| Chain sequence(s) |
A: EAAAKEVIDKINARAAYETAGTYVRLAAYITELVELRYGPGPGEDHEFVPLEVYTRQEGPGPGRNQLHALRFADIDTVGPGPGHKARKKGTSALLSAKGPGPGAPYKFKATMYYKDVTGPGPGPSLSIRAHTVLEGEPGPGPGRNGFSATSTLTSEARKKGYRDGAHAEHTAYAADRFRQVDGYYERDLSTGRRASTPKKLLREQERRPGDAAATPKPSADPPDVERIKTTKKRQEIKDSGLLDKKERTEHKARKKGTSALLSAKKMVMRKRAKPRYSPLGDTDEKKRPSLSIRAHTVLEGEPKKHRDSVSFSRRNEAAAKMLSKDIIKLLNEQVNKEMNSSNLYMSMSSWCYTHSLDGAGLFLFDHAAEEYEHAKKLIIFLNENNVPVQLTSISAPEHKFEGLTQIFQKAYEHEQHISESINNIVDHAIKSKDHATFNFLQWYVAEQHEEEVLFKDILDKIELIGNENHGLYLADQYVKGIAKSRKS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:10:42)
[INFO] Main: Simulation completed successfully. (00:10:45)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -2.3403 | |
| 2 | A | A | -1.5865 | |
| 3 | A | A | -1.1690 | |
| 4 | A | A | -1.4902 | |
| 5 | K | A | -2.5863 | |
| 6 | E | A | -2.3426 | |
| 7 | V | A | -0.1691 | |
| 8 | I | A | -0.6295 | |
| 9 | D | A | -1.9943 | |
| 10 | K | A | -1.8812 | |
| 11 | I | A | -0.0956 | |
| 12 | N | A | -0.8452 | |
| 13 | A | A | -1.2273 | |
| 14 | R | A | -1.8369 | |
| 15 | A | A | -1.1369 | |
| 16 | A | A | 0.0000 | |
| 17 | Y | A | -0.2774 | |
| 18 | E | A | -1.8695 | |
| 19 | T | A | 0.0000 | |
| 20 | A | A | 0.0000 | |
| 21 | G | A | -0.5576 | |
| 22 | T | A | -0.6501 | |
| 23 | Y | A | 0.0000 | |
| 24 | V | A | 0.7123 | |
| 25 | R | A | -0.9182 | |
| 26 | L | A | -0.3657 | |
| 27 | A | A | 0.0265 | |
| 28 | A | A | -0.1923 | |
| 29 | Y | A | -0.1300 | |
| 30 | I | A | -0.1513 | |
| 31 | T | A | -0.4207 | |
| 32 | E | A | -0.9947 | |
| 33 | L | A | -0.0035 | |
| 34 | V | A | -0.1511 | |
| 35 | E | A | -0.6327 | |
| 36 | L | A | 0.3209 | |
| 37 | R | A | 0.0000 | |
| 38 | Y | A | -0.3405 | |
| 39 | G | A | -0.1935 | |
| 40 | P | A | -1.2376 | |
| 41 | G | A | -1.9185 | |
| 42 | P | A | -1.6401 | |
| 43 | G | A | -1.9238 | |
| 44 | E | A | -3.3635 | |
| 45 | D | A | -3.4040 | |
| 46 | H | A | -2.5164 | |
| 47 | E | A | -2.1698 | |
| 48 | F | A | -0.0074 | |
| 49 | V | A | 0.3822 | |
| 50 | P | A | 0.3559 | |
| 51 | L | A | 0.4581 | |
| 52 | E | A | -0.7998 | |
| 53 | V | A | 0.4681 | |
| 54 | Y | A | -0.1375 | |
| 55 | T | A | -0.8497 | |
| 56 | R | A | -2.8012 | |
| 57 | Q | A | -3.0218 | |
| 58 | E | A | -2.9540 | |
| 59 | G | A | -1.8449 | |
| 60 | P | A | -1.1175 | |
| 61 | G | A | -1.2949 | |
| 62 | P | A | -1.4198 | |
| 63 | G | A | 0.0000 | |
| 64 | R | A | -1.2926 | |
| 65 | N | A | 0.0000 | |
| 66 | Q | A | -1.7719 | |
| 67 | L | A | -1.2807 | |
| 68 | H | A | 0.0000 | |
| 69 | A | A | 0.0000 | |
| 70 | L | A | 0.0000 | |
| 71 | R | A | -0.3125 | |
| 72 | F | A | 0.0000 | |
| 73 | A | A | 0.0000 | |
| 74 | D | A | 0.0000 | |
| 75 | I | A | 0.0000 | |
| 76 | D | A | -0.8624 | |
| 77 | T | A | 0.0000 | |
| 78 | V | A | -0.5288 | |
| 79 | G | A | 0.0000 | |
| 80 | P | A | -0.6146 | |
| 81 | G | A | 0.0000 | |
| 82 | P | A | -0.9500 | |
| 83 | G | A | -1.3848 | |
| 84 | H | A | -1.5061 | |
| 85 | K | A | -2.3035 | |
| 86 | A | A | 0.0000 | |
| 87 | R | A | -2.6887 | |
| 88 | K | A | -1.9768 | |
| 89 | K | A | -2.3774 | |
| 90 | G | A | -1.5963 | |
| 91 | T | A | -1.0147 | |
| 92 | S | A | 0.0000 | |
| 93 | A | A | 0.0000 | |
| 94 | L | A | -0.9563 | |
| 95 | L | A | -0.8549 | |
| 96 | S | A | -1.3872 | |
| 97 | A | A | -1.3048 | |
| 98 | K | A | -1.6397 | |
| 99 | G | A | -0.9565 | |
| 100 | P | A | -0.8124 | |
| 101 | G | A | -0.8476 | |
| 102 | P | A | -0.7989 | |
| 103 | G | A | -0.6784 | |
| 104 | A | A | 0.0000 | |
| 105 | P | A | -1.2367 | |
| 106 | Y | A | 0.0000 | |
| 107 | K | A | -2.1861 | |
| 108 | F | A | 0.0000 | |
| 109 | K | A | -1.3620 | |
| 110 | A | A | 0.0000 | |
| 111 | T | A | 0.0000 | |
| 112 | M | A | 0.0000 | |
| 113 | Y | A | -0.3974 | |
| 114 | Y | A | 0.0000 | |
| 115 | K | A | -2.1015 | |
| 116 | D | A | -1.7111 | |
| 117 | V | A | -0.6328 | |
| 118 | T | A | -0.7491 | |
| 119 | G | A | -0.7869 | |
| 120 | P | A | -0.7809 | |
| 121 | G | A | -0.9171 | |
| 122 | P | A | -0.9072 | |
| 123 | G | A | -0.5833 | |
| 124 | P | A | -0.6763 | |
| 125 | S | A | -0.4957 | |
| 126 | L | A | -0.5180 | |
| 127 | S | A | -1.1244 | |
| 128 | I | A | 0.0000 | |
| 129 | R | A | -1.1226 | |
| 130 | A | A | 0.0000 | |
| 131 | H | A | -0.3898 | |
| 132 | T | A | 0.0000 | |
| 133 | V | A | -0.5233 | |
| 134 | L | A | -1.2245 | |
| 135 | E | A | -2.6385 | |
| 136 | G | A | -2.4439 | |
| 137 | E | A | -2.8846 | |
| 138 | P | A | -1.9325 | |
| 139 | G | A | -1.3580 | |
| 140 | P | A | -1.1517 | |
| 141 | G | A | -1.0681 | |
| 142 | P | A | -1.3648 | |
| 143 | G | A | -1.0815 | |
| 144 | R | A | -1.1204 | |
| 145 | N | A | -1.0302 | |
| 146 | G | A | 0.0000 | |
| 147 | F | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | A | A | 0.0000 | |
| 150 | T | A | -0.5828 | |
| 151 | S | A | 0.0000 | |
| 152 | T | A | -0.3074 | |
| 153 | L | A | 0.0000 | |
| 154 | T | A | -1.1813 | |
| 155 | S | A | -2.0274 | |
| 156 | E | A | -3.2957 | |
| 157 | A | A | 0.0000 | |
| 158 | R | A | -2.9591 | |
| 159 | K | A | -3.7277 | |
| 160 | K | A | -3.4577 | |
| 161 | G | A | -2.2890 | |
| 162 | Y | A | -1.3148 | |
| 163 | R | A | -1.2009 | |
| 164 | D | A | 0.0000 | |
| 165 | G | A | 0.0000 | |
| 166 | A | A | -0.1912 | |
| 167 | H | A | 0.0000 | |
| 168 | A | A | 0.0000 | |
| 169 | E | A | -0.2760 | |
| 170 | H | A | -0.3957 | |
| 171 | T | A | 0.0000 | |
| 172 | A | A | 0.0000 | |
| 173 | Y | A | 0.4234 | |
| 174 | A | A | 0.0000 | |
| 175 | A | A | 0.0000 | |
| 176 | D | A | 0.0000 | |
| 177 | R | A | -0.5534 | |
| 178 | F | A | 0.0000 | |
| 179 | R | A | 0.0000 | |
| 180 | Q | A | -0.6353 | |
| 181 | V | A | 0.5700 | |
| 182 | D | A | -0.4430 | |
| 183 | G | A | -0.6012 | |
| 184 | Y | A | -0.2752 | |
| 185 | Y | A | -0.6378 | |
| 186 | E | A | -1.6160 | |
| 187 | R | A | -2.7678 | |
| 188 | D | A | -3.0281 | |
| 189 | L | A | -1.6483 | |
| 190 | S | A | -1.0586 | |
| 191 | T | A | -1.4544 | |
| 192 | G | A | -2.2492 | |
| 193 | R | A | -3.5153 | |
| 194 | R | A | -3.4574 | |
| 195 | A | A | -2.0107 | |
| 196 | S | A | -1.3497 | |
| 197 | T | A | 0.0000 | |
| 198 | P | A | -0.4908 | |
| 199 | K | A | -0.6576 | |
| 200 | K | A | -1.3800 | |
| 201 | L | A | -0.5282 | |
| 202 | L | A | -0.8384 | |
| 203 | R | A | -1.7499 | |
| 204 | E | A | -3.0662 | |
| 205 | Q | A | -2.6877 | |
| 206 | E | A | -2.8520 | |
| 207 | R | A | -3.7565 | |
| 208 | R | A | -3.6105 | |
| 209 | P | A | -2.2098 | |
| 210 | G | A | -1.5763 | |
| 211 | D | A | -1.5954 | |
| 212 | A | A | -1.1293 | |
| 213 | A | A | -0.2828 | |
| 214 | A | A | -1.0648 | |
| 215 | T | A | -1.2334 | |
| 216 | P | A | -1.4831 | |
| 217 | K | A | -1.9805 | |
| 218 | P | A | -1.1131 | |
| 219 | S | A | -0.8357 | |
| 220 | A | A | -0.7232 | |
| 221 | D | A | -1.0218 | |
| 222 | P | A | -0.4036 | |
| 223 | P | A | -0.1739 | |
| 224 | D | A | -0.2804 | |
| 225 | V | A | 0.8475 | |
| 226 | E | A | -0.6870 | |
| 227 | R | A | -0.8771 | |
| 228 | I | A | -0.4223 | |
| 229 | K | A | -2.3190 | |
| 230 | T | A | 0.0000 | |
| 231 | T | A | -2.0905 | |
| 232 | K | A | -3.8316 | |
| 233 | K | A | -4.1935 | |
| 234 | R | A | -3.4372 | |
| 235 | Q | A | -4.2973 | |
| 236 | E | A | -3.9607 | |
| 237 | I | A | -1.7578 | |
| 238 | K | A | -2.7450 | |
| 239 | D | A | -3.3196 | |
| 240 | S | A | -1.8193 | |
| 241 | G | A | -1.0483 | |
| 242 | L | A | 0.6436 | |
| 243 | L | A | -0.6329 | |
| 244 | D | A | -1.8838 | |
| 245 | K | A | -2.6132 | |
| 246 | K | A | -2.2585 | |
| 247 | E | A | -2.0568 | |
| 248 | R | A | -2.6171 | |
| 249 | T | A | -2.2402 | |
| 250 | E | A | 0.0000 | |
| 251 | H | A | -2.8255 | |
| 252 | K | A | -3.5702 | |
| 253 | A | A | -2.9179 | |
| 254 | R | A | -3.1167 | |
| 255 | K | A | -3.7782 | |
| 256 | K | A | -3.3791 | |
| 257 | G | A | -2.1402 | |
| 258 | T | A | -1.5940 | |
| 259 | S | A | -1.2117 | |
| 260 | A | A | -0.6484 | |
| 261 | L | A | 0.4224 | |
| 262 | L | A | 0.5219 | |
| 263 | S | A | 0.0377 | |
| 264 | A | A | 0.2038 | |
| 265 | K | A | -0.6660 | |
| 266 | K | A | -1.4098 | |
| 267 | M | A | -0.5256 | |
| 268 | V | A | -0.7936 | |
| 269 | M | A | -1.8901 | |
| 270 | R | A | -3.1598 | |
| 271 | K | A | -3.5241 | |
| 272 | R | A | -3.5676 | |
| 273 | A | A | -2.6333 | |
| 274 | K | A | -3.3160 | |
| 275 | P | A | -2.1454 | |
| 276 | R | A | -2.1030 | |
| 277 | Y | A | 0.2130 | |
| 278 | S | A | -0.2121 | |
| 279 | P | A | 0.0530 | |
| 280 | L | A | 0.4624 | |
| 281 | G | A | -0.8775 | |
| 282 | D | A | -2.5369 | |
| 283 | T | A | -2.5079 | |
| 284 | D | A | -3.9944 | |
| 285 | E | A | -4.4875 | |
| 286 | K | A | -3.6915 | |
| 287 | K | A | -3.3690 | |
| 288 | R | A | -3.6013 | |
| 289 | P | A | -1.2252 | |
| 290 | S | A | -0.2743 | |
| 291 | L | A | 1.3050 | |
| 292 | S | A | 0.7857 | |
| 293 | I | A | 1.2540 | |
| 294 | R | A | -0.9365 | |
| 295 | A | A | -0.5815 | |
| 296 | H | A | -0.7357 | |
| 297 | T | A | 0.4964 | |
| 298 | V | A | 1.9039 | |
| 299 | L | A | 1.0553 | |
| 300 | E | A | -1.4917 | |
| 301 | G | A | -2.3020 | |
| 302 | E | A | -3.2997 | |
| 303 | P | A | -2.9364 | |
| 304 | K | A | -3.7504 | |
| 305 | K | A | -3.7741 | |
| 306 | H | A | -3.1989 | |
| 307 | R | A | -2.8313 | |
| 308 | D | A | -1.2965 | |
| 309 | S | A | -0.5795 | |
| 310 | V | A | 0.6950 | |
| 311 | S | A | -0.5297 | |
| 312 | F | A | -0.8524 | |
| 313 | S | A | -1.3078 | |
| 314 | R | A | -2.2776 | |
| 315 | R | A | -1.7239 | |
| 316 | N | A | -2.3280 | |
| 317 | E | A | -3.3328 | |
| 318 | A | A | -2.2375 | |
| 319 | A | A | -1.7451 | |
| 320 | A | A | -1.9495 | |
| 321 | K | A | -1.9923 | |
| 322 | M | A | -1.3476 | |
| 323 | L | A | 0.0000 | |
| 324 | S | A | -1.9287 | |
| 325 | K | A | -2.4053 | |
| 326 | D | A | -2.3029 | |
| 327 | I | A | 0.0000 | |
| 328 | I | A | -1.4589 | |
| 329 | K | A | -2.4324 | |
| 330 | L | A | -1.7419 | |
| 331 | L | A | 0.0000 | |
| 332 | N | A | 0.0000 | |
| 333 | E | A | -2.2409 | |
| 334 | Q | A | 0.0000 | |
| 335 | V | A | 0.0000 | |
| 336 | N | A | 0.0000 | |
| 337 | K | A | -1.6289 | |
| 338 | E | A | 0.0000 | |
| 339 | M | A | -0.4192 | |
| 340 | N | A | -0.4917 | |
| 341 | S | A | 0.0000 | |
| 342 | S | A | 0.0000 | |
| 343 | N | A | -0.7661 | |
| 344 | L | A | 0.0000 | |
| 345 | Y | A | 0.0000 | |
| 346 | M | A | -0.0599 | |
| 347 | S | A | -0.8740 | |
| 348 | M | A | 0.0000 | |
| 349 | S | A | 0.0000 | |
| 350 | S | A | 0.0433 | |
| 351 | W | A | -0.7900 | |
| 352 | C | A | 0.0000 | |
| 353 | Y | A | 0.3173 | |
| 354 | T | A | -0.2692 | |
| 355 | H | A | -0.8895 | |
| 356 | S | A | -0.4604 | |
| 357 | L | A | 0.0000 | |
| 358 | D | A | -0.8826 | |
| 359 | G | A | 0.0000 | |
| 360 | A | A | 0.0000 | |
| 361 | G | A | 0.0000 | |
| 362 | L | A | -0.1025 | |
| 363 | F | A | 0.0000 | |
| 364 | L | A | 0.0000 | |
| 365 | F | A | 0.3075 | |
| 366 | D | A | -0.5183 | |
| 367 | H | A | 0.0000 | |
| 368 | A | A | 0.0000 | |
| 369 | A | A | -0.4059 | |
| 370 | E | A | -1.1277 | |
| 371 | E | A | 0.0000 | |
| 372 | Y | A | -0.3441 | |
| 373 | E | A | -0.7226 | |
| 374 | H | A | -0.5763 | |
| 375 | A | A | 0.0000 | |
| 376 | K | A | -0.7793 | |
| 377 | K | A | -0.5659 | |
| 378 | L | A | 0.0000 | |
| 379 | I | A | -0.1165 | |
| 380 | I | A | -0.0334 | |
| 381 | F | A | -0.2186 | |
| 382 | L | A | 0.0000 | |
| 383 | N | A | -1.4467 | |
| 384 | E | A | -1.3101 | |
| 385 | N | A | 0.0000 | |
| 386 | N | A | -2.1885 | |
| 387 | V | A | -1.2002 | |
| 388 | P | A | -0.6926 | |
| 389 | V | A | -0.5608 | |
| 390 | Q | A | -1.1768 | |
| 391 | L | A | -0.0560 | |
| 392 | T | A | -0.2561 | |
| 393 | S | A | 0.0805 | |
| 394 | I | A | 0.4282 | |
| 395 | S | A | -0.3295 | |
| 396 | A | A | -0.6444 | |
| 397 | P | A | -1.4895 | |
| 398 | E | A | -2.5564 | |
| 399 | H | A | -2.6135 | |
| 400 | K | A | -2.8996 | |
| 401 | F | A | -2.0970 | |
| 402 | E | A | -2.2861 | |
| 403 | G | A | -1.2266 | |
| 404 | L | A | 0.0000 | |
| 405 | T | A | -1.0110 | |
| 406 | Q | A | -1.0693 | |
| 407 | I | A | 0.0000 | |
| 408 | F | A | 0.0000 | |
| 409 | Q | A | -1.3934 | |
| 410 | K | A | -1.3714 | |
| 411 | A | A | 0.0000 | |
| 412 | Y | A | -0.9268 | |
| 413 | E | A | -1.4546 | |
| 414 | H | A | -1.5007 | |
| 415 | E | A | 0.0000 | |
| 416 | Q | A | -1.3096 | |
| 417 | H | A | -1.7131 | |
| 418 | I | A | 0.0000 | |
| 419 | S | A | 0.0000 | |
| 420 | E | A | -2.5709 | |
| 421 | S | A | -1.9376 | |
| 422 | I | A | 0.0000 | |
| 423 | N | A | -2.2811 | |
| 424 | N | A | -2.6076 | |
| 425 | I | A | 0.0000 | |
| 426 | V | A | 0.0000 | |
| 427 | D | A | -2.4573 | |
| 428 | H | A | -2.3799 | |
| 429 | A | A | 0.0000 | |
| 430 | I | A | -1.0043 | |
| 431 | K | A | -2.2173 | |
| 432 | S | A | -2.0423 | |
| 433 | K | A | -2.1100 | |
| 434 | D | A | 0.0000 | |
| 435 | H | A | -1.1740 | |
| 436 | A | A | -0.5007 | |
| 437 | T | A | 0.0000 | |
| 438 | F | A | -0.3635 | |
| 439 | N | A | -0.2559 | |
| 440 | F | A | 0.4845 | |
| 441 | L | A | 0.0000 | |
| 442 | Q | A | 0.0000 | |
| 443 | W | A | 0.1718 | |
| 444 | Y | A | 0.0000 | |
| 445 | V | A | 0.0000 | |
| 446 | A | A | -1.2645 | |
| 447 | E | A | -1.6334 | |
| 448 | Q | A | 0.0000 | |
| 449 | H | A | -1.3793 | |
| 450 | E | A | -2.0504 | |
| 451 | E | A | -1.2514 | |
| 452 | E | A | 0.0000 | |
| 453 | V | A | -0.5677 | |
| 454 | L | A | -0.6752 | |
| 455 | F | A | 0.0000 | |
| 456 | K | A | -1.7454 | |
| 457 | D | A | -1.8245 | |
| 458 | I | A | 0.0000 | |
| 459 | L | A | 0.0000 | |
| 460 | D | A | -1.0311 | |
| 461 | K | A | -0.4897 | |
| 462 | I | A | 0.0000 | |
| 463 | E | A | -0.6621 | |
| 464 | L | A | 0.9916 | |
| 465 | I | A | 0.9006 | |
| 466 | G | A | -0.4938 | |
| 467 | N | A | -1.7533 | |
| 468 | E | A | -1.7442 | |
| 469 | N | A | -1.7352 | |
| 470 | H | A | -1.3206 | |
| 471 | G | A | 0.0000 | |
| 472 | L | A | 0.1508 | |
| 473 | Y | A | 1.1870 | |
| 474 | L | A | 1.3124 | |
| 475 | A | A | 0.0000 | |
| 476 | D | A | 0.0000 | |
| 477 | Q | A | -0.4513 | |
| 478 | Y | A | 0.1665 | |
| 479 | V | A | 0.0000 | |
| 480 | K | A | -1.3784 | |
| 481 | G | A | -1.4470 | |
| 482 | I | A | -1.0581 | |
| 483 | A | A | 0.0000 | |
| 484 | K | A | -2.4364 | |
| 485 | S | A | -1.6284 | |
| 486 | R | A | -1.5901 | |
| 487 | K | A | -1.8949 | |
| 488 | S | A | -1.1736 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine