Project name: f078725e60c4960

Chain sequence(s)	A: DYVNYDIIVRHYNYTGKLNIAHRSSVSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKLLLSIVILSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFI
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:08)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:08)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:08)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:08)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:08)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:05:28)
[INFO]       Main:     Simulation completed successfully.                                          (00:05:30)

• Minimal score value: -3.289
• Maximal score value: 4.0333
• Average score: 0.288
• Total score value: 88.1228

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-1.0830
2	Y	A	0.6833
3	V	A	1.2163
4	N	A	-0.0793
5	Y	A	0.1754
6	D	A	-1.3666
7	I	A	0.0000
8	I	A	0.0000
9	V	A	-0.7605
10	R	A	-1.5343
11	H	A	0.0000
12	Y	A	0.0000
13	N	A	-1.1204
14	Y	A	0.2624
15	T	A	0.0000
16	G	A	-0.8439
17	K	A	-0.3924
18	L	A	-0.1022
19	N	A	-0.2204
20	I	A	1.0789
21	A	A	-0.0630
22	H	A	-1.3529
23	R	A	-2.0897
24	S	A	-1.2347
25	S	A	-0.1881
26	V	A	0.4231
27	S	A	0.8836
28	I	A	1.7446
29	K	A	0.3864
30	L	A	1.5347
31	T	A	1.1000
32	S	A	1.5530
33	V	A	2.5083
34	V	A	2.5228
35	F	A	0.0000
36	I	A	2.3872
37	L	A	2.7350
38	I	A	2.5479
39	C	A	0.0000
40	C	A	2.5132
41	F	A	2.9053
42	I	A	0.0000
43	I	A	2.3436
44	L	A	2.1748
45	E	A	1.2786
46	N	A	0.0000
47	I	A	1.9956
48	F	A	2.1347
49	V	A	0.0000
50	L	A	1.3553
51	L	A	1.5255
52	T	A	0.0000
53	I	A	0.0000
54	W	A	0.2314
55	K	A	-1.4488
56	T	A	-1.8240
57	K	A	-3.2559
58	K	A	-3.2890
59	F	A	0.0000
60	H	A	-2.7871
61	R	A	-3.1317
62	P	A	-1.3393
63	M	A	-0.4881
64	Y	A	0.0000
65	Y	A	0.4542
66	F	A	0.0000
67	I	A	0.0000
68	G	A	0.0000
69	N	A	0.0000
70	L	A	0.0000
71	A	A	0.0000
72	L	A	0.9400
73	S	A	0.0000
74	D	A	0.0000
75	L	A	1.5843
76	L	A	1.3620
77	A	A	0.0000
78	G	A	0.0000
79	V	A	1.6623
80	A	A	0.0000
81	Y	A	0.0000
82	T	A	1.3081
83	A	A	0.9345
84	N	A	0.0000
85	L	A	1.1712
86	L	A	1.5563
87	L	A	0.9162
88	S	A	0.4202
89	G	A	-0.0887
90	A	A	0.1408
91	T	A	-0.3427
92	T	A	0.0000
93	Y	A	-0.2369
94	K	A	-1.3906
95	L	A	0.0000
96	T	A	0.2285
97	P	A	0.0000
98	A	A	0.5289
99	Q	A	0.0419
100	W	A	0.0000
101	F	A	0.0000
102	L	A	1.3611
103	R	A	0.0000
104	E	A	0.0000
105	G	A	0.0000
106	S	A	0.9311
107	M	A	0.0000
108	F	A	0.7986
109	V	A	1.3887
110	A	A	0.0000
111	L	A	0.4277
112	S	A	0.7278
113	A	A	0.0000
114	S	A	0.0000
115	V	A	0.0000
116	F	A	0.5301
117	S	A	0.0000
118	L	A	0.0000
119	L	A	0.5622
120	A	A	0.0000
121	I	A	0.0000
122	A	A	0.0000
123	I	A	0.4457
124	E	A	0.1149
125	R	A	0.1705
126	Y	A	0.4024
127	I	A	0.6967
128	T	A	-0.0956
129	M	A	0.4901
130	L	A	0.6174
131	K	A	-0.6303
132	M	A	0.1195
133	K	A	-1.2608
134	L	A	0.0678
135	H	A	-1.1251
136	N	A	-2.0424
137	G	A	-1.9773
138	S	A	-1.9878
139	N	A	-1.6303
140	N	A	-0.4895
141	F	A	1.4805
142	R	A	0.2241
143	L	A	0.0000
144	F	A	2.2563
145	L	A	1.6795
146	L	A	0.0000
147	I	A	0.0000
148	S	A	1.0551
149	A	A	1.3481
150	C	A	0.0000
151	W	A	1.7943
152	V	A	2.6590
153	I	A	2.6323
154	S	A	0.0000
155	L	A	3.2044
156	I	A	3.1317
157	L	A	0.0000
158	G	A	0.0000
159	G	A	1.7538
160	L	A	1.3716
161	P	A	0.0000
162	I	A	1.2813
163	M	A	1.3160
164	G	A	0.7262
165	W	A	0.4232
166	N	A	0.1280
167	C	A	0.0000
168	I	A	-0.1031
169	S	A	-0.2036
170	A	A	0.1087
171	L	A	0.3240
172	S	A	-0.0300
173	S	A	-0.4404
174	C	A	0.0000
175	S	A	0.0000
176	T	A	0.0000
177	V	A	0.1790
178	L	A	0.2363
179	P	A	0.0000
180	L	A	0.0000
181	Y	A	0.0000
182	H	A	-0.3125
183	K	A	-0.3540
184	H	A	-0.5365
185	Y	A	0.0000
186	I	A	0.0000
187	L	A	1.0829
188	F	A	1.0756
189	C	A	0.9892
190	T	A	0.0000
191	T	A	1.2004
192	V	A	1.3900
193	F	A	1.3542
194	T	A	1.4733
195	L	A	2.2079
196	L	A	0.0000
197	L	A	2.0778
198	L	A	2.7305
199	S	A	2.0336
200	I	A	0.0000
201	V	A	2.2102
202	I	A	2.2640
203	L	A	1.2775
204	Y	A	0.0000
205	C	A	1.0556
206	R	A	-0.1735
207	I	A	0.0000
208	Y	A	0.2994
209	S	A	-0.5961
210	L	A	-0.3960
211	V	A	-0.9555
212	R	A	-2.1150
213	T	A	-1.6529
214	R	A	-1.7248
215	S	A	-1.8001
216	R	A	-1.8821
217	R	A	-2.1165
218	L	A	0.3591
219	T	A	0.2659
220	F	A	0.8830
221	R	A	-1.4098
222	K	A	-0.8593
223	L	A	1.6050
224	L	A	2.6542
225	L	A	3.2368
226	S	A	3.0659
227	I	A	4.0333
228	V	A	3.8669
229	I	A	3.8839
230	L	A	2.2355
231	S	A	0.0332
232	E	A	-1.0091
233	K	A	-1.8237
234	S	A	0.0000
235	L	A	0.2751
236	A	A	-0.2421
237	L	A	0.1504
238	L	A	0.5768
239	K	A	-0.1382
240	T	A	0.5773
241	V	A	1.2975
242	I	A	1.7780
243	I	A	1.2355
244	V	A	1.1407
245	L	A	0.0000
246	S	A	1.1027
247	V	A	1.0880
248	F	A	0.0000
249	I	A	1.1466
250	A	A	0.6712
251	C	A	0.8529
252	W	A	0.0000
253	A	A	0.9589
254	P	A	1.2149
255	L	A	0.0000
256	F	A	1.5580
257	I	A	2.1468
258	L	A	0.0000
259	L	A	1.5843
260	L	A	1.7976
261	L	A	1.5630
262	D	A	0.0000
263	V	A	0.5015
264	G	A	0.1144
265	C	A	-0.4335
266	K	A	-1.6398
267	V	A	-1.0324
268	K	A	-1.8706
269	T	A	-1.3972
270	C	A	-0.9296
271	D	A	-1.7696
272	I	A	-0.4447
273	L	A	0.0000
274	F	A	-0.6145
275	R	A	-1.3421
276	A	A	-0.2510
277	E	A	-0.4078
278	Y	A	0.8347
279	F	A	1.1124
280	L	A	0.6797
281	V	A	0.0000
282	L	A	1.2312
283	A	A	0.0000
284	V	A	0.0000
285	L	A	0.8737
286	N	A	0.0000
287	S	A	0.0000
288	G	A	0.8898
289	T	A	0.4830
290	N	A	0.0000
291	P	A	0.0000
292	I	A	1.3366
293	I	A	1.0710
294	Y	A	0.0000
295	T	A	0.0000
296	L	A	-0.0486
297	T	A	-0.7147
298	N	A	-2.1617
299	K	A	-3.2354
300	E	A	-2.8802
301	M	A	0.0000
302	R	A	-2.4877
303	R	A	-2.3723
304	A	A	-1.1660
305	F	A	0.6696
306	I	A	1.5157