| Chain sequence(s) |
A: MTCGSACFSSRSGVRNSSSSVTTQRYCPGRTFSCGSAGGSRPSRCCVTAAPYRGVSCYRGLTGGFSSRSVCGGSRAGSSSRSFGYRSGSPSPPCITSVSVNQSLLKPLNLEIDHNAQRVKNQEKEQIKSLNSKFAAFIDKVRFLEQQNKLLETKWQLYQNQRSCESNLGPLFNGYIETLRREAERVEADTGRLASELNHVQEVLEGYKKKYEEEIALKTTAENEFVKIKQEVNHVYVSKGDLEANAHSLVEEVGFLKTLYEEELRVIQAHISDTSVIVKMDNSRYLNMDSIVAEIKAHYDEIASRSRAEAESWYRSKYEEIKATVNRHGETLRRTKEEINELNRLIQRLTAEIENAKSQNSKLEAAVTQAEQQGEAALNDARGKLAGLEKALQKAKQDMASLVKQYQEVMSSKLGLDIEIATYRRLLEGEEQRLCEGISAVNVSVSSSRGGVVCGDLSGTRTCGISSYGVGACGSSYKKC
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:16:48)
[INFO] Main: Simulation completed successfully. (00:16:54)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 1.1732 | |
| 2 | T | A | 0.6853 | |
| 3 | C | A | 0.6113 | |
| 4 | G | A | -0.1529 | |
| 5 | S | A | 0.1201 | |
| 6 | A | A | 0.7305 | |
| 7 | C | A | 1.5857 | |
| 8 | F | A | 1.9520 | |
| 9 | S | A | 0.3609 | |
| 10 | S | A | -0.7753 | |
| 11 | R | A | -2.0265 | |
| 12 | S | A | -1.0218 | |
| 13 | G | A | -0.7388 | |
| 14 | V | A | 0.3043 | |
| 15 | R | A | -1.7820 | |
| 16 | N | A | -2.0600 | |
| 17 | S | A | -1.2861 | |
| 18 | S | A | -0.8122 | |
| 19 | S | A | -0.1874 | |
| 20 | S | A | 0.4392 | |
| 21 | V | A | 1.4138 | |
| 22 | T | A | 0.1777 | |
| 23 | T | A | -0.5618 | |
| 24 | Q | A | -1.5528 | |
| 25 | R | A | -1.6451 | |
| 26 | Y | A | 0.3564 | |
| 27 | C | A | 0.3199 | |
| 28 | P | A | -0.4470 | |
| 29 | G | A | -0.9789 | |
| 30 | R | A | -1.6327 | |
| 31 | T | A | -0.1432 | |
| 32 | F | A | 1.4295 | |
| 33 | S | A | 0.7329 | |
| 34 | C | A | 0.8311 | |
| 35 | G | A | -0.0951 | |
| 36 | S | A | -0.4341 | |
| 37 | A | A | -0.4120 | |
| 38 | G | A | -1.0238 | |
| 39 | G | A | -1.2503 | |
| 40 | S | A | -1.5228 | |
| 41 | R | A | -2.4977 | |
| 42 | P | A | -1.7062 | |
| 43 | S | A | -1.4578 | |
| 44 | R | A | -1.4808 | |
| 45 | C | A | 0.5145 | |
| 46 | C | A | 1.4436 | |
| 47 | V | A | 2.0877 | |
| 48 | T | A | 1.0870 | |
| 49 | A | A | 0.4953 | |
| 50 | A | A | 0.1961 | |
| 51 | P | A | -0.0630 | |
| 52 | Y | A | 0.3832 | |
| 53 | R | A | -1.0768 | |
| 54 | G | A | -0.1754 | |
| 55 | V | A | 1.4666 | |
| 56 | S | A | 0.7805 | |
| 57 | C | A | 1.1878 | |
| 58 | Y | A | 0.9563 | |
| 59 | R | A | -0.9203 | |
| 60 | G | A | -0.2270 | |
| 61 | L | A | 0.8151 | |
| 62 | T | A | 0.0529 | |
| 63 | G | A | -0.0080 | |
| 64 | G | A | 0.2807 | |
| 65 | F | A | 1.2400 | |
| 66 | S | A | -0.0431 | |
| 67 | S | A | -0.6051 | |
| 68 | R | A | -1.3519 | |
| 69 | S | A | -0.1986 | |
| 70 | V | A | 1.3558 | |
| 71 | C | A | 0.9588 | |
| 72 | G | A | -0.1344 | |
| 73 | G | A | -0.8670 | |
| 74 | S | A | -1.4093 | |
| 75 | R | A | -2.2388 | |
| 76 | A | A | -1.2614 | |
| 77 | G | A | -1.1403 | |
| 78 | S | A | -1.0156 | |
| 79 | S | A | -1.0455 | |
| 80 | S | A | -1.1528 | |
| 81 | R | A | -1.6966 | |
| 82 | S | A | -0.2347 | |
| 83 | F | A | 1.2296 | |
| 84 | G | A | 0.3259 | |
| 85 | Y | A | 0.5480 | |
| 86 | R | A | -1.3518 | |
| 87 | S | A | -1.1279 | |
| 88 | G | A | -1.1040 | |
| 89 | S | A | -0.9114 | |
| 90 | P | A | -0.6951 | |
| 91 | S | A | -0.5411 | |
| 92 | P | A | -0.0971 | |
| 93 | P | A | 0.3779 | |
| 94 | C | A | 1.4513 | |
| 95 | I | A | 2.4347 | |
| 96 | T | A | 1.4189 | |
| 97 | S | A | 1.4297 | |
| 98 | V | A | 2.1811 | |
| 99 | S | A | 0.9665 | |
| 100 | V | A | 1.6188 | |
| 101 | N | A | -0.2071 | |
| 102 | Q | A | -0.7682 | |
| 103 | S | A | -0.1836 | |
| 104 | L | A | 1.3857 | |
| 105 | L | A | 1.2047 | |
| 106 | K | A | -0.6199 | |
| 107 | P | A | 0.1781 | |
| 108 | L | A | 0.9879 | |
| 109 | N | A | -0.3201 | |
| 110 | L | A | 0.8500 | |
| 111 | E | A | -0.9015 | |
| 112 | I | A | -0.1024 | |
| 113 | D | A | -2.4626 | |
| 114 | H | A | -2.9074 | |
| 115 | N | A | -2.9146 | |
| 116 | A | A | -2.3125 | |
| 117 | Q | A | -3.3592 | |
| 118 | R | A | -4.1436 | |
| 119 | V | A | -2.4417 | |
| 120 | K | A | -4.4305 | |
| 121 | N | A | -4.7064 | |
| 122 | Q | A | -4.5261 | |
| 123 | E | A | -4.7957 | |
| 124 | K | A | -4.7953 | |
| 125 | E | A | -4.4591 | |
| 126 | Q | A | -3.5042 | |
| 127 | I | A | -2.1794 | |
| 128 | K | A | -3.1616 | |
| 129 | S | A | -2.0282 | |
| 130 | L | A | -0.9843 | |
| 131 | N | A | -1.2441 | |
| 132 | S | A | -0.5718 | |
| 133 | K | A | -0.1396 | |
| 134 | F | A | 1.4592 | |
| 135 | A | A | 0.9651 | |
| 136 | A | A | 0.6015 | |
| 137 | F | A | 2.2930 | |
| 138 | I | A | 2.2270 | |
| 139 | D | A | -0.4119 | |
| 140 | K | A | -0.0233 | |
| 141 | V | A | 0.7232 | |
| 142 | R | A | -1.1220 | |
| 143 | F | A | 0.3834 | |
| 144 | L | A | -0.2606 | |
| 145 | E | A | -1.8816 | |
| 146 | Q | A | -2.1913 | |
| 147 | Q | A | -1.6317 | |
| 148 | N | A | -2.8373 | |
| 149 | K | A | -3.0796 | |
| 150 | L | A | -1.4970 | |
| 151 | L | A | -1.4339 | |
| 152 | E | A | -2.4368 | |
| 153 | T | A | -1.3673 | |
| 154 | K | A | -1.0227 | |
| 155 | W | A | -0.3440 | |
| 156 | Q | A | -1.4243 | |
| 157 | L | A | -0.1978 | |
| 158 | Y | A | -0.6492 | |
| 159 | Q | A | -2.0504 | |
| 160 | N | A | -2.4808 | |
| 161 | Q | A | -2.4096 | |
| 162 | R | A | -3.4628 | |
| 163 | S | A | -2.2484 | |
| 164 | C | A | -1.8116 | |
| 165 | E | A | -2.8167 | |
| 166 | S | A | -1.8781 | |
| 167 | N | A | -1.1928 | |
| 168 | L | A | 0.3807 | |
| 169 | G | A | 0.0365 | |
| 170 | P | A | 0.5810 | |
| 171 | L | A | 2.1703 | |
| 172 | F | A | 2.2273 | |
| 173 | N | A | 0.4282 | |
| 174 | G | A | 0.5203 | |
| 175 | Y | A | 1.7676 | |
| 176 | I | A | 0.6516 | |
| 177 | E | A | -1.4087 | |
| 178 | T | A | -1.0020 | |
| 179 | L | A | -1.5116 | |
| 180 | R | A | -3.2585 | |
| 181 | R | A | -4.0946 | |
| 182 | E | A | -3.8531 | |
| 183 | A | A | -3.3807 | |
| 184 | E | A | -4.4696 | |
| 185 | R | A | -4.1505 | |
| 186 | V | A | -2.2939 | |
| 187 | E | A | -3.3726 | |
| 188 | A | A | -2.8960 | |
| 189 | D | A | -2.8872 | |
| 190 | T | A | -1.9895 | |
| 191 | G | A | -1.9458 | |
| 192 | R | A | -2.2992 | |
| 193 | L | A | -0.6849 | |
| 194 | A | A | -0.5983 | |
| 195 | S | A | -1.4734 | |
| 196 | E | A | -1.7039 | |
| 197 | L | A | 0.0726 | |
| 198 | N | A | -1.3169 | |
| 199 | H | A | -1.2817 | |
| 200 | V | A | 0.5530 | |
| 201 | Q | A | -0.8752 | |
| 202 | E | A | -1.7382 | |
| 203 | V | A | 0.6171 | |
| 204 | L | A | 0.2748 | |
| 205 | E | A | -1.6799 | |
| 206 | G | A | -0.9204 | |
| 207 | Y | A | -0.6951 | |
| 208 | K | A | -2.8806 | |
| 209 | K | A | -3.6805 | |
| 210 | K | A | -3.3957 | |
| 211 | Y | A | -1.8597 | |
| 212 | E | A | -3.3850 | |
| 213 | E | A | -3.4835 | |
| 214 | E | A | -2.4497 | |
| 215 | I | A | -0.8633 | |
| 216 | A | A | -0.9299 | |
| 217 | L | A | -0.3443 | |
| 218 | K | A | -2.2097 | |
| 219 | T | A | -1.5072 | |
| 220 | T | A | -1.1158 | |
| 221 | A | A | -1.4587 | |
| 222 | E | A | -2.2644 | |
| 223 | N | A | -2.3043 | |
| 224 | E | A | -2.2402 | |
| 225 | F | A | -0.0314 | |
| 226 | V | A | -0.1534 | |
| 227 | K | A | -2.0122 | |
| 228 | I | A | -0.5206 | |
| 229 | K | A | -1.5790 | |
| 230 | Q | A | -2.4138 | |
| 231 | E | A | -1.9701 | |
| 232 | V | A | -0.6587 | |
| 233 | N | A | -1.5537 | |
| 234 | H | A | -0.9360 | |
| 235 | V | A | 0.5269 | |
| 236 | Y | A | 1.2006 | |
| 237 | V | A | 1.0742 | |
| 238 | S | A | 0.0489 | |
| 239 | K | A | -0.9411 | |
| 240 | G | A | -1.0195 | |
| 241 | D | A | -1.8278 | |
| 242 | L | A | -0.9648 | |
| 243 | E | A | -2.4026 | |
| 244 | A | A | -1.8165 | |
| 245 | N | A | -1.8152 | |
| 246 | A | A | -1.0335 | |
| 247 | H | A | -1.4156 | |
| 248 | S | A | -0.8611 | |
| 249 | L | A | 0.6857 | |
| 250 | V | A | 1.0590 | |
| 251 | E | A | -1.1667 | |
| 252 | E | A | -0.8052 | |
| 253 | V | A | 0.5422 | |
| 254 | G | A | 0.1843 | |
| 255 | F | A | 1.1910 | |
| 256 | L | A | 0.3081 | |
| 257 | K | A | -1.3732 | |
| 258 | T | A | -0.5340 | |
| 259 | L | A | 0.0005 | |
| 260 | Y | A | -0.0704 | |
| 261 | E | A | -1.7561 | |
| 262 | E | A | -2.1874 | |
| 263 | E | A | -1.1414 | |
| 264 | L | A | -0.0713 | |
| 265 | R | A | -1.4856 | |
| 266 | V | A | 0.2433 | |
| 267 | I | A | 0.6881 | |
| 268 | Q | A | -0.5428 | |
| 269 | A | A | -0.4225 | |
| 270 | H | A | -0.1870 | |
| 271 | I | A | 1.3167 | |
| 272 | S | A | 0.3152 | |
| 273 | D | A | -0.5360 | |
| 274 | T | A | 0.6693 | |
| 275 | S | A | 1.0987 | |
| 276 | V | A | 1.7804 | |
| 277 | I | A | 1.7377 | |
| 278 | V | A | 0.9389 | |
| 279 | K | A | -0.3191 | |
| 280 | M | A | 0.2600 | |
| 281 | D | A | -1.8655 | |
| 282 | N | A | -2.1144 | |
| 283 | S | A | -1.4486 | |
| 284 | R | A | -1.6711 | |
| 285 | Y | A | 0.7164 | |
| 286 | L | A | 1.0840 | |
| 287 | N | A | -0.1993 | |
| 288 | M | A | 0.3683 | |
| 289 | D | A | -1.2008 | |
| 290 | S | A | -0.7474 | |
| 291 | I | A | 0.1652 | |
| 292 | V | A | -0.0351 | |
| 293 | A | A | -0.8241 | |
| 294 | E | A | -1.8058 | |
| 295 | I | A | -0.9134 | |
| 296 | K | A | -1.7732 | |
| 297 | A | A | -1.7678 | |
| 298 | H | A | -1.6093 | |
| 299 | Y | A | -0.7138 | |
| 300 | D | A | -2.5279 | |
| 301 | E | A | -2.5481 | |
| 302 | I | A | -0.3766 | |
| 303 | A | A | -1.3823 | |
| 304 | S | A | -2.4117 | |
| 305 | R | A | -3.0795 | |
| 306 | S | A | -2.6565 | |
| 307 | R | A | -3.1878 | |
| 308 | A | A | -2.3411 | |
| 309 | E | A | -3.0157 | |
| 310 | A | A | -1.8879 | |
| 311 | E | A | -2.1335 | |
| 312 | S | A | -1.2577 | |
| 313 | W | A | 0.0589 | |
| 314 | Y | A | -0.0993 | |
| 315 | R | A | -1.7689 | |
| 316 | S | A | -1.3755 | |
| 317 | K | A | -1.0434 | |
| 318 | Y | A | -0.4651 | |
| 319 | E | A | -2.4305 | |
| 320 | E | A | -2.1472 | |
| 321 | I | A | -0.0896 | |
| 322 | K | A | -1.7617 | |
| 323 | A | A | -1.7009 | |
| 324 | T | A | -1.0529 | |
| 325 | V | A | -0.5227 | |
| 326 | N | A | -2.2589 | |
| 327 | R | A | -2.8917 | |
| 328 | H | A | -2.4363 | |
| 329 | G | A | -2.1319 | |
| 330 | E | A | -3.1625 | |
| 331 | T | A | -2.4202 | |
| 332 | L | A | -1.9688 | |
| 333 | R | A | -3.7272 | |
| 334 | R | A | -4.0483 | |
| 335 | T | A | -3.0089 | |
| 336 | K | A | -3.7639 | |
| 337 | E | A | -4.4323 | |
| 338 | E | A | -3.9780 | |
| 339 | I | A | -1.8621 | |
| 340 | N | A | -3.0276 | |
| 341 | E | A | -3.1310 | |
| 342 | L | A | -1.1938 | |
| 343 | N | A | -1.9864 | |
| 344 | R | A | -2.2997 | |
| 345 | L | A | -0.1489 | |
| 346 | I | A | 0.0509 | |
| 347 | Q | A | -1.6637 | |
| 348 | R | A | -1.8120 | |
| 349 | L | A | -0.5102 | |
| 350 | T | A | -0.7490 | |
| 351 | A | A | -1.7390 | |
| 352 | E | A | -2.3559 | |
| 353 | I | A | -0.9259 | |
| 354 | E | A | -2.8450 | |
| 355 | N | A | -3.0938 | |
| 356 | A | A | -2.6595 | |
| 357 | K | A | -3.4384 | |
| 358 | S | A | -2.9963 | |
| 359 | Q | A | -3.0382 | |
| 360 | N | A | -3.3878 | |
| 361 | S | A | -2.6037 | |
| 362 | K | A | -2.5110 | |
| 363 | L | A | -1.0818 | |
| 364 | E | A | -1.8423 | |
| 365 | A | A | -1.2979 | |
| 366 | A | A | -0.6642 | |
| 367 | V | A | 0.0558 | |
| 368 | T | A | -1.3823 | |
| 369 | Q | A | -2.2589 | |
| 370 | A | A | -2.0909 | |
| 371 | E | A | -3.2304 | |
| 372 | Q | A | -3.3254 | |
| 373 | Q | A | -2.9991 | |
| 374 | G | A | -2.7757 | |
| 375 | E | A | -3.0598 | |
| 376 | A | A | -2.2487 | |
| 377 | A | A | -1.6782 | |
| 378 | L | A | -1.0768 | |
| 379 | N | A | -2.2039 | |
| 380 | D | A | -2.8266 | |
| 381 | A | A | -1.9098 | |
| 382 | R | A | -2.3164 | |
| 383 | G | A | -2.1346 | |
| 384 | K | A | -2.2873 | |
| 385 | L | A | -0.6604 | |
| 386 | A | A | -1.1876 | |
| 387 | G | A | -1.1058 | |
| 388 | L | A | -0.1035 | |
| 389 | E | A | -1.8196 | |
| 390 | K | A | -2.6651 | |
| 391 | A | A | -1.2928 | |
| 392 | L | A | -1.1361 | |
| 393 | Q | A | -3.1905 | |
| 394 | K | A | -3.6075 | |
| 395 | A | A | -2.6285 | |
| 396 | K | A | -3.1893 | |
| 397 | Q | A | -3.0361 | |
| 398 | D | A | -2.7301 | |
| 399 | M | A | -1.0436 | |
| 400 | A | A | -0.8870 | |
| 401 | S | A | -0.9572 | |
| 402 | L | A | 0.0256 | |
| 403 | V | A | 0.7161 | |
| 404 | K | A | -1.5119 | |
| 405 | Q | A | -1.1127 | |
| 406 | Y | A | 0.3654 | |
| 407 | Q | A | -1.4665 | |
| 408 | E | A | -1.9688 | |
| 409 | V | A | -0.2636 | |
| 410 | M | A | 0.2708 | |
| 411 | S | A | -0.3665 | |
| 412 | S | A | -0.1781 | |
| 413 | K | A | -0.6482 | |
| 414 | L | A | 1.0816 | |
| 415 | G | A | 0.8133 | |
| 416 | L | A | 0.9594 | |
| 417 | D | A | 0.0507 | |
| 418 | I | A | 1.4321 | |
| 419 | E | A | -0.0063 | |
| 420 | I | A | 1.0251 | |
| 421 | A | A | 0.1917 | |
| 422 | T | A | 0.0642 | |
| 423 | Y | A | 0.5194 | |
| 424 | R | A | -1.6125 | |
| 425 | R | A | -2.3379 | |
| 426 | L | A | -0.3020 | |
| 427 | L | A | -1.5321 | |
| 428 | E | A | -3.4305 | |
| 429 | G | A | -2.7152 | |
| 430 | E | A | -3.6559 | |
| 431 | E | A | -3.6297 | |
| 432 | Q | A | -3.2219 | |
| 433 | R | A | -3.2930 | |
| 434 | L | A | -0.9481 | |
| 435 | C | A | -0.7690 | |
| 436 | E | A | -2.0871 | |
| 437 | G | A | -0.3429 | |
| 438 | I | A | 1.6677 | |
| 439 | S | A | 0.6828 | |
| 440 | A | A | 1.0727 | |
| 441 | V | A | 2.0114 | |
| 442 | N | A | 0.8194 | |
| 443 | V | A | 1.9752 | |
| 444 | S | A | 1.3140 | |
| 445 | V | A | 1.8171 | |
| 446 | S | A | 0.6407 | |
| 447 | S | A | -0.4652 | |
| 448 | S | A | -1.1949 | |
| 449 | R | A | -2.3351 | |
| 450 | G | A | -1.2761 | |
| 451 | G | A | 0.1281 | |
| 452 | V | A | 2.5141 | |
| 453 | V | A | 2.8503 | |
| 454 | C | A | 1.3000 | |
| 455 | G | A | -0.2790 | |
| 456 | D | A | -1.1882 | |
| 457 | L | A | 0.3304 | |
| 458 | S | A | -0.4073 | |
| 459 | G | A | -0.8778 | |
| 460 | T | A | -1.0136 | |
| 461 | R | A | -1.9266 | |
| 462 | T | A | -0.5725 | |
| 463 | C | A | 0.4718 | |
| 464 | G | A | 0.5525 | |
| 465 | I | A | 1.9470 | |
| 466 | S | A | 0.8981 | |
| 467 | S | A | 0.8592 | |
| 468 | Y | A | 1.5274 | |
| 469 | G | A | 0.8359 | |
| 470 | V | A | 1.7117 | |
| 471 | G | A | 0.5916 | |
| 472 | A | A | 0.4335 | |
| 473 | C | A | 0.5395 | |
| 474 | G | A | -0.1620 | |
| 475 | S | A | -0.2059 | |
| 476 | S | A | -0.3444 | |
| 477 | Y | A | -0.0690 | |
| 478 | K | A | -1.7893 | |
| 479 | K | A | -1.8583 | |
| 480 | C | A | -0.3772 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine