Project name: ec94f11b044629c

Chain sequence(s)	H: EVQLVESGGGLVQPGRSLRLSCTVAGFNFGDYAMSWVRQAPGKGLEWVGFIRSNTYGGATGYAASVKGRFTISRDDSRNIAYLQMNSLKTEDTALYYCSRVGKDFGDGLFDSWGQGTLVTVSS; L: SVLIQPASVSGSPGQSITISCTGTSSDVGNYNLFSWYQQKPGKVPKLIIYEGYKRPSGVSDRFSGSKSGNTASLTISGLQAEDEADYSCCLYAGRSLWVFGGGTKVTVL
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:53)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:54)

• Minimal score value: -2.897
• Maximal score value: 2.0326
• Average score: -0.6345
• Total score value: -147.2009

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.8984
2	V	H	-1.0645
3	Q	H	-1.0752
4	L	H	0.0000
5	V	H	0.4447
6	E	H	0.0000
7	S	H	-0.4949
8	G	H	-0.8082
9	G	H	-0.1723
10	G	H	0.6720
11	L	H	1.3202
12	V	H	0.0000
13	Q	H	-1.5066
14	P	H	-2.0356
15	G	H	-2.2464
16	R	H	-2.7436
17	S	H	-2.0725
18	L	H	-1.3254
19	R	H	-2.0423
20	L	H	0.0000
21	S	H	-0.5031
22	C	H	0.0000
23	T	H	-0.1926
24	V	H	0.0000
25	A	H	-0.7440
26	G	H	-1.2259
27	F	H	-1.1170
28	N	H	-1.8610
29	F	H	0.0000
30	G	H	-2.0706
31	D	H	-2.4360
32	Y	H	-1.5031
33	A	H	-0.8420
34	M	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.8604
40	A	H	-1.2252
41	P	H	-1.1171
42	G	H	-1.4952
43	K	H	-2.3593
44	G	H	-1.7753
45	L	H	0.0000
46	E	H	-1.2076
47	W	H	0.0000
48	V	H	0.0000
49	G	H	0.0000
50	F	H	0.0000
51	I	H	0.0000
52	R	H	-1.2295
52A	S	H	0.0000
52B	N	H	-1.7627
52C	T	H	-0.6291
53	Y	H	0.2767
54	G	H	-0.4583
55	G	H	-0.8265
56	A	H	-0.4363
57	T	H	-0.3132
58	G	H	-0.4133
59	Y	H	-0.3884
60	A	H	-0.4194
61	A	H	-0.5363
62	S	H	-0.9729
63	V	H	0.0000
64	K	H	-2.0325
65	G	H	-1.5608
66	R	H	-1.5693
67	F	H	0.0000
68	T	H	-0.8073
69	I	H	0.0000
70	S	H	-0.3561
71	R	H	-1.1685
72	D	H	-1.7241
73	D	H	-2.4315
74	S	H	-1.7675
75	R	H	-2.4996
76	N	H	-1.9079
77	I	H	-0.8981
78	A	H	0.0000
79	Y	H	-0.4419
80	L	H	0.0000
81	Q	H	-1.0704
82	M	H	0.0000
82A	N	H	-1.8048
82B	S	H	-1.8781
82C	L	H	0.0000
83	K	H	-2.8970
84	T	H	-1.9723
85	E	H	-2.4514
86	D	H	0.0000
87	T	H	-0.5889
88	A	H	0.0000
89	L	H	0.5168
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	S	H	0.0000
94	R	H	0.0000
95	V	H	-0.7665
96	G	H	0.0000
97	K	H	-2.7245
98	D	H	-2.3236
99	F	H	-0.9203
100	G	H	-1.3847
100A	D	H	-1.5892
100B	G	H	0.0000
100C	L	H	0.0000
100D	F	H	0.0000
101	D	H	-1.0401
102	S	H	-0.4404
103	W	H	0.0000
104	G	H	0.0000
105	Q	H	-1.2780
106	G	H	-0.1508
107	T	H	0.2578
108	L	H	1.1748
109	V	H	0.0000
110	T	H	0.2295
111	V	H	0.0000
112	S	H	-0.6496
113	S	H	-0.4289
2	S	L	0.6544
3	V	L	2.0326
4	L	L	0.0000
5	I	L	1.9819
6	Q	L	0.5132
7	P	L	-0.0838
8	A	L	-0.5007
9	S	L	-0.9825
11	V	L	-0.3903
12	S	L	-0.1195
13	G	L	0.0000
14	S	L	-0.1420
15	P	L	-0.7901
16	G	L	-1.4597
17	Q	L	-1.6296
18	S	L	-1.2065
19	I	L	0.0000
20	T	L	-0.1831
21	I	L	0.0000
22	S	L	0.0369
23	C	L	0.0000
24	T	L	0.5764
25	G	L	0.1941
26	T	L	-0.0738
27	S	L	-0.5516
27A	S	L	-0.6166
27B	D	L	-1.5119
27C	V	L	0.1874
28	G	L	-0.6037
29	N	L	-1.1606
30	Y	L	-0.1359
31	N	L	0.0000
32	L	L	0.0000
33	F	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-2.0244
39	K	L	-2.5575
40	P	L	-1.6559
41	G	L	-1.6359
42	K	L	-2.3573
43	V	L	-1.2040
44	P	L	0.0000
45	K	L	-1.3383
46	L	L	0.0000
47	I	L	0.0000
48	I	L	0.0000
49	Y	L	0.0000
50	E	L	-0.9427
51	G	L	0.0000
52	Y	L	0.1805
53	K	L	-0.7777
54	R	L	-1.0769
55	P	L	-0.6780
56	S	L	-0.5194
57	G	L	-0.7789
58	V	L	-0.8534
59	S	L	-1.2532
60	D	L	-2.2132
61	R	L	-1.5853
62	F	L	0.0000
63	S	L	-0.6116
64	G	L	-0.2476
65	S	L	-0.6361
66	K	L	-1.2084
67	S	L	-1.1612
68	G	L	-1.3107
69	N	L	-1.3954
70	T	L	-0.5845
71	A	L	0.0000
72	S	L	-0.3625
73	L	L	0.0000
74	T	L	-0.3584
75	I	L	0.0000
76	S	L	-1.2849
77	G	L	-1.4532
78	L	L	0.0000
79	Q	L	-1.6839
80	A	L	-1.2953
81	E	L	-2.3824
82	D	L	0.0000
83	E	L	-2.2572
84	A	L	0.0000
85	D	L	-2.6745
86	Y	L	0.0000
87	S	L	0.0000
88	C	L	0.0000
89	C	L	0.0000
90	L	L	0.0000
91	Y	L	-0.0173
92	A	L	-0.2135
93	G	L	-0.6430
94	R	L	-1.3322
95	S	L	-0.6361
95A	L	L	0.2902
96	W	L	0.0000
97	V	L	0.5605
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-0.6665
101	G	L	-1.1913
102	T	L	0.0000
103	K	L	-2.5563
104	V	L	0.0000
105	T	L	-0.8019
106	V	L	-0.0870
106A	L	L	1.2771