| Chain sequence(s) |
A: EVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMVGGSGEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMVGGSGEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:19)
[INFO] Main: Simulation completed successfully. (00:05:23)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -1.2703 | |
| 2 | V | A | 0.3451 | |
| 3 | N | A | -0.3864 | |
| 4 | P | A | 0.0000 | |
| 5 | A | A | 0.0000 | |
| 6 | A | A | 0.0000 | |
| 7 | H | A | 0.0000 | |
| 8 | L | A | 0.0000 | |
| 9 | T | A | 0.0000 | |
| 10 | G | A | 0.0000 | |
| 11 | A | A | -1.0061 | |
| 12 | N | A | -1.7930 | |
| 13 | S | A | -0.5676 | |
| 14 | S | A | 0.0000 | |
| 15 | L | A | -0.1983 | |
| 16 | T | A | -0.1103 | |
| 17 | G | A | -0.8883 | |
| 18 | S | A | -0.6188 | |
| 19 | G | A | -0.4781 | |
| 20 | G | A | -0.4304 | |
| 21 | P | A | -0.2595 | |
| 22 | L | A | 0.0000 | |
| 23 | L | A | -0.2121 | |
| 24 | W | A | 0.0000 | |
| 25 | E | A | -0.5387 | |
| 26 | T | A | -0.2211 | |
| 27 | Q | A | -0.5060 | |
| 28 | L | A | 0.7153 | |
| 29 | G | A | 0.0217 | |
| 30 | L | A | -0.0609 | |
| 31 | A | A | 0.0000 | |
| 32 | F | A | 0.0399 | |
| 33 | L | A | 0.1025 | |
| 34 | R | A | 0.0308 | |
| 35 | G | A | -0.5175 | |
| 36 | L | A | 0.0000 | |
| 37 | S | A | -0.2303 | |
| 38 | Y | A | -0.5853 | |
| 39 | H | A | -1.7092 | |
| 40 | D | A | -2.1481 | |
| 41 | G | A | 0.0000 | |
| 42 | A | A | 0.0000 | |
| 43 | L | A | 0.0000 | |
| 44 | V | A | -0.9009 | |
| 45 | V | A | 0.0000 | |
| 46 | T | A | -1.2715 | |
| 47 | K | A | -2.1072 | |
| 48 | A | A | -1.6125 | |
| 49 | G | A | -1.0481 | |
| 50 | Y | A | -0.5724 | |
| 51 | Y | A | 0.0000 | |
| 52 | Y | A | 0.0000 | |
| 53 | I | A | 0.0000 | |
| 54 | Y | A | 0.0000 | |
| 55 | S | A | 0.0000 | |
| 56 | K | A | 0.0000 | |
| 57 | V | A | 0.0000 | |
| 58 | Q | A | 0.0000 | |
| 59 | L | A | 0.0000 | |
| 60 | G | A | 0.0000 | |
| 61 | G | A | 0.8478 | |
| 62 | V | A | 2.1090 | |
| 63 | G | A | 0.0000 | |
| 64 | C | A | 0.9449 | |
| 65 | P | A | 0.8222 | |
| 66 | L | A | 1.2958 | |
| 67 | G | A | 0.3222 | |
| 68 | L | A | 0.1598 | |
| 69 | A | A | 0.2941 | |
| 70 | S | A | 0.0854 | |
| 71 | T | A | 0.3523 | |
| 72 | I | A | 0.0000 | |
| 73 | T | A | 0.3444 | |
| 74 | H | A | 0.0000 | |
| 75 | G | A | 0.0000 | |
| 76 | L | A | 0.0000 | |
| 77 | Y | A | -0.6167 | |
| 78 | K | A | -0.7561 | |
| 79 | R | A | -1.4576 | |
| 80 | T | A | 0.0000 | |
| 81 | P | A | -1.3141 | |
| 82 | R | A | -1.8268 | |
| 83 | Y | A | -0.7487 | |
| 84 | P | A | -1.2385 | |
| 85 | E | A | -2.1675 | |
| 86 | E | A | -1.3730 | |
| 87 | L | A | -0.4992 | |
| 88 | E | A | -0.9462 | |
| 89 | L | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | V | A | 0.0000 | |
| 92 | S | A | 0.0000 | |
| 93 | Q | A | 0.0390 | |
| 94 | Q | A | 0.0000 | |
| 95 | S | A | 0.0000 | |
| 96 | P | A | 0.0000 | |
| 97 | C | A | 0.2892 | |
| 98 | G | A | -0.1893 | |
| 99 | R | A | 0.0000 | |
| 100 | A | A | 0.4087 | |
| 101 | T | A | -0.1446 | |
| 102 | S | A | -0.0630 | |
| 103 | S | A | 0.2556 | |
| 104 | S | A | 0.2570 | |
| 105 | R | A | 0.5743 | |
| 106 | V | A | 1.7705 | |
| 107 | W | A | 0.0000 | |
| 108 | W | A | 0.5388 | |
| 109 | D | A | 0.0000 | |
| 110 | S | A | -0.1065 | |
| 111 | S | A | 0.0000 | |
| 112 | F | A | 0.0000 | |
| 113 | L | A | 0.0000 | |
| 114 | G | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | V | A | 0.0000 | |
| 117 | V | A | 0.0000 | |
| 118 | H | A | -0.9474 | |
| 119 | L | A | 0.0000 | |
| 120 | E | A | -2.0963 | |
| 121 | A | A | -1.4548 | |
| 122 | G | A | -1.0567 | |
| 123 | E | A | 0.0000 | |
| 124 | K | A | -1.3122 | |
| 125 | V | A | 0.0000 | |
| 126 | V | A | 0.0000 | |
| 127 | V | A | 0.0000 | |
| 128 | R | A | -0.1373 | |
| 129 | V | A | 0.0000 | |
| 130 | L | A | 0.8991 | |
| 131 | D | A | -0.3411 | |
| 132 | E | A | -0.9646 | |
| 133 | R | A | -1.8551 | |
| 134 | L | A | 0.0000 | |
| 135 | V | A | 0.0000 | |
| 136 | R | A | -1.5698 | |
| 137 | L | A | -1.4981 | |
| 138 | R | A | -2.5449 | |
| 139 | D | A | -1.8368 | |
| 140 | G | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | R | A | -0.8762 | |
| 143 | S | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | F | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | F | A | 0.0000 | |
| 149 | M | A | -0.3380 | |
| 150 | V | A | 0.0000 | |
| 151 | G | A | -0.3366 | |
| 152 | G | A | -0.9199 | |
| 153 | S | A | -0.8801 | |
| 154 | G | A | -0.9395 | |
| 155 | E | A | -0.7738 | |
| 156 | V | A | 0.8212 | |
| 157 | N | A | 0.0000 | |
| 158 | P | A | 0.0000 | |
| 159 | A | A | 0.0000 | |
| 160 | A | A | 0.0000 | |
| 161 | H | A | 0.0000 | |
| 162 | L | A | 0.0000 | |
| 163 | T | A | 0.0000 | |
| 164 | G | A | 0.0000 | |
| 165 | A | A | -1.1507 | |
| 166 | N | A | -1.7899 | |
| 167 | S | A | -0.5991 | |
| 168 | S | A | 0.0000 | |
| 169 | L | A | -0.2824 | |
| 170 | T | A | -0.3007 | |
| 171 | G | A | -0.9152 | |
| 172 | S | A | -0.6405 | |
| 173 | G | A | -0.5322 | |
| 174 | G | A | -0.4985 | |
| 175 | P | A | -0.3560 | |
| 176 | L | A | 0.0000 | |
| 177 | L | A | -0.3851 | |
| 178 | W | A | 0.0000 | |
| 179 | E | A | -0.5626 | |
| 180 | T | A | -0.2286 | |
| 181 | Q | A | -0.5009 | |
| 182 | L | A | 0.7157 | |
| 183 | G | A | -0.1378 | |
| 184 | L | A | -0.1903 | |
| 185 | A | A | 0.0000 | |
| 186 | F | A | -0.0289 | |
| 187 | L | A | 0.0190 | |
| 188 | R | A | -0.0385 | |
| 189 | G | A | -0.2972 | |
| 190 | L | A | 0.0000 | |
| 191 | S | A | -0.2499 | |
| 192 | Y | A | -0.6461 | |
| 193 | H | A | -1.7505 | |
| 194 | D | A | -2.1252 | |
| 195 | G | A | 0.0000 | |
| 196 | A | A | 0.0000 | |
| 197 | L | A | 0.0000 | |
| 198 | V | A | -0.8585 | |
| 199 | V | A | 0.0000 | |
| 200 | T | A | -1.1898 | |
| 201 | K | A | -1.9676 | |
| 202 | A | A | -1.3601 | |
| 203 | G | A | -0.8755 | |
| 204 | Y | A | -0.4624 | |
| 205 | Y | A | 0.0000 | |
| 206 | Y | A | 0.0000 | |
| 207 | I | A | 0.0000 | |
| 208 | Y | A | 0.0000 | |
| 209 | S | A | 0.0000 | |
| 210 | K | A | 0.0000 | |
| 211 | V | A | 0.0000 | |
| 212 | Q | A | 0.0000 | |
| 213 | L | A | 0.0000 | |
| 214 | G | A | 0.0000 | |
| 215 | G | A | 0.7760 | |
| 216 | V | A | 1.8556 | |
| 217 | G | A | 0.0000 | |
| 218 | C | A | 0.8287 | |
| 219 | P | A | 0.8240 | |
| 220 | L | A | 1.2933 | |
| 221 | G | A | 0.3207 | |
| 222 | L | A | 0.1398 | |
| 223 | A | A | 0.2893 | |
| 224 | S | A | 0.0612 | |
| 225 | T | A | 0.3640 | |
| 226 | I | A | 0.0000 | |
| 227 | T | A | 0.3418 | |
| 228 | H | A | 0.0000 | |
| 229 | G | A | 0.0000 | |
| 230 | L | A | 0.0000 | |
| 231 | Y | A | -0.5980 | |
| 232 | K | A | -0.7627 | |
| 233 | R | A | -1.4141 | |
| 234 | T | A | -1.3969 | |
| 235 | P | A | -1.3213 | |
| 236 | R | A | -1.8375 | |
| 237 | Y | A | -0.7672 | |
| 238 | P | A | -1.2349 | |
| 239 | E | A | -2.1721 | |
| 240 | E | A | -1.3680 | |
| 241 | L | A | -0.4638 | |
| 242 | E | A | -0.7696 | |
| 243 | L | A | 0.0000 | |
| 244 | L | A | 0.0000 | |
| 245 | V | A | 0.0000 | |
| 246 | S | A | 0.0000 | |
| 247 | Q | A | 0.0530 | |
| 248 | Q | A | 0.0000 | |
| 249 | S | A | 0.0000 | |
| 250 | P | A | 0.0000 | |
| 251 | C | A | 0.3071 | |
| 252 | G | A | 0.0000 | |
| 253 | R | A | 0.0000 | |
| 254 | A | A | 0.1517 | |
| 255 | T | A | -0.3405 | |
| 256 | S | A | -0.3334 | |
| 257 | S | A | -0.0422 | |
| 258 | S | A | -0.2892 | |
| 259 | R | A | -0.6015 | |
| 260 | V | A | 1.5586 | |
| 261 | W | A | 0.0000 | |
| 262 | W | A | 0.6086 | |
| 263 | D | A | 0.0000 | |
| 264 | S | A | -0.1036 | |
| 265 | S | A | 0.0000 | |
| 266 | F | A | 0.0000 | |
| 267 | L | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | G | A | 0.0000 | |
| 270 | V | A | 0.0000 | |
| 271 | V | A | 0.0000 | |
| 272 | H | A | -0.6465 | |
| 273 | L | A | 0.0000 | |
| 274 | E | A | -1.5699 | |
| 275 | A | A | -1.2119 | |
| 276 | G | A | -0.9333 | |
| 277 | E | A | 0.0000 | |
| 278 | K | A | -1.0768 | |
| 279 | V | A | 0.0000 | |
| 280 | V | A | 0.0000 | |
| 281 | V | A | 0.0000 | |
| 282 | R | A | -0.1465 | |
| 283 | V | A | 0.0000 | |
| 284 | L | A | 0.8877 | |
| 285 | D | A | -0.3521 | |
| 286 | E | A | -0.9649 | |
| 287 | R | A | -1.8568 | |
| 288 | L | A | 0.0000 | |
| 289 | V | A | 0.0000 | |
| 290 | R | A | -1.5585 | |
| 291 | L | A | -1.6508 | |
| 292 | R | A | -3.0092 | |
| 293 | D | A | -3.0125 | |
| 294 | G | A | -1.6455 | |
| 295 | T | A | 0.0000 | |
| 296 | R | A | -1.1773 | |
| 297 | S | A | 0.0000 | |
| 298 | Y | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | G | A | 0.0000 | |
| 301 | A | A | 0.0000 | |
| 302 | F | A | 0.0000 | |
| 303 | M | A | -0.1024 | |
| 304 | V | A | 0.0000 | |
| 305 | G | A | -0.4801 | |
| 306 | G | A | -1.0639 | |
| 307 | S | A | -1.0810 | |
| 308 | G | A | -1.2589 | |
| 309 | E | A | -1.4599 | |
| 310 | V | A | 0.1783 | |
| 311 | N | A | -0.6734 | |
| 312 | P | A | 0.0000 | |
| 313 | A | A | 0.0000 | |
| 314 | A | A | 0.0000 | |
| 315 | H | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | T | A | 0.0000 | |
| 318 | G | A | 0.0000 | |
| 319 | A | A | -1.0560 | |
| 320 | N | A | -1.8428 | |
| 321 | S | A | -0.5643 | |
| 322 | S | A | 0.0000 | |
| 323 | L | A | -0.1999 | |
| 324 | T | A | -0.1033 | |
| 325 | G | A | -0.8795 | |
| 326 | S | A | -0.6163 | |
| 327 | G | A | -0.4772 | |
| 328 | G | A | -0.4270 | |
| 329 | P | A | -0.3022 | |
| 330 | L | A | 0.0000 | |
| 331 | L | A | -0.1993 | |
| 332 | W | A | 0.0000 | |
| 333 | E | A | -0.4831 | |
| 334 | T | A | -0.2219 | |
| 335 | Q | A | -0.5119 | |
| 336 | L | A | 0.7267 | |
| 337 | G | A | 0.0209 | |
| 338 | L | A | 0.0198 | |
| 339 | A | A | 0.0000 | |
| 340 | F | A | -0.2781 | |
| 341 | L | A | -0.5542 | |
| 342 | R | A | -1.1148 | |
| 343 | G | A | -0.8215 | |
| 344 | L | A | 0.0000 | |
| 345 | S | A | -0.4687 | |
| 346 | Y | A | -0.6229 | |
| 347 | H | A | -1.7283 | |
| 348 | D | A | -2.1570 | |
| 349 | G | A | 0.0000 | |
| 350 | A | A | 0.0000 | |
| 351 | L | A | 0.0000 | |
| 352 | V | A | -0.8660 | |
| 353 | V | A | 0.0000 | |
| 354 | T | A | -1.2167 | |
| 355 | K | A | -2.0281 | |
| 356 | A | A | -1.4429 | |
| 357 | G | A | -0.7507 | |
| 358 | Y | A | -0.2513 | |
| 359 | Y | A | 0.0000 | |
| 360 | Y | A | 0.0000 | |
| 361 | I | A | 0.0000 | |
| 362 | Y | A | 0.0000 | |
| 363 | S | A | 0.0000 | |
| 364 | K | A | 0.0000 | |
| 365 | V | A | 0.0000 | |
| 366 | Q | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | G | A | 0.0000 | |
| 369 | G | A | 0.7636 | |
| 370 | V | A | 1.8445 | |
| 371 | G | A | 0.0000 | |
| 372 | C | A | 0.7842 | |
| 373 | P | A | 0.8392 | |
| 374 | L | A | 1.2976 | |
| 375 | G | A | 0.3262 | |
| 376 | L | A | 0.1317 | |
| 377 | A | A | 0.2824 | |
| 378 | S | A | 0.1745 | |
| 379 | T | A | 0.2971 | |
| 380 | I | A | 0.0000 | |
| 381 | T | A | 0.3448 | |
| 382 | H | A | 0.0000 | |
| 383 | G | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | Y | A | -0.6559 | |
| 386 | K | A | -0.7410 | |
| 387 | R | A | -1.3608 | |
| 388 | T | A | 0.0000 | |
| 389 | P | A | -1.2847 | |
| 390 | R | A | -1.7947 | |
| 391 | Y | A | -0.6899 | |
| 392 | P | A | -1.1944 | |
| 393 | E | A | -2.1450 | |
| 394 | E | A | -1.3546 | |
| 395 | L | A | -0.5103 | |
| 396 | E | A | -0.8805 | |
| 397 | L | A | 0.0000 | |
| 398 | L | A | 0.0000 | |
| 399 | V | A | 0.0000 | |
| 400 | S | A | 0.0000 | |
| 401 | Q | A | 0.0583 | |
| 402 | Q | A | 0.0000 | |
| 403 | S | A | 0.0000 | |
| 404 | P | A | 0.0000 | |
| 405 | C | A | 0.0000 | |
| 406 | G | A | -0.0889 | |
| 407 | R | A | 0.0000 | |
| 408 | A | A | 0.1248 | |
| 409 | T | A | -0.3661 | |
| 410 | S | A | -0.3815 | |
| 411 | S | A | -0.0721 | |
| 412 | S | A | -0.3025 | |
| 413 | R | A | -0.6073 | |
| 414 | V | A | 1.5701 | |
| 415 | W | A | 0.0000 | |
| 416 | W | A | 0.6582 | |
| 417 | D | A | 0.0000 | |
| 418 | S | A | -0.1010 | |
| 419 | S | A | 0.0000 | |
| 420 | F | A | 0.0000 | |
| 421 | L | A | 0.0000 | |
| 422 | G | A | 0.0000 | |
| 423 | G | A | 0.0000 | |
| 424 | V | A | 0.0000 | |
| 425 | V | A | 0.0000 | |
| 426 | H | A | -0.6857 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -1.7840 | |
| 429 | A | A | -1.3181 | |
| 430 | G | A | -0.9724 | |
| 431 | E | A | 0.0000 | |
| 432 | K | A | -1.2660 | |
| 433 | V | A | 0.0000 | |
| 434 | V | A | 0.0000 | |
| 435 | V | A | 0.0000 | |
| 436 | R | A | -0.1545 | |
| 437 | V | A | 0.0000 | |
| 438 | L | A | 0.8818 | |
| 439 | D | A | -0.3652 | |
| 440 | E | A | -0.9691 | |
| 441 | R | A | -1.8553 | |
| 442 | L | A | 0.0000 | |
| 443 | V | A | 0.0000 | |
| 444 | R | A | -1.6116 | |
| 445 | L | A | 0.0000 | |
| 446 | R | A | -2.6547 | |
| 447 | D | A | -1.9524 | |
| 448 | G | A | 0.0000 | |
| 449 | T | A | -0.6733 | |
| 450 | R | A | -0.8789 | |
| 451 | S | A | 0.0000 | |
| 452 | Y | A | 0.0000 | |
| 453 | F | A | 0.0000 | |
| 454 | G | A | 0.0000 | |
| 455 | A | A | 0.0000 | |
| 456 | F | A | 0.0000 | |
| 457 | M | A | 0.1185 | |
| 458 | V | A | 0.2440 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine