| Chain sequence(s) |
A: MSFNFCLPNLSFRSSCSSRPCVPSSCCGTTLPGACNIPASVGSCNWFCEGSFNGNEKETMQFLNDRLASYLEKVRQLERENAELERRILERSQQQEPLVCPNYQSYFRTIEELQQKILCGKSENARLVVQIDNAKLASDDFRTKYETEVSLRQLVEADLNGLRRILDELTLCKSDLEARVESLKEELICLKQNHEQEVNTLRSQLGDRLNVEVDAAPTVDLNHVLNETRAQYEALVETNRRDVEEWYIRQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALEVELQAQHNLRDSLENTLTETEARYSCQLNQVQSLIVSVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRGLLDSEDCKLPCNPCATTNTCGKPIGPCISNPCVSRTRCGPCNTFVH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:18)
[INFO] Main: Simulation completed successfully. (00:06:21)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 1.3118 | |
| 2 | S | A | 1.1181 | |
| 3 | F | A | 2.1383 | |
| 4 | N | A | 1.0790 | |
| 5 | F | A | 2.6173 | |
| 6 | C | A | 2.0780 | |
| 7 | L | A | 2.0790 | |
| 8 | P | A | 0.7022 | |
| 9 | N | A | -0.0068 | |
| 10 | L | A | 1.3026 | |
| 11 | S | A | 0.5378 | |
| 12 | F | A | 1.1529 | |
| 13 | R | A | -0.8490 | |
| 14 | S | A | -0.5047 | |
| 15 | S | A | -0.3014 | |
| 16 | C | A | -0.0240 | |
| 17 | S | A | -0.5764 | |
| 18 | S | A | -1.0091 | |
| 19 | R | A | -1.6756 | |
| 20 | P | A | -0.4198 | |
| 21 | C | A | 0.9117 | |
| 22 | V | A | 1.6538 | |
| 23 | P | A | 0.6845 | |
| 24 | S | A | 0.1912 | |
| 25 | S | A | 0.3044 | |
| 26 | C | A | 0.7845 | |
| 27 | C | A | 0.8333 | |
| 28 | G | A | 0.1430 | |
| 29 | T | A | 0.5581 | |
| 30 | T | A | 0.5426 | |
| 31 | L | A | 1.2270 | |
| 32 | P | A | 0.3997 | |
| 33 | G | A | -0.1777 | |
| 34 | A | A | 0.2635 | |
| 35 | C | A | 0.4465 | |
| 36 | N | A | -0.0410 | |
| 37 | I | A | 1.4406 | |
| 38 | P | A | 0.4567 | |
| 39 | A | A | 0.6167 | |
| 40 | S | A | 0.7517 | |
| 41 | V | A | 1.4887 | |
| 42 | G | A | 0.4056 | |
| 43 | S | A | 0.2109 | |
| 44 | C | A | 0.3550 | |
| 45 | N | A | 0.1878 | |
| 46 | W | A | 1.5990 | |
| 47 | F | A | 2.0914 | |
| 48 | C | A | 1.0371 | |
| 49 | E | A | -0.8452 | |
| 50 | G | A | -0.8188 | |
| 51 | S | A | -0.3787 | |
| 52 | F | A | -0.1052 | |
| 53 | N | A | -2.0621 | |
| 54 | G | A | -2.5959 | |
| 55 | N | A | -3.4019 | |
| 56 | E | A | -3.6362 | |
| 57 | K | A | -3.6703 | |
| 58 | E | A | -3.4761 | |
| 59 | T | A | -1.7005 | |
| 60 | M | A | -1.1653 | |
| 61 | Q | A | -1.8233 | |
| 62 | F | A | 0.2465 | |
| 63 | L | A | 0.4958 | |
| 64 | N | A | -0.8513 | |
| 65 | D | A | -1.1857 | |
| 66 | R | A | -1.0913 | |
| 67 | L | A | 0.2403 | |
| 68 | A | A | -0.4292 | |
| 69 | S | A | -1.0314 | |
| 70 | Y | A | -0.0914 | |
| 71 | L | A | -0.4904 | |
| 72 | E | A | -2.5350 | |
| 73 | K | A | -2.4880 | |
| 74 | V | A | -1.9010 | |
| 75 | R | A | -3.4665 | |
| 76 | Q | A | -3.4088 | |
| 77 | L | A | -3.0808 | |
| 78 | E | A | -4.3682 | |
| 79 | R | A | -4.5987 | |
| 80 | E | A | -4.4763 | |
| 81 | N | A | -4.1417 | |
| 82 | A | A | -3.6531 | |
| 83 | E | A | -3.8215 | |
| 84 | L | A | -1.7026 | |
| 85 | E | A | -2.5067 | |
| 86 | R | A | -2.6975 | |
| 87 | R | A | -1.6385 | |
| 88 | I | A | -0.0322 | |
| 89 | L | A | -0.2191 | |
| 90 | E | A | -1.9230 | |
| 91 | R | A | -3.1109 | |
| 92 | S | A | -2.3065 | |
| 93 | Q | A | -3.0908 | |
| 94 | Q | A | -3.3389 | |
| 95 | Q | A | -3.0549 | |
| 96 | E | A | -2.8430 | |
| 97 | P | A | -0.4676 | |
| 98 | L | A | 1.4837 | |
| 99 | V | A | 2.0133 | |
| 100 | C | A | 1.6183 | |
| 101 | P | A | 0.5933 | |
| 102 | N | A | -0.3373 | |
| 103 | Y | A | 0.4932 | |
| 104 | Q | A | -0.5590 | |
| 105 | S | A | -0.3484 | |
| 106 | Y | A | 0.8751 | |
| 107 | F | A | 0.5245 | |
| 108 | R | A | -1.6621 | |
| 109 | T | A | -0.6786 | |
| 110 | I | A | -0.3052 | |
| 111 | E | A | -2.5350 | |
| 112 | E | A | -2.6210 | |
| 113 | L | A | -0.5017 | |
| 114 | Q | A | -1.4953 | |
| 115 | Q | A | -2.1130 | |
| 116 | K | A | -1.7759 | |
| 117 | I | A | -0.2924 | |
| 118 | L | A | -0.0853 | |
| 119 | C | A | -0.3498 | |
| 120 | G | A | -1.5219 | |
| 121 | K | A | -2.2053 | |
| 122 | S | A | -1.6996 | |
| 123 | E | A | -1.6481 | |
| 124 | N | A | -1.8517 | |
| 125 | A | A | -0.8253 | |
| 126 | R | A | -1.3374 | |
| 127 | L | A | 0.2213 | |
| 128 | V | A | 1.7354 | |
| 129 | V | A | 1.0235 | |
| 130 | Q | A | -0.1353 | |
| 131 | I | A | 1.1999 | |
| 132 | D | A | -0.6026 | |
| 133 | N | A | -1.1201 | |
| 134 | A | A | -0.9441 | |
| 135 | K | A | -1.7190 | |
| 136 | L | A | -0.7144 | |
| 137 | A | A | -0.8444 | |
| 138 | S | A | -1.6143 | |
| 139 | D | A | -2.0319 | |
| 140 | D | A | -1.7269 | |
| 141 | F | A | -0.4288 | |
| 142 | R | A | -2.1978 | |
| 143 | T | A | -2.0928 | |
| 144 | K | A | -2.0889 | |
| 145 | Y | A | -0.7662 | |
| 146 | E | A | -1.9452 | |
| 147 | T | A | -1.4730 | |
| 148 | E | A | -1.6926 | |
| 149 | V | A | -0.2964 | |
| 150 | S | A | -0.3395 | |
| 151 | L | A | 0.3185 | |
| 152 | R | A | -1.8238 | |
| 153 | Q | A | -1.2736 | |
| 154 | L | A | 0.4487 | |
| 155 | V | A | -0.0095 | |
| 156 | E | A | -1.6251 | |
| 157 | A | A | -1.0199 | |
| 158 | D | A | -1.5177 | |
| 159 | L | A | 0.0089 | |
| 160 | N | A | -0.9282 | |
| 161 | G | A | -0.6626 | |
| 162 | L | A | 0.2350 | |
| 163 | R | A | -1.5439 | |
| 164 | R | A | -1.9273 | |
| 165 | I | A | 0.8550 | |
| 166 | L | A | 0.8260 | |
| 167 | D | A | -1.2215 | |
| 168 | E | A | -0.6844 | |
| 169 | L | A | 0.4379 | |
| 170 | T | A | 0.1426 | |
| 171 | L | A | 0.6586 | |
| 172 | C | A | 0.0845 | |
| 173 | K | A | -1.7114 | |
| 174 | S | A | -1.3046 | |
| 175 | D | A | -1.8453 | |
| 176 | L | A | -0.8072 | |
| 177 | E | A | -2.1822 | |
| 178 | A | A | -2.0851 | |
| 179 | R | A | -2.2465 | |
| 180 | V | A | -0.8783 | |
| 181 | E | A | -2.7024 | |
| 182 | S | A | -1.7912 | |
| 183 | L | A | -0.8492 | |
| 184 | K | A | -1.5821 | |
| 185 | E | A | -2.1911 | |
| 186 | E | A | -1.3265 | |
| 187 | L | A | 0.4311 | |
| 188 | I | A | 0.5082 | |
| 189 | C | A | -0.1230 | |
| 190 | L | A | -0.2387 | |
| 191 | K | A | -2.3280 | |
| 192 | Q | A | -2.8066 | |
| 193 | N | A | -3.0635 | |
| 194 | H | A | -3.5147 | |
| 195 | E | A | -3.8455 | |
| 196 | Q | A | -3.7603 | |
| 197 | E | A | -3.5104 | |
| 198 | V | A | -1.9590 | |
| 199 | N | A | -2.0670 | |
| 200 | T | A | -1.4032 | |
| 201 | L | A | -0.3070 | |
| 202 | R | A | -1.8701 | |
| 203 | S | A | -1.7581 | |
| 204 | Q | A | -1.5367 | |
| 205 | L | A | -0.7282 | |
| 206 | G | A | -1.7296 | |
| 207 | D | A | -2.8919 | |
| 208 | R | A | -2.0775 | |
| 209 | L | A | -0.0689 | |
| 210 | N | A | -0.7886 | |
| 211 | V | A | 0.7066 | |
| 212 | E | A | -0.7419 | |
| 213 | V | A | 0.4071 | |
| 214 | D | A | -1.1817 | |
| 215 | A | A | -0.6078 | |
| 216 | A | A | -0.0076 | |
| 217 | P | A | -0.1579 | |
| 218 | T | A | 0.4798 | |
| 219 | V | A | 1.0908 | |
| 220 | D | A | -0.6767 | |
| 221 | L | A | 0.3575 | |
| 222 | N | A | -1.4802 | |
| 223 | H | A | -1.9813 | |
| 224 | V | A | -0.7233 | |
| 225 | L | A | -1.3898 | |
| 226 | N | A | -2.7634 | |
| 227 | E | A | -3.1937 | |
| 228 | T | A | -2.3879 | |
| 229 | R | A | -3.0002 | |
| 230 | A | A | -2.2132 | |
| 231 | Q | A | -1.9244 | |
| 232 | Y | A | -0.5785 | |
| 233 | E | A | -1.8529 | |
| 234 | A | A | -0.7762 | |
| 235 | L | A | 0.0977 | |
| 236 | V | A | -0.4757 | |
| 237 | E | A | -1.6338 | |
| 238 | T | A | -1.8351 | |
| 239 | N | A | -2.8635 | |
| 240 | R | A | -3.0447 | |
| 241 | R | A | -3.7799 | |
| 242 | D | A | -3.2765 | |
| 243 | V | A | -1.4981 | |
| 244 | E | A | -2.3030 | |
| 245 | E | A | -2.4685 | |
| 246 | W | A | -0.4750 | |
| 247 | Y | A | 0.1054 | |
| 248 | I | A | -0.4591 | |
| 249 | R | A | -2.2882 | |
| 250 | Q | A | -1.9760 | |
| 251 | T | A | -1.7953 | |
| 252 | E | A | -3.1104 | |
| 253 | E | A | -3.2319 | |
| 254 | L | A | -1.4062 | |
| 255 | N | A | -2.2801 | |
| 256 | K | A | -2.5423 | |
| 257 | Q | A | -1.6034 | |
| 258 | V | A | 0.4198 | |
| 259 | V | A | 0.5927 | |
| 260 | S | A | -0.7482 | |
| 261 | S | A | -0.6534 | |
| 262 | S | A | -0.5736 | |
| 263 | E | A | -2.0281 | |
| 264 | Q | A | -1.5441 | |
| 265 | L | A | -0.4982 | |
| 266 | Q | A | -2.0042 | |
| 267 | S | A | -1.5496 | |
| 268 | C | A | -0.9988 | |
| 269 | Q | A | -1.2515 | |
| 270 | A | A | -1.2904 | |
| 271 | E | A | -1.9568 | |
| 272 | I | A | -0.6151 | |
| 273 | I | A | -0.8187 | |
| 274 | E | A | -2.2321 | |
| 275 | L | A | -0.7444 | |
| 276 | R | A | -1.9901 | |
| 277 | R | A | -2.6783 | |
| 278 | T | A | -0.6078 | |
| 279 | V | A | 0.0892 | |
| 280 | N | A | -1.4636 | |
| 281 | A | A | -0.3668 | |
| 282 | L | A | 0.1809 | |
| 283 | E | A | -1.1479 | |
| 284 | V | A | 0.0496 | |
| 285 | E | A | -1.4501 | |
| 286 | L | A | -0.8684 | |
| 287 | Q | A | -1.8380 | |
| 288 | A | A | -1.7103 | |
| 289 | Q | A | -2.4281 | |
| 290 | H | A | -2.3154 | |
| 291 | N | A | -2.5895 | |
| 292 | L | A | -1.2921 | |
| 293 | R | A | -2.4752 | |
| 294 | D | A | -2.5347 | |
| 295 | S | A | -1.3909 | |
| 296 | L | A | -0.5837 | |
| 297 | E | A | -2.1895 | |
| 298 | N | A | -2.2818 | |
| 299 | T | A | -1.1894 | |
| 300 | L | A | -0.5571 | |
| 301 | T | A | -1.6098 | |
| 302 | E | A | -2.5207 | |
| 303 | T | A | -1.8148 | |
| 304 | E | A | -2.2370 | |
| 305 | A | A | -1.5570 | |
| 306 | R | A | -1.9569 | |
| 307 | Y | A | -0.6069 | |
| 308 | S | A | -0.7260 | |
| 309 | C | A | -0.6591 | |
| 310 | Q | A | -1.0804 | |
| 311 | L | A | 0.0239 | |
| 312 | N | A | -1.0634 | |
| 313 | Q | A | -0.7805 | |
| 314 | V | A | 0.5769 | |
| 315 | Q | A | 0.1613 | |
| 316 | S | A | 0.5726 | |
| 317 | L | A | 2.1593 | |
| 318 | I | A | 2.2466 | |
| 319 | V | A | 2.2250 | |
| 320 | S | A | 1.5751 | |
| 321 | V | A | 1.6628 | |
| 322 | E | A | -0.1093 | |
| 323 | S | A | -0.6251 | |
| 324 | Q | A | -0.8848 | |
| 325 | L | A | -0.6512 | |
| 326 | A | A | -1.4498 | |
| 327 | E | A | -2.4193 | |
| 328 | I | A | -1.3404 | |
| 329 | R | A | -2.4964 | |
| 330 | S | A | -2.5170 | |
| 331 | D | A | -2.6387 | |
| 332 | L | A | -1.8945 | |
| 333 | E | A | -3.6260 | |
| 334 | R | A | -3.5169 | |
| 335 | Q | A | -3.1436 | |
| 336 | N | A | -2.9186 | |
| 337 | Q | A | -2.8033 | |
| 338 | E | A | -1.7612 | |
| 339 | Y | A | -0.1219 | |
| 340 | Q | A | -0.4109 | |
| 341 | V | A | 1.0222 | |
| 342 | L | A | 1.2995 | |
| 343 | L | A | 0.5063 | |
| 344 | D | A | -0.1559 | |
| 345 | V | A | 0.4127 | |
| 346 | R | A | -1.6508 | |
| 347 | A | A | -1.4582 | |
| 348 | R | A | -2.3057 | |
| 349 | L | A | -1.6510 | |
| 350 | E | A | -2.4378 | |
| 351 | C | A | -1.5422 | |
| 352 | E | A | -1.9900 | |
| 353 | I | A | -0.8381 | |
| 354 | N | A | -1.6276 | |
| 355 | T | A | -0.3820 | |
| 356 | Y | A | 0.3795 | |
| 357 | R | A | -1.4438 | |
| 358 | G | A | -0.9745 | |
| 359 | L | A | 0.4899 | |
| 360 | L | A | -0.3858 | |
| 361 | D | A | -2.2973 | |
| 362 | S | A | -1.5507 | |
| 363 | E | A | -2.5747 | |
| 364 | D | A | -2.3034 | |
| 365 | C | A | -1.2702 | |
| 366 | K | A | -1.8755 | |
| 367 | L | A | -0.2604 | |
| 368 | P | A | -0.1607 | |
| 369 | C | A | 0.0676 | |
| 370 | N | A | -0.6550 | |
| 371 | P | A | -0.3171 | |
| 372 | C | A | 0.3562 | |
| 373 | A | A | 0.0141 | |
| 374 | T | A | -0.2373 | |
| 375 | T | A | -0.5436 | |
| 376 | N | A | -1.2529 | |
| 377 | T | A | -0.6530 | |
| 378 | C | A | -0.3317 | |
| 379 | G | A | -0.8932 | |
| 380 | K | A | -1.3710 | |
| 381 | P | A | -0.2756 | |
| 382 | I | A | 1.1705 | |
| 383 | G | A | 0.5408 | |
| 384 | P | A | 0.7807 | |
| 385 | C | A | 1.5117 | |
| 386 | I | A | 1.7889 | |
| 387 | S | A | 0.3460 | |
| 388 | N | A | -0.4814 | |
| 389 | P | A | 0.1454 | |
| 390 | C | A | 0.8556 | |
| 391 | V | A | 1.3801 | |
| 392 | S | A | -0.3706 | |
| 393 | R | A | -1.9563 | |
| 394 | T | A | -1.5591 | |
| 395 | R | A | -2.2189 | |
| 396 | C | A | -0.6415 | |
| 397 | G | A | -0.6349 | |
| 398 | P | A | -0.5205 | |
| 399 | C | A | 0.1537 | |
| 400 | N | A | -0.3135 | |
| 401 | T | A | 0.8077 | |
| 402 | F | A | 2.2595 | |
| 403 | V | A | 2.0570 | |
| 404 | H | A | 0.3813 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine