| Chain sequence(s) |
A: GCSALPSSITLTSNSKLVDLFTHFNGTKVTTKAAFACRQAELSELIQRYELGTLPGRPSTLTASFSGNTLTINCGENGKSISFTVTITYPSSGTAPYPAIIGFGGGSIPQPSGVANINFNNDDIAKQDSISSRGQGKFYDLYGSSHSAGAMTAWAWGVSRVIDALELTPAAKIDTTKIGVTGCSRNGKGALVAGAFEKRIVLTLPQESGMGGSACWRISDYLKSQGKNIQTASEIVGEYPWFSTTFNSYVNNVSLLPFDHHSLAALIAPRGLYVIDNDIDWLGPESCTGCMYAARKAWQALGVPDNMGYSQIGSHAHCAFPSSQQSNLTAFVNKFLLGQSANTAIFTSDFSPNPSQWIDWTTPTLS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:26)
[INFO] Main: Simulation completed successfully. (00:05:30)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.1509 | |
| 2 | C | A | 0.4260 | |
| 3 | S | A | -0.1020 | |
| 4 | A | A | -0.0295 | |
| 5 | L | A | -0.1622 | |
| 6 | P | A | -0.3384 | |
| 7 | S | A | -0.3482 | |
| 8 | S | A | -0.2051 | |
| 9 | I | A | 0.0862 | |
| 10 | T | A | 0.1425 | |
| 11 | L | A | 0.2599 | |
| 12 | T | A | -0.0899 | |
| 13 | S | A | -0.6048 | |
| 14 | N | A | -0.8633 | |
| 15 | S | A | -0.8415 | |
| 16 | K | A | -1.2769 | |
| 17 | L | A | 0.0000 | |
| 18 | V | A | -0.3433 | |
| 19 | D | A | -0.6107 | |
| 20 | L | A | 0.0000 | |
| 21 | F | A | 0.0000 | |
| 22 | T | A | -1.0224 | |
| 23 | H | A | -0.9475 | |
| 24 | F | A | -0.3836 | |
| 25 | N | A | -1.4614 | |
| 26 | G | A | -1.3764 | |
| 27 | T | A | -1.4204 | |
| 28 | K | A | -2.0296 | |
| 29 | V | A | 0.0000 | |
| 30 | T | A | -0.8531 | |
| 31 | T | A | -0.8964 | |
| 32 | K | A | -1.2592 | |
| 33 | A | A | -0.4923 | |
| 34 | A | A | -0.5732 | |
| 35 | F | A | 0.0000 | |
| 36 | A | A | -0.1751 | |
| 37 | C | A | 0.0007 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.2882 | |
| 40 | A | A | -0.1942 | |
| 41 | E | A | -0.3105 | |
| 42 | L | A | 0.0000 | |
| 43 | S | A | -0.6063 | |
| 44 | E | A | -1.0270 | |
| 45 | L | A | 0.0000 | |
| 46 | I | A | 0.0000 | |
| 47 | Q | A | -0.6457 | |
| 48 | R | A | -0.7195 | |
| 49 | Y | A | -0.3987 | |
| 50 | E | A | 0.0000 | |
| 51 | L | A | 0.0000 | |
| 52 | G | A | 0.0000 | |
| 53 | T | A | -0.3043 | |
| 54 | L | A | -0.2058 | |
| 55 | P | A | -0.5295 | |
| 56 | G | A | -1.3371 | |
| 57 | R | A | -2.1139 | |
| 58 | P | A | 0.0000 | |
| 59 | S | A | -1.0543 | |
| 60 | T | A | -0.9152 | |
| 61 | L | A | -0.2361 | |
| 62 | T | A | 0.1094 | |
| 63 | A | A | 0.0069 | |
| 64 | S | A | 0.0410 | |
| 65 | F | A | -0.2760 | |
| 66 | S | A | -0.5832 | |
| 67 | G | A | -0.9443 | |
| 68 | N | A | -1.1160 | |
| 69 | T | A | -0.7105 | |
| 70 | L | A | 0.0000 | |
| 71 | T | A | -0.2893 | |
| 72 | I | A | 0.0000 | |
| 73 | N | A | -0.5422 | |
| 74 | C | A | 0.0000 | |
| 75 | G | A | -1.4802 | |
| 76 | E | A | -1.8780 | |
| 77 | N | A | -2.1790 | |
| 78 | G | A | -2.0257 | |
| 79 | K | A | -2.7474 | |
| 80 | S | A | -1.8437 | |
| 81 | I | A | 0.0000 | |
| 82 | S | A | -0.4706 | |
| 83 | F | A | 0.0000 | |
| 84 | T | A | -0.6255 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.7622 | |
| 87 | I | A | 0.0000 | |
| 88 | T | A | -0.3774 | |
| 89 | Y | A | -0.1926 | |
| 90 | P | A | -0.3046 | |
| 91 | S | A | -0.3582 | |
| 92 | S | A | -0.4572 | |
| 93 | G | A | -0.5511 | |
| 94 | T | A | -0.4766 | |
| 95 | A | A | -0.5354 | |
| 96 | P | A | -0.8523 | |
| 97 | Y | A | -0.4577 | |
| 98 | P | A | -0.4222 | |
| 99 | A | A | 0.0000 | |
| 100 | I | A | 0.0000 | |
| 101 | I | A | 0.0000 | |
| 102 | G | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | G | A | -1.3364 | |
| 105 | G | A | -1.0109 | |
| 106 | G | A | -0.6063 | |
| 107 | S | A | -0.2359 | |
| 108 | I | A | -0.0719 | |
| 109 | P | A | -0.4768 | |
| 110 | Q | A | -0.7985 | |
| 111 | P | A | -0.5996 | |
| 112 | S | A | -0.5152 | |
| 113 | G | A | 0.0000 | |
| 114 | V | A | 0.0000 | |
| 115 | A | A | 0.0000 | |
| 116 | N | A | -0.4722 | |
| 117 | I | A | 0.0000 | |
| 118 | N | A | -1.2373 | |
| 119 | F | A | 0.0000 | |
| 120 | N | A | -2.3635 | |
| 121 | N | A | 0.0000 | |
| 122 | D | A | -3.0243 | |
| 123 | D | A | -3.0698 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | K | A | -2.5679 | |
| 127 | Q | A | 0.0000 | |
| 128 | D | A | -2.0763 | |
| 129 | S | A | -0.7814 | |
| 130 | I | A | 0.3152 | |
| 131 | S | A | -0.4481 | |
| 132 | S | A | 0.0000 | |
| 133 | R | A | -0.9718 | |
| 134 | G | A | 0.0000 | |
| 135 | Q | A | -2.1948 | |
| 136 | G | A | -2.3297 | |
| 137 | K | A | -2.1973 | |
| 138 | F | A | 0.0000 | |
| 139 | Y | A | 0.0000 | |
| 140 | D | A | -2.5328 | |
| 141 | L | A | 0.0000 | |
| 142 | Y | A | -1.0946 | |
| 143 | G | A | -1.2018 | |
| 144 | S | A | -1.1911 | |
| 145 | S | A | -0.6381 | |
| 146 | H | A | -0.4756 | |
| 147 | S | A | -0.3544 | |
| 148 | A | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | A | A | 0.0000 | |
| 151 | M | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | A | A | 0.0000 | |
| 154 | W | A | 0.0000 | |
| 155 | A | A | 0.0000 | |
| 156 | W | A | 0.0000 | |
| 157 | G | A | 0.0000 | |
| 158 | V | A | 0.0000 | |
| 159 | S | A | -0.7005 | |
| 160 | R | A | 0.0000 | |
| 161 | V | A | 0.0000 | |
| 162 | I | A | 0.0000 | |
| 163 | D | A | 0.0000 | |
| 164 | A | A | 0.0000 | |
| 165 | L | A | 0.0000 | |
| 166 | E | A | -1.1920 | |
| 167 | L | A | 0.6020 | |
| 168 | T | A | 0.0000 | |
| 169 | P | A | -0.6347 | |
| 170 | A | A | -0.3662 | |
| 171 | A | A | 0.0000 | |
| 172 | K | A | -1.0442 | |
| 173 | I | A | 0.0000 | |
| 174 | D | A | -1.0833 | |
| 175 | T | A | -1.0509 | |
| 176 | T | A | -0.6665 | |
| 177 | K | A | -0.5693 | |
| 178 | I | A | 0.0000 | |
| 179 | G | A | 0.0000 | |
| 180 | V | A | 0.0000 | |
| 181 | T | A | 0.0000 | |
| 182 | G | A | 0.0000 | |
| 183 | C | A | 0.0000 | |
| 184 | S | A | -0.5669 | |
| 185 | R | A | -0.8401 | |
| 186 | N | A | -0.8397 | |
| 187 | G | A | 0.0000 | |
| 188 | K | A | 0.0000 | |
| 189 | G | A | 0.0000 | |
| 190 | A | A | 0.0000 | |
| 191 | L | A | 0.0000 | |
| 192 | V | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | G | A | 0.0000 | |
| 195 | A | A | 0.0000 | |
| 196 | F | A | 0.0000 | |
| 197 | E | A | 0.0000 | |
| 198 | K | A | -1.9754 | |
| 199 | R | A | -1.4596 | |
| 200 | I | A | 0.0000 | |
| 201 | V | A | -0.3883 | |
| 202 | L | A | 0.0000 | |
| 203 | T | A | 0.0000 | |
| 204 | L | A | 0.0000 | |
| 205 | P | A | 0.0000 | |
| 206 | Q | A | 0.0000 | |
| 207 | E | A | 0.0000 | |
| 208 | S | A | 0.0000 | |
| 209 | G | A | 0.0000 | |
| 210 | M | A | 0.0000 | |
| 211 | G | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | S | A | 0.0000 | |
| 214 | A | A | 0.0000 | |
| 215 | C | A | 0.0000 | |
| 216 | W | A | 0.0000 | |
| 217 | R | A | 0.0000 | |
| 218 | I | A | 0.0000 | |
| 219 | S | A | 0.0000 | |
| 220 | D | A | -2.2508 | |
| 221 | Y | A | -0.9601 | |
| 222 | L | A | 0.0000 | |
| 223 | K | A | -2.1383 | |
| 224 | S | A | -1.6907 | |
| 225 | Q | A | -2.0747 | |
| 226 | G | A | -1.7165 | |
| 227 | K | A | -2.0765 | |
| 228 | N | A | -1.9941 | |
| 229 | I | A | 0.0000 | |
| 230 | Q | A | 0.0000 | |
| 231 | T | A | 0.0000 | |
| 232 | A | A | 0.0000 | |
| 233 | S | A | -1.4593 | |
| 234 | E | A | -1.0398 | |
| 235 | I | A | 0.0000 | |
| 236 | V | A | -0.4863 | |
| 237 | G | A | -0.7252 | |
| 238 | E | A | -0.7257 | |
| 239 | Y | A | -0.4111 | |
| 240 | P | A | 0.0000 | |
| 241 | W | A | 0.0000 | |
| 242 | F | A | 0.0000 | |
| 243 | S | A | 0.0000 | |
| 244 | T | A | -0.5925 | |
| 245 | T | A | -0.5717 | |
| 246 | F | A | 0.0000 | |
| 247 | N | A | -1.6579 | |
| 248 | S | A | -1.1177 | |
| 249 | Y | A | -0.9267 | |
| 250 | V | A | 0.0000 | |
| 251 | N | A | -2.1791 | |
| 252 | N | A | -1.7843 | |
| 253 | V | A | 0.0000 | |
| 254 | S | A | -0.9080 | |
| 255 | L | A | -0.2398 | |
| 256 | L | A | 0.0000 | |
| 257 | P | A | 0.1010 | |
| 258 | F | A | 0.0000 | |
| 259 | D | A | 0.0000 | |
| 260 | H | A | 0.0000 | |
| 261 | H | A | 0.0000 | |
| 262 | S | A | 0.0000 | |
| 263 | L | A | 0.0000 | |
| 264 | A | A | 0.0000 | |
| 265 | A | A | 0.0000 | |
| 266 | L | A | 0.0000 | |
| 267 | I | A | 0.0000 | |
| 268 | A | A | 0.0000 | |
| 269 | P | A | -0.4689 | |
| 270 | R | A | -0.5505 | |
| 271 | G | A | 0.0000 | |
| 272 | L | A | 0.0000 | |
| 273 | Y | A | 0.0000 | |
| 274 | V | A | 0.0000 | |
| 275 | I | A | 0.0000 | |
| 276 | D | A | 0.0000 | |
| 277 | N | A | 0.0000 | |
| 278 | D | A | -0.9779 | |
| 279 | I | A | -0.6177 | |
| 280 | D | A | -1.3091 | |
| 281 | W | A | -0.4417 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | 0.0000 | |
| 284 | P | A | 0.0000 | |
| 285 | E | A | -0.8711 | |
| 286 | S | A | 0.0000 | |
| 287 | C | A | 0.0000 | |
| 288 | T | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | C | A | 0.0000 | |
| 291 | M | A | 0.0000 | |
| 292 | Y | A | 0.2035 | |
| 293 | A | A | 0.0000 | |
| 294 | A | A | 0.0000 | |
| 295 | R | A | -0.5368 | |
| 296 | K | A | -0.6756 | |
| 297 | A | A | 0.0000 | |
| 298 | W | A | 0.0000 | |
| 299 | Q | A | -1.3450 | |
| 300 | A | A | 0.0000 | |
| 301 | L | A | 0.0000 | |
| 302 | G | A | -0.9003 | |
| 303 | V | A | -0.4283 | |
| 304 | P | A | -0.8506 | |
| 305 | D | A | -1.0764 | |
| 306 | N | A | -0.8655 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | Y | A | 0.0000 | |
| 310 | S | A | 0.0000 | |
| 311 | Q | A | 0.0000 | |
| 312 | I | A | 0.1059 | |
| 313 | G | A | -0.4697 | |
| 314 | S | A | -0.5419 | |
| 315 | H | A | -0.3345 | |
| 316 | A | A | -0.2986 | |
| 317 | H | A | -0.5538 | |
| 318 | C | A | -0.0828 | |
| 319 | A | A | 0.0095 | |
| 320 | F | A | 0.0743 | |
| 321 | P | A | -0.1111 | |
| 322 | S | A | -0.5254 | |
| 323 | S | A | -0.4033 | |
| 324 | Q | A | 0.0000 | |
| 325 | Q | A | -0.8333 | |
| 326 | S | A | -0.6656 | |
| 327 | N | A | -0.6432 | |
| 328 | L | A | 0.0000 | |
| 329 | T | A | -0.5249 | |
| 330 | A | A | -0.8716 | |
| 331 | F | A | 0.0000 | |
| 332 | V | A | 0.0000 | |
| 333 | N | A | -1.1254 | |
| 334 | K | A | -1.3375 | |
| 335 | F | A | 0.0000 | |
| 336 | L | A | 0.0000 | |
| 337 | L | A | -0.4989 | |
| 338 | G | A | -1.1452 | |
| 339 | Q | A | -1.7685 | |
| 340 | S | A | -1.2918 | |
| 341 | A | A | -1.3961 | |
| 342 | N | A | -1.6620 | |
| 343 | T | A | 0.0000 | |
| 344 | A | A | -0.4602 | |
| 345 | I | A | 0.0274 | |
| 346 | F | A | 0.4607 | |
| 347 | T | A | 0.0804 | |
| 348 | S | A | -0.6087 | |
| 349 | D | A | -1.5966 | |
| 350 | F | A | -0.6466 | |
| 351 | S | A | -0.5761 | |
| 352 | P | A | -0.5088 | |
| 353 | N | A | -0.6471 | |
| 354 | P | A | -0.7773 | |
| 355 | S | A | -0.9738 | |
| 356 | Q | A | -1.1076 | |
| 357 | W | A | 0.0000 | |
| 358 | I | A | -0.9895 | |
| 359 | D | A | -1.8854 | |
| 360 | W | A | -0.8301 | |
| 361 | T | A | -0.4455 | |
| 362 | T | A | -0.3786 | |
| 363 | P | A | -0.5546 | |
| 364 | T | A | -0.5978 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6327 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine