| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGAEAAAKEAAAKEAAAKEAAAKALEAEAAAKEAAAKEAAAKEAAAKAFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:39)
[INFO] Main: Simulation completed successfully. (00:03:41)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4441 | |
| 2 | S | A | -0.2097 | |
| 3 | R | A | -1.7117 | |
| 4 | P | A | -1.0958 | |
| 5 | G | A | -0.9848 | |
| 6 | L | A | -0.6075 | |
| 7 | P | A | -0.2030 | |
| 8 | V | A | 0.0185 | |
| 9 | E | A | -0.2713 | |
| 10 | Y | A | 0.2421 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8920 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.4849 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9362 | |
| 17 | S | A | -0.7161 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.2658 | |
| 20 | R | A | -1.8331 | |
| 21 | D | A | -2.3943 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.7783 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8438 | |
| 29 | G | A | -1.0732 | |
| 30 | G | A | -1.6854 | |
| 31 | N | A | -2.3062 | |
| 32 | N | A | -2.3539 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0448 | |
| 43 | R | A | -2.4501 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.3744 | |
| 46 | D | A | -2.9412 | |
| 47 | D | A | -2.0592 | |
| 48 | Y | A | -0.3352 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 1.0480 | |
| 54 | N | A | 0.0364 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2797 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.8638 | |
| 60 | W | A | -0.4280 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.1480 | |
| 63 | Q | A | -1.1142 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.0190 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.3364 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6789 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9568 | |
| 84 | S | A | 0.1202 | |
| 85 | P | A | -0.2346 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.4360 | |
| 88 | G | A | -1.3712 | |
| 89 | K | A | -1.8890 | |
| 90 | A | A | -0.7789 | |
| 91 | G | A | -0.4531 | |
| 92 | C | A | 0.1945 | |
| 93 | Q | A | -0.3195 | |
| 94 | T | A | -0.3732 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.9022 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.6214 | |
| 99 | T | A | -0.5382 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3534 | |
| 103 | S | A | -0.5143 | |
| 104 | E | A | -0.6739 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4445 | |
| 108 | W | A | -0.8548 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.3289 | |
| 111 | A | A | -0.8835 | |
| 112 | N | A | -1.3238 | |
| 113 | R | A | -1.6664 | |
| 114 | A | A | -1.6535 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.3254 | |
| 117 | P | A | -0.9174 | |
| 118 | T | A | -0.6426 | |
| 119 | G | A | -0.3032 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.0987 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2390 | |
| 139 | H | A | -0.4410 | |
| 140 | P | A | -0.8655 | |
| 141 | Q | A | -1.2126 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.1303 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.1947 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -0.9726 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.0936 | |
| 157 | Q | A | -1.2199 | |
| 158 | G | A | -0.4533 | |
| 159 | M | A | 0.5536 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0267 | |
| 162 | S | A | 0.4271 | |
| 163 | L | A | 0.9031 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | 0.0105 | |
| 166 | L | A | 0.7666 | |
| 167 | A | A | -0.2761 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.2129 | |
| 170 | D | A | -2.0723 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | -1.7545 | |
| 173 | G | A | -1.5584 | |
| 174 | Y | A | -1.3032 | |
| 175 | K | A | -1.7561 | |
| 176 | A | A | -0.7817 | |
| 177 | A | A | -0.6145 | |
| 178 | D | A | -0.4128 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6121 | |
| 183 | S | A | -0.9027 | |
| 184 | S | A | -0.7525 | |
| 185 | D | A | -0.9430 | |
| 186 | P | A | -0.9379 | |
| 187 | A | A | -0.6228 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -1.6797 | |
| 190 | R | A | -1.1922 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.1539 | |
| 195 | Q | A | -1.7122 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.0076 | |
| 199 | K | A | -1.2558 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2141 | |
| 202 | A | A | -0.8804 | |
| 203 | N | A | -1.4310 | |
| 204 | N | A | -1.6785 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.7976 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.6949 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -0.5036 | |
| 216 | P | A | -1.0298 | |
| 217 | N | A | -1.3085 | |
| 218 | E | A | -1.7297 | |
| 219 | L | A | -0.4264 | |
| 220 | G | A | -0.7555 | |
| 221 | G | A | -0.5869 | |
| 222 | A | A | -0.4532 | |
| 223 | N | A | 0.0258 | |
| 224 | I | A | 1.8390 | |
| 225 | P | A | 0.9416 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.5115 | |
| 228 | F | A | 1.9393 | |
| 229 | L | A | 1.3166 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.6314 | |
| 232 | F | A | 0.3373 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5846 | |
| 235 | S | A | -0.6909 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.6468 | |
| 239 | K | A | -2.0234 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.6334 | |
| 242 | D | A | -2.6562 | |
| 243 | A | A | -1.8432 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4096 | |
| 246 | A | A | -1.3236 | |
| 247 | A | A | -0.9712 | |
| 248 | G | A | -1.1012 | |
| 249 | G | A | -1.7318 | |
| 250 | H | A | -1.6549 | |
| 251 | N | A | -1.2231 | |
| 252 | A | A | -0.5279 | |
| 253 | V | A | 0.3134 | |
| 254 | F | A | 0.5240 | |
| 255 | N | A | 0.0667 | |
| 256 | F | A | 0.1542 | |
| 257 | P | A | -0.2778 | |
| 258 | P | A | -0.5720 | |
| 259 | N | A | -0.8391 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.0478 | |
| 263 | S | A | -0.4090 | |
| 264 | W | A | -0.2406 | |
| 265 | E | A | -0.7086 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.3551 | |
| 270 | Q | A | -0.5409 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9224 | |
| 273 | A | A | -0.6178 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0640 | |
| 276 | G | A | -1.0865 | |
| 277 | D | A | -0.8398 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -0.9153 | |
| 280 | S | A | -0.7450 | |
| 281 | S | A | -0.4791 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -0.5590 | |
| 284 | A | A | -0.8660 | |
| 285 | G | A | -1.0620 | |
| 286 | A | A | -0.9445 | |
| 287 | E | A | -1.9447 | |
| 288 | A | A | -1.8207 | |
| 289 | A | A | -1.3553 | |
| 290 | A | A | -1.7658 | |
| 291 | K | A | -3.1699 | |
| 292 | E | A | -3.3772 | |
| 293 | A | A | -2.4880 | |
| 294 | A | A | -2.2610 | |
| 295 | A | A | -2.5647 | |
| 296 | K | A | -3.6369 | |
| 297 | E | A | -3.6844 | |
| 298 | A | A | -2.5315 | |
| 299 | A | A | -2.1921 | |
| 300 | A | A | -2.5283 | |
| 301 | K | A | -3.4180 | |
| 302 | E | A | -3.4002 | |
| 303 | A | A | -2.0126 | |
| 304 | A | A | -1.4193 | |
| 305 | A | A | -1.9079 | |
| 306 | K | A | -2.7065 | |
| 307 | A | A | -1.4336 | |
| 308 | L | A | -0.4010 | |
| 309 | E | A | -2.3104 | |
| 310 | A | A | -2.0000 | |
| 311 | E | A | -2.6785 | |
| 312 | A | A | -2.1950 | |
| 313 | A | A | -1.8537 | |
| 314 | A | A | -2.1642 | |
| 315 | K | A | -3.5511 | |
| 316 | E | A | -3.4859 | |
| 317 | A | A | -2.5484 | |
| 318 | A | A | -2.2047 | |
| 319 | A | A | -2.5328 | |
| 320 | K | A | -3.6266 | |
| 321 | E | A | -3.6810 | |
| 322 | A | A | -2.5436 | |
| 323 | A | A | -2.2175 | |
| 324 | A | A | -2.5495 | |
| 325 | K | A | -3.4323 | |
| 326 | E | A | -3.2179 | |
| 327 | A | A | -1.7802 | |
| 328 | A | A | -0.8967 | |
| 329 | A | A | -0.8794 | |
| 330 | K | A | -1.2542 | |
| 331 | A | A | 0.2201 | |
| 332 | F | A | 1.2740 | |
| 333 | A | A | 0.3301 | |
| 334 | V | A | 1.0848 | |
| 335 | T | A | 0.3074 | |
| 336 | N | A | -0.4041 | |
| 337 | D | A | -0.8762 | |
| 338 | G | A | 0.0349 | |
| 339 | V | A | 1.8050 | |
| 340 | I | A | 2.1659 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine