Project name: 15_x11e6_i14e7_i20e6_x4e7

Chain sequence(s)	A: GPGPGAEKLRHLNEKRRFHNGPGPGLDKKQRFHNIRGRWTGPGPGNPAEKLRHLNEKRRFGPGPGSKISEYRHYCYSLYGGPGPGRAHYNIVTFAAYTLQDIVLHLAAYLLMGTLGIVAAYLPARRAEPQAAYVYDFAFRDLAAYRFHNIAGHYAAYCYSLYGTTLAAYKTVLELTEVAAYLLCHEQLSDSEEENDGPGPGQSTHVDIRTLEDLLMGPGPGTPTLHEYMLDLQPETGPGPGLQDIVLHLEPQNEIPGPGPG
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:04:00)
[INFO]       Main:     Simulation completed successfully.                                          (00:04:02)

• Minimal score value: -4.6453
• Maximal score value: 3.0395
• Average score: -0.5837
• Total score value: -152.3451

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	G	A	-0.7383
2	P	A	-1.0132
3	G	A	-1.1639
4	P	A	-1.3537
5	G	A	-1.5266
6	A	A	-1.8818
7	E	A	-3.1918
8	K	A	-2.7979
9	L	A	-1.4403
10	R	A	-3.4260
11	H	A	-3.4148
12	L	A	-2.3359
13	N	A	-3.1718
14	E	A	-4.1169
15	K	A	-4.1038
16	R	A	-4.2408
17	R	A	-3.7427
18	F	A	-1.4852
19	H	A	-2.5520
20	N	A	-2.6829
21	G	A	-1.7541
22	P	A	-1.0716
23	G	A	-0.9945
24	P	A	-0.6319
25	G	A	-0.6436
26	L	A	-0.8154
27	D	A	-2.9282
28	K	A	-3.6140
29	K	A	-3.6169
30	Q	A	-3.1646
31	R	A	-3.1175
32	F	A	-1.2412
33	H	A	-2.6164
34	N	A	-2.5480
35	I	A	-1.0122
36	R	A	-2.2296
37	G	A	-2.0009
38	R	A	-2.2102
39	W	A	-0.4393
40	T	A	-0.7440
41	G	A	-0.8900
42	P	A	-0.6301
43	G	A	-1.0456
44	P	A	-1.0789
45	G	A	-1.6954
46	N	A	-2.1188
47	P	A	-1.7021
48	A	A	-1.6425
49	E	A	-2.5458
50	K	A	-2.5130
51	L	A	-1.0197
52	R	A	-3.0699
53	H	A	-3.1715
54	L	A	-2.0312
55	N	A	-3.1332
56	E	A	-4.0579
57	K	A	-3.9281
58	R	A	-3.7942
59	R	A	-3.0865
60	F	A	-0.6962
61	G	A	-0.9502
62	P	A	-0.8053
63	G	A	-0.7589
64	P	A	-1.0311
65	G	A	-1.1614
66	S	A	-0.9159
67	K	A	-1.4657
68	I	A	0.3952
69	S	A	-0.9130
70	E	A	-1.7598
71	Y	A	0.2408
72	R	A	-0.8834
73	H	A	-0.5490
74	Y	A	0.9335
75	C	A	1.1252
76	Y	A	1.7003
77	S	A	1.0601
78	L	A	2.0043
79	Y	A	1.9965
80	G	A	0.4378
81	G	A	-0.3371
82	P	A	-0.7587
83	G	A	-1.2248
84	P	A	-1.2584
85	G	A	-1.7412
86	R	A	-2.2587
87	A	A	-1.2503
88	H	A	-0.9566
89	Y	A	1.0057
90	N	A	0.9026
91	I	A	2.8234
92	V	A	3.0197
93	T	A	2.2587
94	F	A	2.6967
95	A	A	1.8086
96	A	A	1.4551
97	Y	A	1.5893
98	T	A	1.0777
99	L	A	1.0602
100	Q	A	0.2100
101	D	A	-0.4536
102	I	A	1.1026
103	V	A	2.1254
104	L	A	1.6927
105	H	A	0.7663
106	L	A	1.9401
107	A	A	1.8794
108	A	A	1.9176
109	Y	A	2.4510
110	L	A	2.2694
111	L	A	2.4079
112	M	A	2.6807
113	G	A	1.8343
114	T	A	2.1144
115	L	A	2.8230
116	G	A	1.5793
117	I	A	2.3382
118	V	A	2.6497
119	A	A	1.6062
120	A	A	1.0711
121	Y	A	0.8631
122	L	A	0.5191
123	P	A	-0.7540
124	A	A	-1.2776
125	R	A	-2.7834
126	R	A	-2.9235
127	A	A	-2.1792
128	E	A	-2.7648
129	P	A	-1.9427
130	Q	A	-1.1687
131	A	A	-0.3443
132	A	A	0.0000
133	Y	A	1.8153
134	V	A	3.0395
135	Y	A	2.0242
136	D	A	1.7418
137	F	A	2.3383
138	A	A	1.2517
139	F	A	1.0875
140	R	A	-0.9957
141	D	A	-1.1012
142	L	A	-0.0463
143	A	A	-0.2005
144	A	A	-0.2351
145	Y	A	0.2557
146	R	A	-0.7509
147	F	A	0.6917
148	H	A	-0.4451
149	N	A	-0.7371
150	I	A	0.1820
151	A	A	0.1481
152	G	A	-0.6363
153	H	A	-0.3394
154	Y	A	0.5288
155	A	A	0.9291
156	A	A	1.0168
157	Y	A	1.9248
158	C	A	1.8388
159	Y	A	2.1890
160	S	A	1.5618
161	L	A	2.1419
162	Y	A	2.0323
163	G	A	0.8525
164	T	A	0.9318
165	T	A	0.9615
166	L	A	1.3741
167	A	A	0.4876
168	A	A	0.6048
169	Y	A	0.7260
170	K	A	-0.8960
171	T	A	-0.3329
172	V	A	0.0369
173	L	A	-0.4037
174	E	A	-1.4341
175	L	A	0.3773
176	T	A	-0.2546
177	E	A	-1.1165
178	V	A	0.4428
179	A	A	0.6679
180	A	A	0.5713
181	Y	A	0.8512
182	L	A	0.7546
183	L	A	1.2575
184	C	A	0.8152
185	H	A	-0.5661
186	E	A	-1.7730
187	Q	A	-1.5640
188	L	A	-0.7162
189	S	A	-2.2677
190	D	A	-3.5342
191	S	A	-2.9991
192	E	A	-4.2087
193	E	A	-4.6453
194	E	A	-4.6032
195	N	A	-4.1251
196	D	A	-3.6848
197	G	A	-2.3369
198	P	A	-1.3646
199	G	A	-1.3507
200	P	A	-1.1678
201	G	A	-1.4236
202	Q	A	-1.8398
203	S	A	-1.3050
204	T	A	-1.0666
205	H	A	-0.9780
206	V	A	-0.0293
207	D	A	-0.6205
208	I	A	0.2720
209	R	A	-1.7445
210	T	A	-1.0255
211	L	A	-0.1976
212	E	A	-1.4777
213	D	A	-1.7422
214	L	A	0.0919
215	L	A	0.9857
216	M	A	0.7583
217	G	A	0.0574
218	P	A	-0.4739
219	G	A	-0.7834
220	P	A	-0.7393
221	G	A	-0.7958
222	T	A	-0.9730
223	P	A	-1.0399
224	T	A	-0.6116
225	L	A	0.0711
226	H	A	-1.2161
227	E	A	-1.5589
228	Y	A	-0.6648
229	M	A	-0.1182
230	L	A	-0.6051
231	D	A	-1.8775
232	L	A	-0.6804
233	Q	A	-1.7084
234	P	A	-1.9034
235	E	A	-2.5418
236	T	A	-1.5736
237	G	A	-1.4288
238	P	A	-1.2373
239	G	A	-1.2547
240	P	A	-0.6629
241	G	A	-0.1169
242	L	A	1.3749
243	Q	A	0.0944
244	D	A	0.2208
245	I	A	1.7002
246	V	A	2.3834
247	L	A	1.5867
248	H	A	0.1938
249	L	A	1.0966
250	E	A	-1.0980
251	P	A	-1.9678
252	Q	A	-2.5856
253	N	A	-2.5161
254	E	A	-2.0145
255	I	A	0.2759
256	P	A	-0.3490
257	G	A	-0.5913
258	P	A	-0.6500
259	G	A	-1.0000
260	P	A	-0.8271
261	G	A	-0.7487