| Chain sequence(s) |
A: LPFGEVFNATRFASVYAWNRKRISNVADYSVLYNSASFSTFKYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPNGVEGFNYFPLQSYGFQPTNGVGYQPYRVVVLSFELAIRMTQSPSFLSASVGDRVTITRASQDINSFLAWYQQRPGKAPKLLIYGASNLETGVPSRFSGGGSGTDFTLTISSLQPEDIATYYQQYDKLPTFGQGTRLEIVQLLETGGGLVKPGGSLRLSAASGFSLSDYYMNWIRQAPGKGLEWVAYISSSSGYTNYGDSVKGRFTISRDAKNSLYLQMNSLRVEDTAVYYVRDRNDFWSGYYKWGLGTLVTVS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:22)
[INFO] Main: Simulation completed successfully. (00:03:24)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | L | A | 1.8483 | |
| 3 | P | A | -0.0904 | |
| 4 | F | A | -0.6490 | |
| 5 | G | A | -1.4766 | |
| 6 | E | A | -2.3886 | |
| 7 | V | A | 0.0000 | |
| 8 | F | A | -1.0399 | |
| 9 | N | A | -2.0183 | |
| 10 | A | A | -1.4391 | |
| 11 | T | A | -1.0593 | |
| 12 | R | A | -1.2726 | |
| 13 | F | A | -0.7950 | |
| 14 | A | A | -0.6087 | |
| 15 | S | A | 0.0823 | |
| 16 | V | A | 0.0000 | |
| 17 | Y | A | 0.4960 | |
| 18 | A | A | 0.1166 | |
| 19 | W | A | 0.0000 | |
| 20 | N | A | -1.9224 | |
| 21 | R | A | -2.1362 | |
| 22 | K | A | -2.3630 | |
| 23 | R | A | -2.4366 | |
| 24 | I | A | 0.0000 | |
| 25 | S | A | -1.2580 | |
| 26 | N | A | -0.9097 | |
| 28 | V | A | 1.7648 | |
| 29 | A | A | 0.5541 | |
| 30 | D | A | -1.1544 | |
| 31 | Y | A | 0.0000 | |
| 32 | S | A | 0.0476 | |
| 33 | V | A | 1.1270 | |
| 34 | L | A | 0.7202 | |
| 35 | Y | A | 0.9261 | |
| 36 | N | A | 0.1217 | |
| 37 | S | A | 0.3404 | |
| 38 | A | A | 0.1686 | |
| 39 | S | A | -0.2122 | |
| 40 | F | A | 0.2719 | |
| 41 | S | A | -0.0267 | |
| 42 | T | A | -0.2851 | |
| 43 | F | A | -0.1668 | |
| 44 | K | A | -1.2126 | |
| 46 | Y | A | -0.6332 | |
| 47 | G | A | -0.7290 | |
| 48 | V | A | -0.0684 | |
| 49 | S | A | -0.6664 | |
| 50 | P | A | -0.7901 | |
| 51 | T | A | -1.0813 | |
| 52 | K | A | -2.1096 | |
| 53 | L | A | 0.0000 | |
| 54 | N | A | -2.0672 | |
| 55 | D | A | -2.3673 | |
| 56 | L | A | -0.1529 | |
| 57 | C | A | 0.5889 | |
| 58 | F | A | 0.5172 | |
| 59 | T | A | -0.4963 | |
| 60 | N | A | -1.0752 | |
| 61 | V | A | 0.0000 | |
| 62 | Y | A | -1.1354 | |
| 63 | A | A | 0.0000 | |
| 64 | D | A | 0.0000 | |
| 65 | S | A | 0.0000 | |
| 66 | F | A | 0.0000 | |
| 67 | V | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | R | A | -0.1281 | |
| 70 | G | A | -0.2728 | |
| 71 | D | A | -0.8098 | |
| 72 | E | A | -1.2267 | |
| 73 | V | A | 0.0000 | |
| 74 | R | A | -2.2734 | |
| 75 | Q | A | -1.6617 | |
| 76 | I | A | 0.0000 | |
| 77 | A | A | -1.4880 | |
| 78 | P | A | -1.7640 | |
| 79 | G | A | -1.9269 | |
| 80 | Q | A | -1.6599 | |
| 81 | T | A | -0.9115 | |
| 82 | G | A | -0.7104 | |
| 83 | K | A | -0.5535 | |
| 84 | I | A | 0.0000 | |
| 85 | A | A | 0.0000 | |
| 86 | D | A | -1.2484 | |
| 87 | Y | A | -0.7772 | |
| 88 | N | A | 0.0000 | |
| 89 | Y | A | 0.0000 | |
| 90 | K | A | -1.5065 | |
| 91 | L | A | 0.0000 | |
| 92 | P | A | -1.9927 | |
| 93 | D | A | -3.0727 | |
| 94 | D | A | -2.8208 | |
| 95 | F | A | 0.0000 | |
| 96 | T | A | -0.6325 | |
| 97 | G | A | -0.4313 | |
| 99 | V | A | 0.0000 | |
| 100 | I | A | 0.0000 | |
| 101 | A | A | 0.0000 | |
| 102 | W | A | -0.1038 | |
| 103 | N | A | -0.3760 | |
| 104 | S | A | 0.0000 | |
| 105 | N | A | -0.5693 | |
| 106 | N | A | -0.9455 | |
| 107 | L | A | 0.6400 | |
| 108 | D | A | 0.0000 | |
| 109 | S | A | -0.1311 | |
| 110 | K | A | 0.1352 | |
| 111 | V | A | 1.4504 | |
| 112 | G | A | 0.7137 | |
| 113 | G | A | 0.0000 | |
| 114 | N | A | 0.0000 | |
| 115 | Y | A | -0.0717 | |
| 116 | N | A | -0.2070 | |
| 117 | Y | A | 0.2460 | |
| 118 | L | A | 0.3145 | |
| 119 | Y | A | 0.5648 | |
| 120 | R | A | 0.0000 | |
| 121 | L | A | 0.6524 | |
| 122 | F | A | -0.0954 | |
| 123 | R | A | -1.3529 | |
| 124 | K | A | -2.2809 | |
| 125 | S | A | -1.7306 | |
| 126 | N | A | -2.2939 | |
| 127 | L | A | 0.0000 | |
| 128 | K | A | -2.4164 | |
| 129 | P | A | -1.6161 | |
| 130 | F | A | -0.6655 | |
| 131 | E | A | -1.6993 | |
| 132 | R | A | -1.4144 | |
| 133 | D | A | 0.0420 | |
| 134 | I | A | 1.4799 | |
| 135 | S | A | 0.2157 | |
| 136 | T | A | -0.2946 | |
| 137 | E | A | -1.3941 | |
| 138 | I | A | -0.0431 | |
| 139 | Y | A | -0.4958 | |
| 140 | Q | A | -1.3847 | |
| 141 | A | A | -0.4717 | |
| 142 | G | A | -0.6764 | |
| 143 | S | A | -0.9329 | |
| 144 | T | A | -0.6696 | |
| 145 | P | A | -0.8302 | |
| 147 | N | A | -1.0763 | |
| 148 | G | A | -0.4226 | |
| 149 | V | A | 1.0902 | |
| 150 | E | A | 0.2912 | |
| 151 | G | A | 0.4706 | |
| 152 | F | A | 1.4692 | |
| 153 | N | A | -0.0417 | |
| 155 | Y | A | 1.0195 | |
| 156 | F | A | 0.2429 | |
| 157 | P | A | 0.0000 | |
| 158 | L | A | 0.0000 | |
| 159 | Q | A | -0.2658 | |
| 160 | S | A | -0.1329 | |
| 161 | Y | A | 0.2206 | |
| 162 | G | A | 0.1732 | |
| 163 | F | A | 0.0000 | |
| 164 | Q | A | -0.2473 | |
| 165 | P | A | -0.4761 | |
| 166 | T | A | -0.1396 | |
| 167 | N | A | 0.0523 | |
| 168 | G | A | 0.6839 | |
| 169 | V | A | 1.5779 | |
| 170 | G | A | 0.7513 | |
| 171 | Y | A | 1.1916 | |
| 172 | Q | A | 0.2148 | |
| 173 | P | A | 0.0000 | |
| 174 | Y | A | 0.0000 | |
| 175 | R | A | -0.3646 | |
| 176 | V | A | 0.0000 | |
| 177 | V | A | 0.0000 | |
| 178 | V | A | 0.0000 | |
| 179 | L | A | 0.0000 | |
| 180 | S | A | -0.2326 | |
| 181 | F | A | 0.0000 | |
| 182 | E | A | -0.5880 | |
| 183 | L | A | 1.2051 | |
| 184 | A | A | -0.6798 | |
| 185 | I | A | -1.1469 | |
| 186 | R | A | -2.1211 | |
| 187 | M | A | -1.6060 | |
| 188 | T | A | -1.5350 | |
| 189 | Q | A | -1.0471 | |
| 190 | S | A | -0.5251 | |
| 191 | P | A | -0.1076 | |
| 192 | S | A | -0.0602 | |
| 193 | F | A | 0.8120 | |
| 194 | L | A | 0.3873 | |
| 195 | S | A | -0.0673 | |
| 196 | A | A | -0.0606 | |
| 197 | S | A | 0.2759 | |
| 198 | V | A | 1.0343 | |
| 199 | G | A | -0.6618 | |
| 200 | D | A | -1.5141 | |
| 201 | R | A | -2.1559 | |
| 202 | V | A | -0.9531 | |
| 203 | T | A | -0.4005 | |
| 204 | I | A | 0.0000 | |
| 205 | T | A | -0.8826 | |
| 207 | R | A | -2.9541 | |
| 208 | A | A | -2.3587 | |
| 209 | S | A | -2.0677 | |
| 210 | Q | A | -2.6424 | |
| 211 | D | A | -2.7943 | |
| 212 | I | A | 0.0000 | |
| 213 | N | A | -1.3122 | |
| 214 | S | A | -0.8164 | |
| 215 | F | A | -0.2976 | |
| 216 | L | A | 0.0000 | |
| 217 | A | A | 0.0000 | |
| 218 | W | A | 0.0000 | |
| 219 | Y | A | 0.0000 | |
| 220 | Q | A | 0.0000 | |
| 221 | Q | A | -1.3071 | |
| 222 | R | A | -2.0422 | |
| 223 | P | A | -1.3409 | |
| 224 | G | A | -1.4449 | |
| 225 | K | A | -2.0416 | |
| 226 | A | A | -0.8352 | |
| 227 | P | A | 0.0000 | |
| 228 | K | A | -1.4800 | |
| 229 | L | A | 0.0000 | |
| 230 | L | A | 0.0000 | |
| 231 | I | A | 0.0000 | |
| 232 | Y | A | -0.1257 | |
| 233 | G | A | -0.2298 | |
| 234 | A | A | 0.0000 | |
| 235 | S | A | -0.5687 | |
| 236 | N | A | -0.4299 | |
| 237 | L | A | 0.1184 | |
| 238 | E | A | 0.0000 | |
| 239 | T | A | -0.2159 | |
| 240 | G | A | -0.3098 | |
| 241 | V | A | 0.0000 | |
| 242 | P | A | -0.3098 | |
| 243 | S | A | -0.3667 | |
| 244 | R | A | -0.7164 | |
| 245 | F | A | 0.0000 | |
| 246 | S | A | -0.3840 | |
| 247 | G | A | -0.4980 | |
| 248 | G | A | -0.8887 | |
| 249 | G | A | -1.4133 | |
| 250 | S | A | -1.4567 | |
| 251 | G | A | -1.8080 | |
| 252 | T | A | -2.3810 | |
| 253 | D | A | -2.5100 | |
| 254 | F | A | 0.0000 | |
| 255 | T | A | -0.8745 | |
| 256 | L | A | 0.0000 | |
| 257 | T | A | -0.5379 | |
| 258 | I | A | 0.0000 | |
| 259 | S | A | -1.2251 | |
| 260 | S | A | -1.0665 | |
| 261 | L | A | 0.0000 | |
| 262 | Q | A | -0.5469 | |
| 263 | P | A | -0.6447 | |
| 264 | E | A | -1.9955 | |
| 265 | D | A | 0.0000 | |
| 266 | I | A | -0.6048 | |
| 267 | A | A | 0.0000 | |
| 268 | T | A | 0.0000 | |
| 269 | Y | A | 0.0000 | |
| 270 | Y | A | 0.0000 | |
| 272 | Q | A | 0.0000 | |
| 273 | Q | A | 0.0000 | |
| 274 | Y | A | 0.0000 | |
| 275 | D | A | 0.0000 | |
| 276 | K | A | -1.3744 | |
| 277 | L | A | 0.3658 | |
| 278 | P | A | -0.1299 | |
| 279 | T | A | -0.4485 | |
| 280 | F | A | -0.4212 | |
| 281 | G | A | 0.0000 | |
| 282 | Q | A | -1.3402 | |
| 283 | G | A | 0.0000 | |
| 284 | T | A | 0.0000 | |
| 285 | R | A | -0.7930 | |
| 286 | L | A | 0.0000 | |
| 287 | E | A | -0.4928 | |
| 288 | I | A | 1.0648 | |
| 289 | V | A | 1.3193 | |
| 290 | Q | A | 0.2891 | |
| 291 | L | A | 0.0000 | |
| 292 | L | A | 1.4784 | |
| 293 | E | A | 0.6243 | |
| 294 | T | A | 0.0526 | |
| 295 | G | A | -0.7349 | |
| 296 | G | A | 0.0680 | |
| 297 | G | A | 0.7173 | |
| 298 | L | A | 1.2569 | |
| 299 | V | A | 0.0000 | |
| 300 | K | A | -1.7766 | |
| 301 | P | A | -1.4938 | |
| 302 | G | A | -1.6219 | |
| 303 | G | A | -1.4567 | |
| 304 | S | A | -1.3871 | |
| 305 | L | A | -0.8660 | |
| 306 | R | A | -1.8781 | |
| 307 | L | A | 0.0000 | |
| 308 | S | A | -0.4535 | |
| 310 | A | A | -0.1593 | |
| 311 | A | A | 0.0000 | |
| 312 | S | A | -0.0355 | |
| 313 | G | A | -0.2231 | |
| 314 | F | A | -0.0776 | |
| 315 | S | A | -0.6496 | |
| 316 | L | A | 0.0000 | |
| 317 | S | A | -1.4146 | |
| 318 | D | A | -1.6630 | |
| 319 | Y | A | -0.8267 | |
| 320 | Y | A | -0.2611 | |
| 321 | M | A | 0.0000 | |
| 322 | N | A | 0.0000 | |
| 323 | W | A | 0.0000 | |
| 324 | I | A | 0.0000 | |
| 325 | R | A | 0.0000 | |
| 326 | Q | A | -0.2775 | |
| 327 | A | A | -0.7219 | |
| 328 | P | A | -0.7916 | |
| 329 | G | A | -0.8725 | |
| 330 | K | A | -1.1743 | |
| 331 | G | A | -0.8354 | |
| 332 | L | A | -0.4876 | |
| 333 | E | A | -0.6110 | |
| 334 | W | A | 0.0000 | |
| 335 | V | A | 0.0000 | |
| 336 | A | A | 0.0000 | |
| 337 | Y | A | 0.0000 | |
| 338 | I | A | 0.0000 | |
| 339 | S | A | 0.0078 | |
| 340 | S | A | -0.6612 | |
| 341 | S | A | -0.6642 | |
| 342 | S | A | -0.3664 | |
| 343 | G | A | -0.1574 | |
| 344 | Y | A | 0.9088 | |
| 345 | T | A | 0.5127 | |
| 346 | N | A | 0.0291 | |
| 347 | Y | A | -0.8108 | |
| 348 | G | A | 0.0000 | |
| 349 | D | A | -2.4308 | |
| 350 | S | A | -1.7593 | |
| 351 | V | A | 0.0000 | |
| 352 | K | A | -2.5627 | |
| 353 | G | A | -1.7543 | |
| 354 | R | A | -1.6129 | |
| 355 | F | A | 0.0000 | |
| 356 | T | A | -0.8379 | |
| 357 | I | A | 0.0000 | |
| 358 | S | A | -0.4747 | |
| 359 | R | A | -1.3274 | |
| 360 | D | A | -1.8581 | |
| 362 | A | A | -1.2366 | |
| 363 | K | A | -2.1940 | |
| 364 | N | A | -1.8613 | |
| 365 | S | A | 0.0000 | |
| 366 | L | A | 0.0000 | |
| 367 | Y | A | -0.6609 | |
| 368 | L | A | 0.0000 | |
| 369 | Q | A | -1.1624 | |
| 370 | M | A | 0.0000 | |
| 371 | N | A | -1.8682 | |
| 372 | S | A | -1.6111 | |
| 373 | L | A | 0.0000 | |
| 374 | R | A | -1.7837 | |
| 375 | V | A | -0.0702 | |
| 376 | E | A | -1.2829 | |
| 377 | D | A | 0.0000 | |
| 378 | T | A | 0.0884 | |
| 379 | A | A | 0.0000 | |
| 380 | V | A | 0.9768 | |
| 381 | Y | A | 0.0000 | |
| 382 | Y | A | 0.0000 | |
| 384 | V | A | 0.0000 | |
| 385 | R | A | -0.8609 | |
| 386 | D | A | 0.0000 | |
| 387 | R | A | -1.1202 | |
| 388 | N | A | 0.0000 | |
| 389 | D | A | -1.7669 | |
| 390 | F | A | 0.0000 | |
| 391 | W | A | -0.2475 | |
| 392 | S | A | 0.0000 | |
| 393 | G | A | 0.0000 | |
| 394 | Y | A | 0.0000 | |
| 395 | Y | A | 0.0000 | |
| 396 | K | A | -1.7183 | |
| 398 | W | A | -0.2509 | |
| 399 | G | A | 0.0000 | |
| 400 | L | A | 1.2792 | |
| 401 | G | A | 0.9621 | |
| 402 | T | A | 0.9445 | |
| 403 | L | A | 1.4900 | |
| 404 | V | A | 0.0000 | |
| 405 | T | A | 0.4738 | |
| 406 | V | A | 0.0000 | |
| 407 | S | A | -0.2768 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine