Project name: f260ad5ecd14d1e

Chain sequence(s)	K: QSVLTQSPSASGTPGQRVTISCSGSRSNIGSNFVYWFHQLPGTAPKLLIHSNDQRPSGVPDRFSGSNSGTSASLAISGLRSEDEADYYCAAWDDSLSSWVFGGGTKLTVL; L: ITLKESGLTLVRPTQTLTLTCTFSGFSLINSGVGVGWIRQPPGKALEWLALIYWDDDKRYNPSLRSRLTISKATSKNQVVLTMTNMDPVDTATYYCTHRGPGHNTPIYFEFWGQGALVTVSS
Selected Chain(s)	L,K
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:02)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:04)

• Minimal score value: -3.3422
• Maximal score value: 1.9184
• Average score: -0.6098
• Total score value: -141.4729

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	I	L	1.9184
3	T	L	0.5431
4	L	L	0.0000
5	K	L	-1.6212
6	E	L	-1.0555
7	S	L	-0.4569
8	G	L	0.3301
9	L	L	1.8558
11	T	L	1.7074
12	L	L	1.7453
13	V	L	-0.1139
14	R	L	-2.2083
15	P	L	-1.7639
16	T	L	-1.7210
17	Q	L	-1.9156
18	T	L	-1.2871
19	L	L	0.0000
20	T	L	0.1739
21	L	L	0.0000
22	T	L	-0.2422
23	C	L	0.0000
24	T	L	-0.9990
25	F	L	0.0000
26	S	L	-0.0953
27	G	L	0.3833
28	F	L	0.3117
29	S	L	0.0446
30	L	L	0.0000
31	I	L	1.0478
34	N	L	-0.5133
35	S	L	-0.6095
36	G	L	-0.4417
37	V	L	0.0000
38	G	L	0.0000
39	V	L	0.0000
40	G	L	0.0000
41	W	L	0.0000
42	I	L	0.0000
43	R	L	-0.4541
44	Q	L	0.0000
45	P	L	-0.5320
46	P	L	-0.6947
47	G	L	-1.4619
48	K	L	-2.1881
49	A	L	-1.2881
50	L	L	0.0000
51	E	L	-0.7566
52	W	L	0.0000
53	L	L	0.0000
54	A	L	0.0000
55	L	L	0.0000
56	I	L	0.0000
57	Y	L	-1.4053
58	W	L	-0.9967
59	D	L	-2.4995
63	D	L	-2.8244
64	D	L	-3.3422
65	K	L	-2.6796
66	R	L	-2.3430
67	Y	L	-1.4194
68	N	L	0.0000
69	P	L	-1.0079
70	S	L	-0.7845
71	L	L	-1.0483
72	R	L	-2.2635
74	S	L	-1.3688
75	R	L	-1.4974
76	L	L	0.0000
77	T	L	-0.6800
78	I	L	0.0000
79	S	L	-0.5658
80	K	L	-1.0454
81	A	L	-1.0133
82	T	L	-0.8570
83	S	L	-1.3767
84	K	L	-2.2904
85	N	L	-1.8215
86	Q	L	-1.4261
87	V	L	0.0000
88	V	L	0.0513
89	L	L	0.0000
90	T	L	-0.0792
91	M	L	0.0000
92	T	L	-1.2228
93	N	L	-2.2194
94	M	L	0.0000
95	D	L	-1.5989
96	P	L	-0.3220
97	V	L	1.1945
98	D	L	0.0000
99	T	L	0.6347
100	A	L	0.0000
101	T	L	0.2844
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	T	L	0.0000
106	H	L	0.0000
107	R	L	0.0000
108	G	L	0.0000
109	P	L	-0.8873
110	G	L	-1.3425
111	H	L	-1.9059
111A	N	L	-2.0049
112A	T	L	-1.1907
112	P	L	-0.7193
113	I	L	0.0000
114	Y	L	0.0028
115	F	L	0.0000
116	E	L	-0.5140
117	F	L	0.5238
118	W	L	-0.1380
119	G	L	0.0000
120	Q	L	-1.3586
121	G	L	-0.6538
122	A	L	0.2208
123	L	L	1.5380
124	V	L	0.0000
125	T	L	0.7890
126	V	L	0.0000
127	S	L	-0.6906
128	S	L	-0.6735
1	Q	K	-1.1219
2	S	K	-0.1254
3	V	K	1.3232
4	L	K	0.0000
5	T	K	0.0756
6	Q	K	0.0000
7	S	K	-0.7221
8	P	K	-1.0831
9	S	K	-1.0951
11	A	K	-0.8176
12	S	K	-0.3501
13	G	K	-0.7639
14	T	K	-0.5769
15	P	K	-1.2698
16	G	K	-1.9205
17	Q	K	-2.5295
18	R	K	-2.6988
19	V	K	-1.1027
20	T	K	-0.4375
21	I	K	0.0000
22	S	K	-0.4655
23	C	K	0.0000
24	S	K	-0.4583
25	G	K	-0.6844
26	S	K	-1.3935
27	R	K	-2.4286
28	S	K	-1.7984
29	N	K	0.0000
30	I	K	0.0000
35	G	K	-1.3324
36	S	K	-0.8613
37	N	K	-0.0864
38	F	K	1.0354
39	V	K	0.0000
40	Y	K	0.0000
41	W	K	0.0000
42	F	K	0.0000
43	H	K	0.0000
44	Q	K	0.0000
45	L	K	-0.5763
46	P	K	-0.5772
47	G	K	-0.6176
48	T	K	-0.6399
49	A	K	-0.6301
50	P	K	0.0000
51	K	K	-1.3706
52	L	K	0.0000
53	L	K	0.0000
54	I	K	0.0000
55	H	K	0.0000
56	S	K	-0.8265
57	N	K	-1.4245
65	D	K	-2.6059
66	Q	K	-2.5865
67	R	K	-1.8482
68	P	K	-1.0791
69	S	K	-0.7126
70	G	K	-0.7758
71	V	K	-0.8528
72	P	K	-1.2927
74	D	K	-2.1560
75	R	K	-1.5399
76	F	K	0.0000
77	S	K	-1.2675
78	G	K	-1.3818
79	S	K	-1.4063
80	N	K	-1.7270
83	S	K	-1.2119
84	G	K	-1.3746
85	T	K	-1.3964
86	S	K	-1.1063
87	A	K	0.0000
88	S	K	-0.6397
89	L	K	0.0000
90	A	K	-0.5146
91	I	K	0.0000
92	S	K	-1.9277
93	G	K	-2.0110
94	L	K	0.0000
95	R	K	-2.8518
96	S	K	-1.9869
97	E	K	-2.7339
98	D	K	0.0000
99	E	K	-2.5149
100	A	K	0.0000
101	D	K	-1.4317
102	Y	K	0.0000
103	Y	K	0.0000
104	C	K	0.0000
105	A	K	0.0000
106	A	K	0.0000
107	W	K	0.0788
108	D	K	0.0000
109	D	K	-1.7827
110	S	K	-1.1909
113	L	K	-0.3034
114	S	K	-0.7054
115	S	K	0.0000
116	W	K	0.0671
117	V	K	0.7283
118	F	K	0.5128
119	G	K	0.0000
120	G	K	-0.6473
121	G	K	-1.1627
122	T	K	0.0000
123	K	K	-2.2715
124	L	K	0.0000
125	T	K	-1.0912
126	V	K	-0.4275
127	L	K	1.2057