| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKDGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEPQHDGADVRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFHVRAGPVGHPLPDGPPPSPLYVPPPPSSPYAVLPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEPNVYDPACFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9432 | |
| 2 | L | A | 1.9642 | |
| 3 | P | A | 0.6620 | |
| 4 | P | A | 0.3712 | |
| 5 | T | A | 0.1205 | |
| 6 | T | A | 0.1309 | |
| 7 | P | A | 0.1652 | |
| 8 | V | A | 1.2403 | |
| 9 | A | A | 0.0883 | |
| 10 | K | A | -1.0193 | |
| 11 | V | A | -0.1522 | |
| 12 | Q | A | -1.3931 | |
| 13 | S | A | -1.5417 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4030 | |
| 16 | E | A | -2.4280 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4640 | |
| 20 | P | A | 0.1333 | |
| 21 | T | A | 0.1620 | |
| 22 | S | A | -0.0931 | |
| 23 | L | A | 0.1026 | |
| 24 | F | A | -0.0256 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2669 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8672 | |
| 31 | R | A | -2.6484 | |
| 32 | L | A | -0.7779 | |
| 33 | L | A | 1.1670 | |
| 34 | T | A | 1.3647 | |
| 35 | V | A | 1.8224 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2235 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6051 | |
| 40 | K | A | -1.6318 | |
| 41 | D | A | -0.9204 | |
| 42 | I | A | 0.8170 | |
| 43 | V | A | 0.8904 | |
| 44 | K | A | -1.4159 | |
| 45 | D | A | -2.4378 | |
| 46 | G | A | -1.4785 | |
| 47 | K | A | -1.1305 | |
| 48 | V | A | 1.3589 | |
| 49 | V | A | 1.9455 | |
| 50 | V | A | 1.2352 | |
| 51 | P | A | 0.4347 | |
| 52 | K | A | -0.6469 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1069 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3868 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2384 | |
| 70 | K | A | -1.7880 | |
| 71 | F | A | -0.6362 | |
| 72 | A | A | -0.5841 | |
| 73 | L | A | -0.8728 | |
| 74 | P | A | -1.2109 | |
| 75 | Q | A | -2.5060 | |
| 76 | K | A | -3.1099 | |
| 77 | D | A | -2.9888 | |
| 78 | F | A | -1.6688 | |
| 79 | Y | A | -1.8867 | |
| 80 | D | A | -2.6864 | |
| 81 | P | A | -2.3604 | |
| 82 | E | A | -3.0513 | |
| 83 | K | A | -3.3961 | |
| 84 | E | A | -2.4624 | |
| 85 | R | A | -1.2958 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6795 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9505 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3192 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6748 | |
| 99 | G | A | -0.5209 | |
| 100 | P | A | -0.3707 | |
| 101 | L | A | 0.1113 | |
| 102 | G | A | -0.1638 | |
| 103 | K | A | -0.5821 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4192 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1475 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4236 | |
| 110 | L | A | 0.4611 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.8910 | |
| 113 | K | A | -0.2283 | |
| 114 | L | A | -1.0972 | |
| 115 | G | A | -1.2662 | |
| 116 | D | A | -1.4702 | |
| 117 | T | A | -1.1110 | |
| 118 | E | A | -1.8227 | |
| 119 | N | A | -2.2342 | |
| 120 | P | A | -2.0133 | |
| 121 | T | A | -1.6673 | |
| 122 | E | A | -2.4523 | |
| 123 | P | A | -1.2032 | |
| 124 | Q | A | -1.4801 | |
| 125 | H | A | -1.8591 | |
| 126 | D | A | -2.8100 | |
| 127 | G | A | -2.0785 | |
| 128 | A | A | -1.4074 | |
| 129 | D | A | -2.0756 | |
| 130 | V | A | -1.2775 | |
| 131 | R | A | -0.6503 | |
| 132 | V | A | 0.5038 | |
| 133 | A | A | 0.4744 | |
| 134 | F | A | 0.3114 | |
| 135 | S | A | -0.0600 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4174 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2426 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5574 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2172 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0905 | |
| 157 | D | A | 0.2448 | |
| 158 | I | A | 0.7942 | |
| 159 | A | A | 0.1032 | |
| 160 | E | A | -1.4834 | |
| 161 | P | A | -0.2271 | |
| 162 | C | A | 0.1860 | |
| 163 | P | A | -0.1713 | |
| 164 | G | A | -0.0778 | |
| 165 | L | A | 0.5932 | |
| 166 | P | A | -0.1107 | |
| 167 | P | A | -0.3382 | |
| 168 | G | A | -0.4197 | |
| 169 | A | A | -0.0220 | |
| 170 | C | A | 0.7426 | |
| 171 | P | A | 0.5457 | |
| 172 | P | A | 0.8086 | |
| 173 | I | A | 2.0338 | |
| 174 | Q | A | 0.8398 | |
| 175 | L | A | 1.4435 | |
| 176 | V | A | 0.8347 | |
| 177 | N | A | -0.2941 | |
| 178 | S | A | 0.0332 | |
| 179 | V | A | 0.4364 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3815 | |
| 182 | D | A | 0.0890 | |
| 183 | G | A | -0.1573 | |
| 184 | D | A | -0.5560 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1030 | |
| 190 | F | A | 0.0633 | |
| 191 | G | A | -0.1034 | |
| 192 | N | A | -0.2846 | |
| 193 | M | A | -0.1621 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4090 | |
| 197 | E | A | -2.6377 | |
| 198 | L | A | -1.2388 | |
| 199 | Q | A | -2.5318 | |
| 200 | Q | A | -3.2911 | |
| 201 | D | A | -3.5231 | |
| 202 | R | A | -3.3021 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1935 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3505 | |
| 211 | S | A | -1.8953 | |
| 212 | T | A | -1.4647 | |
| 213 | R | A | -2.1738 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1699 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3377 | |
| 220 | L | A | 0.5965 | |
| 221 | K | A | -1.1213 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8243 | |
| 224 | N | A | -1.5011 | |
| 225 | E | A | -1.2472 | |
| 226 | A | A | -0.6064 | |
| 227 | Y | A | -0.3727 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6587 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0767 | |
| 234 | F | A | 0.2583 | |
| 235 | G | A | -0.8209 | |
| 236 | R | A | -2.6120 | |
| 237 | R | A | -2.9073 | |
| 238 | E | A | -2.1746 | |
| 239 | Q | A | -0.2315 | |
| 240 | V | A | 1.4257 | |
| 241 | Y | A | 1.2361 | |
| 242 | A | A | 0.3942 | |
| 243 | R | A | -0.6262 | |
| 244 | H | A | -0.8332 | |
| 245 | F | A | 0.0988 | |
| 246 | H | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5174 | |
| 249 | A | A | -1.2073 | |
| 250 | G | A | -0.9650 | |
| 251 | P | A | -0.8060 | |
| 252 | V | A | -0.4897 | |
| 253 | G | A | -0.9309 | |
| 254 | H | A | -1.1778 | |
| 255 | P | A | -0.8339 | |
| 256 | L | A | -0.1499 | |
| 257 | P | A | -0.9465 | |
| 258 | D | A | -1.8059 | |
| 259 | G | A | -0.8853 | |
| 260 | P | A | -0.7693 | |
| 261 | P | A | -0.2550 | |
| 262 | P | A | 0.0467 | |
| 263 | S | A | 0.2295 | |
| 264 | P | A | 0.6638 | |
| 265 | L | A | 1.6675 | |
| 266 | Y | A | 1.5400 | |
| 267 | V | A | 1.9202 | |
| 268 | P | A | 0.9387 | |
| 269 | P | A | 0.7093 | |
| 270 | P | A | -0.1496 | |
| 271 | P | A | -0.1116 | |
| 272 | S | A | -0.1276 | |
| 273 | S | A | 0.2522 | |
| 274 | P | A | 0.2801 | |
| 275 | Y | A | 1.5517 | |
| 276 | A | A | 1.3198 | |
| 277 | V | A | 2.2152 | |
| 278 | L | A | 1.7426 | |
| 279 | P | A | 0.2296 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.2232 | |
| 282 | D | A | -0.4292 | |
| 283 | Y | A | 1.0218 | |
| 284 | F | A | 0.7619 | |
| 285 | G | A | 0.3197 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9649 | |
| 291 | L | A | 1.6109 | |
| 292 | V | A | 0.6414 | |
| 293 | S | A | -0.1462 | |
| 294 | S | A | -0.9503 | |
| 295 | D | A | -1.8424 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1084 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6301 | |
| 301 | R | A | -1.8438 | |
| 302 | P | A | -0.9533 | |
| 303 | F | A | -0.2041 | |
| 304 | W | A | -0.5738 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0897 | |
| 307 | R | A | -2.8388 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2795 | |
| 310 | G | A | -1.2386 | |
| 311 | N | A | -1.2772 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7972 | |
| 319 | N | A | -0.9147 | |
| 320 | E | A | -1.0239 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3056 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0439 | |
| 333 | N | A | 0.5684 | |
| 334 | F | A | 1.7741 | |
| 335 | T | A | 0.7543 | |
| 336 | I | A | 0.4432 | |
| 337 | S | A | -0.8073 | |
| 338 | Q | A | -1.4494 | |
| 339 | Q | A | -1.0633 | |
| 340 | L | A | 0.6179 | |
| 341 | C | A | -0.0462 | |
| 342 | T | A | -0.4698 | |
| 343 | P | A | -1.1951 | |
| 344 | E | A | -1.7446 | |
| 345 | P | A | -0.7476 | |
| 346 | N | A | -0.7597 | |
| 347 | V | A | 1.2765 | |
| 348 | Y | A | 1.2330 | |
| 349 | D | A | 0.0470 | |
| 350 | P | A | -0.2429 | |
| 351 | A | A | -0.0194 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.4544 | |
| 354 | K | A | -1.5639 | |
| 355 | N | A | -1.6803 | |
| 356 | Y | A | -0.0822 | |
| 357 | L | A | 0.6438 | |
| 358 | R | A | 0.9736 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3961 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0603 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9498 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6738 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2724 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3124 | |
| 376 | L | A | -1.7091 | |
| 377 | D | A | -1.9870 | |
| 378 | P | A | -1.0358 | |
| 379 | G | A | -1.0131 | |
| 380 | V | A | -0.9321 | |
| 381 | L | A | -0.5273 | |
| 382 | A | A | -0.6528 | |
| 383 | H | A | -0.8055 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4075 | |
| 386 | T | A | -0.5489 | |
| 387 | M | A | -0.2983 | |
| 388 | N | A | -0.8641 | |
| 389 | P | A | -1.2381 | |
| 390 | T | A | -1.4283 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4203 | |
| 393 | E | A | -2.7426 | |
| 394 | N | A | -2.3243 | |
| 395 | W | A | -1.3424 | |
| 396 | N | A | -1.0869 | |
| 397 | L | A | -0.1535 | |
| 398 | G | A | 0.5237 | |
| 399 | F | A | 2.4186 | |
| 400 | V | A | 1.8386 | |
| 401 | P | A | 0.0467 | |
| 402 | P | A | -1.8404 | |
| 403 | K | A | -3.3019 | |
| 404 | E | A | -3.7622 | |
| 405 | R | A | -3.8794 | |
| 406 | E | A | -3.7715 | |
| 407 | D | A | -2.8510 | |
| 408 | P | A | -1.7560 | |
| 409 | Y | A | -0.9832 | |
| 410 | K | A | -2.1136 | |
| 411 | G | A | -0.6346 | |
| 412 | L | A | 0.6743 | |
| 413 | I | A | 1.5943 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3675 | |
| 416 | E | A | -1.6300 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9152 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0262 | |
| 421 | E | A | -2.7473 | |
| 422 | R | A | -2.5712 | |
| 423 | F | A | -1.2490 | |
| 424 | S | A | -1.4461 | |
| 425 | Q | A | -1.8264 | |
| 426 | D | A | -2.8928 | |
| 427 | L | A | -1.9928 | |
| 428 | D | A | -2.7900 | |
| 429 | Q | A | -2.6284 | |
| 430 | F | A | -1.4498 | |
| 431 | A | A | -0.9139 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5986 | |
| 435 | K | A | -0.7300 | |
| 436 | F | A | 0.1260 | |
| 437 | L | A | 1.0173 | |
| 438 | Y | A | 0.8168 | |
| 439 | Q | A | -0.2794 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine