| Chain sequence(s) |
A: STTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVNIISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIASTYGEQTTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATIFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGIFPAKTIT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:39)
[INFO] Main: Simulation completed successfully. (00:04:42)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 4 | S | A | -0.2617 | |
| 5 | T | A | -0.3479 | |
| 6 | P | A | 0.0000 | |
| 7 | L | A | 0.0000 | |
| 8 | L | A | 0.0000 | |
| 9 | T | A | 0.0000 | |
| 10 | V | A | 0.0000 | |
| 11 | R | A | -0.9302 | |
| 12 | G | A | 0.0000 | |
| 13 | S | A | -1.2759 | |
| 14 | E | A | -1.3208 | |
| 15 | G | A | 0.0000 | |
| 16 | L | A | 0.0000 | |
| 17 | Y | A | 0.0000 | |
| 18 | M | A | 0.0000 | |
| 19 | V | A | 0.0000 | |
| 20 | N | A | -1.1296 | |
| 21 | G | A | 0.0000 | |
| 22 | P | A | 0.0000 | |
| 23 | P | A | -0.6161 | |
| 24 | H | A | -1.2950 | |
| 25 | F | A | -1.0511 | |
| 26 | T | A | -1.3223 | |
| 27 | E | A | -2.1295 | |
| 28 | S | A | 0.0000 | |
| 29 | T | A | -0.8070 | |
| 30 | V | A | -0.8801 | |
| 31 | F | A | 0.0000 | |
| 32 | P | A | -1.3303 | |
| 33 | R | A | -2.3663 | |
| 34 | E | A | -2.7020 | |
| 35 | S | A | -1.8832 | |
| 36 | G | A | 0.0000 | |
| 37 | K | A | -3.2963 | |
| 38 | N | A | -2.8974 | |
| 39 | C | A | 0.0000 | |
| 40 | K | A | -2.2731 | |
| 41 | V | A | -0.5221 | |
| 42 | C | A | 0.0000 | |
| 43 | I | A | 0.1717 | |
| 44 | F | A | 0.0000 | |
| 45 | S | A | 0.0000 | |
| 46 | K | A | -1.9161 | |
| 47 | D | A | -0.8340 | |
| 48 | G | A | 0.0000 | |
| 49 | T | A | -0.7343 | |
| 50 | L | A | 0.0000 | |
| 51 | F | A | 0.0000 | |
| 52 | A | A | 0.0000 | |
| 53 | W | A | 0.0000 | |
| 54 | G | A | 0.0000 | |
| 55 | N | A | -2.3755 | |
| 56 | G | A | -1.9105 | |
| 57 | E | A | -2.7669 | |
| 58 | K | A | -1.9110 | |
| 59 | V | A | 0.0000 | |
| 60 | N | A | 0.0000 | |
| 61 | I | A | 0.0000 | |
| 62 | I | A | 0.0000 | |
| 63 | S | A | 0.0000 | |
| 64 | V | A | 0.0000 | |
| 65 | T | A | -1.2278 | |
| 66 | N | A | -1.9188 | |
| 67 | K | A | -2.0152 | |
| 68 | G | A | -0.4584 | |
| 69 | L | A | 1.2361 | |
| 70 | L | A | 0.7132 | |
| 71 | H | A | 0.1492 | |
| 72 | S | A | -0.0922 | |
| 73 | F | A | -0.8405 | |
| 74 | D | A | -1.7237 | |
| 75 | L | A | -0.2501 | |
| 76 | L | A | -0.9452 | |
| 77 | K | A | -1.9887 | |
| 78 | A | A | 0.0000 | |
| 79 | V | A | -0.0394 | |
| 80 | C | A | 0.0766 | |
| 81 | L | A | 0.0000 | |
| 82 | E | A | -0.8733 | |
| 83 | F | A | 0.0000 | |
| 84 | S | A | 0.0000 | |
| 85 | P | A | -1.8881 | |
| 86 | K | A | -2.4952 | |
| 87 | N | A | -1.6744 | |
| 88 | T | A | -1.0176 | |
| 89 | V | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | A | A | 0.0000 | |
| 92 | T | A | 0.0000 | |
| 93 | W | A | 0.0000 | |
| 94 | Q | A | -0.6331 | |
| 95 | P | A | -0.6088 | |
| 96 | Y | A | -0.0897 | |
| 97 | T | A | 0.0137 | |
| 98 | T | A | 0.1462 | |
| 105 | G | A | 0.6182 | |
| 106 | I | A | 1.9356 | |
| 107 | P | A | 0.8464 | |
| 108 | N | A | 0.0000 | |
| 109 | L | A | 0.0000 | |
| 110 | Q | A | 0.3033 | |
| 111 | L | A | 0.0000 | |
| 112 | Y | A | 0.1708 | |
| 113 | D | A | 0.0000 | |
| 114 | V | A | 0.0000 | |
| 115 | K | A | -1.6782 | |
| 116 | T | A | -0.7274 | |
| 117 | G | A | -0.2969 | |
| 118 | T | A | 0.0295 | |
| 119 | C | A | 0.6621 | |
| 120 | L | A | 0.2213 | |
| 121 | K | A | -0.3238 | |
| 122 | S | A | 0.4434 | |
| 123 | F | A | 0.4752 | |
| 124 | I | A | 0.4962 | |
| 125 | Q | A | -1.1735 | |
| 126 | K | A | -2.2884 | |
| 127 | K | A | -2.7182 | |
| 128 | M | A | -1.2916 | |
| 129 | Q | A | -2.2077 | |
| 130 | N | A | -2.0361 | |
| 131 | W | A | -1.4108 | |
| 132 | C | A | -0.5624 | |
| 133 | P | A | 0.0000 | |
| 134 | S | A | -0.3168 | |
| 135 | W | A | 0.0000 | |
| 136 | S | A | 0.0000 | |
| 137 | E | A | -2.3066 | |
| 138 | D | A | -1.8660 | |
| 139 | E | A | 0.0000 | |
| 140 | T | A | -1.5288 | |
| 141 | L | A | 0.0000 | |
| 142 | C | A | 0.0000 | |
| 143 | A | A | 0.0000 | |
| 144 | R | A | 0.0000 | |
| 145 | N | A | -1.4704 | |
| 146 | V | A | -0.9620 | |
| 147 | N | A | -1.9739 | |
| 148 | N | A | -2.4059 | |
| 149 | E | A | -2.3222 | |
| 150 | V | A | 0.0000 | |
| 151 | H | A | -1.0007 | |
| 152 | F | A | 0.0000 | |
| 153 | F | A | 0.0000 | |
| 154 | E | A | -1.7036 | |
| 155 | N | A | -2.1498 | |
| 156 | N | A | -1.6992 | |
| 157 | N | A | -1.9744 | |
| 158 | F | A | 0.0000 | |
| 159 | N | A | -1.4019 | |
| 160 | T | A | -0.6101 | |
| 161 | I | A | -0.0208 | |
| 162 | A | A | -0.7132 | |
| 163 | N | A | -1.2789 | |
| 164 | K | A | -1.9834 | |
| 165 | L | A | 0.0000 | |
| 166 | H | A | -2.2424 | |
| 167 | L | A | -1.6225 | |
| 168 | Q | A | -2.4364 | |
| 169 | K | A | -3.1849 | |
| 170 | I | A | 0.0000 | |
| 171 | N | A | -2.3057 | |
| 172 | D | A | -1.3845 | |
| 173 | F | A | 0.0000 | |
| 174 | V | A | 0.4792 | |
| 175 | L | A | 0.1458 | |
| 176 | S | A | 0.0000 | |
| 177 | P | A | -1.4872 | |
| 178 | G | A | -1.7205 | |
| 179 | P | A | -1.7429 | |
| 180 | Q | A | -1.8002 | |
| 181 | P | A | -1.1889 | |
| 182 | Y | A | 0.0000 | |
| 183 | K | A | -0.6099 | |
| 184 | V | A | 0.0000 | |
| 185 | A | A | 0.0000 | |
| 186 | V | A | 0.0000 | |
| 187 | Y | A | 0.0000 | |
| 188 | V | A | 0.0000 | |
| 189 | P | A | -1.5675 | |
| 190 | G | A | -1.4262 | |
| 191 | S | A | -1.7961 | |
| 192 | K | A | -2.2078 | |
| 193 | G | A | -1.3097 | |
| 194 | A | A | -0.7900 | |
| 195 | P | A | -0.2349 | |
| 196 | S | A | 0.0000 | |
| 197 | F | A | -0.0855 | |
| 198 | V | A | 0.0000 | |
| 199 | R | A | -0.5833 | |
| 200 | L | A | 0.0000 | |
| 201 | Y | A | 0.0000 | |
| 202 | Q | A | -0.8130 | |
| 203 | Y | A | -0.8137 | |
| 204 | P | A | -1.0862 | |
| 205 | N | A | -1.4678 | |
| 206 | F | A | -1.0086 | |
| 207 | A | A | -0.7486 | |
| 208 | G | A | -1.0005 | |
| 209 | P | A | -0.9040 | |
| 210 | H | A | -1.2743 | |
| 211 | A | A | -0.8983 | |
| 212 | A | A | -0.6582 | |
| 213 | L | A | -0.7996 | |
| 214 | A | A | 0.0000 | |
| 215 | N | A | -1.2076 | |
| 216 | K | A | -0.7107 | |
| 217 | S | A | 0.0295 | |
| 218 | F | A | 0.0000 | |
| 219 | F | A | 1.3366 | |
| 220 | K | A | -0.9627 | |
| 221 | A | A | -1.5750 | |
| 222 | D | A | -2.8098 | |
| 223 | K | A | -2.6108 | |
| 224 | V | A | -1.2964 | |
| 225 | T | A | -0.1510 | |
| 226 | M | A | 0.0000 | |
| 227 | L | A | 0.4560 | |
| 228 | W | A | -0.2765 | |
| 229 | N | A | 0.0000 | |
| 230 | K | A | -2.5563 | |
| 231 | K | A | -2.6049 | |
| 232 | A | A | 0.0000 | |
| 233 | T | A | -1.0709 | |
| 234 | A | A | 0.0000 | |
| 235 | V | A | 0.0000 | |
| 236 | L | A | 0.0000 | |
| 237 | V | A | 0.0000 | |
| 238 | I | A | -0.0566 | |
| 239 | A | A | 0.0000 | |
| 240 | S | A | -1.6270 | |
| 241 | T | A | -1.7099 | |
| 251 | Y | A | 0.9931 | |
| 252 | G | A | -0.2653 | |
| 253 | E | A | -1.9156 | |
| 254 | Q | A | -1.3673 | |
| 255 | T | A | 0.0160 | |
| 256 | L | A | 0.0000 | |
| 257 | H | A | 0.0000 | |
| 258 | Y | A | 0.0000 | |
| 259 | I | A | 0.0000 | |
| 260 | A | A | 0.0000 | |
| 261 | T | A | -1.1511 | |
| 262 | N | A | -1.8770 | |
| 263 | G | A | -1.9108 | |
| 264 | E | A | -2.6558 | |
| 265 | S | A | -1.2179 | |
| 266 | A | A | 0.0421 | |
| 267 | V | A | 1.4561 | |
| 268 | V | A | 0.0000 | |
| 269 | Q | A | -1.0537 | |
| 270 | L | A | -0.9009 | |
| 271 | P | A | -1.0495 | |
| 272 | K | A | -1.0609 | |
| 273 | N | A | -1.4049 | |
| 274 | G | A | -0.3989 | |
| 275 | P | A | 0.0000 | |
| 276 | I | A | 0.0000 | |
| 277 | Y | A | 0.0938 | |
| 278 | D | A | -0.2981 | |
| 279 | V | A | 0.0000 | |
| 280 | V | A | 0.2854 | |
| 281 | W | A | 0.0000 | |
| 282 | N | A | 0.0000 | |
| 283 | S | A | -1.2084 | |
| 284 | S | A | -1.0243 | |
| 285 | S | A | 0.0000 | |
| 286 | T | A | -0.8484 | |
| 287 | E | A | -0.6502 | |
| 288 | F | A | 0.0000 | |
| 289 | C | A | 0.0000 | |
| 290 | A | A | 0.0000 | |
| 291 | V | A | 0.0000 | |
| 292 | Y | A | 0.0000 | |
| 293 | G | A | 0.0000 | |
| 294 | F | A | 1.5802 | |
| 295 | M | A | 1.0697 | |
| 296 | P | A | 0.3814 | |
| 297 | A | A | 0.0000 | |
| 298 | K | A | -0.4795 | |
| 299 | A | A | 0.0000 | |
| 300 | T | A | 0.0000 | |
| 301 | I | A | 0.0000 | |
| 302 | F | A | 0.0000 | |
| 303 | N | A | -1.0065 | |
| 304 | L | A | -0.8125 | |
| 305 | K | A | -2.2929 | |
| 306 | C | A | -1.4346 | |
| 307 | D | A | -2.3010 | |
| 308 | P | A | -1.1163 | |
| 309 | V | A | 0.0950 | |
| 310 | F | A | 0.1543 | |
| 311 | D | A | -0.6515 | |
| 312 | F | A | 0.0000 | |
| 313 | G | A | -0.5849 | |
| 314 | T | A | -0.4172 | |
| 315 | G | A | 0.0000 | |
| 316 | P | A | -0.5523 | |
| 317 | R | A | 0.0000 | |
| 318 | N | A | -0.2405 | |
| 319 | A | A | 0.0000 | |
| 320 | A | A | 0.0000 | |
| 321 | Y | A | 0.2583 | |
| 322 | Y | A | 0.0000 | |
| 323 | S | A | 0.0000 | |
| 324 | P | A | -0.5327 | |
| 325 | H | A | -0.9286 | |
| 326 | G | A | -0.5312 | |
| 327 | H | A | -1.0118 | |
| 328 | I | A | 0.0000 | |
| 329 | L | A | 0.0000 | |
| 330 | V | A | 0.0000 | |
| 331 | L | A | 0.0000 | |
| 332 | A | A | 0.0000 | |
| 333 | G | A | 0.0000 | |
| 334 | F | A | -0.9747 | |
| 335 | G | A | -1.6192 | |
| 336 | N | A | -1.9299 | |
| 337 | L | A | -1.6573 | |
| 338 | R | A | -2.3353 | |
| 339 | G | A | 0.0000 | |
| 340 | Q | A | -0.8737 | |
| 341 | M | A | 0.0000 | |
| 342 | E | A | 0.0000 | |
| 343 | V | A | 0.0000 | |
| 344 | W | A | -0.4849 | |
| 345 | D | A | 0.0000 | |
| 346 | V | A | 0.0000 | |
| 347 | K | A | -2.4536 | |
| 348 | N | A | -2.2882 | |
| 349 | Y | A | -1.3654 | |
| 350 | K | A | -1.5437 | |
| 351 | L | A | -0.2324 | |
| 352 | I | A | 0.0536 | |
| 353 | S | A | -0.5358 | |
| 354 | K | A | -1.1828 | |
| 355 | P | A | -0.3998 | |
| 356 | V | A | -0.2933 | |
| 357 | A | A | 0.0000 | |
| 358 | S | A | -1.3114 | |
| 359 | D | A | -1.8451 | |
| 360 | S | A | 0.0000 | |
| 361 | T | A | -0.5065 | |
| 362 | Y | A | 0.2244 | |
| 363 | F | A | 0.0000 | |
| 364 | A | A | 0.1866 | |
| 365 | W | A | 0.0000 | |
| 366 | C | A | 0.0000 | |
| 367 | P | A | -0.0487 | |
| 368 | D | A | -0.4118 | |
| 369 | G | A | 0.0000 | |
| 370 | E | A | -0.6545 | |
| 371 | H | A | 0.0000 | |
| 372 | I | A | 0.0000 | |
| 373 | L | A | 0.0000 | |
| 374 | T | A | 0.0000 | |
| 375 | A | A | 0.0000 | |
| 376 | T | A | 0.0000 | |
| 377 | C | A | 0.0000 | |
| 378 | A | A | 0.0000 | |
| 379 | P | A | -1.2792 | |
| 380 | R | A | -2.0515 | |
| 381 | L | A | -1.3997 | |
| 382 | R | A | -1.5914 | |
| 383 | V | A | -0.0731 | |
| 384 | N | A | -1.4786 | |
| 385 | N | A | 0.0000 | |
| 386 | G | A | -1.3021 | |
| 387 | Y | A | 0.0000 | |
| 388 | K | A | -1.1261 | |
| 389 | I | A | 0.0000 | |
| 390 | W | A | 0.0000 | |
| 391 | H | A | 0.0317 | |
| 392 | Y | A | 0.0000 | |
| 393 | T | A | -0.1541 | |
| 394 | G | A | -0.1138 | |
| 395 | S | A | 0.3121 | |
| 396 | I | A | 0.6520 | |
| 397 | L | A | 0.5072 | |
| 398 | H | A | -0.5755 | |
| 399 | K | A | -1.8656 | |
| 400 | Y | A | -1.5386 | |
| 401 | D | A | -2.4823 | |
| 402 | V | A | 0.0000 | |
| 403 | P | A | -1.3641 | |
| 404 | S | A | -1.3017 | |
| 405 | N | A | -1.5538 | |
| 406 | A | A | -1.2308 | |
| 407 | E | A | -1.1640 | |
| 408 | L | A | 0.0000 | |
| 409 | W | A | -0.5299 | |
| 410 | Q | A | -0.2389 | |
| 411 | V | A | 0.0000 | |
| 412 | S | A | 0.0245 | |
| 413 | W | A | 0.0000 | |
| 414 | Q | A | 0.0000 | |
| 415 | P | A | -0.3172 | |
| 416 | F | A | 0.3027 | |
| 417 | L | A | 0.2806 | |
| 418 | D | A | -1.1475 | |
| 419 | G | A | -0.2006 | |
| 420 | I | A | 1.3378 | |
| 421 | F | A | 0.3230 | |
| 422 | P | A | -0.5163 | |
| 423 | A | A | -0.6744 | |
| 424 | K | A | -1.4170 | |
| 425 | T | A | -0.8586 | |
| 426 | I | A | -0.5328 | |
| 427 | T | A | -0.1466 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine