Project name: AAB-PP3132

Chain sequence(s)	H: QVQLVESGGGVVQPGESLKISCAASGFTFSSYAMHWVRQAPGKGLEWVSAISGSGGTTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSTYYYSGSGYDYYFEPWGPGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQHIRSSLAWYQQKPGKAPKLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLQPEDFATYYCQHTYITPYTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:02)

• Minimal score value: -3.1588
• Maximal score value: 2.2528
• Average score: -0.5563
• Total score value: -129.0521

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
0	Q	H	-1.3298
1	V	H	-0.7491
2	Q	H	-0.8657
3	L	H	0.0000
4	V	H	1.3784
5	E	H	0.0000
6	S	H	-0.1146
7	G	H	-0.7668
8	G	H	0.1478
9	G	H	0.9342
10	V	H	1.5577
11	V	H	0.0000
12	Q	H	-1.7833
13	P	H	-1.9018
14	G	H	-2.0498
15	E	H	-2.2144
16	S	H	-1.6080
17	L	H	-1.0030
18	K	H	-1.9381
19	I	H	0.0000
20	S	H	-0.3117
21	C	H	0.0000
22	A	H	0.0295
23	A	H	-0.3874
24	S	H	-0.5744
25	G	H	-0.8755
26	F	H	-0.3002
27	T	H	-0.1740
28	F	H	0.0000
29	S	H	-0.8070
30	S	H	-0.0841
31	Y	H	0.2997
32	A	H	0.1733
33	M	H	0.0000
34	H	H	0.0000
35	W	H	0.0000
36	V	H	0.0000
37	R	H	0.0000
38	Q	H	-0.7184
39	A	H	-1.0442
40	P	H	-0.9818
41	G	H	-1.4775
42	K	H	-2.3919
43	G	H	-1.6294
44	L	H	0.0000
45	E	H	-1.2602
46	W	H	0.0000
47	V	H	0.0000
48	S	H	0.0000
49	A	H	0.0000
50	I	H	0.0000
51	S	H	-0.1866
52	G	H	-0.4466
53	S	H	-0.7024
54	G	H	-0.7924
55	G	H	-0.7073
56	T	H	-0.1093
57	T	H	0.5313
58	F	H	1.1189
59	Y	H	-0.1050
60	A	H	0.0000
61	D	H	-2.2786
62	S	H	-1.7083
63	V	H	0.0000
64	K	H	-2.3508
65	G	H	-1.6931
66	R	H	-1.2519
67	F	H	0.0000
68	T	H	-0.6152
69	I	H	0.0000
70	S	H	-0.4781
71	R	H	-1.0796
72	D	H	-1.6478
73	N	H	-1.8103
74	S	H	-1.6380
75	K	H	-2.4387
76	N	H	-1.8653
77	T	H	-1.0025
78	L	H	0.0000
79	Y	H	-0.4604
80	L	H	0.0000
81	Q	H	-1.1231
82	M	H	0.0000
83	N	H	-1.7163
84	S	H	-1.6462
85	L	H	0.0000
86	R	H	-2.7495
87	A	H	-1.9042
88	E	H	-2.3047
89	D	H	0.0000
90	T	H	-0.4134
91	A	H	0.0000
92	V	H	0.8957
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	-0.4147
98	S	H	0.0000
99	T	H	0.8916
100	Y	H	2.2528
101	Y	H	2.1571
102	Y	H	1.7265
103	S	H	0.2354
104	G	H	-0.4592
105	S	H	-0.2837
106	G	H	0.1421
107	Y	H	1.7556
108	D	H	1.5758
109	Y	H	1.5561
110	Y	H	0.5859
111	F	H	0.0000
112	E	H	-0.8136
113	P	H	-0.8207
114	W	H	0.0000
115	G	H	0.0000
116	P	H	-0.3980
117	G	H	0.1677
118	T	H	0.7518
119	L	H	1.7376
120	V	H	0.0000
121	T	H	0.3784
122	V	H	0.0000
123	S	H	-0.6586
124	S	H	-0.6018
125	D	L	-2.0064
126	I	L	0.0000
127	Q	L	-2.1901
128	M	L	0.0000
129	T	L	-1.2790
130	Q	L	0.0000
131	S	L	-0.7296
132	P	L	-0.5978
133	S	L	-0.9600
134	S	L	-1.1323
135	L	L	-0.6514
136	S	L	-0.7036
137	A	L	0.0000
138	S	L	-0.1484
139	V	L	0.7183
140	G	L	-0.7067
141	D	L	-1.6690
142	R	L	-2.3427
143	V	L	0.0000
144	T	L	-0.6348
145	I	L	0.0000
146	T	L	-0.9693
147	C	L	0.0000
148	R	L	-3.0404
149	A	L	0.0000
150	S	L	-2.2507
151	Q	L	-2.8537
152	H	L	-2.5665
153	I	L	0.0000
154	R	L	-2.5987
155	S	L	-1.4727
156	S	L	-0.3943
157	L	L	0.0000
158	A	L	0.0000
159	W	L	0.0000
160	Y	L	0.0000
161	Q	L	-1.0240
162	Q	L	-1.6571
163	K	L	-2.2081
164	P	L	-1.4445
165	G	L	-1.6708
166	K	L	-2.5667
167	A	L	-1.5525
168	P	L	0.0000
169	K	L	-1.9901
170	L	L	0.0000
171	L	L	0.0000
172	I	L	0.0000
173	Y	L	-0.2282
174	G	L	-0.8444
175	A	L	0.0000
176	S	L	-0.8013
177	S	L	-0.8455
178	R	L	-1.6867
179	A	L	-0.9645
180	T	L	-0.6081
181	G	L	-0.9209
182	I	L	0.0000
183	P	L	-1.3869
184	D	L	-2.3068
185	R	L	-1.6179
186	F	L	0.0000
187	S	L	-1.0289
188	G	L	-0.5978
189	S	L	-0.8374
190	G	L	-1.4421
191	S	L	-1.8382
192	G	L	-2.4340
193	T	L	-2.6646
194	D	L	-3.1588
195	F	L	0.0000
196	T	L	-0.9086
197	L	L	0.0000
198	T	L	-0.6143
199	I	L	0.0000
200	S	L	-1.6830
201	S	L	-1.2895
202	L	L	0.0000
203	Q	L	-0.7784
204	P	L	-0.6488
205	E	L	-1.8861
206	D	L	0.0000
207	F	L	-0.5788
208	A	L	0.0000
209	T	L	-1.2823
210	Y	L	0.0000
211	Y	L	0.0000
212	C	L	0.0000
213	Q	L	0.0000
214	H	L	0.0000
215	T	L	1.2095
216	Y	L	1.5705
217	I	L	2.0431
218	T	L	0.8449
219	P	L	-0.0437
220	Y	L	0.0000
221	T	L	-0.4700
222	F	L	-0.4867
223	G	L	0.0000
224	Q	L	-1.5950
225	G	L	0.0000
226	T	L	0.0000
227	K	L	-2.1545
228	V	L	0.0000
229	E	L	-0.9095
230	I	L	0.9389
231	K	L	-0.7861