| Chain sequence(s) |
A: GPLALNPGPELRSTDEYVTPTDLLYYAETDLIEEVGHPTKDIVVDGKVVVPRVSAYDFLVFLLKLPDPNEMPLPSEDFVDFSTEILIWRLRAFKIEVGGPLGKGTYGHKNFNALGDVDNPTEPLHETADDTVDLSWTPKLKQLYIVGDLPPLGKYTAPAPPEPGLPPGAVPPLKEVKTIIQHGDRADIGFGAKDYAALEPEKNRVPDIIRDTTTKVIDYEGMKADPYGRRMFTHNEKESSKNSKNLRLSGPDPLPLPSGLPPPLLYTPPPPTSPYATLPSTRYFSLPDSGEITEADLLFNKPVFLEKTEGLNNGILWGNRLYITVLDNSRAEIETIKTQISTPEKNVYDPKNYVTSERYKREYKLSLIVQLCKIPLTPETLAYLESLDPTILINAKLPDIPPVERPDPLAGLKFIEIDLTDKLSSDLEKSELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.1649 | |
| 2 | P | A | 0.5128 | |
| 3 | L | A | 1.6018 | |
| 4 | A | A | 0.9637 | |
| 5 | L | A | 1.2295 | |
| 6 | N | A | -0.5525 | |
| 7 | P | A | -1.0176 | |
| 8 | G | A | -1.1622 | |
| 9 | P | A | -1.4039 | |
| 10 | E | A | -1.7967 | |
| 11 | L | A | -0.2594 | |
| 12 | R | A | -1.1434 | |
| 13 | S | A | -1.2675 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.9259 | |
| 16 | E | A | -2.7915 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9407 | |
| 20 | P | A | -0.9181 | |
| 21 | T | A | -0.8739 | |
| 22 | D | A | -1.5951 | |
| 23 | L | A | -0.4780 | |
| 24 | L | A | -0.1731 | |
| 25 | Y | A | -0.1763 | |
| 26 | Y | A | -0.9481 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.6037 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.4710 | |
| 31 | L | A | -0.0133 | |
| 32 | I | A | -0.4701 | |
| 33 | E | A | -1.3242 | |
| 34 | E | A | -0.7209 | |
| 35 | V | A | 0.1839 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.3108 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5723 | |
| 40 | K | A | -2.1302 | |
| 41 | D | A | -0.8216 | |
| 42 | I | A | 1.2949 | |
| 43 | V | A | 2.2369 | |
| 44 | V | A | 1.5923 | |
| 45 | D | A | -0.9642 | |
| 46 | G | A | -0.5558 | |
| 47 | K | A | -0.2020 | |
| 48 | V | A | 1.9515 | |
| 49 | V | A | 2.5297 | |
| 50 | V | A | 1.3599 | |
| 51 | P | A | 0.0535 | |
| 52 | R | A | -1.0770 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | L | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0879 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.6600 | |
| 67 | D | A | -1.3942 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3405 | |
| 70 | E | A | -1.9909 | |
| 71 | M | A | -0.9281 | |
| 72 | P | A | -0.6716 | |
| 73 | L | A | -0.6447 | |
| 74 | P | A | -0.6491 | |
| 75 | S | A | -1.5166 | |
| 76 | E | A | -2.8640 | |
| 77 | D | A | -2.8111 | |
| 78 | F | A | -1.4295 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -1.9673 | |
| 81 | F | A | -0.3003 | |
| 82 | S | A | -0.4076 | |
| 83 | T | A | -0.5416 | |
| 84 | E | A | -0.7164 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3471 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6612 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -1.1135 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.8417 | |
| 99 | G | A | -0.9903 | |
| 100 | P | A | -0.6452 | |
| 101 | L | A | -0.5049 | |
| 102 | G | A | -0.9977 | |
| 103 | K | A | -1.6045 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5951 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.4341 | |
| 108 | H | A | 0.0000 | |
| 109 | K | A | -3.1330 | |
| 110 | N | A | -2.9819 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.4453 | |
| 115 | G | A | -1.0095 | |
| 116 | D | A | -1.8094 | |
| 117 | V | A | -1.5622 | |
| 118 | D | A | -2.8279 | |
| 119 | N | A | -2.7551 | |
| 120 | P | A | -1.9524 | |
| 121 | T | A | -1.6558 | |
| 122 | E | A | -2.0834 | |
| 123 | P | A | -0.5736 | |
| 124 | L | A | -0.5263 | |
| 125 | H | A | -1.0061 | |
| 126 | E | A | -1.6362 | |
| 127 | T | A | -1.4001 | |
| 128 | A | A | -1.1497 | |
| 129 | D | A | -2.1026 | |
| 130 | D | A | -1.4272 | |
| 131 | T | A | -1.3633 | |
| 132 | V | A | -1.0917 | |
| 133 | D | A | -2.5099 | |
| 134 | L | A | -1.2849 | |
| 135 | S | A | -0.8575 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.4423 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.0280 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.2392 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -1.0950 | |
| 155 | Y | A | -1.1294 | |
| 156 | T | A | -0.9955 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | 0.0196 | |
| 159 | A | A | -0.5809 | |
| 160 | P | A | -0.8141 | |
| 161 | P | A | -0.9347 | |
| 162 | E | A | -2.0634 | |
| 163 | P | A | -1.2496 | |
| 164 | G | A | -0.7394 | |
| 165 | L | A | 0.1182 | |
| 166 | P | A | 0.0162 | |
| 167 | P | A | -0.2035 | |
| 168 | G | A | -0.0708 | |
| 169 | A | A | 0.8145 | |
| 170 | V | A | 1.8480 | |
| 171 | P | A | 0.6874 | |
| 172 | P | A | 0.4291 | |
| 173 | L | A | 0.6943 | |
| 174 | K | A | -1.4520 | |
| 175 | E | A | -2.3791 | |
| 176 | V | A | -1.6983 | |
| 177 | K | A | -2.0563 | |
| 178 | T | A | -0.8411 | |
| 179 | I | A | -0.1607 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.6886 | |
| 182 | H | A | -0.7423 | |
| 183 | G | A | -0.6851 | |
| 184 | D | A | -0.5845 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5333 | |
| 190 | F | A | 0.0387 | |
| 191 | G | A | -0.1589 | |
| 192 | A | A | -0.3601 | |
| 193 | K | A | -0.5475 | |
| 194 | D | A | -0.6739 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.2196 | |
| 197 | A | A | -0.5190 | |
| 198 | L | A | -0.1001 | |
| 199 | E | A | -1.4164 | |
| 200 | P | A | -1.5463 | |
| 201 | E | A | -2.0843 | |
| 202 | K | A | -2.7941 | |
| 203 | N | A | -2.1607 | |
| 204 | R | A | -1.4240 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -2.4972 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.3984 | |
| 211 | D | A | -2.1463 | |
| 212 | T | A | -1.1556 | |
| 213 | T | A | -0.6328 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1004 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.2399 | |
| 220 | E | A | -2.3599 | |
| 221 | G | A | -1.7722 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.7772 | |
| 224 | A | A | -1.5546 | |
| 225 | D | A | -1.3589 | |
| 226 | P | A | -0.6195 | |
| 227 | Y | A | -0.2449 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | -0.5941 | |
| 230 | R | A | -0.4639 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.9272 | |
| 234 | H | A | -0.8383 | |
| 235 | N | A | -1.1882 | |
| 236 | E | A | -1.7326 | |
| 237 | K | A | -2.2851 | |
| 238 | E | A | -2.2851 | |
| 239 | S | A | -1.8296 | |
| 240 | S | A | -2.1122 | |
| 241 | K | A | -2.9601 | |
| 242 | N | A | -2.6712 | |
| 243 | S | A | -1.9771 | |
| 244 | K | A | -2.3401 | |
| 245 | N | A | -1.5540 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.1420 | |
| 248 | L | A | 0.0000 | |
| 249 | S | A | -0.8802 | |
| 250 | G | A | -0.8624 | |
| 251 | P | A | -0.9672 | |
| 252 | D | A | -0.9998 | |
| 253 | P | A | 0.0828 | |
| 254 | L | A | 1.1773 | |
| 255 | P | A | 0.7697 | |
| 256 | L | A | 1.6805 | |
| 257 | P | A | 0.8256 | |
| 258 | S | A | 0.1774 | |
| 259 | G | A | 0.2594 | |
| 260 | L | A | 1.4450 | |
| 261 | P | A | 0.6656 | |
| 262 | P | A | 0.8147 | |
| 263 | P | A | 1.2953 | |
| 264 | L | A | 2.4525 | |
| 265 | L | A | 2.6593 | |
| 266 | Y | A | 2.0608 | |
| 267 | T | A | 0.8078 | |
| 268 | P | A | 0.4660 | |
| 269 | P | A | 0.0824 | |
| 270 | P | A | -0.3395 | |
| 271 | P | A | -0.3107 | |
| 272 | T | A | -0.1617 | |
| 273 | S | A | 0.0689 | |
| 274 | P | A | 0.1329 | |
| 275 | Y | A | 1.1648 | |
| 276 | A | A | 0.6133 | |
| 277 | T | A | 0.7261 | |
| 278 | L | A | 1.5289 | |
| 279 | P | A | 0.1808 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.0082 | |
| 282 | R | A | -0.0649 | |
| 283 | Y | A | 1.0519 | |
| 284 | F | A | 0.3410 | |
| 285 | S | A | -0.7472 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.9178 | |
| 289 | S | A | 0.0000 | |
| 290 | G | A | -1.8318 | |
| 291 | E | A | -2.2449 | |
| 292 | I | A | -1.3897 | |
| 293 | T | A | -1.6129 | |
| 294 | E | A | -2.1613 | |
| 295 | A | A | -1.5644 | |
| 296 | D | A | -2.3703 | |
| 297 | L | A | 0.0000 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6650 | |
| 301 | K | A | -1.9804 | |
| 302 | P | A | -1.0680 | |
| 303 | V | A | -0.2252 | |
| 304 | F | A | -0.5583 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5805 | |
| 307 | K | A | -3.1168 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.3731 | |
| 310 | G | A | -1.4179 | |
| 311 | L | A | -0.6910 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -0.9166 | |
| 319 | N | A | -1.0797 | |
| 320 | R | A | -1.1648 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.9671 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.5467 | |
| 333 | I | A | -1.7430 | |
| 334 | E | A | -2.0026 | |
| 335 | T | A | -1.0131 | |
| 336 | I | A | 0.0615 | |
| 337 | K | A | -0.9736 | |
| 338 | T | A | -0.1400 | |
| 339 | Q | A | -0.4096 | |
| 340 | I | A | 1.3158 | |
| 341 | S | A | 0.1996 | |
| 342 | T | A | -0.5636 | |
| 343 | P | A | -1.3123 | |
| 344 | E | A | -2.3596 | |
| 345 | K | A | -2.4871 | |
| 346 | N | A | -1.4663 | |
| 347 | V | A | 0.4719 | |
| 348 | Y | A | 0.6671 | |
| 349 | D | A | -0.6359 | |
| 350 | P | A | -0.9379 | |
| 351 | K | A | -1.4276 | |
| 352 | N | A | -0.7809 | |
| 353 | Y | A | -0.0197 | |
| 354 | V | A | 0.7177 | |
| 355 | T | A | -0.3971 | |
| 356 | S | A | -0.4368 | |
| 357 | E | A | -1.2436 | |
| 358 | R | A | -1.1489 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -1.4199 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.9000 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -1.1252 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -1.0201 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3799 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5957 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.5196 | |
| 376 | L | A | -0.1675 | |
| 377 | T | A | -0.6343 | |
| 378 | P | A | -0.9634 | |
| 379 | E | A | -1.7783 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.4787 | |
| 382 | A | A | -0.8215 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -1.0310 | |
| 386 | S | A | -0.6993 | |
| 387 | L | A | -0.2655 | |
| 388 | D | A | -0.5822 | |
| 389 | P | A | -0.6720 | |
| 390 | T | A | -1.0025 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | I | A | -1.0407 | |
| 394 | N | A | -1.7690 | |
| 395 | A | A | -1.3575 | |
| 396 | K | A | -2.2588 | |
| 397 | L | A | -1.2013 | |
| 398 | P | A | -1.2715 | |
| 399 | D | A | -1.9081 | |
| 400 | I | A | -0.6035 | |
| 401 | P | A | -0.4813 | |
| 402 | P | A | -0.7333 | |
| 403 | V | A | 0.1970 | |
| 404 | E | A | -2.0307 | |
| 405 | R | A | -2.1353 | |
| 406 | P | A | -1.6070 | |
| 407 | D | A | -1.6347 | |
| 408 | P | A | -0.8889 | |
| 409 | L | A | 0.0000 | |
| 410 | A | A | -0.6893 | |
| 411 | G | A | -0.7805 | |
| 412 | L | A | -0.6856 | |
| 413 | K | A | -1.8486 | |
| 414 | F | A | -1.0831 | |
| 415 | I | A | -1.0446 | |
| 416 | E | A | -2.2830 | |
| 417 | I | A | -1.8723 | |
| 418 | D | A | -2.9355 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0712 | |
| 421 | D | A | -2.8881 | |
| 422 | K | A | -2.7895 | |
| 423 | L | A | -1.2647 | |
| 424 | S | A | -1.1211 | |
| 425 | S | A | -0.7664 | |
| 426 | D | A | -1.9468 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.4934 | |
| 429 | K | A | -3.4134 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.7622 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.1964 | |
| 435 | E | A | -2.1220 | |
| 436 | Y | A | -1.1830 | |
| 437 | L | A | -0.7189 | |
| 438 | N | A | -1.9963 | |
| 439 | R | A | -2.2243 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine