| Chain sequence(s) |
A: GPLLLNPEPELKPTSEYVTPTDLLVVAETDLLTETGHPFRDIVENGKVVVPRVSAYDFDVFLLTLPDPNTLPLPSPDFVNPETEILIWRLLAFKIGVGGPLGKGTYGHPNFNALGDVTNPTEYQHGTADDTQNLSFTPKLKQLFIIGDEPPTGVYTAPAAPEPGLPPGAEPPLEVKRTTIQDGDMADIGFGAKDFKALEPRKDDVPDLILDTTTKRIDLEGMRAEPTGRRMFTYDEYEKSKPVKNLVRDGPDLNPLPAEEPPSKLYVPPPPDSPYAVLPSTDYFTLPDAGEITAEDELFNKPIFLKKTEGKNQGILWHNRLYVTVLDNRRAAIATNRTRTSTPLLDVYDPSNYTTSQSYTREYQLSLILQLCKIPLTPETLALIERIDPSILVDAKLPFIPPVTRPDPLAGLKFREIDLTNSLSTNLSESELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.0689 | |
| 2 | P | A | 0.8876 | |
| 3 | L | A | 2.3435 | |
| 4 | L | A | 2.5023 | |
| 5 | L | A | 1.7366 | |
| 6 | N | A | -0.5422 | |
| 7 | P | A | -1.4050 | |
| 8 | E | A | -2.7097 | |
| 9 | P | A | -2.7393 | |
| 10 | E | A | -2.8753 | |
| 11 | L | A | 0.0000 | |
| 12 | K | A | -2.3505 | |
| 13 | P | A | -1.7906 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.4782 | |
| 16 | E | A | -2.2985 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6374 | |
| 20 | P | A | -0.7562 | |
| 21 | T | A | -0.9167 | |
| 22 | D | A | -1.6579 | |
| 23 | L | A | -0.5298 | |
| 24 | L | A | -0.2368 | |
| 25 | V | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.2727 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2659 | |
| 31 | L | A | 0.3758 | |
| 32 | L | A | 0.0898 | |
| 33 | T | A | -0.2860 | |
| 34 | E | A | -0.6494 | |
| 35 | T | A | -0.3848 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.8429 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -1.0642 | |
| 40 | R | A | -1.8968 | |
| 41 | D | A | -1.0169 | |
| 42 | I | A | 0.6443 | |
| 43 | V | A | 0.7135 | |
| 44 | E | A | -1.4921 | |
| 45 | N | A | -2.1031 | |
| 46 | G | A | -1.4138 | |
| 47 | K | A | -1.1613 | |
| 48 | V | A | 1.1394 | |
| 49 | V | A | 1.5644 | |
| 50 | V | A | 1.1134 | |
| 51 | P | A | 0.0834 | |
| 52 | R | A | -1.0774 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | D | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3702 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.1139 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.1554 | |
| 70 | T | A | -0.4370 | |
| 71 | L | A | -0.0250 | |
| 72 | P | A | -0.0463 | |
| 73 | L | A | 0.0079 | |
| 74 | P | A | -0.2761 | |
| 75 | S | A | -0.6967 | |
| 76 | P | A | -1.1848 | |
| 77 | D | A | -2.0362 | |
| 78 | F | A | -0.9457 | |
| 79 | V | A | 0.0000 | |
| 80 | N | A | -2.3035 | |
| 81 | P | A | -2.0964 | |
| 82 | E | A | -2.4386 | |
| 83 | T | A | -1.5668 | |
| 84 | E | A | -1.5355 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.4003 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.2709 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -1.0374 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -0.7155 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.4403 | |
| 99 | G | A | -0.5518 | |
| 100 | P | A | -0.2101 | |
| 101 | L | A | 0.3985 | |
| 102 | G | A | -0.3116 | |
| 103 | K | A | -0.8653 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.2425 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.7429 | |
| 108 | H | A | -1.5498 | |
| 109 | P | A | -1.8585 | |
| 110 | N | A | -2.7551 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.8271 | |
| 115 | G | A | -0.8828 | |
| 116 | D | A | -1.3061 | |
| 117 | V | A | -0.6927 | |
| 118 | T | A | -1.0100 | |
| 119 | N | A | -1.8474 | |
| 120 | P | A | -1.4725 | |
| 121 | T | A | -1.3581 | |
| 122 | E | A | -2.0318 | |
| 123 | Y | A | -0.2807 | |
| 124 | Q | A | -0.7458 | |
| 125 | H | A | -0.5149 | |
| 126 | G | A | -1.2396 | |
| 127 | T | A | -1.0422 | |
| 128 | A | A | -1.0218 | |
| 129 | D | A | -2.3158 | |
| 130 | D | A | -1.8029 | |
| 131 | T | A | -2.1217 | |
| 132 | Q | A | -2.5855 | |
| 133 | N | A | -2.3748 | |
| 134 | L | A | -1.2329 | |
| 135 | S | A | -0.6830 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.3191 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.0944 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.4788 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.9652 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.0000 | |
| 155 | Y | A | -0.7014 | |
| 156 | T | A | -0.0438 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.0071 | |
| 159 | A | A | -0.1038 | |
| 160 | A | A | -0.5532 | |
| 161 | P | A | -1.0649 | |
| 162 | E | A | -2.0264 | |
| 163 | P | A | -1.2768 | |
| 164 | G | A | -0.8516 | |
| 165 | L | A | -0.6600 | |
| 166 | P | A | -0.5543 | |
| 167 | P | A | -0.7418 | |
| 168 | G | A | -0.7685 | |
| 169 | A | A | -0.8174 | |
| 170 | E | A | -1.5057 | |
| 171 | P | A | -1.1440 | |
| 172 | P | A | -0.4990 | |
| 173 | L | A | 0.6216 | |
| 174 | E | A | 0.1173 | |
| 175 | V | A | 0.8120 | |
| 176 | K | A | -0.8527 | |
| 177 | R | A | -2.0313 | |
| 178 | T | A | -1.1162 | |
| 179 | T | A | -0.6228 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.8924 | |
| 182 | D | A | -1.1086 | |
| 183 | G | A | -0.7946 | |
| 184 | D | A | -0.8382 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3769 | |
| 190 | F | A | -0.0449 | |
| 191 | G | A | -0.5247 | |
| 192 | A | A | -0.5090 | |
| 193 | K | A | -0.6961 | |
| 194 | D | A | -1.2014 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.6811 | |
| 197 | A | A | -1.1470 | |
| 198 | L | A | -1.0888 | |
| 199 | E | A | -1.8220 | |
| 200 | P | A | -1.9972 | |
| 201 | R | A | -2.5905 | |
| 202 | K | A | -2.8643 | |
| 203 | D | A | 0.0000 | |
| 204 | D | A | -1.3149 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.3267 | |
| 208 | L | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6953 | |
| 211 | D | A | -2.1531 | |
| 212 | T | A | -1.2379 | |
| 213 | T | A | -0.8211 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -1.7437 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | L | A | -1.5014 | |
| 220 | E | A | -2.5150 | |
| 221 | G | A | -1.9474 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -3.0721 | |
| 224 | A | A | -1.6863 | |
| 225 | E | A | -1.5496 | |
| 226 | P | A | -1.2199 | |
| 227 | T | A | -1.1725 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.8987 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.8813 | |
| 234 | Y | A | -0.7540 | |
| 235 | D | A | -1.3126 | |
| 236 | E | A | -1.9021 | |
| 237 | Y | A | -1.6349 | |
| 238 | E | A | -2.3935 | |
| 239 | K | A | -2.0869 | |
| 240 | S | A | -1.6573 | |
| 241 | K | A | -1.4183 | |
| 242 | P | A | -0.6074 | |
| 243 | V | A | 0.2324 | |
| 244 | K | A | -1.0420 | |
| 245 | N | A | -0.7339 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5490 | |
| 249 | D | A | -1.1226 | |
| 250 | G | A | -0.8593 | |
| 251 | P | A | -0.6553 | |
| 252 | D | A | -0.5039 | |
| 253 | L | A | 0.1547 | |
| 254 | N | A | -0.7884 | |
| 255 | P | A | -0.4122 | |
| 256 | L | A | 0.1017 | |
| 257 | P | A | -0.9847 | |
| 258 | A | A | -1.0371 | |
| 259 | E | A | -2.7449 | |
| 260 | E | A | -2.9045 | |
| 261 | P | A | -1.6394 | |
| 262 | P | A | -0.6909 | |
| 263 | S | A | -0.7046 | |
| 264 | K | A | -1.1407 | |
| 265 | L | A | 0.8877 | |
| 266 | Y | A | 1.1635 | |
| 267 | V | A | 1.6988 | |
| 268 | P | A | 0.9214 | |
| 269 | P | A | 0.4571 | |
| 270 | P | A | -0.6363 | |
| 271 | P | A | -0.9154 | |
| 272 | D | A | -1.7075 | |
| 273 | S | A | -0.5704 | |
| 274 | P | A | 0.2020 | |
| 275 | Y | A | 1.2430 | |
| 276 | A | A | 0.8400 | |
| 277 | V | A | 2.0272 | |
| 278 | L | A | 1.6219 | |
| 279 | P | A | 0.4015 | |
| 280 | S | A | -0.2068 | |
| 281 | T | A | -0.2341 | |
| 282 | D | A | -0.3918 | |
| 283 | Y | A | 0.8235 | |
| 284 | F | A | 0.2900 | |
| 285 | T | A | -0.1033 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.9732 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -2.0160 | |
| 292 | I | A | -1.0664 | |
| 293 | T | A | -1.0184 | |
| 294 | A | A | -0.9156 | |
| 295 | E | A | -2.1594 | |
| 296 | D | A | -1.7426 | |
| 297 | E | A | -1.2360 | |
| 298 | L | A | -1.0721 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.4854 | |
| 301 | K | A | -1.7947 | |
| 302 | P | A | -0.8075 | |
| 303 | I | A | -0.1299 | |
| 304 | F | A | -0.3912 | |
| 305 | L | A | 0.0000 | |
| 306 | K | A | -2.3784 | |
| 307 | K | A | -3.0002 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.7599 | |
| 310 | G | A | -2.1009 | |
| 311 | K | A | -1.8757 | |
| 312 | N | A | 0.0000 | |
| 313 | Q | A | -1.5743 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9640 | |
| 319 | N | A | -0.9783 | |
| 320 | R | A | -1.0723 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | R | A | -0.2350 | |
| 331 | A | A | 0.0000 | |
| 332 | A | A | -0.1229 | |
| 333 | I | A | -0.0364 | |
| 334 | A | A | -0.2173 | |
| 335 | T | A | -1.0756 | |
| 336 | N | A | -1.9253 | |
| 337 | R | A | -2.5614 | |
| 338 | T | A | -1.5498 | |
| 339 | R | A | -1.0725 | |
| 340 | T | A | -0.7529 | |
| 341 | S | A | -0.0462 | |
| 342 | T | A | 0.2169 | |
| 343 | P | A | 0.5046 | |
| 344 | L | A | 1.9359 | |
| 345 | L | A | 1.9197 | |
| 346 | D | A | 0.3040 | |
| 347 | V | A | 1.9857 | |
| 348 | Y | A | 1.7799 | |
| 349 | D | A | 0.0771 | |
| 350 | P | A | -0.4858 | |
| 351 | S | A | -0.5154 | |
| 352 | N | A | -0.5214 | |
| 353 | Y | A | -0.7990 | |
| 354 | T | A | -0.9685 | |
| 355 | T | A | -1.3003 | |
| 356 | S | A | -1.1919 | |
| 357 | Q | A | -0.9501 | |
| 358 | S | A | -0.3320 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.3904 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.4707 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.7389 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4453 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6123 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8520 | |
| 376 | L | A | -0.8194 | |
| 377 | T | A | -0.7107 | |
| 378 | P | A | -1.0483 | |
| 379 | E | A | -1.9767 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.7686 | |
| 382 | A | A | -1.3432 | |
| 383 | L | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | E | A | -1.5020 | |
| 386 | R | A | -1.7820 | |
| 387 | I | A | -0.6673 | |
| 388 | D | A | -0.7726 | |
| 389 | P | A | -1.0917 | |
| 390 | S | A | -1.0653 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.1479 | |
| 394 | D | A | -2.1583 | |
| 395 | A | A | -1.7046 | |
| 396 | K | A | -1.8432 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.0229 | |
| 399 | F | A | 1.6706 | |
| 400 | I | A | 0.8578 | |
| 401 | P | A | 0.4316 | |
| 402 | P | A | -0.0817 | |
| 403 | V | A | 0.4356 | |
| 404 | T | A | -0.6659 | |
| 405 | R | A | -2.0590 | |
| 406 | P | A | -1.4948 | |
| 407 | D | A | -1.5905 | |
| 408 | P | A | -0.9081 | |
| 409 | L | A | -0.4395 | |
| 410 | A | A | -0.6051 | |
| 411 | G | A | -0.6943 | |
| 412 | L | A | -0.5809 | |
| 413 | K | A | -1.9428 | |
| 414 | F | A | -1.3554 | |
| 415 | R | A | -1.6748 | |
| 416 | E | A | -2.4816 | |
| 417 | I | A | -1.8507 | |
| 418 | D | A | -2.4874 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.2555 | |
| 421 | N | A | -1.5738 | |
| 422 | S | A | -1.2624 | |
| 423 | L | A | -0.3604 | |
| 424 | S | A | -0.7201 | |
| 425 | T | A | -0.5258 | |
| 426 | N | A | -1.4932 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -2.0473 | |
| 429 | E | A | -2.8810 | |
| 430 | S | A | -2.3750 | |
| 431 | E | A | -2.5492 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.5754 | |
| 435 | L | A | -0.9829 | |
| 436 | Y | A | -0.4320 | |
| 437 | L | A | -0.0316 | |
| 438 | N | A | -1.6525 | |
| 439 | R | A | -1.9460 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine