| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFRDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEYQHETADDRVDFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRSGPVGHPLPAAPPPSPLYVPPPPSSPYATLPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPAIKVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9509 | |
| 2 | L | A | 1.9727 | |
| 3 | P | A | 0.6535 | |
| 4 | P | A | 0.3583 | |
| 5 | T | A | 0.1137 | |
| 6 | T | A | 0.1255 | |
| 7 | P | A | 0.1603 | |
| 8 | V | A | 1.2164 | |
| 9 | A | A | 0.0236 | |
| 10 | K | A | -1.1692 | |
| 11 | V | A | -0.4230 | |
| 12 | Q | A | -1.5453 | |
| 13 | S | A | -1.6024 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4025 | |
| 16 | E | A | -2.4326 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4650 | |
| 20 | P | A | 0.1326 | |
| 21 | T | A | 0.1649 | |
| 22 | S | A | -0.0971 | |
| 23 | L | A | 0.0968 | |
| 24 | F | A | -0.0341 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2752 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8751 | |
| 31 | R | A | -2.6404 | |
| 32 | L | A | -0.7655 | |
| 33 | L | A | 1.2161 | |
| 34 | T | A | 1.4522 | |
| 35 | V | A | 1.9667 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2794 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6703 | |
| 40 | R | A | -1.9527 | |
| 41 | D | A | -0.6973 | |
| 42 | I | A | 1.1389 | |
| 43 | V | A | 2.0698 | |
| 44 | V | A | 1.6011 | |
| 45 | N | A | -0.5429 | |
| 46 | G | A | -0.4014 | |
| 47 | K | A | -0.1518 | |
| 48 | V | A | 2.1757 | |
| 49 | L | A | 2.4959 | |
| 50 | V | A | 1.4320 | |
| 51 | P | A | 0.3583 | |
| 52 | K | A | -0.6728 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1097 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4285 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2940 | |
| 70 | K | A | -1.8098 | |
| 71 | F | A | -0.6650 | |
| 72 | A | A | -0.5764 | |
| 73 | L | A | -0.8521 | |
| 74 | P | A | -1.2502 | |
| 75 | Q | A | -2.4807 | |
| 76 | K | A | -3.0975 | |
| 77 | D | A | -2.9942 | |
| 78 | F | A | -1.6424 | |
| 79 | Y | A | -1.9239 | |
| 80 | D | A | -2.7736 | |
| 81 | P | A | -2.3628 | |
| 82 | E | A | -3.0798 | |
| 83 | K | A | -3.4541 | |
| 84 | E | A | -2.5175 | |
| 85 | R | A | -1.3193 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6732 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9627 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3183 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6780 | |
| 99 | G | A | -0.5380 | |
| 100 | P | A | -0.4309 | |
| 101 | L | A | -0.0020 | |
| 102 | G | A | -0.2544 | |
| 103 | K | A | -0.7016 | |
| 104 | G | A | -0.5218 | |
| 105 | T | A | -0.4711 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.2102 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.4547 | |
| 110 | L | A | -0.2938 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.3856 | |
| 113 | K | A | -0.7703 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.8570 | |
| 117 | T | A | -1.4905 | |
| 118 | E | A | -2.6033 | |
| 119 | N | A | -2.6110 | |
| 120 | P | A | -2.2223 | |
| 121 | T | A | -1.7547 | |
| 122 | E | A | -2.4060 | |
| 123 | Y | A | -1.1054 | |
| 124 | Q | A | -2.1934 | |
| 125 | H | A | -1.9880 | |
| 126 | E | A | -2.2585 | |
| 127 | T | A | -1.7025 | |
| 128 | A | A | -1.2836 | |
| 129 | D | A | -2.2642 | |
| 130 | D | A | -1.8362 | |
| 131 | R | A | -1.4912 | |
| 132 | V | A | -0.7404 | |
| 133 | D | A | -1.4490 | |
| 134 | F | A | -0.6612 | |
| 135 | S | A | -0.4894 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7175 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2065 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5513 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2247 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1215 | |
| 157 | D | A | 0.2846 | |
| 158 | L | A | 0.7628 | |
| 159 | A | A | 0.1556 | |
| 160 | E | A | -1.4469 | |
| 161 | P | A | -0.1944 | |
| 162 | C | A | 0.1976 | |
| 163 | P | A | -0.1584 | |
| 164 | G | A | -0.0603 | |
| 165 | L | A | 0.6122 | |
| 166 | P | A | -0.1075 | |
| 167 | P | A | -0.3381 | |
| 168 | G | A | -0.4177 | |
| 169 | A | A | -0.0183 | |
| 170 | C | A | 0.6641 | |
| 171 | P | A | 0.5208 | |
| 172 | P | A | 0.7738 | |
| 173 | I | A | 1.9629 | |
| 174 | Q | A | 0.8113 | |
| 175 | L | A | 1.4445 | |
| 176 | V | A | 0.8211 | |
| 177 | N | A | -0.3252 | |
| 178 | S | A | 0.0292 | |
| 179 | V | A | 0.4335 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3794 | |
| 182 | D | A | 0.0797 | |
| 183 | G | A | -0.1576 | |
| 184 | D | A | -0.5520 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1325 | |
| 190 | F | A | 0.0574 | |
| 191 | G | A | -0.1075 | |
| 192 | N | A | -0.2730 | |
| 193 | M | A | -0.1535 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4351 | |
| 197 | E | A | -2.6731 | |
| 198 | L | A | -1.2658 | |
| 199 | Q | A | -2.5708 | |
| 200 | Q | A | -3.3597 | |
| 201 | D | A | -3.6114 | |
| 202 | R | A | -3.3430 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1621 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3879 | |
| 211 | S | A | -1.9299 | |
| 212 | T | A | -1.4646 | |
| 213 | R | A | -2.1312 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1645 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3089 | |
| 220 | L | A | 0.5235 | |
| 221 | K | A | -1.2654 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9519 | |
| 224 | N | A | -1.5638 | |
| 225 | E | A | -1.3147 | |
| 226 | A | A | -0.6760 | |
| 227 | Y | A | -0.4486 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7013 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1348 | |
| 234 | F | A | 0.0361 | |
| 235 | G | A | -0.9357 | |
| 236 | R | A | -2.6991 | |
| 237 | R | A | -3.0023 | |
| 238 | E | A | -2.1614 | |
| 239 | Q | A | -0.1725 | |
| 240 | V | A | 1.5298 | |
| 241 | Y | A | 1.2211 | |
| 242 | A | A | 0.1404 | |
| 243 | R | A | -1.3674 | |
| 244 | H | A | -1.2252 | |
| 245 | F | A | -0.2299 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5669 | |
| 249 | S | A | -1.1743 | |
| 250 | G | A | -0.8548 | |
| 251 | P | A | -0.6882 | |
| 252 | V | A | -0.4589 | |
| 253 | G | A | -0.9004 | |
| 254 | H | A | -1.1323 | |
| 255 | P | A | -0.4419 | |
| 256 | L | A | 0.5187 | |
| 257 | P | A | 0.0419 | |
| 258 | A | A | 0.1300 | |
| 259 | A | A | 0.4587 | |
| 260 | P | A | -0.2302 | |
| 261 | P | A | -0.1570 | |
| 262 | P | A | 0.0467 | |
| 263 | S | A | 0.5516 | |
| 264 | P | A | 0.6776 | |
| 265 | L | A | 1.9289 | |
| 266 | Y | A | 1.7540 | |
| 267 | V | A | 1.9405 | |
| 268 | P | A | 1.0434 | |
| 269 | P | A | 0.5007 | |
| 270 | P | A | -0.1369 | |
| 271 | P | A | -0.3708 | |
| 272 | S | A | -0.3111 | |
| 273 | S | A | -0.0268 | |
| 274 | P | A | 0.1102 | |
| 275 | Y | A | 1.0527 | |
| 276 | A | A | 0.4796 | |
| 277 | T | A | 0.4593 | |
| 278 | L | A | 1.0440 | |
| 279 | P | A | -0.0619 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.3128 | |
| 282 | D | A | -0.3187 | |
| 283 | Y | A | 1.0529 | |
| 284 | F | A | 0.8017 | |
| 285 | G | A | 0.1276 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9253 | |
| 291 | L | A | 1.6363 | |
| 292 | V | A | 0.6552 | |
| 293 | S | A | -0.1421 | |
| 294 | S | A | -0.9675 | |
| 295 | D | A | -1.8380 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1551 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6477 | |
| 301 | R | A | -1.8939 | |
| 302 | P | A | -0.9716 | |
| 303 | F | A | -0.1975 | |
| 304 | W | A | -0.5342 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0888 | |
| 307 | R | A | -2.9264 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6554 | |
| 310 | G | A | -1.4179 | |
| 311 | N | A | -1.3878 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8029 | |
| 319 | N | A | -0.8503 | |
| 320 | E | A | -1.0290 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3541 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1741 | |
| 333 | N | A | 0.3901 | |
| 334 | F | A | 1.4353 | |
| 335 | T | A | 0.6129 | |
| 336 | I | A | 0.3702 | |
| 337 | S | A | -0.9935 | |
| 338 | Q | A | -1.6932 | |
| 339 | Q | A | -1.1701 | |
| 340 | L | A | 0.4524 | |
| 341 | S | A | 0.2062 | |
| 342 | T | A | -0.0102 | |
| 343 | P | A | -0.3202 | |
| 344 | A | A | -0.1913 | |
| 345 | I | A | 0.3840 | |
| 346 | K | A | -0.4175 | |
| 347 | V | A | 1.4932 | |
| 348 | Y | A | 1.3998 | |
| 349 | D | A | -0.1368 | |
| 350 | P | A | -0.7339 | |
| 351 | S | A | -0.5709 | |
| 352 | N | A | -0.3104 | |
| 353 | F | A | -0.9148 | |
| 354 | K | A | -1.9538 | |
| 355 | N | A | -1.7895 | |
| 356 | Y | A | -0.1502 | |
| 357 | L | A | 0.5523 | |
| 358 | R | A | 0.8885 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4602 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0013 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9168 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6621 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3055 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3327 | |
| 376 | L | A | -1.7695 | |
| 377 | D | A | -2.0630 | |
| 378 | P | A | -1.0755 | |
| 379 | G | A | -1.0284 | |
| 380 | V | A | -0.9391 | |
| 381 | L | A | -0.5424 | |
| 382 | A | A | -0.6564 | |
| 383 | H | A | -0.8479 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3779 | |
| 386 | T | A | -0.5660 | |
| 387 | M | A | -0.3238 | |
| 388 | N | A | -0.8587 | |
| 389 | P | A | -1.2324 | |
| 390 | T | A | -1.4442 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4465 | |
| 393 | E | A | -2.7942 | |
| 394 | N | A | -2.4104 | |
| 395 | W | A | -1.4139 | |
| 396 | N | A | -1.3224 | |
| 397 | L | A | -0.2022 | |
| 398 | G | A | 0.5343 | |
| 399 | F | A | 2.4140 | |
| 400 | V | A | 1.8399 | |
| 401 | P | A | 0.0470 | |
| 402 | P | A | -1.8504 | |
| 403 | K | A | -3.4274 | |
| 404 | E | A | -3.7395 | |
| 405 | R | A | -3.8586 | |
| 406 | E | A | -3.7124 | |
| 407 | D | A | -2.8122 | |
| 408 | P | A | -1.7032 | |
| 409 | Y | A | -0.9497 | |
| 410 | K | A | -2.0812 | |
| 411 | G | A | -0.6083 | |
| 412 | L | A | 0.7733 | |
| 413 | I | A | 1.5958 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3971 | |
| 416 | E | A | -1.6633 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9370 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0693 | |
| 421 | E | A | -2.8015 | |
| 422 | R | A | -2.6782 | |
| 423 | F | A | -1.3181 | |
| 424 | S | A | -1.4727 | |
| 425 | Q | A | -1.8767 | |
| 426 | D | A | -2.8866 | |
| 427 | L | A | -1.9873 | |
| 428 | D | A | -2.7737 | |
| 429 | Q | A | -2.6123 | |
| 430 | F | A | -1.4391 | |
| 431 | A | A | -0.9002 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5660 | |
| 435 | K | A | -0.7082 | |
| 436 | F | A | 0.1540 | |
| 437 | L | A | 1.0372 | |
| 438 | Y | A | 0.8320 | |
| 439 | Q | A | -0.2602 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine