| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEPVHETADVRVSFSFDPKQTQLFIVGCEPPTGEHWDLAEPCGGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPEGHPLPDAPPPSPLYVRPPPSSPYWKRPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPEPNVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9434 | |
| 2 | L | A | 1.9636 | |
| 3 | P | A | 0.8421 | |
| 4 | P | A | 0.3932 | |
| 5 | T | A | 0.1327 | |
| 6 | T | A | 0.1265 | |
| 7 | P | A | 0.1999 | |
| 8 | V | A | 1.2087 | |
| 9 | A | A | 0.0892 | |
| 10 | K | A | -1.0292 | |
| 11 | V | A | -0.1808 | |
| 12 | Q | A | -1.4070 | |
| 13 | S | A | -1.5435 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.3858 | |
| 16 | E | A | -2.4223 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4655 | |
| 20 | P | A | 0.1335 | |
| 21 | T | A | 0.1610 | |
| 22 | S | A | -0.0949 | |
| 23 | L | A | 0.0951 | |
| 24 | F | A | -0.0290 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2893 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9045 | |
| 31 | R | A | -2.6924 | |
| 32 | L | A | -0.8099 | |
| 33 | L | A | 1.1565 | |
| 34 | T | A | 1.3706 | |
| 35 | V | A | 1.8300 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2293 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6031 | |
| 40 | K | A | -1.6362 | |
| 41 | D | A | -0.9488 | |
| 42 | I | A | 0.8128 | |
| 43 | V | A | 1.0045 | |
| 44 | K | A | -1.1902 | |
| 45 | N | A | -1.9322 | |
| 46 | G | A | -1.2346 | |
| 47 | K | A | -0.9881 | |
| 48 | V | A | 1.4189 | |
| 49 | V | A | 2.0119 | |
| 50 | V | A | 1.2251 | |
| 51 | P | A | 0.4224 | |
| 52 | K | A | -0.6503 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1371 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3633 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2645 | |
| 70 | K | A | -1.7834 | |
| 71 | F | A | -0.6263 | |
| 72 | A | A | -0.5801 | |
| 73 | L | A | -0.8743 | |
| 74 | P | A | -1.2123 | |
| 75 | Q | A | -2.5064 | |
| 76 | K | A | -3.1110 | |
| 77 | D | A | -2.9934 | |
| 78 | F | A | -1.6738 | |
| 79 | Y | A | -1.8892 | |
| 80 | D | A | -2.6835 | |
| 81 | P | A | -2.3057 | |
| 82 | E | A | -3.0509 | |
| 83 | K | A | -3.3934 | |
| 84 | E | A | -2.4558 | |
| 85 | R | A | -1.2935 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6638 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9611 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3642 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6924 | |
| 99 | G | A | -0.5217 | |
| 100 | P | A | -0.3632 | |
| 101 | L | A | 0.1275 | |
| 102 | G | A | -0.1278 | |
| 103 | K | A | -0.4946 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4052 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1013 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3079 | |
| 110 | L | A | 0.3096 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0737 | |
| 113 | K | A | -0.4701 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4331 | |
| 117 | T | A | -0.8680 | |
| 118 | E | A | -1.8083 | |
| 119 | N | A | -2.2091 | |
| 120 | P | A | -1.8573 | |
| 121 | T | A | -1.5457 | |
| 122 | E | A | -2.1673 | |
| 123 | P | A | -1.1174 | |
| 124 | V | A | -0.8731 | |
| 125 | H | A | -1.8934 | |
| 126 | E | A | -2.2727 | |
| 127 | T | A | -1.6070 | |
| 128 | A | A | -1.2522 | |
| 129 | D | A | -2.0768 | |
| 130 | V | A | -1.3320 | |
| 131 | R | A | -0.8266 | |
| 132 | V | A | 0.2415 | |
| 133 | S | A | 0.1726 | |
| 134 | F | A | 0.1445 | |
| 135 | S | A | -0.1266 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4300 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5490 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1851 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1693 | |
| 157 | D | A | 0.3588 | |
| 158 | L | A | 0.8911 | |
| 159 | A | A | 0.2366 | |
| 160 | E | A | -1.4837 | |
| 161 | P | A | -0.3687 | |
| 162 | C | A | 0.0530 | |
| 163 | G | A | -0.4518 | |
| 164 | G | A | -0.4124 | |
| 165 | L | A | 0.4616 | |
| 166 | P | A | -0.1338 | |
| 167 | P | A | -0.3331 | |
| 168 | G | A | -0.4753 | |
| 169 | A | A | -0.0544 | |
| 170 | C | A | 0.6748 | |
| 171 | P | A | 0.4950 | |
| 172 | P | A | 0.8707 | |
| 173 | I | A | 2.0005 | |
| 174 | Q | A | 0.8569 | |
| 175 | L | A | 1.4942 | |
| 176 | V | A | 0.8652 | |
| 177 | N | A | -0.3001 | |
| 178 | S | A | 0.0219 | |
| 179 | V | A | 0.4255 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3856 | |
| 182 | D | A | 0.0849 | |
| 183 | G | A | -0.1556 | |
| 184 | D | A | -0.5297 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1263 | |
| 190 | F | A | 0.0647 | |
| 191 | G | A | -0.1005 | |
| 192 | N | A | -0.2486 | |
| 193 | M | A | -0.1067 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4322 | |
| 197 | E | A | -2.6566 | |
| 198 | L | A | -1.2570 | |
| 199 | Q | A | -2.5839 | |
| 200 | Q | A | -3.3318 | |
| 201 | D | A | -3.5907 | |
| 202 | R | A | -3.3452 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2199 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3539 | |
| 211 | S | A | -1.8885 | |
| 212 | T | A | -1.4339 | |
| 213 | R | A | -2.0734 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1548 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3895 | |
| 220 | L | A | 0.6290 | |
| 221 | K | A | -1.0642 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.7982 | |
| 224 | N | A | -1.4776 | |
| 225 | E | A | -1.2210 | |
| 226 | A | A | -0.6053 | |
| 227 | Y | A | -0.3680 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6646 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0791 | |
| 234 | F | A | 0.2657 | |
| 235 | G | A | -0.8043 | |
| 236 | R | A | -2.5738 | |
| 237 | R | A | -2.8068 | |
| 238 | E | A | -2.0652 | |
| 239 | Q | A | -0.1454 | |
| 240 | V | A | 1.4447 | |
| 241 | Y | A | 1.1148 | |
| 242 | A | A | 0.2161 | |
| 243 | R | A | -0.9461 | |
| 244 | H | A | -0.9412 | |
| 245 | F | A | 0.0314 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | -0.2785 | |
| 248 | R | A | -0.6773 | |
| 249 | A | A | -1.2028 | |
| 250 | G | A | -1.1152 | |
| 251 | P | A | -1.0158 | |
| 252 | E | A | -1.3995 | |
| 253 | G | A | -1.2721 | |
| 254 | H | A | -1.4542 | |
| 255 | P | A | -1.3500 | |
| 256 | L | A | -0.3869 | |
| 257 | P | A | -0.8550 | |
| 258 | D | A | -2.0270 | |
| 259 | A | A | -0.8339 | |
| 260 | P | A | -0.8421 | |
| 261 | P | A | -0.4276 | |
| 262 | P | A | -0.0758 | |
| 263 | S | A | 0.1404 | |
| 264 | P | A | 0.7171 | |
| 265 | L | A | 1.7492 | |
| 266 | Y | A | 1.2783 | |
| 267 | V | A | 1.4200 | |
| 268 | R | A | -0.2544 | |
| 269 | P | A | -0.1613 | |
| 270 | P | A | -0.2306 | |
| 271 | P | A | -0.5423 | |
| 272 | S | A | -0.3431 | |
| 273 | S | A | -0.2101 | |
| 274 | P | A | -0.1335 | |
| 275 | Y | A | 0.3152 | |
| 276 | W | A | -0.2724 | |
| 277 | K | A | -1.4822 | |
| 278 | R | A | -0.9929 | |
| 279 | P | A | -1.0256 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.5405 | |
| 282 | D | A | -0.9387 | |
| 283 | Y | A | 0.7739 | |
| 284 | F | A | 0.6492 | |
| 285 | G | A | 0.2224 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9377 | |
| 291 | L | A | 1.6357 | |
| 292 | V | A | 0.6686 | |
| 293 | S | A | -0.1449 | |
| 294 | S | A | -0.9473 | |
| 295 | D | A | -1.8421 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0917 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6226 | |
| 301 | R | A | -1.8258 | |
| 302 | P | A | -0.9597 | |
| 303 | F | A | -0.1850 | |
| 304 | W | A | -0.5597 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0840 | |
| 307 | R | A | -2.8281 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2508 | |
| 310 | G | A | -1.2179 | |
| 311 | N | A | -1.2643 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7162 | |
| 319 | N | A | -0.8179 | |
| 320 | E | A | -1.0151 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.2908 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0368 | |
| 333 | N | A | 0.5459 | |
| 334 | F | A | 1.7151 | |
| 335 | T | A | 0.7324 | |
| 336 | I | A | 0.3991 | |
| 337 | S | A | -0.9994 | |
| 338 | Q | A | -1.7593 | |
| 339 | Q | A | -1.5749 | |
| 340 | L | A | 0.1791 | |
| 341 | S | A | -0.3080 | |
| 342 | T | A | -0.7064 | |
| 343 | P | A | -1.3214 | |
| 344 | E | A | -1.9530 | |
| 345 | P | A | -1.0363 | |
| 346 | N | A | -0.8027 | |
| 347 | V | A | 1.2089 | |
| 348 | Y | A | 1.1311 | |
| 349 | D | A | -0.1188 | |
| 350 | P | A | -0.7173 | |
| 351 | S | A | -0.5612 | |
| 352 | N | A | -0.6524 | |
| 353 | F | A | -1.0569 | |
| 354 | K | A | -1.9678 | |
| 355 | N | A | -1.8046 | |
| 356 | Y | A | -0.1349 | |
| 357 | L | A | 0.6340 | |
| 358 | R | A | 0.9509 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3700 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0857 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0746 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6926 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2987 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3135 | |
| 376 | L | A | -1.7132 | |
| 377 | D | A | -1.9892 | |
| 378 | P | A | -1.0351 | |
| 379 | G | A | -1.0094 | |
| 380 | V | A | -0.9294 | |
| 381 | L | A | -0.5245 | |
| 382 | A | A | -0.6503 | |
| 383 | H | A | -0.8056 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3978 | |
| 386 | T | A | -0.5491 | |
| 387 | M | A | -0.2987 | |
| 388 | N | A | -0.8639 | |
| 389 | P | A | -1.2172 | |
| 390 | T | A | -1.3792 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.3641 | |
| 393 | E | A | -2.6994 | |
| 394 | N | A | -2.3808 | |
| 395 | W | A | -1.2623 | |
| 396 | N | A | -1.2307 | |
| 397 | L | A | -0.1948 | |
| 398 | G | A | 0.5376 | |
| 399 | F | A | 2.4161 | |
| 400 | V | A | 1.8220 | |
| 401 | P | A | 0.0473 | |
| 402 | P | A | -1.7425 | |
| 403 | K | A | -3.3944 | |
| 404 | E | A | -3.7839 | |
| 405 | R | A | -3.7588 | |
| 406 | E | A | -3.7189 | |
| 407 | D | A | -2.8555 | |
| 408 | P | A | -1.7549 | |
| 409 | Y | A | -0.9947 | |
| 410 | K | A | -2.1000 | |
| 411 | G | A | -0.6434 | |
| 412 | L | A | 0.6703 | |
| 413 | I | A | 1.5881 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3953 | |
| 416 | E | A | -1.7007 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9533 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0515 | |
| 421 | E | A | -2.7837 | |
| 422 | R | A | -2.5682 | |
| 423 | F | A | -1.2759 | |
| 424 | S | A | -1.4639 | |
| 425 | Q | A | -1.7241 | |
| 426 | D | A | -2.8935 | |
| 427 | L | A | -1.9794 | |
| 428 | D | A | -2.7652 | |
| 429 | Q | A | -2.6128 | |
| 430 | F | A | -1.4179 | |
| 431 | A | A | -0.8896 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5585 | |
| 435 | K | A | -0.6923 | |
| 436 | F | A | 0.1478 | |
| 437 | L | A | 1.0319 | |
| 438 | Y | A | 0.8316 | |
| 439 | Q | A | -0.2685 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine