -2.3214 | |
| 276 | T | A | -2.1213 | |
| 277 | Q | A | -3.2282 | |
| 278 | D | A | -4.0269 | |
| 279 | E | A | -3.7580 | |
| 280 | L | A | -2.8654 | |
| 281 | D | A | -4.0220 | |
| 282 | K | A | -4.3933 | |
| 283 | E | A | -3.8392 | |
| 284 | A | A | -2.6569 | |
| 285 | A | A | -2.3632 | |
| 286 | E | A | -2.9005 | |
| 287 | A | A | -2.6086 | |
| 288 | E | A | -3.4218 | |
| 289 | L | A | -2.6220 | |
| 290 | N | A | -2.4842 | |
| 291 | K | A | -3.6246 | |
| 292 | K | A | -3.2901 | |
| 293 | V | A | 0.0000 | |
| 294 | E | A | -3.5478 | |
| 295 | A | A | -2.2395 | |
| 296 | L | A | -2.4010 | |
| 297 | Q | A | -2.5079 | |
| 298 | N | A | -2.6039 | |
| 299 | Q | A | -2.4210 | |
| 300 | V | A | 0.0000 | |
| 301 | A | A | -2.4123 | |
| 302 | E | A | -3.2753 | |
| 303 | L | A | 0.0000 | |
| 304 | E | A | -2.5543 | |
| 305 | E | A | -3.8540 | |
| 306 | E | A | -3.3755 | |
| 307 | L | A | 0.0000 | |
| 308 | S | A | -3.3220 | |
| 309 | K | A | -3.7102 | |
| 310 | L | A | -3.2801 | |
| 311 | E | A | -3.8263 | |
| 312 | D | A | -4.3561 | |
| 313 | N | A | -4.0924 | |
| 314 | L | A | -3.9532 | |
| 315 | K | A | -4.7947 | |
| 316 | D | A | -4.5952 | |
| 317 | A | A | 0.0000 | |
| 318 | E | A | -4.3896 | |
| 319 | T | A | -3.0641 | |
| 320 | N | A | -3.2510 | |
| 321 | N | A | -3.4554 | |
| 322 | V | A | -2.1336 | |
| 323 | E | A | -2.6761 | |
| 324 | D | A | -2.6097 | |
| 325 | Y | A | -0.5377 | |
| 326 | I | A | -0.9106 | |
| 327 | K | A | -2.9728 | |
| 328 | E | A | -3.0900 | |
| 329 | G | A | -1.9928 | |
| 330 | L | A | -2.5242 | |
| 331 | E | A | -3.4642 | |
| 332 | E | A | -3.3603 | |
| 333 | A | A | -2.2441 | |
| 334 | I | A | 0.0000 | |
| 335 | A | A | -1.8075 | |
| 336 | T | A | -1.5987 | |
| 337 | K | A | -2.4385 | |
| 338 | K | A | -2.7808 | |
| 339 | A | A | -2.3549 | |
| 340 | E | A | -3.1545 | |
| 341 | L | A | -3.1682 | |
| 342 | E | A | -4.0401 | |
| 343 | K | A | -4.2723 | |
| 344 | T | A | -3.1529 | |
| 345 | Q | A | -3.1634 | |
| 346 | K | A | -3.8840 | |
| 347 | E | A | -3.3397 | |
| 348 | L | A | 0.0000 | |
| 349 | D | A | -2.6112 | |
| 350 | A | A | -2.1379 | |
| 351 | A | A | 0.0000 | |
| 352 | L | A | -1.5880 | |
| 353 | N | A | -2.6194 | |
| 354 | E | A | -2.8239 | |
| 355 | L | A | 0.0000 | |
| 356 | G | A | -1.9423 | |
| 357 | P | A | -2.3768 | |
| 358 | D | A | -3.2088 | |
| 359 | G | A | -2.9877 | |
| 360 | D | A | -4.1315 | |
| 361 | E | A | -4.4254 | |
| 362 | E | A | -4.2200 | |
| 363 | E | A | -3.5105 | |
| 364 | T | A | -1.8417 | |
| 365 | P | A | -1.0282 | |
| 366 | A | A | -0.5087 | |
| 367 | P | A | -0.5187 | |
| 368 | A | A | -0.5425 | |
| 369 | P | A | -1.2132 | |
| 370 | Q | A | -2.1916 | |
| 371 | P | A | -2.2285 | |
| 372 | E | A | -3.1856 | |
| 373 | K | A | -2.9499 | |
| 374 | P | A | -1.6088 | |
| 375 | A | A | -0.9286 | |
| 376 | P | A | -0.5469 | |
| 377 | A | A | -0.2263 | |
| 378 | P | A | -0.5491 | |
| 379 | A | A | -0.6665 | |
| 380 | P | A | -1.1661 | |
| 381 | K | A | -1.9668 | |
| 382 | P | A | -1.1326 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine