Project name: ee1a1fb60db0886

Chain sequence(s)	H: EVQLVESGGDLVQPGRSLRLSCVASGFTFDDYAMHWVRQAPGKGLEWVSGVSWSGSTVGYADSVKGRFTVSRDNAQKSLYLQMNSLRAEDTALYYCVKDAYKFNYYYYGLDVWGQGTTVTVSS; L: EIVMTQSPATLSVSPGERATLSCRASQTILSNLAWYLQKPGQAPRLLIYGASTRATGLPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:09)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:12)

• Minimal score value: -2.7257
• Maximal score value: 2.0666
• Average score: -0.4827
• Total score value: -111.0268

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.8051
2	V	H	-0.6520
3	Q	H	-0.5852
4	L	H	0.0000
5	V	H	1.0145
6	E	H	0.0000
7	S	H	-0.5011
8	G	H	-1.2564
9	G	H	-1.0291
11	D	H	-1.3362
12	L	H	0.5848
13	V	H	-0.5948
14	Q	H	-1.3945
15	P	H	-2.0945
16	G	H	-2.0926
17	R	H	-2.6755
18	S	H	-2.0230
19	L	H	-1.4453
20	R	H	-1.9241
21	L	H	0.0000
22	S	H	-0.1262
23	C	H	0.0000
24	V	H	1.0923
25	A	H	0.0000
26	S	H	-0.3490
27	G	H	-0.8740
28	F	H	-0.4475
29	T	H	-0.4300
30	F	H	0.0000
35	D	H	-0.9129
36	D	H	0.2283
37	Y	H	0.7195
38	A	H	0.0000
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8245
45	A	H	-1.2052
46	P	H	-0.9619
47	G	H	-1.4563
48	K	H	-2.2688
49	G	H	-1.3949
50	L	H	0.0000
51	E	H	-0.9307
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	G	H	0.0000
56	V	H	0.0000
57	S	H	0.0000
58	W	H	0.7547
59	S	H	-0.0805
62	G	H	-0.1977
63	S	H	-0.0490
64	T	H	0.3870
65	V	H	1.0795
66	G	H	0.1865
67	Y	H	-0.6549
68	A	H	-1.6094
69	D	H	-2.7257
70	S	H	-1.7544
71	V	H	0.0000
72	K	H	-2.6223
74	G	H	-1.7903
75	R	H	-1.6304
76	F	H	0.0000
77	T	H	-0.9315
78	V	H	0.0000
79	S	H	-0.3530
80	R	H	-1.0091
81	D	H	-1.5511
82	N	H	-1.5620
83	A	H	-1.2802
84	Q	H	-1.8206
85	K	H	-1.7227
86	S	H	0.0000
87	L	H	0.0000
88	Y	H	-0.3786
89	L	H	0.0000
90	Q	H	-1.5081
91	M	H	0.0000
92	N	H	-2.1784
93	S	H	-1.7760
94	L	H	0.0000
95	R	H	-2.4859
96	A	H	-1.6256
97	E	H	-2.2325
98	D	H	0.0000
99	T	H	-0.8020
100	A	H	0.0000
101	L	H	0.1075
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	V	H	0.0000
106	K	H	0.0000
107	D	H	0.0000
108	A	H	0.5232
109	Y	H	1.0257
110	K	H	0.5418
111	F	H	1.8615
111A	N	H	1.2579
112B	Y	H	2.0666
112A	Y	H	1.3342
112	Y	H	1.4059
113	Y	H	0.9725
114	G	H	0.0000
115	L	H	0.0000
116	D	H	-0.4153
117	V	H	-0.2389
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.2845
121	G	H	-0.5126
122	T	H	0.0000
123	T	H	-0.3731
124	V	H	0.0000
125	T	H	-0.3599
126	V	H	0.0000
127	S	H	-0.4761
128	S	H	-0.4778
1	E	L	-1.8761
2	I	L	0.0000
3	V	L	0.7434
4	M	L	0.0000
5	T	L	-0.6562
6	Q	L	-0.6989
7	S	L	-0.6615
8	P	L	-0.3677
9	A	L	-0.2659
10	T	L	-0.3373
11	L	L	-0.0673
12	S	L	-0.2147
13	V	L	-0.5250
14	S	L	-0.9211
15	P	L	-1.2988
16	G	L	-1.6028
17	E	L	-2.2976
18	R	L	-2.3172
19	A	L	0.0000
20	T	L	-0.6402
21	L	L	0.0000
22	S	L	-0.8624
23	C	L	0.0000
24	R	L	-2.2840
25	A	L	0.0000
26	S	L	-0.8215
27	Q	L	-1.0988
28	T	L	-0.6034
29	I	L	0.0000
36	L	L	0.9751
37	S	L	0.0879
38	N	L	0.0085
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	-0.3170
44	Q	L	0.0000
45	K	L	-1.2503
46	P	L	-1.0193
47	G	L	-1.4157
48	Q	L	-2.0115
49	A	L	-1.3024
50	P	L	0.0000
51	R	L	-1.3249
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.1060
56	G	L	-0.0693
57	A	L	0.0000
65	S	L	-0.6352
66	T	L	-0.6988
67	R	L	-1.2178
68	A	L	-0.7656
69	T	L	-0.5389
70	G	L	-0.5245
71	L	L	-0.2235
72	P	L	-0.3619
74	A	L	-0.3060
75	R	L	-0.7118
76	F	L	0.0000
77	S	L	-0.5306
78	G	L	0.0000
79	S	L	-0.6188
80	G	L	-0.8811
83	S	L	-0.5746
84	G	L	-0.4888
85	T	L	-1.3132
86	E	L	-1.9398
87	F	L	0.0000
88	T	L	-0.7762
89	L	L	0.0000
90	T	L	-0.5718
91	I	L	0.0000
92	S	L	-1.2703
93	S	L	-1.5898
94	L	L	0.0000
95	Q	L	-1.7937
96	S	L	-0.9962
97	E	L	-1.4830
98	D	L	0.0000
99	F	L	-0.0737
100	A	L	0.0000
101	V	L	-0.0084
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	N	L	-0.5603
109	N	L	-1.4782
114	W	L	-0.6842
115	P	L	-1.0316
116	L	L	0.0000
117	T	L	-0.2707
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.7461
121	G	L	-0.6363
122	T	L	0.0000
123	K	L	-0.3413
124	V	L	0.0000
125	E	L	-0.0418
126	I	L	0.8696
127	K	L	-0.8745