| Chain sequence(s) |
A: GLLPLNPEPEPRPTSAYVEPTDLLYVAETDDITETGNPTADIVVNGKVVVPKVSATQWKVFLLKLPDPNKLPLPSADFLDPSTERLIWQLRAFYIGKGGPLGKGTYGHKHFNALGDVDNPTEYQHESEDDTVDFSFTPKRLQEFIVGDRPPLGKYTAPAAPEPGLPPGAEPPTETVSDVIEHGDVADIGFGAKDFAALEPKKDEVPDIILNTTTKVVDYDAMRAEPYGDRMFTSGKKESSKDVKKLVLDGPELRPLPSAPPPSKLYKKPPPSSPYAVLPSYRYFTIPDAGEITAEDELFNQPFVLEETEGLNQGVLWHNRLYITVVDNSRATITTNQTKTSTPLPNVYNPADYVTSKTYTETYRLSLILQLCRVPLTPEVLAEIERRDPSILVDWNLPFVPPVERPDPYAGKKFHEIDLTDKLSSELEKTELGRWYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.6768 | |
| 2 | L | A | 2.2519 | |
| 3 | L | A | 2.1832 | |
| 4 | P | A | 0.8929 | |
| 5 | L | A | 1.2195 | |
| 6 | N | A | -1.0414 | |
| 7 | P | A | -1.5998 | |
| 8 | E | A | -2.7477 | |
| 9 | P | A | -2.4056 | |
| 10 | E | A | -2.7414 | |
| 11 | P | A | -1.8162 | |
| 12 | R | A | -1.3778 | |
| 13 | P | A | -0.6738 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -0.7342 | |
| 16 | A | A | -0.5357 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.0436 | |
| 20 | P | A | -1.5837 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.5986 | |
| 23 | L | A | -0.4732 | |
| 24 | L | A | -0.1528 | |
| 25 | Y | A | -0.2069 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.7632 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -3.0828 | |
| 31 | D | A | -3.2363 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -1.1242 | |
| 34 | E | A | -0.5612 | |
| 35 | T | A | -0.2082 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.7038 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.6624 | |
| 40 | A | A | -0.1298 | |
| 41 | D | A | 0.3521 | |
| 42 | I | A | 2.2830 | |
| 43 | V | A | 2.7571 | |
| 44 | V | A | 1.8667 | |
| 45 | N | A | -0.5081 | |
| 46 | G | A | -0.3039 | |
| 47 | K | A | 0.0063 | |
| 48 | V | A | 2.3996 | |
| 49 | V | A | 2.8839 | |
| 50 | V | A | 2.0959 | |
| 51 | P | A | 0.6375 | |
| 52 | K | A | -0.2161 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0949 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.5099 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3670 | |
| 70 | K | A | -1.8668 | |
| 71 | L | A | -0.7158 | |
| 72 | P | A | -0.3138 | |
| 73 | L | A | -0.0436 | |
| 74 | P | A | -0.1939 | |
| 75 | S | A | -0.5893 | |
| 76 | A | A | -0.9205 | |
| 77 | D | A | -1.9111 | |
| 78 | F | A | -0.9193 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -1.9323 | |
| 81 | P | A | -1.1544 | |
| 82 | S | A | -0.8836 | |
| 83 | T | A | -0.8264 | |
| 84 | E | A | -1.1044 | |
| 85 | R | A | -0.8549 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7479 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | Y | A | -0.3372 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | K | A | 0.0000 | |
| 98 | G | A | -0.9216 | |
| 99 | G | A | -0.5724 | |
| 100 | P | A | -0.3977 | |
| 101 | L | A | 0.0077 | |
| 102 | G | A | -0.5807 | |
| 103 | K | A | -1.1973 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3340 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.2311 | |
| 108 | H | A | 0.0000 | |
| 109 | K | A | -2.8547 | |
| 110 | H | A | -2.6750 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | -0.2602 | |
| 114 | L | A | -0.7452 | |
| 115 | G | A | -1.2209 | |
| 116 | D | A | -1.9418 | |
| 117 | V | A | -1.4147 | |
| 118 | D | A | -2.7283 | |
| 119 | N | A | -2.8117 | |
| 120 | P | A | -1.9463 | |
| 121 | T | A | -1.6750 | |
| 122 | E | A | -2.2185 | |
| 123 | Y | A | -0.7412 | |
| 124 | Q | A | -1.4923 | |
| 125 | H | A | -1.8361 | |
| 126 | E | A | -3.2892 | |
| 127 | S | A | -2.9141 | |
| 128 | E | A | -3.2596 | |
| 129 | D | A | -3.1988 | |
| 130 | D | A | -2.1075 | |
| 131 | T | A | -1.4891 | |
| 132 | V | A | -0.9363 | |
| 133 | D | A | -2.3569 | |
| 134 | F | A | -1.1406 | |
| 135 | S | A | -0.7634 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.6058 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.6983 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.4011 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.6887 | |
| 155 | Y | A | -0.5445 | |
| 156 | T | A | -0.7494 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.6312 | |
| 159 | A | A | -0.8730 | |
| 160 | A | A | -0.8165 | |
| 161 | P | A | -1.2052 | |
| 162 | E | A | -2.0265 | |
| 163 | P | A | -1.2368 | |
| 164 | G | A | -0.7797 | |
| 165 | L | A | -0.5529 | |
| 166 | P | A | -0.4808 | |
| 167 | P | A | -0.7291 | |
| 168 | G | A | -1.1080 | |
| 169 | A | A | -0.9695 | |
| 170 | E | A | -1.9017 | |
| 171 | P | A | -1.4830 | |
| 172 | P | A | -1.3295 | |
| 173 | T | A | -1.1850 | |
| 174 | E | A | -1.4218 | |
| 175 | T | A | -0.8668 | |
| 176 | V | A | -0.4692 | |
| 177 | S | A | -0.5360 | |
| 178 | D | A | -0.7030 | |
| 179 | V | A | 0.0000 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2512 | |
| 182 | H | A | -1.2158 | |
| 183 | G | A | -0.7210 | |
| 184 | D | A | -0.7040 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5760 | |
| 190 | F | A | -0.0778 | |
| 191 | G | A | -0.2314 | |
| 192 | A | A | -0.3188 | |
| 193 | K | A | -0.5611 | |
| 194 | D | A | -0.6353 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.1766 | |
| 197 | A | A | -0.5395 | |
| 198 | L | A | -0.9464 | |
| 199 | E | A | -1.5701 | |
| 200 | P | A | -1.8222 | |
| 201 | K | A | -2.7259 | |
| 202 | K | A | -3.1007 | |
| 203 | D | A | 0.0000 | |
| 204 | E | A | -1.2668 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.5223 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.1697 | |
| 211 | N | A | -1.6219 | |
| 212 | T | A | -0.8247 | |
| 213 | T | A | -0.5781 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.2359 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.2640 | |
| 220 | D | A | -2.4079 | |
| 221 | A | A | -1.6131 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.9016 | |
| 224 | A | A | -1.5901 | |
| 225 | E | A | -1.3390 | |
| 226 | P | A | -1.0639 | |
| 227 | Y | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6789 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.7601 | |
| 234 | S | A | -0.6000 | |
| 235 | G | A | -0.8497 | |
| 236 | K | A | -1.9390 | |
| 237 | K | A | -2.0498 | |
| 238 | E | A | -1.7800 | |
| 239 | S | A | -1.4602 | |
| 240 | S | A | -1.8477 | |
| 241 | K | A | -2.7504 | |
| 242 | D | A | -2.4139 | |
| 243 | V | A | -0.8140 | |
| 244 | K | A | -1.8307 | |
| 245 | K | A | -1.5908 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0000 | |
| 249 | D | A | -1.2790 | |
| 250 | G | A | -0.5459 | |
| 251 | P | A | -0.5971 | |
| 252 | E | A | -0.6646 | |
| 253 | L | A | -0.0379 | |
| 254 | R | A | -1.3617 | |
| 255 | P | A | -0.2527 | |
| 256 | L | A | 0.9738 | |
| 257 | P | A | -0.0282 | |
| 258 | S | A | 0.0751 | |
| 259 | A | A | -0.3391 | |
| 260 | P | A | -0.4821 | |
| 261 | P | A | -0.7241 | |
| 262 | P | A | -0.9314 | |
| 263 | S | A | -1.4002 | |
| 264 | K | A | -1.3876 | |
| 265 | L | A | 0.1821 | |
| 266 | Y | A | -0.7447 | |
| 267 | K | A | -2.4571 | |
| 268 | K | A | -1.9431 | |
| 269 | P | A | -0.9298 | |
| 270 | P | A | -0.9972 | |
| 271 | P | A | -0.4081 | |
| 272 | S | A | -0.3486 | |
| 273 | S | A | -0.0001 | |
| 274 | P | A | 0.6253 | |
| 275 | Y | A | 1.3243 | |
| 276 | A | A | 1.0361 | |
| 277 | V | A | 2.2897 | |
| 278 | L | A | 2.1692 | |
| 279 | P | A | 0.8726 | |
| 280 | S | A | 0.4138 | |
| 281 | Y | A | 1.5004 | |
| 282 | R | A | 0.6267 | |
| 283 | Y | A | 1.4384 | |
| 284 | F | A | 0.6352 | |
| 285 | T | A | -0.4584 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.5837 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -2.2077 | |
| 292 | I | A | -1.2022 | |
| 293 | T | A | -1.1996 | |
| 294 | A | A | -1.1578 | |
| 295 | E | A | -2.3773 | |
| 296 | D | A | -2.3134 | |
| 297 | E | A | -1.5858 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0060 | |
| 301 | Q | A | -0.7528 | |
| 302 | P | A | -0.1974 | |
| 303 | F | A | 0.1357 | |
| 304 | V | A | -0.2209 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.6655 | |
| 307 | E | A | -3.1445 | |
| 308 | T | A | -2.2048 | |
| 309 | E | A | -2.5611 | |
| 310 | G | A | -1.6040 | |
| 311 | L | A | -0.6478 | |
| 312 | N | A | 0.0000 | |
| 313 | Q | A | -1.2446 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -1.1538 | |
| 319 | N | A | -1.1382 | |
| 320 | R | A | -1.3256 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | T | A | -0.2906 | |
| 333 | I | A | -0.3248 | |
| 334 | T | A | -0.7670 | |
| 335 | T | A | -1.4901 | |
| 336 | N | A | -2.0721 | |
| 337 | Q | A | -1.8725 | |
| 338 | T | A | -1.1517 | |
| 339 | K | A | -1.5813 | |
| 340 | T | A | -0.6569 | |
| 341 | S | A | -0.3829 | |
| 342 | T | A | -0.1918 | |
| 343 | P | A | 0.4813 | |
| 344 | L | A | 1.7093 | |
| 345 | P | A | 0.6160 | |
| 346 | N | A | 0.1022 | |
| 347 | V | A | 1.9975 | |
| 348 | Y | A | 1.7054 | |
| 349 | N | A | 0.3771 | |
| 350 | P | A | 0.0986 | |
| 351 | A | A | 0.0104 | |
| 352 | D | A | -0.2317 | |
| 353 | Y | A | -0.0876 | |
| 354 | V | A | 0.7925 | |
| 355 | T | A | -0.7092 | |
| 356 | S | A | -1.3592 | |
| 357 | K | A | -2.2502 | |
| 358 | T | A | -1.1030 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.2352 | |
| 361 | E | A | 0.0000 | |
| 362 | T | A | -1.0128 | |
| 363 | Y | A | 0.0000 | |
| 364 | R | A | -2.5447 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.3508 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.3217 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -0.9385 | |
| 376 | L | A | -0.4337 | |
| 377 | T | A | -0.6801 | |
| 378 | P | A | -1.0481 | |
| 379 | E | A | -1.9646 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -0.8458 | |
| 382 | A | A | -1.1855 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | E | A | -1.7095 | |
| 386 | R | A | -1.4723 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -0.8673 | |
| 389 | P | A | -1.1103 | |
| 390 | S | A | -1.1720 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.1287 | |
| 394 | D | A | -2.2999 | |
| 395 | W | A | -1.4550 | |
| 396 | N | A | -1.3612 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.3955 | |
| 399 | F | A | 1.6984 | |
| 400 | V | A | 0.7776 | |
| 401 | P | A | 0.2599 | |
| 402 | P | A | -0.4126 | |
| 403 | V | A | -0.2038 | |
| 404 | E | A | -2.1359 | |
| 405 | R | A | -2.3497 | |
| 406 | P | A | -1.7534 | |
| 407 | D | A | -2.0243 | |
| 408 | P | A | -1.1386 | |
| 409 | Y | A | -0.9900 | |
| 410 | A | A | -1.0778 | |
| 411 | G | A | -1.2727 | |
| 412 | K | A | -1.7898 | |
| 413 | K | A | -2.4536 | |
| 414 | F | A | -1.5573 | |
| 415 | H | A | -1.6037 | |
| 416 | E | A | -2.5545 | |
| 417 | I | A | -2.0150 | |
| 418 | D | A | -3.0053 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0945 | |
| 421 | D | A | -2.9288 | |
| 422 | K | A | -2.7879 | |
| 423 | L | A | -1.2511 | |
| 424 | S | A | -1.1090 | |
| 425 | S | A | -0.7960 | |
| 426 | E | A | -1.9749 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.4776 | |
| 429 | K | A | -3.5024 | |
| 430 | T | A | -2.7454 | |
| 431 | E | A | -2.8149 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.6486 | |
| 435 | W | A | -1.1593 | |
| 436 | Y | A | -0.6159 | |
| 437 | L | A | -0.1406 | |
| 438 | N | A | -1.7301 | |
| 439 | R | A | -1.9722 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine